Zfyve16 (zinc finger, FYVE domain containing 16) - Rat Genome Database

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Gene: Zfyve16 (zinc finger, FYVE domain containing 16) Mus musculus
Analyze
Symbol: Zfyve16
Name: zinc finger, FYVE domain containing 16
RGD ID: 1558542
MGI Page MGI
Description: Predicted to enable 1-phosphatidylinositol binding activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in endosomal transport and protein targeting to lysosome. Predicted to be located in cytosol and early endosome. Predicted to be active in early endosome membrane. Is expressed in central nervous system and genitourinary system. Orthologous to human ZFYVE16 (zinc finger FYVE-type containing 16).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AI035632; B130024H06Rik; B130031L15; endofin; endosomal-associated FYVE domain protein; mKIAA0305; zinc finger FYVE domain-containing protein 16
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,624,257 - 92,667,318 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,623,616 - 92,667,376 (-)EnsemblGRCm39 Ensembl
GRCm381392,487,749 - 92,530,810 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,487,108 - 92,530,868 (-)EnsemblGRCm38mm10GRCm38
MGSCv371393,257,704 - 93,300,765 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,588,502 - 93,631,563 (-)NCBIMGSCv36mm8
Celera1396,096,082 - 96,139,872 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
aflatoxin B1  (EXP)
aflatoxin M1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
choline  (EXP)
clorgyline  (ISO)
coumarin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
fenfluramine  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (EXP)
N-nitrosodimethylamine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
succimer  (ISO)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18287559   PMID:21677750   PMID:21873635   PMID:29247407  
PMID:32325033  


Genomics

Comparative Map Data
Zfyve16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,624,257 - 92,667,318 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,623,616 - 92,667,376 (-)EnsemblGRCm39 Ensembl
GRCm381392,487,749 - 92,530,810 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,487,108 - 92,530,868 (-)EnsemblGRCm38mm10GRCm38
MGSCv371393,257,704 - 93,300,765 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,588,502 - 93,631,563 (-)NCBIMGSCv36mm8
Celera1396,096,082 - 96,139,872 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.72NCBI
ZFYVE16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,407,610 - 80,483,379 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,408,013 - 80,483,379 (+)EnsemblGRCh38hg38GRCh38
GRCh37579,703,883 - 79,779,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,739,594 - 79,811,254 (+)NCBINCBI36Build 36hg18NCBI36
Build 34579,739,638 - 79,810,476NCBI
Celera575,605,155 - 75,676,813 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef574,911,945 - 74,983,612 (+)NCBIHuRef
CHM1_1579,136,930 - 79,208,592 (+)NCBICHM1_1
T2T-CHM13v2.0580,891,319 - 80,967,378 (+)NCBIT2T-CHM13v2.0
Zfyve16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,448,264 - 25,495,180 (-)NCBIGRCr8
mRatBN7.2223,713,018 - 23,757,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,713,766 - 23,756,990 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,743,711 - 30,787,027 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,844,064 - 28,887,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,672,210 - 23,715,577 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0222,060,879 - 22,105,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,062,050 - 22,105,710 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,264,066 - 41,308,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,725,949 - 22,769,174 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera219,803,598 - 19,846,829 (-)NCBICelera
Cytogenetic Map2q12NCBI
Zfyve16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541829,353,276 - 29,403,336 (-)NCBIChiLan1.0ChiLan1.0
ZFYVE16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,829,084 - 34,901,988 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,982,728 - 33,054,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,837,410 - 34,910,416 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1535,107,699 - 35,182,606 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl535,111,723 - 35,183,028 (-)Ensemblpanpan1.1panPan2
ZFYVE16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,662,750 - 26,714,184 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,664,068 - 26,699,073 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,900,978 - 27,960,841 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,581,169 - 26,641,100 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,582,965 - 26,635,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,523,973 - 26,581,294 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,492,081 - 26,551,959 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,778,831 - 26,830,351 (-)NCBIUU_Cfam_GSD_1.0
Zfyve16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,748,407 - 182,789,631 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365498,082,464 - 8,110,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFYVE16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,045,362 - 89,106,975 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,044,860 - 89,109,237 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2290,895,666 - 90,954,884 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZFYVE16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,579,573 - 74,644,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl474,579,982 - 74,644,784 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,441,512 - 23,506,157 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfyve16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247431,339,650 - 1,383,883 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfyve16
1324 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:467
Count of miRNA genes:307
Interacting mature miRNAs:361
Transcripts:ENSMUST00000022217, ENSMUST00000136135, ENSMUST00000154850, ENSMUST00000156586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
1301610Dps1_mdelta power in slow-wave sleep 1 (mouse)Not determined137719586295730894Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
12880402Emlq1_memotional learning QTL 1 (mouse)137810885896866553Mouse
12879495Fexq1_mfear expression QTL 1 (mouse)137826885895836553Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse

Markers in Region
41.MMHAP75FLF5.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,487,526 - 92,487,630UniSTSGRCm38
MGSCv371393,257,481 - 93,257,585UniSTSGRCm37
Celera1396,095,859 - 96,095,963UniSTS
Cytogenetic Map13C3UniSTS
Whitehead_YAC13 UniSTS
AI035632  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,488,110 - 92,488,190UniSTSGRCm38
MGSCv371393,258,065 - 93,258,145UniSTSGRCm37
Celera1396,096,443 - 96,096,523UniSTS
Cytogenetic Map13C3UniSTS
Whitehead/MRC_RH13780.68UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000022217   ⟹   ENSMUSP00000022217
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,623,616 - 92,667,376 (-)Ensembl
GRCm38.p6 Ensembl1392,487,108 - 92,530,868 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136135
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,644,632 - 92,646,104 (-)Ensembl
GRCm38.p6 Ensembl1392,508,124 - 92,509,596 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154850
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,650,295 - 92,658,166 (-)Ensembl
GRCm38.p6 Ensembl1392,513,787 - 92,521,658 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156586
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,624,355 - 92,653,582 (-)Ensembl
GRCm38.p6 Ensembl1392,487,847 - 92,517,074 (-)Ensembl
RefSeq Acc Id: NM_173392   ⟹   NP_775568
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,624,257 - 92,667,318 (-)NCBI
GRCm381392,487,749 - 92,530,810 (-)NCBI
MGSCv371393,257,704 - 93,300,765 (-)RGD
Celera1396,096,082 - 96,139,872 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_775568   ⟸   NM_173392
- UniProtKB: Q8BRD2 (UniProtKB/Swiss-Prot),   Q8CG97 (UniProtKB/Swiss-Prot),   Q80U44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022217   ⟸   ENSMUST00000022217
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80U44-F1-model_v2 AlphaFold Q80U44 1-1528 view protein structure

Promoters
RGD ID:8680988
Promoter ID:EPDNEW_M18525
Type:initiation region
Name:Zfyve16_1
Description:Mus musculus zinc finger, FYVE domain containing 16 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381392,530,821 - 92,530,881EPDNEW
RGD ID:6824527
Promoter ID:MM_KWN:14897
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   Brain,   ES_Cell,   Kidney
Transcripts:OTTMUST00000060623
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361393,300,544 - 93,301,044 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2145181 AgrOrtholog
Ensembl Genes ENSMUSG00000021706 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022217 ENTREZGENE
  ENSMUST00000022217.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
  3.30.500.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Domain of unknown function (DUF3480), N-terminal subdomain UniProtKB/Swiss-Prot
InterPro DUF3480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARA/endofin UniProtKB/Swiss-Prot
  Znf_FYVE UniProtKB/Swiss-Prot
  Znf_FYVE-rel UniProtKB/Swiss-Prot
  Znf_FYVE_PHD UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
KEGG Report mmu:218441 UniProtKB/Swiss-Prot
MGD MGI:2145181 ENTREZGENE
NCBI Gene 218441 ENTREZGENE
PANTHER PTHR46319:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYVE UniProtKB/Swiss-Prot
PhenoGen Zfyve16 PhenoGen
PIRSF SARA/endofin UniProtKB/Swiss-Prot
PROSITE ZF_FYVE UniProtKB/Swiss-Prot
SMART DUF3480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYVE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57903 UniProtKB/Swiss-Prot
UniProt Q3TD11_MOUSE UniProtKB/TrEMBL
  Q3UTT2_MOUSE UniProtKB/TrEMBL
  Q80U44 ENTREZGENE
  Q8BRD2 ENTREZGENE
  Q8CG97 ENTREZGENE
  ZFY16_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8BRD2 UniProtKB/Swiss-Prot
  Q8CG97 UniProtKB/Swiss-Prot