Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Comp (cartilage oligomeric matrix protein) Mus musculus
Analyze
Symbol: Comp
Name: cartilage oligomeric matrix protein
RGD ID: 10374
Description: Exhibits BMP binding activity; integrin binding activity; and protease binding activity. Involved in several processes, including animal organ development; chondrocyte proliferation; and muscle cell development. Localizes to extracellular space and protein-containing complex. Is expressed in bone; cartilage; and knee. Used to study multiple epiphyseal dysplasia and pseudoachondroplasia. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein); PARTICIPATES IN cell-extracellular matrix signaling pathway; malaria pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: thrombospondin-5; TS; TSP5
Orthologs:
Homo sapiens (human) : COMP (cartilage oligomeric matrix protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Comp (cartilage oligomeric matrix protein)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : COMP (cartilage oligomeric matrix protein)
Canis lupus familiaris (dog) : COMP (cartilage oligomeric matrix protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Comp (cartilage oligomeric matrix protein)
Sus scrofa (pig) : COMP (cartilage oligomeric matrix protein)
Chlorocebus sabaeus (African green monkey) : COMP (cartilage oligomeric matrix protein)
Heterocephalus glaber (naked mole-rat) : Comp (cartilage oligomeric matrix protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl870,373,558 - 70,382,066 (+)EnsemblGRCm38mm10GRCm38
GRCm38870,373,548 - 70,382,066 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37872,897,447 - 72,905,965 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,302,547 - 73,311,055 (+)NCBImm8
Celera872,929,973 - 72,938,489 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Comp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10374
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.