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Gene: Comp (cartilage oligomeric matrix protein) Mus musculus
Symbol: Comp
Name: cartilage oligomeric matrix protein
RGD ID: 10374
Description: Exhibits BMP binding activity; integrin binding activity; and protease binding activity. Involved in several processes, including animal organ development; chondrocyte proliferation; and muscle cell development. Localizes to extracellular space and protein-containing complex. Is expressed in bone; cartilage; and knee. Used to study multiple epiphyseal dysplasia and pseudoachondroplasia. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein); PARTICIPATES IN cell-extracellular matrix signaling pathway; malaria pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: thrombospondin-5; TS; TSP5
Homo sapiens (human) : COMP (cartilage oligomeric matrix protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Comp (cartilage oligomeric matrix protein)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : COMP (cartilage oligomeric matrix protein)
Canis lupus familiaris (dog) : COMP (cartilage oligomeric matrix protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Comp (cartilage oligomeric matrix protein)
Sus scrofa (pig) : COMP (cartilage oligomeric matrix protein)
Chlorocebus sabaeus (African green monkey) : COMP (cartilage oligomeric matrix protein)
Heterocephalus glaber (naked mole-rat) : Comp (cartilage oligomeric matrix protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl870,373,558 - 70,382,066 (+)EnsemblGRCm38mm10GRCm38
GRCm38870,373,548 - 70,382,066 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37872,897,447 - 72,905,965 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,302,547 - 73,311,055 (+)NCBImm8
Celera872,929,973 - 72,938,489 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Comp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10374
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.