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Gene: Gdf5 (growth differentiation factor 5) Mus musculus
Symbol: Gdf5
Name: growth differentiation factor 5
Description: Predicted to have BMP binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in several processes, including limb morphogenesis; negative regulation of mesenchymal cell apoptotic process; and positive regulation of chondrocyte differentiation. Predicted to localize to the extracellular space. Used to study bone disease (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; bone disease (multiple); and proximal symphalangism. Is expressed in several structures, including connective tissue; heart; limb; metanephros; and skeleton. Orthologous to human GDF5 (growth differentiation factor 5).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP-14; bone morphogenetic protein 14; bp; brachypodism; brp; cartilage-derived morphogenetic protein-1; Cdmp-1; GDF-5; growth/differentiation factor 5
Homo sapiens (human) : GDF5 (growth differentiation factor 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gdf5 (growth differentiation factor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdf5 (growth differentiation factor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GDF5 (growth differentiation factor 5)
Canis lupus familiaris (dog) : GDF5 (growth differentiation factor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdf5 (growth differentiation factor 5)
Sus scrofa (pig) : GDF5 (growth differentiation factor 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2155,941,023 - 155,945,367 (-)Ensembl
GRCm382155,941,023 - 155,945,367 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372155,766,759 - 155,771,100 (-)NCBIGRCm37mm9NCBIm37
MGSCv362155,632,468 - 155,636,808 (-)NCBImm8
Celera2161,874,286 - 161,878,600 (-)NCBICelera
Cytogenetic Map2 H1NCBI
cM Map277.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gdf5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1622400
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.