Symbol:
Ctdspl
Name:
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
Description:
Predicted to have RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to localize to the nucleus. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human CTDSPL (CTD small phosphatase like); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
2810418J22Rik; AI426263; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD small phosphatase-like protein; CTDSP-like; HYA22; NIF-like protein; NLI-interacting factor 1; nuclear LIM interactor-interacting factor 1; SCP3; small C-terminal domain phosphatase 3; small CTD phosphatase 3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CTDSPL (CTD small phosphatase like) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Ctdspl (CTD small phosphatase like) HGNC
NCBI, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ctdspl (CTD small phosphatase like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CTDSPL (CTD small phosphatase like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CTDSPL (CTD small phosphatase like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ctdspl (CTD small phosphatase like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CTDSPL (CTD small phosphatase like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Ctdspl (CTD small phosphatase like)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Homo sapiens (human):
CTDSPL (CTD small phosphatase like)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
ctdsplb (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
ctdspla (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
CG5830
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
PSR1
Alliance
DIOPT (InParanoid, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
PSR2
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
scpl-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 118,926,536 - 119,044,119 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 118,835,654 - 118,953,237 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 118,775,151 - 118,892,696 (+) NCBI mm8 Celera 9 119,394,549 - 119,512,016 (+) NCBI Celera Cytogenetic Map 9 F3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(+)-schisandrin B multiple interactions ISO RGD:1304841 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTDSPL mRNA] CTD PMID:31150632 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1304841 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CTDSPL mRNA CTD PMID:25729387 1,3-dinitrobenzene increases expression ISO RGD:1304841 6480464 3-dinitrobenzene results in increased expression of CTDSPL mRNA CTD PMID:21983209 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of CTDSPL mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CTDSPL mRNA CTD PMID:17942748 2,2',5,5'-tetrachlorobiphenyl increases expression ISO RGD:1304841 6480464 2 more ... CTD PMID:23829299 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1345284 6480464 Tetrachlorodibenzodioxin results in decreased expression of CTDSPL mRNA CTD PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CTDSPL mRNA CTD PMID:26377647 2,4-dinitrotoluene affects expression ISO RGD:1304841 6480464 2, 4-dinitrotoluene affects the expression of CTDSPL mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1345284 6480464 beta-methylcholine affects the expression of CTDSPL mRNA CTD PMID:21179406 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CTDSPL mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1345284 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA CTD PMID:28628672 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of CTDSPL mRNA CTD PMID:28973697 6-propyl-2-thiouracil increases expression ISO RGD:1304841 6480464 Propylthiouracil results in increased expression of CTDSPL mRNA CTD PMID:25825206 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of CTDSPL mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1345284 6480464 Aflatoxin B1 results in increased methylation of CTDSPL gene, Aflatoxin B1 results in increased methylation of CTDSPL intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 increases methylation ISO RGD:1345284 6480464 aflatoxin B2 results in increased methylation of CTDSPL intron CTD PMID:30157460 antirheumatic drug increases expression ISO RGD:1345284 6480464 Antirheumatic Agents results in increased expression of CTDSPL mRNA CTD PMID:24449571 arachidonic acid decreases expression ISO RGD:1345284 6480464 Arachidonic Acid results in decreased expression of CTDSPL mRNA CTD PMID:16704987 arsane affects methylation ISO RGD:1345284 6480464 Arsenic affects the methylation of CTDSPL gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1345284 6480464 Arsenic affects the methylation of CTDSPL gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:1345284 6480464 Arsenic affects the methylation of CTDSPL gene CTD PMID:25304211 benzo[a]pyrene decreases expression ISO RGD:1345284 6480464 Benzo(a)pyrene results in decreased expression of CTDSPL mRNA CTD PMID:20064835 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to CTDSPL promoter] CTD PMID:19654925 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CTDSPL mRNA CTD PMID:19770486 bisphenol A increases expression ISO RGD:1304841 6480464 bisphenol A results in increased expression of CTDSPL mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:1304841 6480464 bisphenol A results in increased methylation of CTDSPL gene CTD PMID:28505145 bisphenol F multiple interactions ISO RGD:1345284 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA CTD PMID:28628672 butanal decreases expression ISO RGD:1345284 6480464 butyraldehyde results in decreased expression of CTDSPL mRNA CTD PMID:26079696 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of CTDSPL mRNA, Nanotubes, Carbon results in decreased expression of CTDSPL mRNA CTD PMID:25554681 chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of CTDSPL mRNA CTD PMID:28472532 cisplatin multiple interactions ISO RGD:1345284 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of CTDSPL mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:1345284 6480464 Cisplatin results in increased expression of CTDSPL mRNA CTD PMID:27392435 copper(II) sulfate decreases expression ISO RGD:1345284 6480464 Copper Sulfate results in decreased expression of CTDSPL mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1345284 6480464 Cyclosporine results in decreased expression of CTDSPL mRNA CTD PMID:25562108 dexamethasone multiple interactions ISO RGD:1345284 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA CTD PMID:28628672 dorsomorphin multiple interactions ISO RGD:1345284 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTDSPL mRNA CTD PMID:27188386 indometacin multiple interactions ISO RGD:1345284 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTDSPL mRNA CTD PMID:28628672 mitomycin C affects response to substance ISO RGD:1345284 6480464 CTDSPL protein affects the susceptibility to Mitomycin CTD PMID:16217747 nickel atom decreases expression ISO RGD:1345284 6480464 Nickel results in decreased expression of CTDSPL mRNA CTD PMID:24768652 , PMID:25583101 oxaliplatin multiple interactions ISO RGD:1304841 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CTDSPL mRNA CTD PMID:25729387 paracetamol decreases expression ISO RGD:1345284 6480464 Acetaminophen results in decreased expression of CTDSPL mRNA CTD PMID:21420995 paricalcitol multiple interactions ISO RGD:1345284 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA CTD PMID:17715259 phenobarbital affects expression ISO RGD:1345284 6480464 Phenobarbital affects the expression of CTDSPL mRNA CTD PMID:19159669 phosphorus atom multiple interactions ISO RGD:1345284 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA CTD PMID:17715259 phosphorus(.) multiple interactions ISO RGD:1345284 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA CTD PMID:17715259 pirinixic acid multiple interactions ISO RGD:1345284 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CTDSPL mRNA CTD PMID:19710929 potassium chromate decreases expression ISO RGD:1345284 6480464 potassium chromate(VI) results in decreased expression of CTDSPL mRNA CTD PMID:22714537 progesterone increases expression ISO RGD:1345284 6480464 Progesterone results in increased expression of CTDSPL mRNA CTD PMID:18497975 SB 431542 multiple interactions ISO RGD:1345284 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTDSPL mRNA CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:1345284 6480464 Silicon Dioxide results in decreased expression of CTDSPL mRNA CTD PMID:25351596 sodium arsenite affects methylation ISO RGD:1345284 6480464 sodium arsenite affects the methylation of CTDSPL gene CTD PMID:28589171 Soman decreases expression ISO RGD:1304841 6480464 Soman results in decreased expression of CTDSPL mRNA CTD PMID:19281266 sulforaphane decreases expression EXP 6480464 sulforafan results in decreased expression of CTDSPL mRNA CTD PMID:30529165 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of CTDSPL mRNA CTD PMID:17555576 tert-butyl hydroperoxide decreases expression ISO RGD:1345284 6480464 tert-Butylhydroperoxide results in decreased expression of CTDSPL mRNA CTD PMID:15336504 tetrachloromethane multiple interactions ISO RGD:1304841 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTDSPL mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:1304841 6480464 Carbon Tetrachloride results in decreased expression of CTDSPL mRNA CTD PMID:31150632 thioacetamide increases methylation ISO RGD:1304841 6480464 Thioacetamide results in increased methylation of CTDSPL promoter CTD PMID:27914986 topotecan multiple interactions ISO RGD:1304841 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CTDSPL mRNA CTD PMID:25729387 triacsin C decreases expression ISO RGD:1345284 6480464 triacsin C results in decreased expression of CTDSPL mRNA CTD PMID:16704987 trichostatin A increases expression ISO RGD:1345284 6480464 trichostatin A results in increased expression of CTDSPL mRNA CTD PMID:24935251 urethane decreases expression ISO RGD:1345284 6480464 Urethane results in decreased expression of CTDSPL mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:1345284 6480464 Valproic Acid results in increased methylation of CTDSPL gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1345284 6480464 Valproic Acid results in increased expression of CTDSPL mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1345284 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTDSPL mRNA CTD PMID:27188386 vitamin E increases expression ISO RGD:1345284 6480464 Vitamin E results in increased expression of CTDSPL mRNA CTD PMID:19244175 
Gene-Chemical Interaction Annotations
