Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | RGD:1304841 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTDSPL mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CTDSPL mRNA | CTD | PMID:22206623 | 1,3-dinitrobenzene | increases expression | ISO | RGD:1304841 | 6480464 | 3-dinitrobenzene results in increased expression of CTDSPL mRNA | CTD | PMID:21983209 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of CTDSPL mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of CTDSPL mRNA | CTD | PMID:17942748 | 2,2',5,5'-tetrachlorobiphenyl | increases expression | ISO | RGD:1304841 | 6480464 | 2 more ... | CTD | PMID:23829299 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1345284 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CTDSPL mRNA | CTD | PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CTDSPL mRNA | CTD | PMID:26377647 | 2,4-dinitrotoluene | affects expression | ISO | RGD:1304841 | 6480464 | 2, 4-dinitrotoluene affects the expression of CTDSPL mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | RGD:1345284 | 6480464 | beta-methylcholine affects the expression of CTDSPL mRNA | CTD | PMID:21179406 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CTDSPL mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1345284 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bis4-hydroxyphenylsulfone results in increased expression of CTDSPL mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | decreases expression | EXP | | 6480464 | Fenretinide results in decreased expression of CTDSPL mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | ISO | RGD:1304841 | 6480464 | Propylthiouracil results in increased expression of CTDSPL mRNA | CTD | PMID:25825206 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of CTDSPL mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | RGD:1345284 | 6480464 | Aflatoxin B1 results in increased methylation of CTDSPL gene, Aflatoxin B1 results in increased methylation of CTDSPL intron | CTD | PMID:27153756, PMID:30157460 | aflatoxin B2 | increases methylation | ISO | RGD:1345284 | 6480464 | aflatoxin B2 results in increased methylation of CTDSPL intron | CTD | PMID:30157460 | antirheumatic drug | increases expression | ISO | RGD:1345284 | 6480464 | Antirheumatic Agents results in increased expression of CTDSPL mRNA | CTD | PMID:24449571 | arachidonic acid | decreases expression | ISO | RGD:1345284 | 6480464 | Arachidonic Acid results in decreased expression of CTDSPL mRNA | CTD | PMID:16704987 | arsane | affects methylation | ISO | RGD:1345284 | 6480464 | Arsenic affects the methylation of CTDSPL gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:1345284 | 6480464 | Arsenic affects the methylation of CTDSPL gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases expression | ISO | RGD:1345284 | 6480464 | Benzoapyrene results in decreased expression of CTDSPL mRNA | CTD | PMID:20064835 | benzo[a]pyrene | decreases methylation | ISO | RGD:1345284 | 6480464 | Benzoapyrene results in decreased methylation of CTDSPL promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | Benzoapyrene promotes the reaction [AHR protein binds to CTDSPL promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzoapyrene results in decreased expression of CTDSPL mRNA | CTD | PMID:19770486 | bisphenol A | increases expression | ISO | RGD:1304841 | 6480464 | bisphenol A results in increased expression of CTDSPL mRNA | CTD | PMID:25181051 | bisphenol A | affects expression | ISO | RGD:1345284 | 6480464 | bisphenol A affects the expression of CTDSPL mRNA | CTD | PMID:30903817 | bisphenol A | increases methylation | ISO | RGD:1304841 | 6480464 | bisphenol A results in increased methylation of CTDSPL gene | CTD | PMID:28505145 | bisphenol F | multiple interactions | ISO | RGD:1345284 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA | CTD | PMID:28628672 | butanal | decreases expression | ISO | RGD:1345284 | 6480464 | butyraldehyde results in decreased expression of CTDSPL mRNA | CTD | PMID:26079696 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of CTDSPL mRNA | CTD | PMID:28472532 | cisplatin | multiple interactions | ISO | RGD:1345284 | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of CTDSPL mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | RGD:1345284 | 6480464 | Cisplatin results in increased expression of CTDSPL mRNA | CTD | PMID:27392435 | copper(II) sulfate | decreases expression | ISO | RGD:1345284 | 6480464 | Copper Sulfate results in decreased expression of CTDSPL mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1345284 | 6480464 | Cyclosporine results in decreased expression of CTDSPL mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | RGD:1345284 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA | CTD | PMID:28628672 | dorsomorphin | multiple interactions | ISO | RGD:1345284 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of CTDSPL mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | ISO | RGD:1304841 | 6480464 | fenvalerate results in increased expression of CTDSPL mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CTDSPL mRNA | CTD | PMID:22206623 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of CTDSPL mRNA | CTD | PMID:25629700 | indometacin | multiple interactions | ISO | RGD:1345284 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA | CTD | PMID:28628672 | mitomycin C | affects response to substance | ISO | RGD:1345284 | 6480464 | CTDSPL protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | nickel atom | decreases expression | ISO | RGD:1345284 | 6480464 | Nickel results in decreased expression of CTDSPL mRNA | CTD | PMID:24768652, PMID:25583101 | oxaliplatin | multiple interactions | ISO | RGD:1304841 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CTDSPL mRNA | CTD | PMID:25729387 | paracetamol | decreases expression | ISO | RGD:1345284 | 6480464 | Acetaminophen results in decreased expression of CTDSPL mRNA | CTD | PMID:21420995 | paricalcitol | multiple interactions | ISO | RGD:1345284 | 6480464 | [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA | CTD | PMID:17715259 | phenobarbital | affects expression | ISO | RGD:1345284 | 6480464 | Phenobarbital affects the expression of CTDSPL mRNA | CTD | PMID:19159669 | phosphorus atom | multiple interactions | ISO | RGD:1345284 | 6480464 | [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA | CTD | PMID:17715259 | phosphorus(.) | multiple interactions | ISO | RGD:1345284 | 6480464 | [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA | CTD | PMID:17715259 | pirinixic acid | multiple interactions | ISO | RGD:1345284 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CTDSPL mRNA | CTD | PMID:19710929 | potassium chromate | decreases expression | ISO | RGD:1345284 | 6480464 | potassium chromateVI results in decreased expression of CTDSPL mRNA | CTD | PMID:22714537 | progesterone | increases expression | ISO | RGD:1345284 | 6480464 | Progesterone results in increased expression of CTDSPL mRNA | CTD | PMID:18497975 | SB 431542 | multiple interactions | ISO | RGD:1345284 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of CTDSPL mRNA | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | RGD:1345284 | 6480464 | Silicon Dioxide results in decreased expression of CTDSPL mRNA | CTD | PMID:25351596 | sodium arsenite | affects methylation | ISO | RGD:1345284 | 6480464 | sodium arsenite affects the methylation of CTDSPL gene | CTD | PMID:28589171 | Soman | decreases expression | ISO | RGD:1304841 | 6480464 | Soman results in decreased expression of CTDSPL mRNA | CTD | PMID:19281266 | sulforaphane | decreases expression | EXP | | 6480464 | sulforafan results in decreased expression of CTDSPL mRNA | CTD | PMID:30529165 | sunitinib | increases expression | ISO | RGD:1345284 | 6480464 | Sunitinib results in increased expression of CTDSPL mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of CTDSPL mRNA | CTD | PMID:17555576 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1345284 | 6480464 | tert-Butylhydroperoxide results in decreased expression of CTDSPL mRNA | CTD | PMID:15336504 | tetrachloromethane | multiple interactions | ISO | RGD:1304841 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTDSPL mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | ISO | RGD:1304841 | 6480464 | Carbon Tetrachloride results in decreased expression of CTDSPL mRNA | CTD | PMID:31150632 | thioacetamide | increases methylation | ISO | RGD:1304841 | 6480464 | Thioacetamide results in increased methylation of CTDSPL promoter | CTD | PMID:27914986 | topotecan | multiple interactions | ISO | RGD:1304841 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CTDSPL mRNA | CTD | PMID:25729387 | triacsin C | decreases expression | ISO | RGD:1345284 | 6480464 | triacsin C results in decreased expression of CTDSPL mRNA | CTD | PMID:16704987 | trichostatin A | increases expression | ISO | RGD:1345284 | 6480464 | trichostatin A results in increased expression of CTDSPL mRNA | CTD | PMID:24935251 | urethane | decreases expression | ISO | RGD:1345284 | 6480464 | Urethane results in decreased expression of CTDSPL mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | RGD:1345284 | 6480464 | Valproic Acid results in increased methylation of CTDSPL gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | RGD:1345284 | 6480464 | Valproic Acid results in increased expression of CTDSPL mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | RGD:1345284 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of CTDSPL mRNA | CTD | PMID:27188386 | vitamin E | increases expression | ISO | RGD:1345284 | 6480464 | Vitamin E results in increased expression of CTDSPL mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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References
References - curated
| 1. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | MGD data from the GO Consortium |
| 3. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 5. | RGD automated import pipeline |
| 6. | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:12477932 | PMID:14610273 | PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:16806845 | PMID:17369397 | PMID:21267068 | PMID:21873635 |
| PMID:22210897 | PMID:24194600 | PMID:27626380 |
Genomics
