Grem1 (gremlin 1, DAN family BMP antagonist) - Rat Genome Database

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Gene: Grem1 (gremlin 1, DAN family BMP antagonist) Mus musculus
Analyze
Symbol: Grem1
Name: gremlin 1, DAN family BMP antagonist
RGD ID: 735959
MGI Page MGI
Description: Enables receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including nephron epithelium morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Located in extracellular space. Colocalizes with cell surface. Is expressed in several structures, including embryo mesenchyme; limb bud; neural ectoderm; sensory organ; and skeleton. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cktsf1b; Cktsf1b1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Dr; Drm; gre; Grem; gremlin 1; gremlin-1; ld
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392113,579,020 - 113,588,993 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2113,576,509 - 113,588,991 (-)EnsemblGRCm39 Ensembl
GRCm382113,748,675 - 113,758,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2113,746,164 - 113,758,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv372113,588,832 - 113,598,805 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362113,549,514 - 113,559,485 (-)NCBIMGSCv36mm8
Celera2114,881,929 - 114,891,879 (-)NCBICelera
Cytogenetic Map2E4NCBI
cM Map257.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenvalerate  (ISO)
furan  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
lead diacetate  (ISO)
mercaptopurine  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
progesterone  (ISO)
Ptaquiloside  (EXP)
purine-6-thiol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IDA)
animal organ morphogenesis  (IBA,IMP)
apoptotic process  (ISO)
cardiac muscle cell differentiation  (IDA)
cardiac muscle cell myoblast differentiation  (IDA)
cell migration involved in sprouting angiogenesis  (IDA)
cell morphogenesis  (ISO)
cell-cell signaling  (IMP)
collagen fibril organization  (ISO)
determination of dorsal identity  (ISO)
embryonic limb morphogenesis  (IMP)
endothelial cell migration  (IDA)
limb development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (IDA)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (IMP,ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of bone mineralization involved in bone maturation  (ISO)
negative regulation of bone remodeling  (ISO)
negative regulation of bone trabecula formation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of DNA-templated transcription  (IMP)
negative regulation of leukocyte chemotaxis  (ISO)
negative regulation of monocyte chemotaxis  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of osteoclast proliferation  (ISO)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of angiogenesis  (IMP,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IDA,IGI)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of NIK/NF-kappaB signaling  (IDA)
positive regulation of peptidyl-tyrosine autophosphorylation  (IDA)
positive regulation of protein tyrosine kinase activity  (IDA)
positive regulation of receptor internalization  (IDA)
positive regulation of signaling receptor activity  (IDA)
positive regulation of telomerase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
proximal/distal pattern formation  (IMP)
regulation of epithelial to mesenchymal transition  (ISO)
regulation of focal adhesion assembly  (IDA)
regulation of stress-activated MAPK cascade  (IDA)
sequestering of BMP from receptor via BMP binding  (IBA)
signal transduction  (IDA)
signal transduction by p53 class mediator  (IGI)
ureteric bud formation  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal digit morphology  (IAGP)
abnormal fibula morphology  (IEA)
abnormal forelimb morphology  (IAGP)
abnormal head development  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb long bone morphology  (IAGP)
abnormal limb mesenchyme morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone morphology  (IEA)
abnormal lung epithelium morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal tail development  (IAGP)
abnormal tibia morphology  (IEA)
abnormal ureteric bud elongation  (IAGP)
abnormal ureteric bud invasion  (IAGP)
abnormal urinary bladder morphology  (IAGP)
absent kidney  (IAGP)
absent metanephros  (IAGP)
absent sclerotome  (IAGP)
absent ureter  (IAGP)
cyanosis  (IAGP)
decreased somite size  (IAGP)
enhanced osteoblast differentiation  (IAGP)
fused metacarpal bones  (IAGP)
fused radius and ulna  (IEA)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
increased apoptosis  (IAGP)
increased bone mineralization  (IAGP)
increased bone ossification  (IAGP)
increased metanephric mesenchyme apoptosis  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
kinked neural tube  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oligodactyly  (IAGP)
open neural tube  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
prenatal lethality  (IAGP)
renal hypoplasia  (IEA)
respiratory distress  (IAGP)
single kidney  (IAGP)
syndactyly  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Yada Y, etal., Int J Dev Biol 2002;46(7):975-82.
Additional References at PubMed
PMID:1643305   PMID:1673046   PMID:2320577   PMID:2612902   PMID:2997621   PMID:7517224   PMID:8792607   PMID:8889548   PMID:9006074   PMID:9234242   PMID:9639362   PMID:9660951  
PMID:10208746   PMID:10349636   PMID:10524628   PMID:10753507   PMID:10802662   PMID:10804186   PMID:10965135   PMID:11042159   PMID:11076861   PMID:11101846   PMID:11217851   PMID:11290528  
PMID:11389830   PMID:11748835   PMID:11850405   PMID:12135612   PMID:12152071   PMID:12175489   PMID:12198547   PMID:12215652   PMID:12399319   PMID:12413903   PMID:12435353   PMID:12435361  
PMID:12477932   PMID:12666204   PMID:12808456   PMID:14507778   PMID:14597661   PMID:14723846   PMID:15071597   PMID:15133038   PMID:15198975   PMID:15201225   PMID:15256670   PMID:15385444  
PMID:15475267   PMID:15489334   PMID:15539560   PMID:15919833   PMID:15930102   PMID:16015334   PMID:16039644   PMID:16120640   PMID:16141072   PMID:16141073   PMID:16308330   PMID:16495310  
PMID:16556916   PMID:16602821   PMID:16606614   PMID:16611729   PMID:16630606   PMID:16672333   PMID:16880207   PMID:16908629   PMID:16987511   PMID:17077323   PMID:17151017   PMID:17164417  
PMID:17166921   PMID:17222543   PMID:17360777   PMID:17400206   PMID:17504940   PMID:17522159   PMID:17537800   PMID:17554679   PMID:17588959   PMID:17714700   PMID:17785465   PMID:17975199  
PMID:17980714   PMID:18028901   PMID:18039967   PMID:18216176   PMID:18359901   PMID:18469115   PMID:18505784   PMID:18545679   PMID:18594511   PMID:18832070   PMID:19085239   PMID:19168674  
PMID:19210962   PMID:19211672   PMID:19229034   PMID:19248778   PMID:19304889   PMID:19383632   PMID:19386268   PMID:19386269   PMID:19401426   PMID:19422820   PMID:19592253   PMID:19660448  
PMID:19776033   PMID:19783740   PMID:19818739   PMID:19877272   PMID:19922873   PMID:20212115   PMID:20359476   PMID:20386744   PMID:20503368   PMID:20660291   PMID:20661431   PMID:20705941  
PMID:20826535   PMID:20920500   PMID:20962035   PMID:21045211   PMID:21068065   PMID:21143873   PMID:21145498   PMID:21209331   PMID:21267068   PMID:21268093   PMID:21281623   PMID:21303853  
PMID:21384471   PMID:21412775   PMID:21465616   PMID:21552539   PMID:21677750   PMID:21725307   PMID:21731775   PMID:21832168   PMID:21873635   PMID:21968101   PMID:21978004   PMID:22114682  
PMID:22174793   PMID:22178153   PMID:22182508   PMID:22228095   PMID:22240098   PMID:22247494   PMID:22302143   PMID:22465667   PMID:22573616   PMID:22644325   PMID:22698544   PMID:22847922  
PMID:22888807   PMID:22912798   PMID:23034633   PMID:23053782   PMID:23213437   PMID:23382810   PMID:23499659   PMID:23548835   PMID:23553804   PMID:23633510   PMID:23633963   PMID:23644062  
PMID:23818325   PMID:23913870   PMID:23994639   PMID:24003215   PMID:24009529   PMID:24160323   PMID:24233491   PMID:24238961   PMID:24302887   PMID:24415953   PMID:24514266   PMID:24700818  
PMID:24705356   PMID:24726283   PMID:24990743   PMID:24995796   PMID:25034710   PMID:25082826   PMID:25194662   PMID:25419707   PMID:25448692   PMID:25594183   PMID:25774506   PMID:25810250  
PMID:26001200   PMID:26141517   PMID:26238476   PMID:26284554   PMID:26495794   PMID:26674308   PMID:26837467   PMID:26930384   PMID:26959361   PMID:27046536   PMID:27352137   PMID:27428020  
PMID:27769098   PMID:27894090   PMID:27979781   PMID:28074039   PMID:28100499   PMID:28264835   PMID:28379358   PMID:28467108   PMID:28530676   PMID:29038301   PMID:29222391   PMID:29292497  
PMID:29315280   PMID:29437042   PMID:29483821   PMID:29593116   PMID:29665134   PMID:29771958   PMID:30021842   PMID:30116001   PMID:30375332   PMID:30926814   PMID:31076486   PMID:31539501  
PMID:31694641   PMID:31843520   PMID:31896583   PMID:32015493   PMID:32098917   PMID:32268095   PMID:32297672   PMID:32467233   PMID:32580008   PMID:33046507   PMID:33729579   PMID:33819486  
PMID:33903764   PMID:34184027   PMID:34548488   PMID:34633599   PMID:34750251   PMID:34878091   PMID:34928956   PMID:35105870   PMID:35768509  


Genomics

Comparative Map Data
Grem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392113,579,020 - 113,588,993 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2113,576,509 - 113,588,991 (-)EnsemblGRCm39 Ensembl
GRCm382113,748,675 - 113,758,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2113,746,164 - 113,758,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv372113,588,832 - 113,598,805 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362113,549,514 - 113,559,485 (-)NCBIMGSCv36mm8
Celera2114,881,929 - 114,891,879 (-)NCBICelera
Cytogenetic Map2E4NCBI
cM Map257.43NCBI
GREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381532,718,004 - 32,745,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1532,718,004 - 32,745,106 (+)EnsemblGRCh38hg38GRCh38
GRCh371533,010,205 - 33,037,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,797,497 - 30,814,158 (+)NCBINCBI36Build 36hg18NCBI36
Build 341530,797,593 - 30,814,158NCBI
Celera159,812,058 - 9,828,720 (+)NCBICelera
Cytogenetic Map15q13.3NCBI
HuRef159,872,067 - 9,888,724 (+)NCBIHuRef
CHM1_11533,128,259 - 33,144,912 (+)NCBICHM1_1
T2T-CHM13v2.01530,514,530 - 30,541,636 (+)NCBIT2T-CHM13v2.0
Grem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23100,512,317 - 100,524,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,512,313 - 100,524,082 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3104,139,268 - 104,150,909 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03112,738,300 - 112,749,941 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03110,428,191 - 110,439,832 (-)NCBIRnor_WKY
Rnor_6.03105,203,309 - 105,214,989 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,203,309 - 105,214,989 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03111,779,965 - 111,791,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4399,597,201 - 99,608,935 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1399,493,630 - 99,505,363 (-)NCBI
Celera399,483,712 - 99,495,442 (-)NCBICelera
Cytogenetic Map3q35NCBI
Grem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554161,812,676 - 1,826,271 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554161,812,725 - 1,825,528 (-)NCBIChiLan1.0ChiLan1.0
GREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11530,051,483 - 30,068,243 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01511,213,870 - 11,230,619 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1302,219,535 - 2,231,868 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl302,222,898 - 2,225,418 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha302,269,149 - 2,281,447 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0302,332,148 - 2,344,441 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1302,268,479 - 2,281,286 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0302,367,729 - 2,380,025 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0302,496,103 - 2,508,404 (-)NCBIUU_Cfam_GSD_1.0
Grem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864080,752,116 - 80,764,323 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366731,394,743 - 1,399,726 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1136,617,105 - 136,629,292 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11136,617,041 - 136,629,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21152,742,118 - 152,749,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,152,097 - 50,169,760 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604890,715,793 - 90,733,042 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248041,608,757 - 1,620,938 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248041,606,182 - 1,620,932 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
UniSTS:234488  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382113,748,722 - 113,748,921UniSTSGRCm38
MGSCv372113,588,879 - 113,589,078UniSTSGRCm37
Celera2114,881,976 - 114,882,175UniSTS
Cytogenetic Map2E4UniSTS
cM Map264.5UniSTS
Grem1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E4UniSTS
cM Map257.43UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112024987128173821Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112024987128173821Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1220
Count of miRNA genes:592
Interacting mature miRNAs:763
Transcripts:ENSMUST00000099575
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000099575   ⟹   ENSMUSP00000097170
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2113,576,509 - 113,588,991 (-)Ensembl
GRCm38.p6 Ensembl2113,746,164 - 113,758,646 (-)Ensembl
RefSeq Acc Id: NM_011824   ⟹   NP_035954
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392113,579,020 - 113,588,993 (-)NCBI
GRCm382113,748,675 - 113,758,648 (-)NCBI
MGSCv372113,588,832 - 113,598,805 (-)RGD
Celera2114,881,929 - 114,891,879 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035954   ⟸   NM_011824
- Peptide Label: precursor
- UniProtKB: O70326 (UniProtKB/Swiss-Prot),   Q3TNY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000097170   ⟸   ENSMUST00000099575
Protein Domains
CTCK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70326-F1-model_v2 AlphaFold O70326 1-184 view protein structure

Promoters
RGD ID:6831541
Promoter ID:MM_KWN:31085
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   MEF_B6
Transcripts:OTTMUST00000035164
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362113,598,451 - 113,598,951 (-)MPROMDB
RGD ID:6878228
Promoter ID:EPDNEW_M2565
Type:multiple initiation site
Name:Grem1_1
Description:Mus musculus gremlin 1, DAN family BMP antagonist , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382113,758,648 - 113,758,708EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344337 AgrOrtholog
Ensembl Genes ENSMUSG00000047926
  ENSMUSG00000074934 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000097170 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000099575 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gremlin-1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1344337 ENTREZGENE
NCBI Gene 23892 ENTREZGENE
Pfam DAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grem1 PhenoGen
PIRSF Gremlin_precursor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GREM1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TNY7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UY25_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Grem1  gremlin 1, DAN family BMP antagonist    gremlin 1  Symbol and/or name change 5135510 APPROVED