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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:transforming growth factor-beta superfamily mediated signaling pathway
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Accession:PW:0000329 term browser browse the term
Definition:The TGF-beta superfamily of growth factors regulates a broad spectrum of processes such as angiogenesis, embryonic development, cell differentiation, proliferation and wound healing. Binding to two types of serine/threonine receptors and activation of Smad proteins is a common theme. However, ligand-receptor interaction and the identity of the activated Smad protein(s) appear to be member-specific.
Synonyms:related_synonym: Signaling by TGF-beta family members;   TGF-beta superfamily mediated signaling pathway


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transforming growth factor-beta superfamily mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor, type 1 IEA KEGG mmu:04350 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Acvr1c activin A receptor, type IC IEA KEGG mmu:04350 NCBI chr 2:58,157,465...58,247,909
Ensembl chr 2:58,157,465...58,247,907 		JBrowse link
G Acvr2a activin receptor IIA IEA KEGG mmu:04350 NCBI chr 2:48,704,121...48,793,276
Ensembl chr 2:48,704,121...48,793,281 		JBrowse link
G Acvr2b activin receptor IIB IEA KEGG mmu:04350 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Amh anti-Mullerian hormone IEA KEGG mmu:04350 NCBI chr10:80,641,074...80,643,513
Ensembl chr10:80,641,077...80,643,482 		JBrowse link
G Amhr2 anti-Mullerian hormone type 2 receptor IEA KEGG mmu:04350 NCBI chr15:102,353,437...102,363,075
Ensembl chr15:102,353,802...102,363,068 		JBrowse link
G Bmp2 bone morphogenetic protein 2 IEA KEGG mmu:04350 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmp4 bone morphogenetic protein 4 IEA KEGG mmu:04350 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Bmp5 bone morphogenetic protein 5 IEA KEGG mmu:04350 NCBI chr 9:75,682,647...75,807,598
Ensembl chr 9:75,682,646...75,807,592 		JBrowse link
G Bmp6 bone morphogenetic protein 6 IEA KEGG mmu:04350 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Bmp7 bone morphogenetic protein 7 IEA KEGG mmu:04350 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114 		JBrowse link
G Bmp8a bone morphogenetic protein 8a IEA KEGG mmu:04350 NCBI chr 4:123,206,438...123,237,045
Ensembl chr 4:123,206,438...123,237,045 		JBrowse link
G Bmp8b bone morphogenetic protein 8b IEA KEGG mmu:04350 NCBI chr 4:122,998,101...123,019,887
Ensembl chr 4:122,998,958...123,025,892 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor, type 1A IEA KEGG mmu:04350 NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor, type 1B IEA KEGG mmu:04350 NCBI chr 3:141,540,230...141,875,335
Ensembl chr 3:141,542,897...141,875,186 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 IEA KEGG mmu:04350 NCBI chr 1:59,802,721...59,917,240
Ensembl chr 1:59,802,559...59,918,173 		JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B IEA KEGG mmu:04350 NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276 		JBrowse link
G Chrd chordin IEA KEGG mmu:04350 NCBI chr16:20,551,528...20,561,132
Ensembl chr16:20,551,877...20,561,134 		JBrowse link
G Comp cartilage oligomeric matrix protein IEA KEGG mmu:04350 NCBI chr 8:70,826,186...70,834,721
Ensembl chr 8:70,826,208...70,834,716 		JBrowse link
G Crebbp CREB binding protein IEA KEGG mmu:04350 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Cul1 cullin 1 IEA KEGG mmu:04350 NCBI chr 6:47,430,516...47,503,078
Ensembl chr 6:47,430,332...47,503,073 		JBrowse link
G Dcn decorin IEA KEGG mmu:04350 NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005 		JBrowse link
G E2f4 E2F transcription factor 4 IEA KEGG mmu:04350 NCBI chr 8:106,024,295...106,032,002
Ensembl chr 8:106,024,295...106,032,002 		JBrowse link
G E2f5 E2F transcription factor 5 IEA KEGG mmu:04350 NCBI chr 3:14,638,370...14,671,369
Ensembl chr 3:14,643,701...14,671,369 		JBrowse link
G Ep300 E1A binding protein p300 IEA KEGG mmu:04350 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Fst follistatin IEA KEGG mmu:04350 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487 		JBrowse link
G Gdf5 growth differentiation factor 5 IEA KEGG mmu:04350 NCBI chr 2:155,782,943...155,787,204
Ensembl chr 2:155,782,943...155,787,287 		JBrowse link
G Gdf6 growth differentiation factor 6 IEA KEGG mmu:04350 NCBI chr 4:9,844,372...9,862,345
Ensembl chr 4:9,844,372...9,862,345 		JBrowse link
G Gdf7 growth differentiation factor 7 IEA KEGG mmu:04350 NCBI chr12:8,347,918...8,351,954
Ensembl chr12:8,347,918...8,351,954 		JBrowse link
G Gm12844 predicted gene 12844 IEA KEGG mmu:04350 NCBI chr 4:117,585,320...117,586,796
Ensembl chr 4:117,585,915...117,586,496 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein IEA KEGG mmu:04350 NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330 		JBrowse link
G Id2 inhibitor of DNA binding 2 IEA KEGG mmu:04350 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139 		JBrowse link
G Id3 inhibitor of DNA binding 3 IEA KEGG mmu:04350 NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066 		JBrowse link
G Id4 inhibitor of DNA binding 4 IEA KEGG mmu:04350 NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502 		JBrowse link
G Ifng interferon gamma IEA KEGG mmu:04350 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Inhba inhibin beta-A IEA KEGG mmu:04350 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206 		JBrowse link
G Inhbb inhibin beta-B IEA KEGG mmu:04350 NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978 		JBrowse link
G Inhbc inhibin beta-C IEA KEGG mmu:04350 NCBI chr10:127,192,191...127,206,417
Ensembl chr10:127,192,191...127,206,300 		JBrowse link
G Inhbe inhibin beta-E IEA KEGG mmu:04350 NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280 		JBrowse link
G Lefty1 left right determination factor 1 IEA KEGG mmu:04350 NCBI chr 1:180,762,587...180,765,966
Ensembl chr 1:180,762,587...180,765,965 		JBrowse link
G Lefty2 left-right determination factor 2 IEA KEGG mmu:04350 NCBI chr 1:180,720,673...180,726,672
Ensembl chr 1:180,720,673...180,726,668 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 IEA KEGG mmu:04350 NCBI chr17:75,312,475...75,699,507
Ensembl chr17:75,312,563...75,699,507 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 IEA KEGG mmu:04350 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 IEA KEGG mmu:04350 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Myc myelocytomatosis oncogene IEA KEGG mmu:04350 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nodal nodal growth differentiation factor IEA KEGG mmu:04350 NCBI chr10:61,253,751...61,261,117
Ensembl chr10:61,253,751...61,261,117 		JBrowse link
G Nog noggin IEA KEGG mmu:04350 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 IEA KEGG mmu:04350 NCBI chr 3:128,993,527...129,013,243
Ensembl chr 3:128,993,527...129,013,240 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform IEA KEGG mmu:04350 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform IEA KEGG mmu:04350 NCBI chr 8:34,089,672...34,109,831
Ensembl chr 8:34,089,653...34,109,469 		JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha IEA KEGG mmu:04350 NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178 		JBrowse link
G Ppp2r1b protein phosphatase 2, regulatory subunit A, beta IEA KEGG mmu:04350 NCBI chr 9:50,767,946...50,810,625
Ensembl chr 9:50,756,601...50,805,529 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 IEA KEGG mmu:04350 NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 IEA KEGG mmu:04350 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472 		JBrowse link
G Rbx1 ring-box 1 IEA KEGG mmu:04350 NCBI chr15:81,350,517...81,360,570
Ensembl chr15:81,350,497...81,360,570 		JBrowse link
G Rhoa ras homolog family member A IEA KEGG mmu:04350 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 IEA KEGG mmu:04350 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA KEGG mmu:04350 NCBI chr12:16,944,808...17,038,275
Ensembl chr12:16,944,896...17,037,824 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 IEA KEGG mmu:04350 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase, polypeptide 2 IEA KEGG mmu:04350 NCBI chr19:4,206,791...4,213,382
Ensembl chr19:4,203,990...4,213,353 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 IEA KEGG mmu:04350 NCBI chr11:52,121,349...52,137,685
Ensembl chr11:52,122,822...52,137,685 		JBrowse link
G Smad1 SMAD family member 1 IEA KEGG mmu:04350 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147 		JBrowse link
G Smad2 SMAD family member 2 IEA KEGG mmu:04350 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 IEA KEGG mmu:04350 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 IEA KEGG mmu:04350 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smad5 SMAD family member 5 IEA KEGG mmu:04350 NCBI chr13:56,850,804...56,890,191
Ensembl chr13:56,850,823...56,890,190 		JBrowse link
G Smad6 SMAD family member 6 IEA KEGG mmu:04350 NCBI chr 9:63,860,358...63,929,374
Ensembl chr 9:63,860,358...63,929,341 		JBrowse link
G Smad7 SMAD family member 7 IEA KEGG mmu:04350 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Smad9 SMAD family member 9 IEA KEGG mmu:04350 NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 IEA KEGG mmu:04350 NCBI chr 5:144,813,305...144,902,657
Ensembl chr 5:144,813,305...144,902,657 		JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 IEA KEGG mmu:04350 NCBI chr11:106,710,887...106,811,544
Ensembl chr11:106,710,892...106,811,541 		JBrowse link
G Sp1 trans-acting transcription factor 1 IEA KEGG mmu:04350 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Tfdp1 transcription factor Dp 1 IEA KEGG mmu:04350 NCBI chr 8:13,388,273...13,428,448
Ensembl chr 8:13,388,751...13,428,448 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEA KEGG mmu:04350 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEA KEGG mmu:04350 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEA KEGG mmu:04350 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I IEA KEGG mmu:04350 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II IEA KEGG mmu:04350 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Thbs1 thrombospondin 1 IEA KEGG mmu:04350 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Thbs2 thrombospondin 2 IEA KEGG mmu:04350 NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497 		JBrowse link
G Thbs3 thrombospondin 3 IEA KEGG mmu:04350 NCBI chr 3:89,122,470...89,134,148
Ensembl chr 3:89,122,487...89,134,144 		JBrowse link
G Thbs4 thrombospondin 4 IEA KEGG mmu:04350 NCBI chr13:92,888,094...92,931,326
Ensembl chr13:92,888,098...92,931,326 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG mmu:04350 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Zfyve16 zinc finger, FYVE domain containing 16 IEA KEGG mmu:04350 NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376 		JBrowse link
G Zfyve9 zinc finger, FYVE domain containing 9 IEA KEGG mmu:04350 NCBI chr 4:108,494,663...108,642,514
Ensembl chr 4:108,494,663...108,637,995 		JBrowse link
activin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor, type 1 ISS
ISO		 PID
RGD		 PMID:12770730 PID:200029, RGD:1559169 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Acvr1b activin A receptor, type 1B ISS
ISO		 RGD PMID:12770730 PMID:17040568 RGD:1559169, RGD:2315948 NCBI chr15:101,071,953...101,111,565
Ensembl chr15:101,071,948...101,111,565 		JBrowse link
G Acvr2a activin receptor IIA ISS RGD PMID:12770730 RGD:1559169 NCBI chr 2:48,704,121...48,793,276
Ensembl chr 2:48,704,121...48,793,281 		JBrowse link
G Acvr2b activin receptor IIB ISS RGD PMID:12770730 RGD:1559169 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Acvrl1 activin A receptor, type II-like 1 ISS
ISO		 PID
RGD		 PMID:12770730 PID:200029, RGD:1559169 NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217 		JBrowse link
G Fkbp1a FK506 binding protein 1a ISO PID PID:200029 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Smad2 SMAD family member 2 ISS RGD PMID:12770730 RGD:1559169 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 ISS RGD PMID:12770730 RGD:1559169 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II ISO RGD PMID:18313409 PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005, RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
Bone morphogenetic proteins signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein ISO PID PID:200144 NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200144 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404 		JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO PID
RGD		 PMID:16361357 PID:200144, RGD:1580077 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO
IDA		 PID
RGD		 PMID:18985159 PID:200144, RGD:11553861 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO PID PID:200144 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO PID PID:200144 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor, type 1A ISO PID PID:200144 NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor, type 1B ISO PID PID:200144 NCBI chr 3:141,540,230...141,875,335
Ensembl chr 3:141,542,897...141,875,186 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO PID
RGD		 PMID:16361357 PID:200144, RGD:1580077 NCBI chr 1:59,802,721...59,917,240
Ensembl chr 1:59,802,559...59,918,173 		JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist ISO PID PID:200144 NCBI chr 4:82,799,988...82,803,388
Ensembl chr 4:82,799,988...82,803,385 		JBrowse link
G Chrd chordin ISO PID PID:200144 NCBI chr16:20,551,528...20,561,132
Ensembl chr16:20,551,877...20,561,134 		JBrowse link
G Chrdl1 chordin-like 1 ISO PID PID:200144 NCBI chr  X:142,068,670...142,177,282
Ensembl chr  X:142,068,670...142,177,258 		JBrowse link
G Ctdsp1 CTD small phosphatase 1 ISO PID PID:200144 NCBI chr 1:74,430,625...74,436,444
Ensembl chr 1:74,430,668...74,436,444 		JBrowse link
G Ctdsp2 CTD small phosphatase 2 ISO PID PID:200144 NCBI chr10:126,814,586...126,835,844
Ensembl chr10:126,814,586...126,835,844 		JBrowse link
G Ctdspl CTD small phosphatase like ISO PID PID:200144 NCBI chr 9:118,751,313...118,873,187
Ensembl chr 9:118,755,521...118,873,066 		JBrowse link
G Fst follistatin ISO PID PID:200144 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist ISO PID PID:200144 NCBI chr 2:113,579,020...113,588,993
Ensembl chr 2:113,576,509...113,588,991 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200144 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hjv hemojuvelin BMP co-receptor ISO PID PID:200144 NCBI chr 3:96,432,479...96,436,532
Ensembl chr 3:96,432,488...96,436,526 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO PID PID:200144 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO PID PID:200144 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Nog noggin ISO PID PID:200144 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Nup214 nucleoporin 214 ISO PID PID:200144 NCBI chr 2:31,864,446...31,943,204
Ensembl chr 2:31,864,448...31,943,987 		JBrowse link
G Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform ISO PID PID:200144 NCBI chr12:72,804,231...72,846,593
Ensembl chr12:72,804,229...72,846,593 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200144 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO PID PID:200144 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692 		JBrowse link
G Rgma repulsive guidance molecule family member A ISO PID PID:200144 NCBI chr 7:73,025,268...73,069,647
Ensembl chr 7:73,025,257...73,069,647 		JBrowse link
G Rgmb repulsive guidance molecule family member B ISO PID PID:200144 NCBI chr17:16,024,923...16,051,508
Ensembl chr17:16,023,450...16,051,301 		JBrowse link
G Ski ski sarcoma viral oncogene homolog (avian) ISO PID PID:200144 NCBI chr 4:155,238,532...155,307,536
Ensembl chr 4:155,238,532...155,307,049 		JBrowse link
G Slc39a13 solute carrier family 39 (metal ion transporter), member 13 IMP RGD PMID:18985159 RGD:11553861 NCBI chr 2:90,892,136...90,900,754
Ensembl chr 2:90,892,136...90,900,762 		JBrowse link
G Smad1 SMAD family member 1 ISO
IDA		 PID
RGD		 PMID:16361357 PMID:18985159 PID:200144, RGD:1580077, RGD:11553861 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147 		JBrowse link
G Smad4 SMAD family member 4 ISO PID PID:200144 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smad5 SMAD family member 5 ISO
IDA		 PID
RGD		 PMID:16361357 PMID:18985159 PID:200144, RGD:1580077, RGD:11553861 NCBI chr13:56,850,804...56,890,191
Ensembl chr13:56,850,823...56,890,190 		JBrowse link
G Smad6 SMAD family member 6 ISO PID PID:200144 NCBI chr 9:63,860,358...63,929,374
Ensembl chr 9:63,860,358...63,929,341 		JBrowse link
G Smad7 SMAD family member 7 ISO PID PID:200144 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Smad9 SMAD family member 9 ISO PID
RGD		 PMID:16361357 PID:200144, RGD:1580077 NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID PID:200144 NCBI chr 5:144,813,305...144,902,657
Ensembl chr 5:144,813,305...144,902,657 		JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID PID:200144 NCBI chr11:106,710,887...106,811,544
Ensembl chr11:106,710,892...106,811,541 		JBrowse link
G Sostdc1 sclerostin domain containing 1 ISO PID PID:200144 NCBI chr12:36,364,168...36,368,451
Ensembl chr12:36,364,138...36,368,451 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200144 NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200144 NCBI chr10:7,781,412...7,832,039
Ensembl chr10:7,781,417...7,831,994 		JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200144 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
G Zfyve16 zinc finger, FYVE domain containing 16 ISO PID PID:200144 NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376 		JBrowse link
transforming growth factor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1, caveolae protein ISO RGD PMID:29069575 RGD:151347449 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 ISO RGD PMID:29069575 RGD:151347449 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:15066998 RGD:1580519 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IMP RGD PMID:12809600 RGD:2298922 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Arrb2 arrestin, beta 2 ISO PID PID:200227 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Atf3 activating transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236 		JBrowse link
G Axin1 axin 1 ISO PID PID:200227 NCBI chr17:26,350,294...26,414,784
Ensembl chr17:26,357,662...26,414,785 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200227 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200227 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Cav1 caveolin 1, caveolae protein ISO PID PID:200227 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO PID PID:200227 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311 RGD:1625706 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200227 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein ISO PID PID:200227 NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193 		JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO PID PID:200227 NCBI chr17:14,415,492...14,424,595
Ensembl chr17:14,415,314...14,424,566 		JBrowse link
G Daxx Fas death domain-associated protein ISO PID PID:200227 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Dcn decorin ISO RGD PMID:12809600 RGD:2298922 NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005 		JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 ISO PID PID:200227 NCBI chr 2:155,078,453...155,092,197
Ensembl chr 2:155,078,453...155,092,197 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO PID PID:200227 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922 		JBrowse link
G Fkbp1a FK506 binding protein 1a ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr15:76,552,029...76,554,286
Ensembl chr15:76,552,425...76,554,148 		JBrowse link
G Foxo1 forkhead box O1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Foxo4 forkhead box O4 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr  X:100,297,855...100,304,479
Ensembl chr  X:100,298,134...100,304,479 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200227 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423 		JBrowse link
G Itch itchy, E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr 2:154,975,401...155,068,775
Ensembl chr 2:154,975,429...155,068,775 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO PID PID:200227 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like ISO PID PID:200227 NCBI chr18:65,017,551...65,350,888
Ensembl chr18:65,020,776...65,350,899 		JBrowse link
G Ocln occludin ISO PID PID:200227 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO PID PID:200227 NCBI chr 8:106,427,780...106,430,126
Ensembl chr 8:106,427,780...106,430,128 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200227 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898 		JBrowse link
G Pml promyelocytic leukemia ISO PID PID:200227 NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200227 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO PID PID:200227 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ISO PID PID:200227 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform ISO PID PID:200227 NCBI chr 8:34,089,672...34,109,831
Ensembl chr 8:34,089,653...34,109,469 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO PID PID:200227 NCBI chr14:67,251,505...67,309,920
Ensembl chr14:67,251,505...67,309,893 		JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200227 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rnf111 ring finger 111 ISO PID PID:200227 NCBI chr 9:70,332,706...70,411,122
Ensembl chr 9:70,332,706...70,411,007 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 ISO PID PID:200227 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Runx1 runt related transcription factor 1 IMP RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Runx2 runt related transcription factor 2 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Runx3 runt related transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 4:134,847,956...134,905,301
Ensembl chr 4:134,847,963...134,905,301 		JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 ISO PID PID:200227 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334 		JBrowse link
G Skil SKI-like ISO PID PID:200227 NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726 		JBrowse link
G Smad2 SMAD family member 2 ISO PID
RGD		 PMID:16959941 PMID:18684975 PMID:12809600 PMID:12809600 PID:200227, RGD:1599906, RGD:2302517, RGD:2298922, RGD:2298922 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 ISO PID
RGD		 PMID:16891311 PID:200227, RGD:1625706 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 ISO PID
RGD		 PMID:16959941 PMID:12809600 PID:200227, RGD:1599906, RGD:2298922 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smad7 SMAD family member 7 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:144,813,305...144,902,657
Ensembl chr 5:144,813,305...144,902,657 		JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr11:106,710,887...106,811,544
Ensembl chr11:106,710,892...106,811,541 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200227 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882 		JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 ISO PID PID:200227 NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175 		JBrowse link
G Strap serine/threonine kinase receptor associated protein ISO PID PID:200227 NCBI chr 6:137,712,080...137,728,928
Ensembl chr 6:137,712,076...137,728,930 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200227 NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200227 NCBI chr10:7,781,412...7,832,039
Ensembl chr10:7,781,417...7,831,994 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 TAS
ISO		 PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 TAS
ISO		 PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I ISO PID
RGD		 PMID:12809600 PMID:18684975 PID:200227, RGD:2298922, RGD:2302517 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II ISO PID
RGD		 PMID:15109563 PMID:14729511 PMID:18684975 PID:200227, RGD:2298921, RGD:1579921, RGD:2302517 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Tgfbr3 transforming growth factor, beta receptor III ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:107,254,433...107,437,495
Ensembl chr 5:107,254,436...107,437,495 		JBrowse link
G Tgfbrap1 transforming growth factor, beta receptor associated protein 1 ISO PID PID:200227 NCBI chr 1:43,086,360...43,137,788
Ensembl chr 1:43,086,360...43,137,797 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200227 NCBI chr 4:19,608,296...19,709,004
Ensembl chr 4:19,608,303...19,708,993 		JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200227 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
G Yap1 yes-associated protein 1 ISO PID PID:200227 NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide ISO PID PID:200227 NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671 		JBrowse link
G Zfyve16 zinc finger, FYVE domain containing 16 ISO PID PID:200227 NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376 		JBrowse link
G Zfyve9 zinc finger, FYVE domain containing 9 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 4:108,494,663...108,642,514
Ensembl chr 4:108,494,663...108,637,995 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    signaling pathway 2500
      growth factor signaling pathway 529
        transforming growth factor-beta superfamily mediated signaling pathway 153
          Bone morphogenetic proteins signaling pathway + 43
          Nodal signaling pathway 0
          activin signaling pathway 8
          altered transforming growth factor-beta superfamily mediated signaling pathway + 7
          transforming growth factor-beta signaling pathway + 69
paths to the root