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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:transforming growth factor-beta Smad dependent signaling pathway
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Accession:PW:0000490 term browser browse the term
Definition:Transforming growth factor-beta (TGF-beta) signaling is one of the best characterized modules of the Tgf-b superfamily pathways. Binding to the type II receptor leads to activation of the type I receptor and subsequent activation of the Smad pathway. Nuclear translocation of Smad(s) and interaction with transcription factors leads to activation or repression of many genes.
Synonyms:related_synonym: TGF- beta signaling pathway - SMAD dependent;   TGF-beta Smad dependent signaling pathway
 alt_id: PID:200227;   Reactome:R-HSA-170834
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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IMP RGD PMID:12809600 RGD:2298922 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Arrb2 arrestin, beta 2 ISO PID PID:200227 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Atf3 activating transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236 		JBrowse link
G Axin1 axin 1 ISO PID PID:200227 NCBI chr17:26,350,294...26,414,784
Ensembl chr17:26,357,662...26,414,785 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200227 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200227 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Cav1 caveolin 1, caveolae protein ISO PID PID:200227 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO PID PID:200227 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311 RGD:1625706 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200227 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein ISO PID PID:200227 NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193 		JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO PID PID:200227 NCBI chr17:14,415,492...14,424,595
Ensembl chr17:14,415,314...14,424,566 		JBrowse link
G Daxx Fas death domain-associated protein ISO PID PID:200227 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Dcn decorin ISO RGD PMID:12809600 RGD:2298922 NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005 		JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 ISO PID PID:200227 NCBI chr 2:155,078,453...155,092,197
Ensembl chr 2:155,078,453...155,092,197 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO PID PID:200227 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922 		JBrowse link
G Fkbp1a FK506 binding protein 1a ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr15:76,552,029...76,554,286
Ensembl chr15:76,552,425...76,554,148 		JBrowse link
G Foxo1 forkhead box O1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Foxo4 forkhead box O4 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr  X:100,297,855...100,304,479
Ensembl chr  X:100,298,134...100,304,479 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200227 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423 		JBrowse link
G Itch itchy, E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr 2:154,975,401...155,068,775
Ensembl chr 2:154,975,429...155,068,775 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO PID PID:200227 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like ISO PID PID:200227 NCBI chr18:65,017,551...65,350,888
Ensembl chr18:65,020,776...65,350,899 		JBrowse link
G Ocln occludin ISO PID PID:200227 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO PID PID:200227 NCBI chr 8:106,427,780...106,430,126
Ensembl chr 8:106,427,780...106,430,128 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200227 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898 		JBrowse link
G Pml promyelocytic leukemia ISO PID PID:200227 NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200227 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A ISO PID PID:200227 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ISO PID PID:200227 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform ISO PID PID:200227 NCBI chr 8:34,089,672...34,109,831
Ensembl chr 8:34,089,653...34,109,469 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO PID PID:200227 NCBI chr14:67,251,505...67,309,920
Ensembl chr14:67,251,505...67,309,893 		JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200227 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rnf111 ring finger 111 ISO PID PID:200227 NCBI chr 9:70,332,706...70,411,122
Ensembl chr 9:70,332,706...70,411,007 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 ISO PID PID:200227 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Runx1 runt related transcription factor 1 IMP RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Runx2 runt related transcription factor 2 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Runx3 runt related transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 4:134,847,956...134,905,301
Ensembl chr 4:134,847,963...134,905,301 		JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 ISO PID PID:200227 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334 		JBrowse link
G Skil SKI-like ISO PID PID:200227 NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726 		JBrowse link
G Smad2 SMAD family member 2 ISO PID
RGD		 PMID:16959941 PMID:18684975 PMID:12809600 PMID:12809600 PID:200227, RGD:1599906, RGD:2302517, RGD:2298922, RGD:2298922 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 ISO PID
RGD		 PMID:16891311 PID:200227, RGD:1625706 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 ISO PID
RGD		 PMID:16959941 PMID:12809600 PID:200227, RGD:1599906, RGD:2298922 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smad7 SMAD family member 7 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:144,813,305...144,902,657
Ensembl chr 5:144,813,305...144,902,657 		JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr11:106,710,887...106,811,544
Ensembl chr11:106,710,892...106,811,541 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200227 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882 		JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 ISO PID PID:200227 NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175 		JBrowse link
G Strap serine/threonine kinase receptor associated protein ISO PID PID:200227 NCBI chr 6:137,712,080...137,728,928
Ensembl chr 6:137,712,076...137,728,930 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200227 NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200227 NCBI chr10:7,781,412...7,832,039
Ensembl chr10:7,781,417...7,831,994 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 TAS
ISO		 PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 TAS
ISO		 PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I ISO PID
RGD		 PMID:12809600 PMID:18684975 PID:200227, RGD:2298922, RGD:2302517 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II ISO PID
RGD		 PMID:15109563 PMID:14729511 PMID:18684975 PID:200227, RGD:2298921, RGD:1579921, RGD:2302517 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Tgfbr3 transforming growth factor, beta receptor III ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:107,254,433...107,437,495
Ensembl chr 5:107,254,436...107,437,495 		JBrowse link
G Tgfbrap1 tansforming growth factor, beta receptor associated protein 1 ISO PID PID:200227 NCBI chr 1:43,086,360...43,137,788
Ensembl chr 1:43,086,360...43,137,797 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200227 NCBI chr 4:19,608,296...19,709,004
Ensembl chr 4:19,608,303...19,708,993 		JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200227 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
G Yap1 yes-associated protein 1 ISO PID PID:200227 NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide ISO PID PID:200227 NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671 		JBrowse link
G Zfyve16 zinc finger, FYVE domain containing 16 ISO PID PID:200227 NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376 		JBrowse link
G Zfyve9 zinc finger, FYVE domain containing 9 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 4:108,494,663...108,642,514
Ensembl chr 4:108,494,663...108,637,995 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II ISO RGD PMID:18313409 PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005, RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6071
    signaling pathway 2499
      signaling pathway pertinent to development 536
        transforming growth factor-beta Smad dependent signaling pathway 67
          altered transforming growth factor-beta Smad dependent signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 6071
    signaling pathway 2499
      growth factor signaling pathway 529
        transforming growth factor-beta superfamily mediated signaling pathway 153
          transforming growth factor-beta signaling pathway 69
            transforming growth factor-beta Smad dependent signaling pathway 67
              altered transforming growth factor-beta Smad dependent signaling pathway 7
paths to the root