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Gene: Gdf5 (growth differentiation factor 5) Mus musculus
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Symbol: Gdf5
Name: growth differentiation factor 5
Description: Predicted to have BMP binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in several processes, including limb morphogenesis; negative regulation of mesenchymal cell apoptotic process; and positive regulation of chondrocyte differentiation. Predicted to localize to the extracellular space. Used to study bone disease (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; bone disease (multiple); and proximal symphalangism. Is expressed in several structures, including connective tissue; heart; limb; metanephros; and skeleton. Orthologous to human GDF5 (growth differentiation factor 5).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP-14; bone morphogenetic protein 14; bp; brachypodism; brp; cartilage-derived morphogenetic protein-1; Cdmp-1; GDF-5; growth/differentiation factor 5
Orthologs:
Homo sapiens (human) : GDF5 (growth differentiation factor 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gdf5 (growth differentiation factor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdf5 (growth differentiation factor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GDF5 (growth differentiation factor 5)
Canis lupus familiaris (dog) : GDF5 (growth differentiation factor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdf5 (growth differentiation factor 5)
Sus scrofa (pig) : GDF5 (growth differentiation factor 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl2155,941,023 - 155,945,367 (-)Ensembl
GRCm382155,941,023 - 155,945,367 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372155,766,759 - 155,771,100 (-)NCBIGRCm37mm9NCBIm37
MGSCv362155,632,468 - 155,636,808 (-)NCBImm8
Celera2161,874,286 - 161,878,600 (-)NCBICelera
Cytogenetic Map2 H1NCBI
cM Map277.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gdf5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1622400
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.