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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:parthenolide
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Accession:CHEBI:7939 term browser browse the term
Definition:A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
Synonyms:exact_synonym: (1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
 related_synonym: 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone;   Formula=C15H20O3;   InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1;   InChIKey=KTEXNACQROZXEV-PVLRGYAZSA-N;   SMILES=[H][C@@]12CC\\C(C)=C\\CC[C@@]3(C)O[C@]3([H])[C@@]1([H])OC(=O)C2=C
 xref: Beilstein:3550011;   CAS:20554-84-1;   KEGG:C07609;   KNApSAcK:C00003345;   LIPID_MAPS_instance:LMPR0103090002
 xref_mesh: MESH:C002669
 xref: PMID:11410248;   PMID:11837788;   PMID:11961112;   PMID:12417429;   PMID:12628675;   PMID:14501955;   PMID:15501437;   PMID:15616293;   PMID:15987517;   PMID:16778086;   PMID:17051330;   PMID:17200339;   PMID:17986299;   PMID:19201992;   PMID:19555300;   PMID:19949351;   PMID:22688575;   PMID:23065294;   PMID:23192276;   PMID:23264600;   PMID:23688583;   PMID:23746953;   PMID:23792430;   PMID:23797801;   PMID:23876538;   PMID:23898080;   PMID:23933184;   Reaxys:3550011;   Wikipedia:Parthenolide


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parthenolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO parthenolide results in increased expression of BAK1 protein CTD PMID:16024633 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO parthenolide results in increased expression of BAX protein CTD PMID:16024633 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 protein]
parthenolide results in decreased expression of BCL2 mRNA; parthenolide results in decreased expression of BCL2 protein
CTD PMID:20154269 PMID:21928377 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to parthenolide CTD PMID:16024633 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO parthenolide results in increased cleavage of BID protein CTD PMID:16024633 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G C5 complement C5 multiple interactions ISO parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA] CTD PMID:30259999 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein CTD PMID:20154269 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
CTD PMID:15728586 PMID:22748497 PMID:23958496 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 protein]
parthenolide results in decreased expression of CCND1 mRNA; parthenolide results in decreased expression of CCND1 protein
CTD PMID:21928377 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] CTD PMID:20089671 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cfb complement factor B decreases expression ISO parthenolide results in decreased expression of CFB mRNA CTD PMID:16921510 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO parthenolide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA]
parthenolide results in increased expression of CXCL1 mRNA
CTD PMID:17320037 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO parthenolide promotes the reaction [Calcimycin results in increased expression of DDIT3 mRNA]
parthenolide results in increased expression of DDIT3 mRNA
CTD PMID:11360202 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO parthenolide results in decreased expression of FAS mRNA CTD PMID:16024633 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand decreases expression ISO parthenolide results in decreased expression of FASLG mRNA CTD PMID:16024633 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA] CTD PMID:16921510 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 multiple interactions ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of FLT3 mRNA] CTD PMID:21928377 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein CTD PMID:21669866 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO parthenolide inhibits the reaction [resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [resveratrol results in increased expression of ICAM1 mRNA] CTD PMID:22748497 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il12b interleukin 12B decreases expression ISO parthenolide results in decreased expression of IL12B mRNA CTD PMID:16921510 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO parthenolide results in decreased expression of IL1A mRNA CTD PMID:16921510 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO parthenolide inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL1B protein] CTD PMID:24444433 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL6 protein]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of IL6 mRNA]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]
CTD PMID:22748497 PMID:23958496 PMID:24444433 PMID:30259999 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO parthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA] CTD PMID:12574384 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinine co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; parthenolide inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO
EXP
parthenolide results in increased expression of MAPK8 mRNA
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]
parthenolide results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD PMID:16921510 PMID:30259999 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO parthenolide results in increased expression of MAPK9 mRNA CTD PMID:16921510 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter] CTD PMID:20093109 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects localization
multiple interactions
ISO parthenolide affects the localization of NCOR2 protein
SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein]
CTD PMID:21928377 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
CTD PMID:16921510 PMID:18463201 PMID:30259999 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18413660 PMID:18463201 PMID:19303104 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] CTD PMID:30259999 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO parthenolide results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions EXP parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15728586 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein CTD PMID:21669866 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased expression of PTGS2 mRNA]
CTD PMID:19095747 PMID:19303104 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity
ISO
EXP
parthenolide affects the localization of RELA protein
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein modified form]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein]
parthenolide results in decreased activity of RELA protein
[[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein]; parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; SC-203048 promotes the reaction [parthenolide affects the localization of RELA protein]
CTD PMID:16921510 PMID:18413660 PMID:18463201 PMID:19095747 PMID:19284563 PMID:19303104 PMID:20093109 PMID:20154269 PMID:21928377 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rtkn rhotekin multiple interactions ISO parthenolide inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates] CTD PMID:15480428 NCBI chr 4:114,833,453...114,850,705
Ensembl chr 4:114,835,064...114,850,701
JBrowse link
G Sele selectin E decreases expression ISO parthenolide results in decreased expression of SELE mRNA CTD PMID:16921510 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selp selectin P decreases expression ISO parthenolide results in decreased expression of SELP mRNA CTD PMID:16921510 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO parthenolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sts steroid sulfatase multiple interactions ISO parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein CTD PMID:21669866 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tlr5 toll-like receptor 5 decreases expression ISO parthenolide results in decreased expression of TLR5 mRNA CTD PMID:16921510 NCBI chr13:101,364,784...101,385,764
Ensembl chr13:101,381,510...101,385,764
JBrowse link
G Tlr6 toll-like receptor 6 decreases expression ISO parthenolide results in decreased expression of TLR6 mRNA CTD PMID:16921510 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of TNF mRNA]]; parthenolide inhibits the reaction [Resveratrol results in increased expression of TNF mRNA]; parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]
parthenolide results in decreased activity of TNF protein
CTD PMID:19303104 PMID:20093109 PMID:22748497 PMID:30259999 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO parthenolide results in increased expression of TP53 protein CTD PMID:16024633 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO parthenolide results in increased expression of TRADD mRNA CTD PMID:16921510 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA]
parthenolide results in decreased expression of TRAF1 mRNA; parthenolide results in decreased expression of TRAF1 protein
CTD PMID:16921510 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA]
parthenolide results in decreased expression of TRAF2 mRNA; parthenolide results in decreased expression of TRAF2 protein
CTD PMID:16921510 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO parthenolide results in decreased expression of VCAM1 mRNA CTD PMID:16921510 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA] CTD PMID:16921510 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        inhibitor 18274
          parthenolide 60
            3beta-hydroxyparthenolide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic ester 14370
                                        lactone 5993
                                          terpene lactone 1772
                                            sesquiterpene lactone 1621
                                              parthenolide 60
                                                3beta-hydroxyparthenolide 0
paths to the root