Comp (cartilage oligomeric matrix protein) - Rat Genome Database

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Gene: Comp (cartilage oligomeric matrix protein) Mus musculus
Analyze
Symbol: Comp
Name: cartilage oligomeric matrix protein
RGD ID: 10374
MGI Page MGI
Description: Enables BMP binding activity; integrin binding activity; and protease binding activity. Involved in cartilage homeostasis and protein homooligomerization. Acts upstream of or within several processes, including cartilage development; chondrocyte proliferation; and vasculature development. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including connective tissue; embryo mesenchyme; notochord; placenta; and skeletal system. Used to study multiple epiphyseal dysplasia and pseudoachondroplasia. Human ortholog(s) of this gene implicated in carpal tunnel syndrome; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thrombospondin-5; TS; TSP5
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,826,186 - 70,834,721 (+)NCBIGRCm39mm39
GRCm39 Ensembl870,826,208 - 70,834,716 (+)Ensembl
GRCm38870,373,548 - 70,382,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,373,558 - 70,382,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,897,447 - 72,905,965 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,302,547 - 73,311,055 (+)NCBImm8
Celera872,929,973 - 72,938,489 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning, sequencing and expression analysis of mouse cartilage matrix protein cDNA. Aszodi A, etal., Eur J Biochem 1996 Mar 15;236(3):970-7.
2. Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Briggs MD, etal., Nat Genet. 1995 Jul;10(3):330-6.
3. Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia. Hecht JT, etal., Nat Genet. 1995 Jul;10(3):325-9.
4. Matrilin-3 is dispensable for mouse skeletal growth and development. Ko Y, etal., Mol Cell Biol 2004 Feb;24(4):1691-9.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Smits P, etal., Dev Cell 2001 Aug;1(2):277-90.
Additional References at PubMed
PMID:7713493   PMID:9832566   PMID:10579729   PMID:10601736   PMID:11052496   PMID:11117291   PMID:11353399   PMID:11680679   PMID:12024046   PMID:12414734   PMID:12426368   PMID:12477932  
PMID:12837285   PMID:15183430   PMID:16141072   PMID:16537572   PMID:16585064   PMID:16602821   PMID:16611630   PMID:16774856   PMID:16783635   PMID:17307734   PMID:17588960   PMID:18191556  
PMID:18467703   PMID:18802027   PMID:19014566   PMID:19272164   PMID:19767744   PMID:19808781   PMID:19950300   PMID:20033473   PMID:20138147   PMID:20421976   PMID:20466812   PMID:21308778  
PMID:21350216   PMID:21606205   PMID:21624478   PMID:21873635   PMID:21939397   PMID:22006726   PMID:22154935   PMID:22378539   PMID:23098652   PMID:23530037   PMID:23754310   PMID:23951406  
PMID:23956175   PMID:24006456   PMID:24312420   PMID:24460873   PMID:24558358   PMID:24892720   PMID:25133350   PMID:25147951   PMID:25340332   PMID:25712208   PMID:25995382   PMID:26045608  
PMID:26465321   PMID:26746240   PMID:27151399   PMID:27498005   PMID:28860005   PMID:29030641   PMID:29309831   PMID:29867124   PMID:29981303   PMID:30188931   PMID:30502484   PMID:30553437  
PMID:30622267   PMID:30720083   PMID:31199918   PMID:31389735   PMID:31550482   PMID:31961823   PMID:32325033   PMID:32347019   PMID:32686688   PMID:32747625   PMID:33068727   PMID:34983194  
PMID:35468843  


Genomics

Comparative Map Data
Comp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,826,186 - 70,834,721 (+)NCBIGRCm39mm39
GRCm39 Ensembl870,826,208 - 70,834,716 (+)Ensembl
GRCm38870,373,548 - 70,382,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,373,558 - 70,382,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,897,447 - 72,905,965 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,302,547 - 73,311,055 (+)NCBImm8
Celera872,929,973 - 72,938,489 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
COMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,782,773 - 18,791,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1918,782,773 - 18,791,305 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,893,583 - 18,902,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,754,583 - 18,763,114 (-)NCBINCBI36hg18NCBI36
Build 341918,754,583 - 18,763,114NCBI
Celera1918,798,378 - 18,806,909 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,458,025 - 18,466,569 (-)NCBIHuRef
CHM1_11918,893,587 - 18,902,107 (-)NCBICHM1_1
T2T-CHM13v2.01918,918,369 - 18,926,902 (-)NCBI
Comp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21619,047,206 - 19,055,584 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1619,047,207 - 19,055,845 (-)Ensembl
Rnor_6.01620,798,437 - 20,807,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,798,437 - 20,807,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,647,382 - 20,657,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1619,237,609 - 19,245,998 (-)NCBICelera
Cytogenetic Map16p14NCBI
COMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,229,420 - 19,238,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,229,562 - 19,238,008 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,222,270 - 18,230,936 (-)NCBIMhudiblu_PPA_v0panPan3
COMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,306,813 - 44,314,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,306,859 - 44,314,625 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,221,457 - 44,229,145 (+)NCBI
ROS_Cfam_1.02044,793,007 - 44,800,779 (+)NCBI
ROS_Cfam_1.0 Ensembl2044,793,063 - 44,800,711 (+)Ensembl
UMICH_Zoey_3.12044,030,270 - 44,038,042 (+)NCBI
UNSW_CanFamBas_1.02044,440,677 - 44,448,355 (+)NCBI
UU_Cfam_GSD_1.02044,715,955 - 44,723,648 (+)NCBI
LOC101958591
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,995,236 - 203,002,126 (+)NCBI
SpeTri2.0NW_0049365962,544,389 - 2,551,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COMP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,061,426 - 59,069,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,061,409 - 59,068,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,815,756 - 58,823,293 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103234192
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,246,617 - 17,255,561 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl617,246,762 - 17,255,126 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660742,070,833 - 2,079,420 (+)NCBIVero_WHO_p1.0
Comp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,871,002 - 1,877,369 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046249081,870,975 - 1,877,434 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:202
Interacting mature miRNAs:213
Transcripts:ENSMUST00000003659
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000003659   ⟹   ENSMUSP00000003659
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl870,826,208 - 70,834,716 (+)Ensembl
GRCm38.p6 Ensembl870,373,558 - 70,382,066 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212439
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl870,827,688 - 70,828,403 (+)Ensembl
GRCm38.p6 Ensembl870,375,038 - 70,375,753 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212488   ⟹   ENSMUSP00000148712
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl870,832,810 - 70,834,715 (+)Ensembl
GRCm38.p6 Ensembl870,380,160 - 70,382,065 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213072   ⟹   ENSMUSP00000148626
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl870,826,521 - 70,829,117 (+)Ensembl
GRCm38.p6 Ensembl870,373,871 - 70,376,467 (+)Ensembl
RefSeq Acc Id: NM_016685   ⟹   NP_057894
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,826,198 - 70,834,716 (+)NCBI
GRCm38870,373,548 - 70,382,066 (+)ENTREZGENE
MGSCv37872,897,447 - 72,905,965 (+)RGD
Celera872,929,973 - 72,938,489 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509539   ⟹   XP_006509602
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,827,634 - 70,834,717 (+)NCBI
GRCm38870,374,981 - 70,382,066 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153742   ⟹   XP_036009635
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,826,186 - 70,834,721 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057894   ⟸   NM_016685
- Peptide Label: precursor
- UniProtKB: Q9R0G6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509602   ⟸   XM_006509539
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000003659   ⟸   ENSMUST00000003659
RefSeq Acc Id: ENSMUSP00000148626   ⟸   ENSMUST00000213072
RefSeq Acc Id: ENSMUSP00000148712   ⟸   ENSMUST00000212488
RefSeq Acc Id: XP_036009635   ⟸   XM_036153742
- Peptide Label: isoform X1
Protein Domains
COMP   EGF-like   TSP C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0G6-F1-model_v2 AlphaFold Q9R0G6 1-755 view protein structure

Promoters
RGD ID:8667305
Promoter ID:EPDNEW_M11683
Type:single initiation site
Name:Comp_1
Description:Mus musculus cartilage oligomeric matrix protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,373,551 - 70,373,611EPDNEW
RGD ID:6848274
Promoter ID:MM_ACW:47824
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   MEF_B4
Transcripts:COMP.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,898,461 - 72,898,961 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88469 AgrOrtholog
Ensembl Genes ENSMUSG00000031849 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000003659 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148626.2 UniProtKB/TrEMBL
  ENSMUSP00000148712.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000003659 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212488.2 UniProtKB/TrEMBL
  ENSMUST00000213072.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thbs/COMP_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP-5_cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12845 UniProtKB/Swiss-Prot
MGD MGI:88469 ENTREZGENE
NCBI Gene 12845 ENTREZGENE
PANTHER PTHR10199:SF88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Comp PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103647 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RM48_MOUSE UniProtKB/TrEMBL
  A0A1D5RMB8_MOUSE UniProtKB/TrEMBL
  A1A557_MOUSE UniProtKB/TrEMBL
  A2VCQ0_MOUSE UniProtKB/TrEMBL
  COMP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3X8Q4 UniProtKB/Swiss-Prot