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Gene: Bmpr2 (bone morphogenetic protein receptor, type II (serine/threonine kinase)) Mus musculus
Symbol: Bmpr2
Name: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Description: Exhibits BMP receptor activity. Involved in several processes, including circulatory system development; negative regulation of cell proliferation involved in heart valve morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to the cell surface; plasma membrane; and postsynaptic density. Predicted to colocalize with the caveola. Used to study primary pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Is expressed in several structures, including central nervous system; early conceptus; embryo ectoderm; genitourinary system; and lung. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2610024H22Rik; AL117858; AW546137; BB189135; BMP type II receptor; BMP type-2 receptor; BMP-2; BMPR-2; BMPR-II; BMPRII; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2; bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; Gm20272; predicted gene, 20272
Homo sapiens (human) : BMPR2 (bone morphogenetic protein receptor type 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bmpr2 (bone morphogenetic protein receptor type 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmpr2 (bone morphogenetic protein receptor type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BMPR2 (bone morphogenetic protein receptor type 2)
Canis lupus familiaris (dog) : BMPR2 (bone morphogenetic protein receptor type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bmpr2 (bone morphogenetic protein receptor type 2)
Sus scrofa (pig) : BMPR2 (bone morphogenetic protein receptor type 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38159,764,279 - 59,878,081 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37159,821,481 - 59,927,703 (+)NCBIGRCm37mm9NCBIm37
MGSCv36159,709,183 - 59,815,405 (+)NCBImm8
Celera160,279,084 - 60,393,044 (+)NCBICelera
Cytogenetic Map1 C2NCBI
cM Map130.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Bmpr2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735374
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.