Bmpr2 (bone morphogenetic protein receptor, type II (serine/threonine kinase)) - Rat Genome Database

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Gene: Bmpr2 (bone morphogenetic protein receptor, type II (serine/threonine kinase)) Mus musculus
Analyze
Symbol: Bmpr2
Name: bone morphogenetic protein receptor, type II (serine/threonine kinase)
RGD ID: 735374
MGI Page MGI
Description: Enables several functions, including BMP binding activity; BMP receptor activity; and enzyme activator activity. Involved in several processes, including circulatory system development; negative regulation of cell proliferation involved in heart valve morphogenesis; and positive regulation of axon extension involved in axon guidance. Acts upstream of or within several processes, including limb development; maternal placenta development; and mesoderm formation. Located in cell surface; plasma membrane; and postsynaptic density. Is active in clathrin-coated pit. Is expressed in several structures, including central nervous system; early conceptus; embryo ectoderm; genitourinary system; and limb. Used to study primary pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2610024H22Rik; AL117858; AW546137; BB189135; BM; BMP; BMP type II receptor; BMP type-2 receptor; BMP-; BMP-2; BMPR-2; BMPR-II; BMPRII; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2; bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; Gm20272; predicted gene, 20272
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,802,721 - 59,917,240 (+)NCBIGRCm39mm39
GRCm39 Ensembl159,802,559 - 59,918,173 (+)Ensembl
GRCm38159,764,279 - 59,878,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,763,400 - 59,879,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,821,481 - 59,927,703 (+)NCBIGRCm37mm9NCBIm37
MGSCv36159,709,183 - 59,815,405 (+)NCBImm8
Celera160,279,442 - 60,385,822 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (EXP)
CGS 15943  (ISO)
chloroprene  (ISO)
choline  (EXP)
chrysene  (EXP)
clobetasol  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenfluramine  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
fosinopril  (ISO)
iloprost  (ISO)
L-methionine  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methacholine chloride  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
miconazole  (EXP)
monocrotaline  (ISO)
nitrofen  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
Rutecarpine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sunitinib  (ISO)
taurine  (ISO)
tetrachloroethene  (EXP)
tetraphene  (EXP)
titanium dioxide  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IGI,IMP)
aortic valve development  (IMP)
artery development  (IMP)
atrial septum morphogenesis  (IMP)
atrioventricular valve morphogenesis  (IMP)
blood vessel development  (IBA)
blood vessel remodeling  (IMP)
BMP signaling pathway  (IBA,IDA,IMP,ISO)
brain development  (ISO)
cardiac muscle tissue development  (IMP)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to starvation  (ISO)
chondrocyte development  (ISO)
endocardial cushion development  (IMP)
endothelial cell apoptotic process  (ISO)
endothelial cell proliferation  (ISO)
limb development  (IGI)
lung alveolus development  (IMP)
lymphangiogenesis  (IMP)
lymphatic endothelial cell differentiation  (IMP)
maternal placenta development  (IMP)
mesoderm formation  (IMP)
mitral valve morphogenesis  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (IMP)
negative regulation of chondrocyte proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of muscle cell differentiation  (IDA)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of vasoconstriction  (IMP)
osteoblast differentiation  (IDA)
outflow tract morphogenesis  (IMP)
outflow tract septum morphogenesis  (IMP)
pharyngeal arch artery morphogenesis  (IMP)
phosphorylation  (IEA)
positive regulation of axon extension involved in axon guidance  (IMP)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ossification  (IMP)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
protein phosphorylation  (IBA)
pulmonary valve development  (IMP)
regulation of cell population proliferation  (ISO)
regulation of lung blood pressure  (IMP,ISO)
retina development in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (IMP)
semi-lunar valve development  (IMP)
transmembrane receptor protein serine/threonine kinase signaling pathway  (IBA,ISO)
tricuspid valve morphogenesis  (IMP)
venous blood vessel development  (IMP)
ventricular septum morphogenesis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auchene hair morphology  (IAGP)
abnormal awl hair morphology  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair cycle catagen phase  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle melanin granule morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair follicle regression  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair medulla  (IAGP)
abnormal hair medullary septa cells  (IAGP)
abnormal hair shaft melanin granule distribution  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal lung thrombosis  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal motor neuron innervation pattern  (IAGP)
abnormal myocardium compact layer morphology  (IEA)
abnormal ophthalmic nerve morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary artery morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal sternocostal joint morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vibrissa follicle morphology  (IAGP)
abnormal zigzag hair morphology  (IAGP)
absent hair club  (IAGP)
absent hair follicle bulb  (IAGP)
absent heart valves  (IEA)
absent mesoderm  (IAGP)
absent vibrissae  (IAGP)
absent vitelline blood vessels  (IAGP)
alopecia  (IAGP)
artery occlusion  (IAGP)
atrioventricular septal defect  (IEA)
decreased grip strength  (IAGP)
decreased rib number  (IAGP)
delayed bone ossification  (IAGP)
diluted coat color  (IAGP)
disorganized embryonic tissue  (IAGP)
disorganized extraembryonic tissue  (IAGP)
early exit from anagen phase  (IAGP)
early exit from telogen phase  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and placentation, incomplete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
eyelids open at birth  (IAGP)
failure of primitive streak formation  (IAGP)
failure to gastrulate  (IAGP)
heart right ventricle hypertrophy  (IAGP)
hydronephrosis  (IEA)
increased curvature of awl hairs  (IAGP)
increased curvature of guard hairs  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased lung endothelial cell proliferation  (IAGP)
increased pulmonary artery pressure  (IAGP)
increased pulmonary vascular resistance  (IAGP)
increased right ventricle systolic pressure  (IAGP)
increased vascular permeability  (IAGP)
increased vasoconstriction  (IAGP)
interrupted aortic arch  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
long nails  (IAGP)
mosaic coat color  (IAGP)
muscular ventricular septal defect  (IEA)
no abnormal phenotype detected  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosus type i  (IEA)
persistent truncus arteriosus type iv  (IEA)
premature hair regrowth  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary hypertension  (IAGP)
reduced hair shaft melanin granule number  (IAGP)
small melanosome  (IAGP)
striated fur  (IAGP)
thick epidermis  (IAGP)
thin hair shaft  (IAGP)
underdeveloped hair follicles  (IAGP)
vertebral transformation  (IAGP)
References

References - curated
1. Austin ED, etal., Respir Res. 2009 Sep 28;10:87.
2. Charytoniuk DA, etal., Neuroscience. 2000;100(1):33-43.
3. Cogan JD, etal., Genet Med. 2005 Mar;7(3):169-74.
4. Dewachter L, etal., Eur Respir J. 2009 Nov;34(5):1100-10. Epub 2009 Mar 26.
5. Girerd B, etal., Respir Res. 2010 Jun 10;11:73.
6. Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18.
7. Hong KH, etal., Circulation. 2008 Aug 12;118(7):722-30. Epub 2008 Jul 28.
8. Kariyawasam HH, etal., Am J Respir Crit Care Med. 2008 May 15;177(10):1074-81. Epub 2008 Feb 21.
9. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
10. Lewen A, etal., Neuroreport. 1997 Jan 20;8(2):475-9.
11. Lopez-Lopez JG, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):400-7. Epub 2011 Apr 26.
12. MGD and Homologene mouse data transfer
13. MGD data from the GO Consortium
14. MGD IEA
15. Moller T, etal., Scand Cardiovasc J. 2010 Dec;44(6):331-6. Epub 2010 Nov 11.
16. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. OMIM Disease Annotation Pipeline
18. Onishi T, etal., Bone. 1998 Jun;22(6):605-12.
19. Pipeline to import KEGG annotations from KEGG into RGD
20. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
22. Reynolds AM, etal., Eur Respir J. 2012 Feb;39(2):329-43. doi: 10.1183/09031936.00187310. Epub 2011 Jul 7.
23. RGD automated import pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
27. Tian W, etal., Circulation. 2019 Aug 29. doi: 10.1161/CIRCULATIONAHA.119.040629.
28. Wang H, etal., Clin Genet. 2010 Feb;77(2):189-92. Epub 2009 Dec 10.
29. West J, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L744-55. Epub 2008 Aug 22.
Additional References at PubMed
PMID:7671812   PMID:7798324   PMID:8889548   PMID:9207184   PMID:9303341   PMID:9547239   PMID:10349636   PMID:10772805   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11701996  
PMID:11714695   PMID:12117821   PMID:12351174   PMID:12421925   PMID:12441304   PMID:12520002   PMID:12654290   PMID:12666204   PMID:12783783   PMID:14584896   PMID:15031260   PMID:15188402  
PMID:15286002   PMID:15342482   PMID:15538389   PMID:15542835   PMID:15736264   PMID:15752764   PMID:15761153   PMID:15883158   PMID:15913604   PMID:15963767   PMID:16027259   PMID:16141072  
PMID:16141073   PMID:16155937   PMID:16432712   PMID:16497988   PMID:16602821   PMID:16923969   PMID:17114649   PMID:17203235   PMID:17322283   PMID:17347486   PMID:17369292   PMID:17472960  
PMID:17515463   PMID:17662325   PMID:17700526   PMID:17823941   PMID:18024717   PMID:18042551   PMID:18087045   PMID:18483623   PMID:18552156   PMID:18621057   PMID:18725205   PMID:18796535  
PMID:18799693   PMID:18927151   PMID:19139264   PMID:19153222   PMID:19224984   PMID:19246680   PMID:19272526   PMID:19393343   PMID:19409885   PMID:19424179   PMID:19762341   PMID:19897402  
PMID:19903896   PMID:20176805   PMID:20392248   PMID:20493948   PMID:20534673   PMID:20562228   PMID:20663871   PMID:20724539   PMID:20801928   PMID:20837004   PMID:21084449   PMID:21220513  
PMID:21267068   PMID:21503889   PMID:21538804   PMID:21571370   PMID:21576484   PMID:21696628   PMID:21731673   PMID:21821917   PMID:21873635   PMID:21900197   PMID:21976273   PMID:22094042  
PMID:22180660   PMID:22227206   PMID:22307907   PMID:22371328   PMID:22388934   PMID:22427841   PMID:22485132   PMID:22560297   PMID:22611050   PMID:22750402   PMID:23041979   PMID:23103586  
PMID:23341776   PMID:23360989   PMID:23527555   PMID:23559633   PMID:23560082   PMID:23572558   PMID:23610558   PMID:23676271   PMID:23676498   PMID:23712751   PMID:23742019   PMID:23867624  
PMID:24018044   PMID:24052814   PMID:24116187   PMID:24173804   PMID:24224048   PMID:24235143   PMID:24274756   PMID:24314167   PMID:24398041   PMID:24446489   PMID:24491691   PMID:24586530  
PMID:24951762   PMID:24952961   PMID:25075125   PMID:25205038   PMID:25209090   PMID:25354296   PMID:25382630   PMID:25411245   PMID:25514175   PMID:25615642   PMID:25663702   PMID:25670795  
PMID:25765937   PMID:25807483   PMID:25863249   PMID:26030479   PMID:26076038   PMID:26100917   PMID:26321200   PMID:26444546   PMID:26689975   PMID:26774823   PMID:26813283   PMID:26827654  
PMID:27006481   PMID:27030100   PMID:27045138   PMID:27068110   PMID:27273096   PMID:28084316   PMID:28188225   PMID:28232325   PMID:28463231   PMID:28465421   PMID:28578352   PMID:28619995  
PMID:28759002   PMID:28844842   PMID:28922976   PMID:29031500   PMID:29127007   PMID:29352019   PMID:29438559   PMID:29463648   PMID:30352686   PMID:30582451   PMID:30809644   PMID:31129811  
PMID:31291246   PMID:31311865   PMID:31389735   PMID:31724029   PMID:32212159   PMID:32325033   PMID:32350411   PMID:33741934  


Genomics

Comparative Map Data
Bmpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,802,721 - 59,917,240 (+)NCBIGRCm39mm39
GRCm39 Ensembl159,802,559 - 59,918,173 (+)Ensembl
GRCm38159,764,279 - 59,878,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,763,400 - 59,879,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,821,481 - 59,927,703 (+)NCBIGRCm37mm9NCBIm37
MGSCv36159,709,183 - 59,815,405 (+)NCBImm8
Celera160,279,442 - 60,385,822 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.44NCBI
BMPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2202,376,327 - 202,567,751 (+)EnsemblGRCh38hg38GRCh38
GRCh382202,376,310 - 202,567,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372203,241,050 - 203,432,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,949,916 - 203,140,719 (+)NCBINCBI36hg18NCBI36
Build 342203,067,104 - 203,257,979NCBI
Celera2196,992,827 - 197,184,404 (+)NCBI
Cytogenetic Map2q33.1-q33.2NCBI
HuRef2195,088,272 - 195,279,312 (+)NCBIHuRef
CHM1_12203,247,530 - 203,439,226 (+)NCBICHM1_1
Bmpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2961,192,718 - 61,307,280 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl961,190,566 - 61,301,809 (+)Ensembl
Rnor_6.0966,568,074 - 66,683,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0966,371,542 - 66,486,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4958,327,587 - 58,436,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1958,524,438 - 58,554,549 (+)NCBI
Celera958,627,253 - 58,735,336 (+)NCBICelera
Cytogenetic Map9q31NCBI
Bmpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545712,235,780 - 12,316,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545712,235,780 - 12,315,680 (-)NCBIChiLan1.0ChiLan1.0
BMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B207,780,568 - 207,968,900 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,780,741 - 207,961,072 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B89,631,622 - 89,823,438 (+)NCBIMhudiblu_PPA_v0panPan3
BMPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13711,342,292 - 11,540,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3711,342,384 - 11,533,024 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3712,225,170 - 12,423,716 (+)NCBI
ROS_Cfam_1.03711,278,198 - 11,476,750 (+)NCBI
UMICH_Zoey_3.13711,228,404 - 11,433,107 (+)NCBI
UNSW_CanFamBas_1.03711,207,452 - 11,404,742 (+)NCBI
UU_Cfam_GSD_1.03711,200,863 - 11,398,681 (+)NCBI
Bmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303159,573,093 - 159,741,130 (+)NCBI
SpeTri2.0NW_0049367261,543,263 - 1,711,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,970,427 - 106,135,730 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,971,577 - 106,132,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215117,426,776 - 117,589,050 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11088,103,442 - 88,302,578 (+)NCBI
ChlSab1.1 Ensembl1088,106,072 - 88,303,734 (+)Ensembl
Vero_WHO_p1.0NW_023666040111,076,327 - 111,285,567 (-)NCBI
Bmpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476513,849,689 - 13,950,839 (-)NCBI

Position Markers
AW546137  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38159,877,094 - 59,877,191UniSTSGRCm38
MGSCv37159,933,938 - 59,934,035UniSTSGRCm37
Celera160,392,057 - 60,392,154UniSTS
Cytogenetic Map1C1.3UniSTS
Whitehead/MRC_RH1870.57UniSTS
BB189135  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38159,878,828 - 59,878,956UniSTSGRCm38
MGSCv37159,935,672 - 59,935,800UniSTSGRCm37
Celera160,393,791 - 60,393,919UniSTS
Cytogenetic Map1C1.3UniSTS
Whitehead/MRC_RH1870.77UniSTS
Bmpr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C1.3UniSTS
cM Map1 UniSTS
21.MMHAP94FLG3.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38159,786,953 - 59,787,152UniSTSGRCm38
MGSCv37159,843,797 - 59,843,996UniSTSGRCm37
Celera160,301,759 - 60,301,958UniSTS
Cytogenetic Map1C1.3UniSTS
Whitehead_YAC1 UniSTS
D17S756  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38159,785,068 - 59,785,364UniSTSGRCm38
MGSCv37159,841,912 - 59,842,208UniSTSGRCm37
Celera160,299,847 - 60,300,143UniSTS
Cytogenetic Map1C1.3UniSTS
Bmpr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C1.3UniSTS
cM Map1 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12307051073937756Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12551111062907723Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12600000060000000Mouse
1357822Lvrq3_mliver weight QTL 3 (mouse)Not determined13472105773937756Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13472105773937756Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13472105773937756Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13472105773937756Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13472105773937756Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13472105773937756Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13472105773937756Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13909372774477206Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14082884867231097Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14082884867231097Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14082884867231097Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14123396575234112Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14123624075236240Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4222050876220508Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14289887276899008Mouse
12879917Shm3_msperm head morphology 3 (mouse)14414774462907723Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14537861372935898Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5192486670367430Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
4141724Idd5.1_minsulin dependent diabetes susceptibility 5.1 (mouse)Not determined5768911762907723Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir370mmu-miR-370-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22587915

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSMUST00000087435
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000087435   ⟹   ENSMUSP00000084701
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl159,802,559 - 59,918,173 (+)Ensembl
GRCm38.p6 Ensembl159,763,400 - 59,879,014 (+)Ensembl
RefSeq Acc Id: ENSMUST00000186246
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl159,890,636 - 59,895,354 (+)Ensembl
GRCm38.p6 Ensembl159,851,477 - 59,856,195 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190659
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl159,889,824 - 59,891,510 (+)Ensembl
GRCm38.p6 Ensembl159,850,665 - 59,852,351 (+)Ensembl
RefSeq Acc Id: NM_007561   ⟹   NP_031587
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39159,803,438 - 59,917,240 (+)NCBI
GRCm38159,764,279 - 59,878,081 (+)NCBI
MGSCv37159,821,481 - 59,927,703 (+)RGD
Celera160,279,084 - 60,393,044 (+)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495633   ⟹   XP_006495696
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39159,802,721 - 59,916,775 (+)NCBI
GRCm38159,764,311 - 59,877,616 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031587   ⟸   NM_007561
- Peptide Label: precursor
- UniProtKB: O35607 (UniProtKB/Swiss-Prot),   Q3UER5 (UniProtKB/TrEMBL),   Q3UG09 (UniProtKB/TrEMBL),   Q3UU71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495696   ⟸   XM_006495633
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000084701   ⟸   ENSMUST00000087435
Protein Domains
Protein kinase

Promoters
RGD ID:6873854
Promoter ID:EPDNEW_M378
Type:initiation region
Name:Bmpr2_1
Description:Mus musculus bone morphogenetic protein receptor, type II (serine/threoninekinase) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38159,764,279 - 59,764,339EPDNEW
RGD ID:6818025
Promoter ID:MM_KWN:885
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:AK046573_B430105G09RIK,   LINCRNA_21,   NM_007561
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36159,819,946 - 59,821,662 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1095407 AgrOrtholog
Ensembl Genes ENSMUSG00000067336 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000084701 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087435 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BMPR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transform_growth_fac-b_typ-2 UniProtKB/TrEMBL
KEGG Report mmu:12168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1095407 ENTREZGENE
NCBI Gene 12168 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23255:SF97 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmpr2 PhenoGen
PIRSF TGFRII UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BMPR2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UER5 ENTREZGENE, UniProtKB/TrEMBL
  Q3UG09 ENTREZGENE, UniProtKB/TrEMBL
  Q3UU71 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Bmpr2  bone morphogenetic protein receptor, type II (serine/threonine kinase)  Gm20272  predicted gene, 20272  Data Merged 737654 PROVISIONAL
2012-09-19 Bmpr2  bone morphogenetic protein receptor, type II (serine/threonine kinase)  Bmpr2  bone morphogenic protein receptor, type II (serine/threonine kinase)  Symbol and/or name change 5135510 APPROVED