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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sesquiterpene lactone
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Accession:CHEBI:37667 term browser browse the term
Definition:Any member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
Synonyms:related_synonym: sesquiterpene lactones


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(+)-artemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases activity		 ISO artemisinin results in increased expression of ABCB1 mRNA
artemisinin results in decreased activity of ABCB1 protein		 CTD PMID:15761118 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Casp3 caspase 3 increases activity EXP artemisinin results in increased activity of CASP3 protein CTD PMID:17948936 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression		 ISO
EXP		 artemisinin results in decreased activity of CYP1A2 protein
artemisinin results in increased expression of CYP1A2 mRNA		 CTD PMID:11124226 PMID:16919048 PMID:17962186 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
increases expression		 ISO artemisinin results in increased activity of CYP2A5 protein
artemisinin results in increased expression of CYP2A5 mRNA		 CTD PMID:16919048 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
increases activity		 EXP
ISO		 artemisinin results in increased expression of CYP2B1 mRNA
artemisinin results in increased expression of CYP2B10 mRNA
artemisinin results in increased activity of CYP2B10 protein		 CTD PMID:16919048 PMID:17962186 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
affects metabolic processing
increases expression		 ISO [artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
CYP2B6 protein affects the metabolism of artemisinin
artemisinin results in increased expression of CYP2B6 mRNA		 CTD PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO artemisinin results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO artemisinin results in increased expression of CYP2E1 mRNA CTD PMID:17962186 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases expression		 ISO [artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of artemisinin
artemisinin results in increased expression of CYP3A4 mRNA		 CTD PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; artemisinin inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO artemisinin results in decreased activity of GSTA1 protein CTD PMID:11807801 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO artemisinin results in decreased activity of GSTP1 protein CTD PMID:11807801 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO artemisinin results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein] CTD PMID:18463201 PMID:23355332 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein] CTD PMID:18463201 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; artemisinin binds to and results in increased activity of NR1I2 protein CTD PMID:15761118 PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
affects expression
affects localization
increases activity		 ISO
EXP		 [artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; artemisinin binds to and results in increased activity of NR1I3 protein; artemisinin binds to and results in increased activity of NR1I3 protein mutant form
artemisinin binds to and results in increased activity of NR1I3 protein; fenvalerate inhibits the reaction [artemisinin binds to and results in increased activity of NR1I3 protein]
artemisinin results in increased expression of NR1I3 mRNA
artemisinin affects the expression of NR1I3 mRNA alternative form
artemisinin affects the localization of NR1I3 protein
artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form
artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein mutant form		 CTD PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 PMID:20686338 More... NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of RELA protein] CTD PMID:18463201 PMID:23355332 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO artemisinin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO artemisinin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO artemisinin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] CTD PMID:27504015 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Tp53 tumor protein p53 increases activity ISO artemisinin results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
alantolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO alantolactone results in increased expression of BAK1 protein CTD PMID:22721982 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression		 ISO alantolactone results in decreased expression of BAX protein
alantolactone results in increased expression of BAX protein		 CTD PMID:22721982 PMID:24252419 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression		 ISO alantolactone results in increased expression of BCL2 protein
alantolactone results in decreased expression of BCL2 protein		 CTD PMID:22721982 PMID:24252419 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO alantolactone results in increased cleavage of BID protein CTD PMID:22721982 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO alantolactone results in increased cleavage of CASP3 protein CTD PMID:22721982 PMID:24252419 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO alantolactone results in increased cleavage of CASP8 protein CTD PMID:22721982 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity		 ISO alantolactone results in increased cleavage of CASP9 protein
alantolactone results in increased activity of CASP9 protein		 CTD PMID:22721982 PMID:24252419 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alantolactone results in increased cleavage of PARP1 protein CTD PMID:22721982 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prss50 serine protease 50 decreases expression ISO alantolactone results in decreased expression of PRSS50 mRNA; alantolactone results in decreased expression of PRSS50 protein CTD PMID:24252419 NCBI chr 8:110,842,525...110,848,855
Ensembl chr 8:110,842,671...110,848,802 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alantolactone results in decreased expression of RELA protein CTD PMID:22721982 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO alantolactone results in increased expression of TP53 protein CTD PMID:22721982 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
alpha-santonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO [Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
artemether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA CTD PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression
multiple interactions		 ISO artemether affects the expression of NR1I3 mRNA alternative form
[Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; Artemether binds to and results in increased activity of NR1I3 protein alternative form		 CTD PMID:24721719 PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
artemotil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression ISO artemotil affects the expression of NR1I3 mRNA alternative form CTD PMID:24721719 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]		 CTD PMID:30551460 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein		 CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein		 CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions		 ISO artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]		 CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression
decreases response to substance		 ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate		 CTD PMID:19513562 PMID:20144594 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation		 ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation		 ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874 		JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Des desmin multiple interactions
decreases expression		 ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein		 CTD PMID:30551460 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Flna filamin A increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression		 ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein		 CTD PMID:30551460 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
multiple interactions		 ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]		 CTD PMID:30551460 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance		 ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate		 CTD PMID:15796179 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases activity
multiple interactions		 ISO Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]		 CTD PMID:30551460 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt2 glutathione S-transferase, theta 2 affects response to substance ISO GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation		 ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] CTD PMID:31664825 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 EXP
ISO		 artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]		 CTD PMID:29031619 PMID:30551460 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Naca nascent polypeptide associated complex subunit alpha decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992 		JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein		 CTD PMID:30551460 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]		 CTD PMID:24704559 PMID:33002460 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:977,885...978,965 JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921 		JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:3,217,184...3,220,192 JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014 		JBrowse link
G Rps15a ribosomal protein S15a decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995 		JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Slc25a19 solute carrier family 25 member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447 		JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein		 CTD PMID:30551460 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions		 ISO Artesunate results in increased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]		 CTD PMID:30551460 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]		 CTD PMID:33259807 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions		 ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]		 CTD PMID:15878303 PMID:33259807 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
multiple interactions		 ISO Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]		 CTD PMID:33002460 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492 		JBrowse link
bilobalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] CTD PMID:18001288 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] CTD PMID:18001288 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 EXP bilobalide results in increased expression of and results in increased activity of CYP1A2 protein
bilobalide results in increased expression of CYP1A2 mRNA		 CTD PMID:18421621 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP bilobalide results in increased expression of CYP2B1 mRNA; bilobalide results in increased expression of CYP2B1 protein CTD PMID:16258077 PMID:18421621 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP bilobalide results in increased expression of CYP2B2 protein CTD PMID:18421621 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity EXP bilobalide results in increased activity of CYP2E1 protein CTD PMID:18421621 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression		 EXP bilobalide results in increased expression of and results in increased activity of CYP3A23-3A1 protein
bilobalide results in increased expression of CYP3A23-3A1 mRNA		 CTD PMID:18421621 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]] CTD PMID:32319158 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]] CTD PMID:32319158 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]] CTD PMID:32319158 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
costunolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity EXP costunolide results in increased activity of CAT protein CTD PMID:20709041 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO costunolide inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26970604 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO costunolide inhibits the reaction [Ethanol results in increased expression of NOS2 protein] CTD PMID:26970604 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO costunolide inhibits the reaction [Ethanol results in decreased expression of PCNA protein] CTD PMID:26970604 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO costunolide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] CTD PMID:26970604 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO costunolide inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26970604 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Cynaropicrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization		 ISO AHR mutant form inhibits the reaction [cynaropicrin affects the localization of NFE2L2 protein]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NFE2L2 mRNA]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA]
cynaropicrin affects the localization of AHR protein		 CTD PMID:25680693 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of CYP1A1 mRNA] CTD PMID:25680693 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
affects localization		 ISO AHR mutant form inhibits the reaction [cynaropicrin affects the localization of NFE2L2 protein]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NFE2L2 mRNA]; NFE2L2 mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA] CTD PMID:25680693 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA] CTD PMID:25680693 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
dehydrocostus lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO dehydrocostus lactone results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein] CTD PMID:19457452 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of NOS2 protein] CTD PMID:26970604 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] CTD PMID:26970604 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26970604 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein] CTD PMID:19457452 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
Eremanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity EXP eremanthin results in increased activity of CAT protein CTD PMID:20709041 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
helenalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression ISO helenalin results in increased expression of ATF4 protein CTD PMID:23123298 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO helenalin inhibits the reaction [CD 437 results in increased activity of CASP3 protein] CTD PMID:16024638 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO helenalin inhibits the reaction [CD 437 results in increased activity of CASP8 protein] CTD PMID:16024638 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD40 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD40 protein] CTD PMID:15894585 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD80 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD80 protein] CTD PMID:15894585 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd83 CD83 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD83 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD83 protein] CTD PMID:15894585 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD86 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD86 protein] CTD PMID:15894585 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO helenalin results in increased expression of DDIT3 protein CTD PMID:23123298 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO helenalin results in increased expression of DDIT4 protein CTD PMID:23123298 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of ICAM1 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of ICAM1 protein]
helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]		 CTD PMID:15894585 PMID:19608869 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL10 protein]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of IL10 protein] CTD PMID:15894585 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:15894585 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL12B protein]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of IL12B protein] CTD PMID:15894585 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO helenalin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:17532054 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO helenalin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein] CTD PMID:16678799 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO helenalin inhibits the reaction [CD 437 results in decreased expression of NFKBIA protein] CTD PMID:16024638 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO helenalin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; helenalin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein] CTD PMID:28495310 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity		 ISO helenalin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; helenalin inhibits the reaction [CD 437 results in increased localization of RELA protein]; helenalin inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein]
helenalin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
helenalin results in decreased activity of RELA protein		 CTD PMID:15930313 PMID:16024638 PMID:18413660 PMID:19608869 PMID:28495310 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO helenalin inhibits the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein] CTD PMID:16540396 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO helenalin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:16678799 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; helenalin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:19608869 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO helenalin inhibits the reaction [CD 437 results in increased expression of TNFRSF10A protein] CTD PMID:16024638 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:19608869 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
inuviscolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO inuviscolide results in decreased expression of BIRC5 protein CTD PMID:17919456 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity ISO inuviscolide results in increased activity of CASP3 protein CTD PMID:17919456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO inuviscolide affects the expression of CCNB1 protein CTD PMID:17919456 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO inuviscolide results in decreased expression of and affects the phosphorylation of CDK1 protein CTD PMID:17919456 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO inuviscolide results in increased expression of CDKN1A protein CTD PMID:17919456 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO inuviscolide results in decreased expression of RELA protein CTD PMID:17919456 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Caffeine inhibits the reaction [inuviscolide results in increased phosphorylation of TP53 protein]; inuviscolide results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:17919456 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
isoalantolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression ISO isoalantolactone results in increased expression of CASP3 protein modified form CTD PMID:29800641 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage
increases expression
multiple interactions		 ISO isoalantolactone results in increased cleavage of CASP7 protein
isoalantolactone results in increased expression of CASP7 protein modified form
Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]		 CTD PMID:29800641 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
increases cleavage		 ISO isoalantolactone results in increased expression of PARP1 protein modified form
Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]
isoalantolactone results in increased cleavage of PARP1 protein		 CTD PMID:29800641 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
Parthenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO parthenin analog results in decreased phosphorylation of AKT1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [parthenin analog results in decreased phosphorylation of AKT1 protein]		 CTD PMID:25196075 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO parthenin analog affects the localization of BAX protein CTD PMID:25196075 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 increases activity ISO parthenin analog results in increased activity of CASP3 protein CTD PMID:25196075 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO parthenin analog results in increased activity of CASP8 protein CTD PMID:25196075 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO parthenin analog results in increased activity of CASP9 protein CTD PMID:25196075 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO parthenin analog results in increased cleavage of DFFA protein CTD PMID:25196075 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO parthenin analog results in decreased phosphorylation of MAPK1 protein CTD PMID:25196075 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO parthenin analog results in decreased phosphorylation of MAPK3 protein CTD PMID:25196075 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO parthenin analog results in increased cleavage of PARP1 protein CTD PMID:25196075 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO parthenin analog results in decreased phosphorylation of RAF1 protein CTD PMID:25196075 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [parthenin analog results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:25196075 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
parthenolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO parthenolide results in increased expression of BAK1 protein CTD PMID:16024633 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO parthenolide results in increased expression of BAX protein CTD PMID:16024633 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 protein]
parthenolide results in decreased expression of BCL2 mRNA; parthenolide results in decreased expression of BCL2 protein		 CTD PMID:20154269 PMID:21928377 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to parthenolide CTD PMID:16024633 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO parthenolide results in increased cleavage of BID protein CTD PMID:16024633 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G C5 complement C5 multiple interactions ISO parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA] CTD PMID:30259999 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein CTD PMID:20154269 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]		 CTD PMID:15728586 PMID:22748497 PMID:23958496 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 protein]
parthenolide results in decreased expression of CCND1 mRNA; parthenolide results in decreased expression of CCND1 protein		 CTD PMID:21928377 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd14 CD14 molecule multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] CTD PMID:20089671 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cfb complement factor B decreases expression ISO parthenolide results in decreased expression of CFB mRNA CTD PMID:16921510 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression		 ISO parthenolide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA]
parthenolide results in increased expression of CXCL1 mRNA		 CTD PMID:17320037 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO parthenolide promotes the reaction [Calcimycin results in increased expression of DDIT3 mRNA]
parthenolide results in increased expression of DDIT3 mRNA		 CTD PMID:11360202 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO parthenolide results in decreased expression of FAS mRNA CTD PMID:16024633 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand decreases expression ISO parthenolide results in decreased expression of FASLG mRNA CTD PMID:16024633 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA] CTD PMID:16921510 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 multiple interactions ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of FLT3 mRNA] CTD PMID:21928377 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein CTD PMID:21669866 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO parthenolide results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO parthenolide inhibits the reaction [resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [resveratrol results in increased expression of ICAM1 mRNA] CTD PMID:22748497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifna1 interferon, alpha 1 decreases expression ISO parthenolide results in decreased expression of IFNA1 mRNA CTD PMID:16921510 NCBI chr 5:103,095,767...103,098,260
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il12b interleukin 12B decreases expression ISO parthenolide results in decreased expression of IL12B mRNA CTD PMID:16921510 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO parthenolide results in decreased expression of IL1A mRNA CTD PMID:16921510 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO parthenolide inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL1B protein] CTD PMID:24444433 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 parthenolide inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL6 protein]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of IL6 mRNA]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]		 CTD PMID:22748497 PMID:23958496 PMID:24444433 PMID:30259999 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO parthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA] CTD PMID:12574384 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; parthenolide inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions		 ISO
EXP		 parthenolide results in increased expression of MAPK8 mRNA
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]
parthenolide results in increased phosphorylation of and results in increased activity of MAPK8 protein		 CTD PMID:16921510 PMID:30259999 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO parthenolide results in increased expression of MAPK9 mRNA CTD PMID:16921510 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter] CTD PMID:20093109 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects localization
multiple interactions		 ISO parthenolide affects the localization of NCOR2 protein
SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein]		 CTD PMID:21928377 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP		 parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]		 CTD PMID:16921510 PMID:18463201 PMID:30259999 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18413660 PMID:18463201 PMID:19303104 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] CTD PMID:30259999 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO parthenolide results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions EXP parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15728586 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein CTD PMID:21669866 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP		 parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased expression of PTGS2 mRNA]		 CTD PMID:19095747 PMID:19303104 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity		 ISO
EXP		 parthenolide affects the localization of RELA protein
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein modified form]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein]
parthenolide results in decreased activity of RELA protein
[[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein]; parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; SC-203048 promotes the reaction [parthenolide affects the localization of RELA protein]		 CTD PMID:16921510 PMID:18413660 PMID:18463201 PMID:19095747 PMID:19284563 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rtkn rhotekin multiple interactions ISO parthenolide inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates] CTD PMID:15480428 NCBI chr 4:115,640,801...115,657,952
Ensembl chr 4:115,640,774...115,657,952 		JBrowse link
G Sele selectin E decreases expression ISO parthenolide results in decreased expression of SELE mRNA CTD PMID:16921510 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selp selectin P decreases expression ISO parthenolide results in decreased expression of SELP mRNA CTD PMID:16921510 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO parthenolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein CTD PMID:21669866 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Tlr5 toll-like receptor 5 decreases expression ISO parthenolide results in decreased expression of TLR5 mRNA CTD PMID:16921510 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tlr6 toll-like receptor 6 decreases expression ISO parthenolide results in decreased expression of TLR6 mRNA CTD PMID:16921510 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO
EXP		 parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of TNF mRNA]]; parthenolide inhibits the reaction [Resveratrol results in increased expression of TNF mRNA]; parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]
parthenolide results in decreased activity of TNF protein		 CTD PMID:19303104 PMID:20093109 PMID:22748497 PMID:30259999 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO parthenolide results in increased expression of TP53 protein CTD PMID:16024633 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO parthenolide results in increased expression of TRADD mRNA CTD PMID:16921510 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
decreases expression		 ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA]
parthenolide results in decreased expression of TRAF1 mRNA; parthenolide results in decreased expression of TRAF1 protein		 CTD PMID:16921510 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions
decreases expression		 ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA]
parthenolide results in decreased expression of TRAF2 mRNA; parthenolide results in decreased expression of TRAF2 protein		 CTD PMID:16921510 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO parthenolide inhibits the reaction [Glupearl 19S results in increased expression of TSLP mRNA] CTD PMID:32493875 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO parthenolide results in decreased expression of VCAM1 mRNA CTD PMID:16921510 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA] CTD PMID:16921510 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
thapsigargin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO Thapsigargin results in increased expression of AARS protein CTD PMID:24648495 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions		 ISO Thapsigargin results in decreased expression of ABCB1 mRNA; Thapsigargin results in decreased expression of ABCB1 protein
1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Thapsigargin results in decreased expression of ABCB1 protein]		 CTD PMID:34915026 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acad11 acyl-CoA dehydrogenase family, member 11 increases expression ISO Thapsigargin results in increased expression of ACAD11 mRNA CTD PMID:22378314 NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560 		JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 decreases expression ISO Thapsigargin results in decreased expression of ACAD9 mRNA CTD PMID:22378314 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression ISO Thapsigargin results in increased expression of ACADVL mRNA CTD PMID:22378314 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression ISO Thapsigargin results in decreased expression of ACAT2 mRNA CTD PMID:22378314 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 increases expression ISO Thapsigargin results in increased expression of ACBD3 mRNA CTD PMID:22378314 NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380 		JBrowse link
G Ackr1 atypical chemokine receptor 1 increases expression ISO Thapsigargin results in increased expression of ACKR1 mRNA CTD PMID:22378314 NCBI chr13:85,782,396...85,786,002
Ensembl chr13:85,782,398...85,783,983 		JBrowse link
G Acly ATP citrate lyase increases expression ISO Thapsigargin results in increased expression of ACLY protein CTD PMID:24648495 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Aco2 aconitase 2 increases expression ISO Thapsigargin results in increased expression of ACO2 protein CTD PMID:24648495 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO Thapsigargin results in decreased expression of ACOT13 mRNA CTD PMID:22378314 NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851 		JBrowse link
G Acot7 acyl-CoA thioesterase 7 decreases expression ISO Thapsigargin results in decreased expression of ACOT7 mRNA CTD PMID:22378314 NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
decreases expression		 ISO Thapsigargin results in increased expression of ACTA2 mRNA
Thapsigargin results in decreased expression of ACTA2 mRNA		 CTD PMID:22378314 PMID:29453283 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actg1 actin, gamma 1 decreases expression ISO Thapsigargin results in decreased expression of ACTG1 mRNA CTD PMID:22378314 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232 		JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO Thapsigargin results in decreased expression of ACTN1 mRNA CTD PMID:22378314 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Acvr1 activin A receptor type 1 increases expression ISO Thapsigargin results in increased expression of ACVR1 mRNA CTD PMID:29453283 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression ISO Thapsigargin results in decreased expression of ADAMTS4 mRNA CTD PMID:22378314 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065 		JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 decreases expression ISO Thapsigargin results in decreased expression of ADAMTS9 mRNA CTD PMID:22378314 NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929 		JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 increases expression ISO Thapsigargin results in increased expression of ADHFE1 mRNA CTD PMID:22378314 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517 		JBrowse link
G Adi1 acireductone dioxygenase 1 decreases expression ISO Thapsigargin results in decreased expression of ADI1 protein CTD PMID:24648495 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842 		JBrowse link
G Adm adrenomedullin decreases expression
increases expression		 ISO Thapsigargin results in decreased expression of ADM mRNA
Thapsigargin results in increased expression of ADM mRNA		 CTD PMID:20682585 PMID:22378314 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adm2 adrenomedullin 2 increases expression ISO Thapsigargin results in increased expression of ADM2 mRNA CTD PMID:22378314 NCBI chr 7:120,393,219...120,394,965
Ensembl chr 7:120,393,179...120,396,331 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] CTD PMID:10742289 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Afap1 actin filament associated protein 1 increases expression ISO Thapsigargin results in increased expression of AFAP1 protein CTD PMID:24648495 NCBI chr14:74,743,322...74,856,295
Ensembl chr14:74,743,320...74,856,263 		JBrowse link
G Afdn afadin, adherens junction formation factor increases expression ISO Thapsigargin results in increased expression of AFDN protein CTD PMID:24648495 NCBI chr 1:53,884,711...54,034,216
Ensembl chr 1:53,905,373...54,034,216 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 multiple interactions
affects localization		 ISO Cycloheximide inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] CTD PMID:29576526 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ahnak AHNAK nucleoprotein increases expression ISO Thapsigargin results in increased expression of AHNAK mRNA CTD PMID:19442820 NCBI chr 1:205,882,223...205,970,934
Ensembl chr 1:205,882,273...205,970,926 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Thapsigargin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:15364539 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ak2 adenylate kinase 2 decreases expression ISO Thapsigargin results in decreased expression of AK2 mRNA CTD PMID:22378314 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632 		JBrowse link
G Ak3 adenylate kinase 3 decreases expression ISO Thapsigargin results in decreased expression of AK3 mRNA CTD PMID:22378314 NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625 		JBrowse link
G Ak4 adenylate kinase 4 decreases expression ISO Thapsigargin results in decreased expression of AK4 mRNA CTD PMID:22378314 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618 		JBrowse link
G Akap17a A-kinase anchoring protein 17A increases expression ISO Thapsigargin results in increased expression of AKAP17A mRNA CTD PMID:22378314 NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479 		JBrowse link
G Akap8l A-kinase anchoring protein 8 like increases expression ISO Thapsigargin results in increased expression of AKAP8L protein CTD PMID:24648495 NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275 		JBrowse link
G Akirin1 akirin 1 decreases expression ISO Thapsigargin results in decreased expression of AKIRIN1 protein CTD PMID:24648495 NCBI chr 5:135,989,378...136,004,782
Ensembl chr 5:135,989,465...136,004,762 		JBrowse link
G Akna AT-hook transcription factor increases expression ISO Thapsigargin results in increased expression of AKNA mRNA CTD PMID:22378314 NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
decreases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; NRF1 protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein]; TFAM protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]
[Thapsigargin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein
Thapsigargin results in decreased expression of AKT1 protein modified form		 CTD PMID:15339911 PMID:16338971 PMID:22378314 PMID:24898257 PMID:25398788 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aktip AKT interacting protein decreases expression ISO Thapsigargin results in decreased expression of AKTIP protein CTD PMID:24648495 NCBI chr19:15,866,811...15,877,123
Ensembl chr19:15,866,928...15,886,663 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO Thapsigargin results in increased expression of ALCAM mRNA CTD PMID:22378314 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression ISO Thapsigargin results in increased expression of ALDH18A1 protein CTD PMID:24648495 NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Thapsigargin results in decreased expression of ALDH1A2 mRNA CTD PMID:29453283 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO Thapsigargin results in decreased expression of ALDH1A3 mRNA CTD PMID:22378314 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases expression ISO Thapsigargin results in decreased expression of ALDH5A1 mRNA CTD PMID:22378314 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO Thapsigargin results in increased expression of ALDH6A1 mRNA CTD PMID:22378314 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Thapsigargin results in decreased expression of ALDOC mRNA CTD PMID:22378314 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Alg5 ALG5, dolichyl-phosphate beta-glucosyltransferase increases expression ISO Thapsigargin results in increased expression of ALG5 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO 1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]; 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]]; SB 203580 inhibits the reaction [Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein; Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein CTD PMID:10779545 PMID:18218859 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alpp alkaline phosphatase, placental increases expression ISO Thapsigargin results in increased expression of ALPP mRNA CTD PMID:29453283 NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606 		JBrowse link
G Amot angiomotin decreases expression ISO Thapsigargin results in decreased expression of AMOT mRNA CTD PMID:29453283 NCBI chr  X:108,982,399...109,041,265
Ensembl chr  X:108,984,022...109,041,272 		JBrowse link
G Amt aminomethyltransferase increases expression ISO Thapsigargin results in increased expression of AMT mRNA CTD PMID:22378314 NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126 		JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression ISO Thapsigargin results in decreased expression of ANGPTL2 protein CTD PMID:24648495 NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Thapsigargin results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957 		JBrowse link
G Ankrd10 ankyrin repeat domain 10 increases expression ISO Thapsigargin results in increased expression of ANKRD10 mRNA CTD PMID:29453283 NCBI chr16:77,866,489...77,889,745
Ensembl chr16:77,864,261...77,889,745 		JBrowse link
G Ankrd17 ankyrin repeat domain 17 increases expression ISO Thapsigargin results in increased expression of ANKRD17 protein CTD PMID:24648495 NCBI chr14:17,723,239...17,862,625
Ensembl chr14:17,721,932...17,862,617 		JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO Thapsigargin results in increased expression of ANTXR2 mRNA CTD PMID:22378314 NCBI chr14:11,542,266...11,682,112
Ensembl chr14:11,541,772...11,682,094 		JBrowse link
G Anxa5 annexin A5 increases expression ISO Thapsigargin results in increased expression of ANXA5 mRNA CTD PMID:22378314 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 decreases expression ISO Thapsigargin results in decreased expression of AP2M1 protein CTD PMID:24648495 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Ap3b1 adaptor related protein complex 3 subunit beta 1 increases expression ISO Thapsigargin results in increased expression of AP3B1 protein CTD PMID:24648495 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935 		JBrowse link
G Apob apolipoprotein B decreases secretion
decreases expression		 ISO Thapsigargin results in decreased secretion of APOB protein
Thapsigargin results in decreased expression of APOB mRNA		 CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO Thapsigargin results in decreased expression of APOC3 mRNA CTD PMID:32535746 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Aqr aquarius intron-binding spliceosomal factor increases expression ISO Thapsigargin results in increased expression of AQR protein CTD PMID:24648495 NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044 		JBrowse link
G Ar androgen receptor multiple interactions ISO Thapsigargin results in increased degradation of and results in decreased expression of AR protein CTD PMID:30280407 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arcn1 archain 1 increases expression ISO Thapsigargin results in increased expression of ARCN1 mRNA CTD PMID:22378314 NCBI chr 8:45,057,617...45,082,224
Ensembl chr 8:45,057,619...45,082,247 		JBrowse link
G Arf3 ADP-ribosylation factor 3 decreases expression ISO Thapsigargin results in decreased expression of ARF3 mRNA CTD PMID:29453283 NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002 		JBrowse link
G Arf4 ADP-ribosylation factor 4 increases expression ISO Thapsigargin results in increased expression of ARF4 mRNA CTD PMID:22378314 NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261 		JBrowse link
G Arfgap3 ADP-ribosylation factor GTPase activating protein 3 increases expression ISO Thapsigargin results in increased expression of ARFGAP3 mRNA CTD PMID:22378314 NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208 		JBrowse link
G Arg2 arginase 2 decreases expression ISO Thapsigargin results in decreased expression of ARG2 mRNA CTD PMID:22378314 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO Thapsigargin results in increased expression of ARHGEF2 mRNA CTD PMID:22378314 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Arid4a AT-rich interaction domain 4A increases expression ISO Thapsigargin results in increased expression of ARID4A protein CTD PMID:24648495 NCBI chr 6:89,522,463...89,593,868
Ensembl chr 6:89,522,442...89,593,510 		JBrowse link
G Arid4b AT-rich interaction domain 4B increases expression ISO Thapsigargin results in increased expression of ARID4B protein CTD PMID:24648495 NCBI chr17:51,138,419...51,262,956
Ensembl chr17:51,138,535...51,262,906 		JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression ISO Thapsigargin results in increased expression of ARL1 mRNA CTD PMID:22378314 NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898 		JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression ISO Thapsigargin results in increased expression of ARMCX1 mRNA CTD PMID:22378314 NCBI chr  X:97,898,969...97,902,874
Ensembl chr  X:97,898,883...97,903,299 		JBrowse link
G Armcx3 armadillo repeat containing, X-linked 3 increases expression ISO Thapsigargin results in increased expression of ARMCX3 mRNA CTD PMID:22378314 NCBI chr  X:97,937,115...97,942,098
Ensembl chr  X:97,936,999...97,942,098 		JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 increases expression ISO Thapsigargin results in increased expression of ARPC3 mRNA CTD PMID:22378314 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651 		JBrowse link
G Asb5 ankyrin repeat and SOCS box-containing 5 decreases expression ISO Thapsigargin results in decreased expression of ASB5 protein CTD PMID:24648495 NCBI chr16:37,237,869...37,305,207
Ensembl chr16:37,235,405...37,278,109 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 increases expression ISO Thapsigargin results in increased expression of ASCL1 mRNA CTD PMID:22378314 NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO Thapsigargin results in decreased expression of ASF1B mRNA CTD PMID:22378314 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549 		JBrowse link
G Asgr1 asialoglycoprotein receptor 1 increases expression ISO Thapsigargin results in increased expression of ASGR1 mRNA CTD PMID:29453283 NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Thapsigargin results in increased expression of ASNS mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Asph aspartate-beta-hydroxylase increases expression ISO Thapsigargin results in increased expression of ASPH protein CTD PMID:24648495 NCBI chr 5:22,603,879...22,814,107
Ensembl chr 5:22,603,486...22,813,876 		JBrowse link
G Atad2 ATPase family, AAA domain containing 2 decreases expression
increases expression		 ISO Thapsigargin results in decreased expression of ATAD2 mRNA
Thapsigargin results in increased expression of ATAD2 protein		 CTD PMID:22378314 PMID:24648495 NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression		 ISO
EXP		 ATF3 mutant form promotes the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]
Thapsigargin results in increased expression of ATF3 mRNA
Thapsigargin results in increased expression of ATF3 mRNA; Thapsigargin results in increased expression of ATF3 protein		 CTD PMID:17332266 PMID:20022965 PMID:21694771 PMID:22641616 PMID:22935518 More... NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
increases activity
decreases response to substance		 ISO
EXP		 ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]; ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; NUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Thapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter]
4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]
Thapsigargin results in increased expression of ATF4 mRNA; Thapsigargin results in increased expression of ATF4 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; ATF4 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; GSK2656157 inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]
Thapsigargin results in increased activity of ATF4 protein
ATF4 results in decreased susceptibility to Thapsigargin		 CTD PMID:16298333 PMID:17283163 PMID:20022965 PMID:20589738 PMID:22378314 More... NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Thapsigargin results in increased expression of ATF5 mRNA
Thapsigargin results in increased expression of ATF5 mRNA; Thapsigargin results in increased expression of ATF5 protein		 CTD PMID:22378314 PMID:24648495 PMID:28942281 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases cleavage
increases expression
increases activity		 ISO
EXP		 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein]
Thapsigargin results in increased expression of ATF6 mRNA; Thapsigargin results in increased expression of ATF6 protein; Thapsigargin results in increased expression of ATF6 protein modified form
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Thapsigargin results in increased cleavage of and affects the localization of ATF6 protein
Thapsigargin results in increased activity of ATF6 protein		 CTD PMID:17963750 PMID:18477628 PMID:20493918 PMID:22378314 PMID:23383089 More... NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atg10 autophagy related 10 decreases expression ISO Thapsigargin results in decreased expression of ATG10 protein CTD PMID:24648495 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression ISO Thapsigargin results in increased expression of ATP1B1 mRNA CTD PMID:33770205 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects response to substance
increases expression
decreases activity
multiple interactions		 ISO
EXP		 ATP2A2 protein affects the susceptibility to Thapsigargin
Thapsigargin results in increased expression of ATP2A2 mRNA
Thapsigargin results in decreased activity of ATP2A2 protein
[Thapsigargin results in decreased activity of ATP2A2 protein] which results in decreased transport of Calcium; Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of ATP2A2 mRNA]; Thapsigargin results in increased expression of and results in decreased activity of ATP2A2 protein		 CTD PMID:17287366 PMID:17475205 PMID:19244478 PMID:20816668 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 multiple interactions ISO [Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein] CTD PMID:18439569 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO Thapsigargin results in increased expression of ATP5F1A mRNA CTD PMID:22378314 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 decreases expression ISO Thapsigargin results in decreased expression of ATP5MC1 mRNA CTD PMID:22378314 NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124 		JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 decreases expression ISO Thapsigargin results in decreased expression of ATP5MC3 mRNA CTD PMID:22378314 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279 		JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Thapsigargin results in decreased expression of ATP5MF mRNA CTD PMID:22378314 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236 		JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression ISO Thapsigargin results in increased expression of ATP6V0A1 mRNA CTD PMID:29453283 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895 		JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 increases expression ISO Thapsigargin results in increased expression of ATP6V0A2 mRNA CTD PMID:29453283 NCBI chr12:31,949,863...31,979,777
Ensembl chr12:31,822,733...32,007,069 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions
decreases expression		 ISO 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] CTD PMID:19442820 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 increases expression ISO Thapsigargin results in increased expression of ATP8A1 protein CTD PMID:24648495 NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611 		JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Thapsigargin results in increased expression of ATRX protein CTD PMID:24648495 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330 		JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase increases expression ISO Thapsigargin results in increased expression of AUH mRNA CTD PMID:22378314 NCBI chr17:12,329,522...12,424,896
Ensembl chr17:12,329,524...12,424,896 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Thapsigargin results in decreased expression of AURKB mRNA CTD PMID:22378314 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Aven apoptosis and caspase activation inhibitor increases expression ISO Thapsigargin results in increased expression of AVEN mRNA CTD PMID:29453283 NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634 		JBrowse link
G B4galt5 beta-1,4-galactosyltransferase 5 increases expression ISO Thapsigargin results in increased expression of B4GALT5 mRNA CTD PMID:29453283 NCBI chr 3:156,018,056...156,033,983
Ensembl chr 3:156,018,053...156,070,074 		JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO Thapsigargin results in increased expression of BACH2 mRNA CTD PMID:24247028 NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Thapsigargin results in increased expression of BAD mRNA CTD PMID:22378314 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Banf1 BAF nuclear assembly factor 1 decreases expression ISO Thapsigargin results in decreased expression of BANF1 mRNA CTD PMID:22378314 NCBI chr 1:202,672,170...202,674,215
Ensembl chr 1:202,671,305...202,674,188 		JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO Thapsigargin results in decreased expression of BASP1 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases activity
increases expression
multiple interactions		 ISO Thapsigargin results in increased activity of BAX protein
Thapsigargin results in increased expression of BAX protein
Thapsigargin promotes the reaction [arsenite results in increased expression of BAX protein]		 CTD PMID:20130848 PMID:26677073 PMID:35033536 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Baz1a bromodomain adjacent to zinc finger domain, 1A increases expression ISO Thapsigargin results in increased expression of BAZ1A protein CTD PMID:24648495 NCBI chr 6:72,389,701...72,512,516
Ensembl chr 6:72,389,703...72,512,459 		JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B increases expression ISO Thapsigargin results in increased expression of BAZ1B protein CTD PMID:24648495 NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Thapsigargin results in increased expression of BBC3 mRNA CTD PMID:16018998 PMID:22378314 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcas2 BCAS2, pre-mRNA processing factor decreases expression ISO Thapsigargin results in decreased expression of BCAS2 protein CTD PMID:24648495 NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression ISO Thapsigargin results in increased expression of BCAT1 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 increases expression ISO Thapsigargin results in increased expression of BCAT2 mRNA CTD PMID:22378314 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007 		JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase decreases expression ISO Thapsigargin results in decreased expression of BCKDK mRNA
Thapsigargin results in decreased expression of BCKDK protein		 CTD PMID:22378314 PMID:24648495 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression
decreases phosphorylation		 ISO Thapsigargin results in increased expression of BCL2 mRNA
4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein]
Thapsigargin promotes the reaction [arsenite results in decreased expression of BCL2 protein]
Thapsigargin results in decreased phosphorylation of BCL2 protein		 CTD PMID:22378314 PMID:25611565 PMID:26677073 PMID:30841431 PMID:35033536 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
increases expression
affects splicing		 EXP
ISO		 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; GW 4869 inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; PLA2G6 mutant form inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]
Thapsigargin results in decreased expression of BCL2L1 protein
4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in decreased expression of BCL2L1 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in decreased expression of BCL2L1 protein]
BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein alternative form]
Thapsigargin results in increased expression of BCL2L1 protein		 CTD PMID:23885834 PMID:25762722 PMID:30841431 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 increases expression ISO Thapsigargin results in increased expression of BCLAF1 protein CTD PMID:24648495 NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832 		JBrowse link
G Begain brain-enriched guanylate kinase-associated decreases expression ISO Thapsigargin results in decreased expression of BEGAIN mRNA CTD PMID:22378314 NCBI chr 6:127,943,651...127,979,876
Ensembl chr 6:127,943,651...127,979,841 		JBrowse link
G Bend6 BEN domain containing 6 increases expression ISO Thapsigargin results in increased expression of BEND6 mRNA CTD PMID:22378314 NCBI chr 9:36,081,033...36,135,309
Ensembl chr 9:36,081,484...36,135,228 		JBrowse link
G Best1 bestrophin 1 increases expression ISO Thapsigargin results in increased expression of BEST1 mRNA CTD PMID:22378314 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063 		JBrowse link
G Bet1 Bet1 golgi vesicular membrane trafficking protein decreases expression
multiple interactions		 ISO Thapsigargin results in decreased expression of BET1 mRNA
[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of BET1 mRNA		 CTD PMID:19442820 NCBI chr 4:32,116,232...32,126,592
Ensembl chr 4:32,116,235...32,126,617 		JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like increases expression ISO Thapsigargin results in increased expression of BET1L mRNA CTD PMID:22378314 NCBI chr 1:195,930,165...195,935,072
Ensembl chr 1:195,931,411...195,935,040 		JBrowse link
G Bex2 brain expressed X-linked 2 increases expression ISO Thapsigargin results in increased expression of BEX2 mRNA CTD PMID:29453283 NCBI chr  X:99,219,015...99,220,411
Ensembl chr  X:99,219,014...99,220,958 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 decreases expression ISO Thapsigargin results in decreased expression of BHLHE40 mRNA CTD PMID:22378314 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO Thapsigargin results in decreased expression of BID mRNA CTD PMID:22378314 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Thapsigargin results in decreased expression of BIRC2 protein CTD PMID:16382148 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 protein]
Thapsigargin results in increased expression of BIRC3 mRNA; Thapsigargin results in increased expression of BIRC3 protein		 CTD PMID:15339911 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Blm BLM RecQ like helicase increases expression ISO Thapsigargin results in increased expression of BLM protein CTD PMID:24648495 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Blnk B-cell linker decreases expression ISO Thapsigargin results in decreased expression of BLNK protein CTD PMID:24648495 NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 increases expression ISO Thapsigargin results in increased expression of BLOC1S2 mRNA CTD PMID:22378314 NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653 		JBrowse link
G Bmf Bcl2 modifying factor decreases expression ISO Thapsigargin results in decreased expression of BMF mRNA CTD PMID:33770205 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145 		JBrowse link
G Bmp2k BMP-2 inducible kinase decreases expression ISO Thapsigargin results in decreased expression of BMP2K protein CTD PMID:24648495 NCBI chr14:12,481,194...12,579,411
Ensembl chr14:12,484,729...12,579,134 		JBrowse link
G Bms1 BMS1 ribosome biogenesis factor increases expression ISO Thapsigargin results in increased expression of BMS1 protein CTD PMID:24648495 NCBI chr 4:151,558,163...151,595,187
Ensembl chr 4:151,558,163...151,595,127 		JBrowse link
G Bnc2 basonuclin 2 decreases expression ISO Thapsigargin results in decreased expression of BNC2 mRNA CTD PMID:22378314 NCBI chr 5:98,679,071...99,079,742
Ensembl chr 5:98,687,410...99,079,426 		JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Thapsigargin results in decreased expression of BNIP3 mRNA
Thapsigargin results in decreased expression of BNIP3 protein		 CTD PMID:22378314 PMID:24648495 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bola3 bolA family member 3 decreases expression ISO Thapsigargin results in decreased expression of BOLA3 mRNA CTD PMID:22378314 NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797 		JBrowse link
G Bphl biphenyl hydrolase like decreases expression ISO Thapsigargin results in decreased expression of BPHL mRNA CTD PMID:22378314 NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression
multiple interactions
affects localization		 ISO Thapsigargin results in increased expression of BRCA1 mRNA; Thapsigargin results in increased expression of BRCA1 protein
Cycloheximide inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA]		 CTD PMID:16434996 PMID:29576526 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated increases expression ISO Thapsigargin results in increased expression of BRCA2 mRNA; Thapsigargin results in increased expression of BRCA2 protein CTD PMID:16434996 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Brinp1 BMP/retinoic acid inducible neural specific 1 decreases expression ISO Thapsigargin results in decreased expression of BRINP1 mRNA CTD PMID:22378314 NCBI chr 5:82,348,501...82,550,506
Ensembl chr 5:82,348,930...82,493,150 		JBrowse link
G Brsk1 BR serine/threonine kinase 1 increases expression ISO Thapsigargin results in increased expression of BRSK1 mRNA CTD PMID:29453283 NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO Thapsigargin results in decreased expression of BUB1B mRNA CTD PMID:22378314 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G C1qbp complement C1q binding protein decreases expression ISO Thapsigargin results in decreased expression of C1QBP mRNA CTD PMID:22378314 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G C5 complement C5 increases expression ISO Thapsigargin results in increased expression of C5 mRNA CTD PMID:22378314 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A increases expression ISO Thapsigargin results in increased expression of CACNA1A mRNA CTD PMID:19442820 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 decreases expression ISO Thapsigargin results in decreased expression of CACNA2D1 protein CTD PMID:24648495 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 decreases expression ISO Thapsigargin results in decreased expression of CACNA2D2 mRNA CTD PMID:22378314 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173 		JBrowse link
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 decreases expression ISO Thapsigargin results in decreased expression of CACNG4 mRNA CTD PMID:22378314 NCBI chr10:92,686,100...92,745,601
Ensembl chr10:92,683,761...92,746,126 		JBrowse link
G Cadm1 cell adhesion molecule 1 decreases expression ISO Thapsigargin results in decreased expression of CADM1 mRNA CTD PMID:29453283 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO Thapsigargin promotes the reaction [Lipopolysaccharides results in increased expression of CALCA mRNA] CTD PMID:20682585 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calcb calcitonin-related polypeptide, beta increases expression ISO Thapsigargin results in increased expression of CALCB mRNA CTD PMID:29453283 NCBI chr 1:168,966,465...168,970,125
Ensembl chr 1:168,966,465...168,970,125 		JBrowse link
G Calr calreticulin increases expression ISO Thapsigargin results in increased expression of CALR mRNA; Thapsigargin results in increased expression of CALR protein CTD PMID:17353921 PMID:22378314 PMID:27587023 PMID:29453283 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Calu calumenin decreases expression
increases expression		 ISO Thapsigargin results in decreased expression of CALU mRNA; Thapsigargin results in decreased expression of CALU protein
Thapsigargin results in increased expression of CALU mRNA		 CTD PMID:21692457 PMID:22378314 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions EXP Thapsigargin inhibits the reaction [LIF protein results in increased activity of CAMK4 protein] CTD PMID:11073891 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Canx calnexin increases expression
affects localization		 ISO
EXP		 Thapsigargin results in increased expression of CANX mRNA; Thapsigargin results in increased expression of CANX protein
Thapsigargin affects the localization of CANX protein		 CTD PMID:17353921 PMID:22378314 PMID:28315715 PMID:28940366 PMID:29453283 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Capn1 calpain 1 increases expression
multiple interactions		 EXP Thapsigargin results in increased expression of CAPN1 protein
Thapsigargin promotes the reaction [cadmium acetate results in increased expression of CAPN1 protein]		 CTD PMID:28347754 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Car10 carbonic anhydrase 10 decreases expression ISO Thapsigargin results in decreased expression of CA10 mRNA CTD PMID:22378314 NCBI chr10:78,055,875...78,556,490
Ensembl chr10:78,054,114...78,555,834 		JBrowse link
G Car5b carbonic anhydrase 5B increases expression ISO Thapsigargin results in increased expression of CA5B mRNA CTD PMID:22378314 NCBI chr  X:30,474,697...30,534,797
Ensembl chr  X:30,474,784...30,533,837 		JBrowse link
G Card9 caspase recruitment domain family, member 9 increases expression ISO Thapsigargin results in increased expression of CARD9 mRNA CTD PMID:22378314 NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237 		JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 decreases expression ISO Thapsigargin results in decreased expression of CARHSP1 mRNA CTD PMID:22378314 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019 		JBrowse link
G Casp1 caspase 1 increases expression ISO Thapsigargin results in increased expression of CASP1 mRNA CTD PMID:30796460 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions
increases expression
increases activity
increases cleavage		 ISO
EXP		 demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Resveratrol inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased cleavage of CASP12 protein]
Thapsigargin results in increased cleavage of CASP12 protein alternative form
4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]		 CTD PMID:12198651 PMID:16338971 PMID:18477628 PMID:20493918 PMID:24224909 More... NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp2 caspase 2 multiple interactions
increases activity		 ISO Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein] CTD PMID:16388830 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases activity
increases metabolic processing		 ISO
EXP		 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of CASP3 protein]; Bortezomib promotes the reaction [Thapsigargin results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]
Thapsigargin results in increased cleavage of CASP3 protein
1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of CASP3 protein]; 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; HR protein affects the reaction [Thapsigargin results in increased activity of CASP3 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased cleavage of CASP3 protein]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]
Thapsigargin results in increased metabolism of CASP3 protein
Thapsigargin results in increased expression of CASP3 protein; Thapsigargin results in increased expression of CASP3 protein alternative form		 CTD PMID:12198651 PMID:12871656 PMID:16338971 PMID:16357177 PMID:16382148 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 multiple interactions ISO Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP4 protein]; Thapsigargin results in increased cleavage of and results in increased activity of CASP4 protein CTD PMID:17559149 PMID:25341683 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 decreases expression ISO Thapsigargin results in decreased expression of CASP6 protein CTD PMID:24648495 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Doxorubicin inhibits the reaction [Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein]; Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP7 protein] CTD PMID:12198651 PMID:16298333 PMID:17559149 PMID:19139269 PMID:20022965 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Thapsigargin results in increased activity of CASP8 protein CTD PMID:16018998 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity		 ISO Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP9 protein]
Thapsigargin results in increased cleavage of CASP9 protein
4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased cleavage of CASP9 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased cleavage of CASP9 protein]		 CTD PMID:16018998 PMID:16388830 PMID:20130848 PMID:25341683 PMID:30841431 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP Thapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] CTD PMID:11071898 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Catsper2 cation channel, sperm associated 2 decreases expression ISO Thapsigargin results in decreased expression of CATSPER2 mRNA CTD PMID:19442820 NCBI chr 3:108,368,654...108,389,380
Ensembl chr 3:108,368,668...108,388,050 		JBrowse link
G Cbln2 cerebellin 2 precursor decreases expression ISO Thapsigargin results in decreased expression of CBLN2 mRNA CTD PMID:22378314 NCBI chr18:79,940,412...79,948,766
Ensembl chr18:79,942,590...79,947,855 		JBrowse link
G Ccdc171 coiled-coil domain containing 171 decreases expression ISO Thapsigargin results in decreased expression of CCDC171 mRNA CTD PMID:22378314 NCBI chr 5:97,919,965...98,403,853
Ensembl chr 5:97,920,002...98,282,833 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Thapsigargin results in increased expression of CCL2 mRNA
Thapsigargin inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Thapsigargin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Thapsigargin results in decreased expression of CCL2 mRNA		 CTD PMID:8764118 PMID:18799549 PMID:18951912 PMID:20830808 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Thapsigargin results in increased expression of CCL3 mRNA; Thapsigargin results in increased expression of CCL3 protein CTD PMID:20830808 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Thapsigargin results in increased expression of CCN1 mRNA CTD PMID:29453283 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Thapsigargin results in decreased expression of CCNA2 mRNA CTD PMID:22378314 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Thapsigargin results in decreased expression of CCNB1 mRNA CTD PMID:22378314 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 increases expression ISO Thapsigargin results in increased expression of CCNB1IP1 mRNA CTD PMID:22378314 NCBI chr15:24,014,905...24,031,357
Ensembl chr15:24,014,908...24,028,475 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thapsigargin results in decreased expression of CCND1 mRNA CTD PMID:17332266 PMID:22378314 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnf cyclin F decreases expression ISO Thapsigargin results in decreased expression of CCNF mRNA CTD PMID:22378314 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Thapsigargin results in increased expression of CCNG2 mRNA CTD PMID:17332266 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Ccnq cyclin Q decreases expression ISO Thapsigargin results in decreased expression of CCNQ protein CTD PMID:24648495 NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961 		JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO Thapsigargin results in increased expression of CCPG1 mRNA CTD PMID:22378314 NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Thapsigargin results in increased expression of CD44 mRNA CTD PMID:29453283 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Thapsigargin results in increased expression of CD55 mRNA CTD PMID:24247028 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd69 Cd69 molecule increases expression ISO Thapsigargin results in increased expression of CD69 mRNA CTD PMID:24247028 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cd70 Cd70 molecule increases expression ISO Thapsigargin results in increased expression of CD70 mRNA CTD PMID:29453283 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions
increases expression		 ISO [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of CDC20 mRNA; [Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA; [Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of CDC20 mRNA
Thapsigargin results in increased expression of CDC20 mRNA		 CTD PMID:19442820 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO Thapsigargin results in decreased expression of CDC45 mRNA CTD PMID:22378314 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Cdc5l cell division cycle 5-like increases expression ISO Thapsigargin results in increased expression of CDC5L protein CTD PMID:24648495 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450 		JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO Thapsigargin results in decreased expression of CDC7 mRNA CTD PMID:22378314 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778 		JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO Thapsigargin results in increased expression of CDCA2 protein CTD PMID:24648495 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611 		JBrowse link
G Cdca7 cell division cycle associated 7 decreases expression ISO Thapsigargin results in decreased expression of CDCA7 mRNA CTD PMID:22378314 NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353 		JBrowse link
G Cdca7l cell division cycle associated 7 like decreases expression ISO Thapsigargin results in decreased expression of CDCA7L mRNA CTD PMID:22378314 NCBI chr 6:138,793,953...138,839,889
Ensembl chr 6:138,794,228...138,839,888 		JBrowse link
G Cdh15 cadherin 15 increases expression ISO Thapsigargin results in increased expression of CDH15 mRNA CTD PMID:22378314 NCBI chr19:50,903,757...50,927,151
Ensembl chr19:50,903,638...50,927,105 		JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase decreases expression ISO Thapsigargin results in decreased expression of CDIPT protein CTD PMID:24648495 NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Thapsigargin results in decreased expression of CDK1 mRNA CTD PMID:22378314 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases expression
increases expression		 ISO 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]
Thapsigargin results in decreased expression of CDK2 mRNA		 CTD PMID:19442820 PMID:22378314 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 increases expression ISO Thapsigargin results in increased expression of CDK2AP2 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 increases expression ISO Thapsigargin results in increased expression of CDK5RAP2 protein CTD PMID:24648495 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 increases expression ISO Thapsigargin results in increased expression of CDK5RAP3 mRNA CTD PMID:29453283 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 decreases expression ISO Thapsigargin results in decreased expression of CDK7 protein CTD PMID:24648495 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Thapsigargin results in increased expression of CDKN1A mRNA CTD PMID:29453283 PMID:33770205 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdr2 cerebellar degeneration-related protein 2 increases expression ISO Thapsigargin results in increased expression of CDR2 mRNA CTD PMID:22378314 NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions		 ISO Thapsigargin results in increased expression of CEBPB mRNA; Thapsigargin results in increased expression of CEBPB protein alternative form
Thapsigargin promotes the reaction [CEBPB protein binds to NR1I2 promoter]		 CTD PMID:22378314 PMID:25616597 PMID:29453283 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon increases expression ISO Thapsigargin results in increased expression of CEBPE mRNA CTD PMID:29453283 NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO Thapsigargin results in increased expression of CEBPG mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569 		JBrowse link
G Cenpa centromere protein A decreases expression ISO Thapsigargin results in decreased expression of CENPA mRNA CTD PMID:22378314 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675 		JBrowse link
G Cenpf centromere protein F increases expression ISO Thapsigargin results in increased expression of CENPF mRNA CTD PMID:19442820 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669 		JBrowse link
G Cenpu centromere protein U decreases expression ISO Thapsigargin results in decreased expression of CENPU mRNA CTD PMID:22378314 NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823 		JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO Thapsigargin results in increased expression of CEP290 protein CTD PMID:24648495 NCBI chr 7:35,310,071...35,399,392
Ensembl chr 7:35,310,199...35,399,392 		JBrowse link
G Ces5a carboxylesterase 5A decreases expression ISO Thapsigargin results in decreased expression of CES5A protein CTD PMID:24648495 NCBI chr19:11,469,469...11,499,007
Ensembl chr19:11,469,469...11,499,006 		JBrowse link
G Cetn2 centrin 2 decreases expression ISO Thapsigargin results in decreased expression of CETN2 protein CTD PMID:24648495 NCBI chr  X:150,769,944...150,775,052
Ensembl chr  X:150,769,953...150,774,919 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium results in increased activity of CFTR protein mutant form]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression ISO Thapsigargin results in increased expression of CGA mRNA CTD PMID:21694771 PMID:29453283 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Cgn cingulin decreases expression ISO Thapsigargin results in decreased expression of CGN mRNA CTD PMID:29453283 NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645 		JBrowse link
G Cgnl1 cingulin-like 1 increases expression
decreases expression		 ISO Thapsigargin results in increased expression of CGNL1 protein
Thapsigargin results in decreased expression of CGNL1 mRNA		 CTD PMID:24648495 PMID:29453283 NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 decreases expression ISO Thapsigargin results in decreased expression of CHAC1 mRNA CTD PMID:19442820 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A increases expression
decreases expression		 ISO Thapsigargin results in increased expression of CHAF1A mRNA
Thapsigargin results in decreased expression of CHAF1A mRNA		 CTD PMID:19442820 PMID:22378314 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO Thapsigargin results in decreased expression of CHAF1B mRNA CTD PMID:22378314 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 decreases expression ISO Thapsigargin results in decreased expression of CHCHD6 protein CTD PMID:24648495 NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216 		JBrowse link
G Chchd7 coiled-coil-helix-coiled-coil-helix domain containing 7 decreases expression ISO Thapsigargin results in decreased expression of CHCHD7 protein CTD PMID:24648495 NCBI chr 5:16,957,081...16,969,388
Ensembl chr 5:16,957,188...16,961,184 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 increases expression ISO Thapsigargin results in increased expression of CHD4 protein CTD PMID:24648495 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Thapsigargin results in decreased expression of CHEK1 mRNA CTD PMID:22378314 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chga chromogranin A decreases expression
increases expression		 ISO Thapsigargin results in decreased expression of CHGA mRNA
Thapsigargin results in increased expression of CHGA mRNA		 CTD PMID:22378314 PMID:29453283 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Chid1 chitinase domain containing 1 decreases expression ISO Thapsigargin results in decreased expression of CHID1 protein CTD PMID:24648495 NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606 		JBrowse link
G Chpf chondroitin polymerizing factor increases expression ISO Thapsigargin results in increased expression of CHPF mRNA CTD PMID:22378314 NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878 		JBrowse link
G Chpt1 choline phosphotransferase 1 increases expression ISO Thapsigargin results in increased expression of CHPT1 mRNA CTD PMID:22378314 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Thapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression ISO Thapsigargin results in decreased expression of CHRNA3 mRNA CTD PMID:22378314 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit decreases expression ISO Thapsigargin results in decreased expression of CHRNA5 mRNA CTD PMID:22378314 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit decreases expression ISO Thapsigargin results in decreased expression of CHRNB4 mRNA CTD PMID:22378314 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Chst15 carbohydrate sulfotransferase 15 increases expression ISO Thapsigargin results in increased expression of CHST15 mRNA CTD PMID:22378314 NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707 		JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Thapsigargin results in increased expression of CIRBP mRNA CTD PMID:29453283 NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818 		JBrowse link
G Ckap5 cytoskeleton associated protein 5 increases expression ISO Thapsigargin results in increased expression of CKAP5 protein CTD PMID:24648495 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264 		JBrowse link
G Ckb creatine kinase B decreases expression ISO Thapsigargin results in decreased expression of CKB mRNA; Thapsigargin results in decreased expression of CKB protein CTD PMID:21692457 PMID:22378314 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clcc1 chloride channel CLIC-like 1 increases expression ISO Thapsigargin results in increased expression of CLCC1 mRNA CTD PMID:22378314 NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913 		JBrowse link
G Clec11a C-type lectin domain containing 11A increases expression ISO Thapsigargin results in increased expression of CLEC11A mRNA CTD PMID:19442820 NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633 		JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein decreases expression ISO Thapsigargin results in decreased expression of CLN8 protein CTD PMID:24648495 NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774 		JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit increases expression ISO Thapsigargin results in increased expression of CLPP mRNA CTD PMID:22378314 NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693 		JBrowse link
G Cltc clathrin heavy chain increases expression ISO Thapsigargin results in increased expression of CLTC protein CTD PMID:24648495 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Cnn3 calponin 3 decreases expression ISO Thapsigargin results in decreased expression of CNN3 mRNA CTD PMID:22378314 NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104 		JBrowse link
G Cntnap2 contactin associated protein 2 increases expression ISO Thapsigargin results in increased expression of CNTNAP2 mRNA CTD PMID:22378314 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027 		JBrowse link
G Cog1 component of oligomeric golgi complex 1 increases expression ISO Thapsigargin results in increased expression of COG1 mRNA CTD PMID:22378314 NCBI chr10:98,695,481...98,708,495
Ensembl chr10:98,695,423...98,709,292 		JBrowse link
G Cog3 component of oligomeric golgi complex 3 increases expression ISO Thapsigargin results in increased expression of COG3 mRNA CTD PMID:22378314 NCBI chr15:51,020,808...51,071,288
Ensembl chr15:51,020,813...51,070,570 		JBrowse link
G Cog6 component of oligomeric golgi complex 6 increases expression ISO Thapsigargin results in increased expression of COG6 mRNA CTD PMID:22378314 NCBI chr 2:137,062,127...137,099,176
Ensembl chr 2:137,061,346...137,099,190 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain increases expression ISO Thapsigargin results in increased expression of COL11A1 protein CTD PMID:24648495 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853 		JBrowse link
G Col5a1 collagen type V alpha 1 chain increases expression
decreases expression		 ISO Thapsigargin results in increased expression of COL5A1 mRNA
Thapsigargin results in decreased expression of COL5A1 mRNA		 CTD PMID:22378314 PMID:29453283 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588 		JBrowse link
G Col5a2 collagen type V alpha 2 chain increases expression ISO Thapsigargin results in increased expression of COL5A2 protein CTD PMID:24648495 NCBI chr 9:47,448,736...47,598,396
Ensembl chr 9:47,448,736...47,598,154 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain multiple interactions ISO Thapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] CTD PMID:18435905 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471 		JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO Thapsigargin results in decreased expression of COLEC12 protein CTD PMID:24648495 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618 		JBrowse link
G Copa COPI coat complex subunit alpha increases expression ISO Thapsigargin results in increased expression of COPA mRNA CTD PMID:22378314 NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874 		JBrowse link
G Copg1 COPI coat complex subunit gamma 1 increases expression ISO Thapsigargin results in increased expression of COPG1 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616 		JBrowse link
G Cops4 COP9 signalosome subunit 4 decreases expression ISO Thapsigargin results in decreased expression of COPS4 protein CTD PMID:21692457 NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887 		JBrowse link
G Cops7a COP9 signalosome subunit 7A decreases expression ISO Thapsigargin results in decreased expression of COPS7A protein CTD PMID:24648495 NCBI chr 4:157,766,626...157,792,632
Ensembl chr 4:157,766,588...157,773,948 		JBrowse link
G Coq3 coenzyme Q3 methyltransferase decreases expression ISO Thapsigargin results in decreased expression of COQ3 mRNA CTD PMID:22378314 NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607 		JBrowse link
G Coq8a coenzyme Q8A increases expression ISO Thapsigargin results in increased expression of COQ8A mRNA CTD PMID:22378314 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431 		JBrowse link
G Coro1a coronin 1A decreases expression ISO Thapsigargin results in decreased expression of CORO1A mRNA CTD PMID:22378314 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 decreases expression ISO Thapsigargin results in decreased expression of COTL1 protein CTD PMID:24648495 NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689 		JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 increases expression ISO Thapsigargin results in increased expression of COX10 mRNA CTD PMID:22378314 NCBI chr10:48,630,993...48,742,835
Ensembl chr10:48,630,676...48,746,667 		JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 increases expression ISO Thapsigargin results in increased expression of COX11 mRNA CTD PMID:22378314 NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322 		JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 decreases expression ISO Thapsigargin results in decreased expression of COX17 mRNA CTD PMID:22378314 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 decreases expression ISO Thapsigargin results in decreased expression of COX6B1 mRNA CTD PMID:22378314 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001 		JBrowse link
G Cox6c cytochrome c oxidase subunit 6C decreases expression ISO Thapsigargin results in decreased expression of COX6C mRNA CTD PMID:22378314 NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963 		JBrowse link
G Cox7b cytochrome c oxidase subunit 7B decreases expression ISO Thapsigargin results in decreased expression of COX7B mRNA CTD PMID:22378314 NCBI chr  X:71,083,486...71,089,733
Ensembl chr  X:71,083,456...71,089,732 		JBrowse link
G Cpne1 copine 1 decreases expression ISO Thapsigargin results in decreased expression of CPNE1 protein CTD PMID:21692457 NCBI chr 3:144,587,548...144,629,603
Ensembl chr 3:144,588,995...144,598,636 		JBrowse link
G Cpsf1 cleavage and polyadenylation specific factor 1 increases expression ISO Thapsigargin results in increased expression of CPSF1 protein CTD PMID:24648495 NCBI chr 7:108,319,429...108,330,023
Ensembl chr 7:108,319,434...108,329,934 		JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression ISO Thapsigargin results in increased expression of CPT1C mRNA CTD PMID:22378314 NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342 		JBrowse link
G Crabp1 cellular retinoic acid binding protein 1 decreases expression ISO Thapsigargin results in decreased expression of CRABP1 mRNA CTD PMID:22378314 NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO Thapsigargin results in decreased expression of CRABP2 mRNA CTD PMID:22378314 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Crat carnitine O-acetyltransferase increases expression ISO Thapsigargin results in increased expression of CRAT mRNA CTD PMID:22378314 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects localization
multiple interactions		 ISO Thapsigargin affects the localization of CREB1 mRNA
Cycloheximide inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA]		 CTD PMID:29576526 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 increases activity
multiple interactions		 ISO Thapsigargin results in increased activity of CREB3L1 protein
[Thapsigargin results in increased activity of CREB3L1 protein] which results in increased expression of VEGFA mRNA		 CTD PMID:23383089 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 increases expression ISO Thapsigargin results in increased expression of CREB3L2 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763 		JBrowse link
G Crebbp CREB binding protein increases expression ISO Thapsigargin results in increased expression of CREBBP mRNA CTD PMID:24247028 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 decreases expression ISO Thapsigargin results in decreased expression of CREG1 protein CTD PMID:24648495 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308 		JBrowse link
G Creld1 cysteine-rich with EGF-like domains 1 increases expression ISO Thapsigargin results in increased expression of CRELD1 mRNA CTD PMID:22378314 NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499 		JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression
decreases expression		 ISO Thapsigargin results in increased expression of CRELD2 mRNA; Thapsigargin results in increased expression of CRELD2 protein
Thapsigargin results in decreased expression of CRELD2 protein		 CTD PMID:22378314 PMID:24648495 PMID:29453283 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP Thapsigargin inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein] CTD PMID:16187300 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Crtac1 cartilage acidic protein 1 increases expression ISO Thapsigargin results in increased expression of CRTAC1 mRNA CTD PMID:29453283 NCBI chr 1:241,091,679...241,233,677
Ensembl chr 1:241,078,864...241,233,421 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Thapsigargin results in decreased expression of CRY1 mRNA CTD PMID:22378314 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Crybb2 crystallin, beta B2 increases expression ISO Thapsigargin results in increased expression of CRYBB2 mRNA CTD PMID:29453283 NCBI chr12:43,569,747...43,579,671
Ensembl chr12:43,569,747...43,579,671 		JBrowse link
G Crybg3 crystallin beta-gamma domain containing 3 increases expression ISO Thapsigargin results in increased expression of CRYBG3 protein CTD PMID:24648495 NCBI chr11:40,749,198...40,861,753
Ensembl chr11:40,749,214...40,861,752 		JBrowse link
G Cryz crystallin zeta multiple interactions
decreases expression
increases expression		 ISO Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CRYZ mRNA]
Thapsigargin results in decreased expression of CRYZ mRNA		 CTD PMID:19442820 PMID:22378314 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758 		JBrowse link
G Cs citrate synthase decreases expression ISO Thapsigargin results in decreased expression of CS mRNA CTD PMID:28223344 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 increases expression ISO Thapsigargin results in increased expression of CSNK2A2 mRNA CTD PMID:22378314 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 decreases expression ISO Thapsigargin results in decreased expression of CSPG5 mRNA CTD PMID:22378314 NCBI chr 8:110,220,653...110,234,750
Ensembl chr 8:110,220,653...110,234,758 		JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO Thapsigargin results in increased expression of CSRNP1 mRNA CTD PMID:29453283 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183 		JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 decreases expression ISO Thapsigargin results in decreased expression of CSRP2 mRNA CTD PMID:22378314 NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745 		JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 decreases expression ISO Thapsigargin results in decreased expression of CSTF2 mRNA CTD PMID:22378314 NCBI chr  X:97,253,559...97,279,476
Ensembl chr  X:97,253,586...97,279,476 		JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of CTF1 mRNA; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA] CTD PMID:19442820 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Thapsigargin results in increased expression of CTH mRNA; Thapsigargin results in increased expression of CTH protein CTD PMID:29453283 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctps1 CTP synthase 1 decreases expression ISO Thapsigargin results in decreased expression of CTPS mRNA CTD PMID:22378314 NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180 		JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component increases expression ISO Thapsigargin results in increased expression of CTR9 protein CTD PMID:24648495 NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO Thapsigargin inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein] CTD PMID:25639782 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctxn1 cortexin 1 decreases expression ISO Thapsigargin results in decreased expression of CTXN1 mRNA CTD PMID:29453283 NCBI chr12:2,610,465...2,612,076 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] CTD PMID:19442820 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Thapsigargin results in increased expression of CXCL1 mRNA CTD PMID:8764118 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyb561d2 cytochrome b561 family, member D2 decreases expression ISO Thapsigargin results in decreased expression of CYB561D2 protein CTD PMID:24648495 NCBI chr 8:108,213,201...108,215,778
Ensembl chr 8:108,213,205...108,215,759 		JBrowse link
G Cyb5a cytochrome b5 type A decreases expression ISO Thapsigargin results in decreased expression of CYB5A mRNA CTD PMID:22378314 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyb5b cytochrome b5 type B decreases expression ISO Thapsigargin results in decreased expression of CYB5B mRNA CTD PMID:22378314 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249 		JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 increases expression ISO Thapsigargin results in increased expression of CYB5R1 mRNA CTD PMID:29453283 NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression ISO Thapsigargin results in decreased expression of CYBA mRNA CTD PMID:29453283 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cycs cytochrome c, somatic decreases expression ISO Thapsigargin results in decreased expression of CYCS mRNA CTD PMID:22378314 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 increases expression ISO Thapsigargin results in increased expression of CYFIP1 protein CTD PMID:24648495 NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386 		JBrowse link
G Cygb cytoglobin decreases expression ISO Thapsigargin results in decreased expression of CYGB mRNA CTD PMID:22378314 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Thapsigargin results in increased expression of CYP1B1 mRNA CTD PMID:29453283 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:25616597 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 decreases expression ISO Thapsigargin results in decreased expression of CYP4F3 mRNA CTD PMID:19442820 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 increases expression ISO Thapsigargin results in increased expression of CYP4V2 mRNA CTD PMID:22378314 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395 		JBrowse link
G Cyp4x1 cytochrome P450, family 4, subfamily x, polypeptide 1 increases expression ISO Thapsigargin results in increased expression of CYP4X1 mRNA CTD PMID:29453283 NCBI chr 5:128,652,844...128,683,338
Ensembl chr 5:128,651,776...128,682,779 		JBrowse link
G Dap death-associated protein multiple interactions
increases expression		 ISO 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]
Thapsigargin results in increased expression of DAP mRNA		 CTD PMID:19442820 PMID:22378314 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752 		JBrowse link
G Dbi diazepam binding inhibitor decreases expression ISO Thapsigargin results in decreased expression of DBI mRNA CTD PMID:22378314 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693 		JBrowse link
G Dbnl drebrin-like decreases expression ISO Thapsigargin results in decreased expression of DBNL mRNA CTD PMID:22378314 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155 		JBrowse link
G Dctpp1 dCTP pyrophosphatase 1 decreases expression ISO Thapsigargin results in decreased expression of DCTPP1 mRNA CTD PMID:22378314 NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression ISO Thapsigargin results in decreased expression of DDAH1 mRNA CTD PMID:22378314 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression ISO Thapsigargin results in increased expression of DDB1 protein CTD PMID:24648495 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676 		JBrowse link
G Ddc dopa decarboxylase decreases expression ISO Thapsigargin results in decreased expression of DDC mRNA CTD PMID:22378314 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor decreases expression ISO Thapsigargin results in decreased expression of DDIAS mRNA CTD PMID:22378314 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
increases activity
decreases response to substance		 ISO
EXP		 ATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Quercetin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Thapsigargin promotes the reaction [DDIT3 protein binds to LCN2 promoter]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 protein
Thapsigargin results in increased expression of DDIT3 mRNA; Thapsigargin results in increased expression of DDIT3 protein
1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; GW 506033X inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 protein
Thapsigargin results in increased activity of DDIT3 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 protein]]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Vaticanol B inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]
DDIT3 results in decreased susceptibility to Thapsigargin		 CTD PMID:16298333 PMID:16330322 PMID:16338971 PMID:17283163 PMID:17332266 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit increases expression ISO Thapsigargin results in increased expression of DDOST mRNA CTD PMID:22378314 NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 increases expression ISO Thapsigargin results in increased expression of DDR2 protein CTD PMID:24648495 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 increases expression ISO Thapsigargin results in increased expression of DDRGK1 mRNA CTD PMID:29453283 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Dennd4c DENN domain containing 4C increases expression ISO Thapsigargin results in increased expression of DENND4C protein CTD PMID:24648495 NCBI chr 5:101,272,298...101,369,529
Ensembl chr 5:101,272,005...101,368,118 		JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO Thapsigargin results in decreased expression of DEPDC1B mRNA CTD PMID:22378314 NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779 		JBrowse link
G Deptor DEP domain containing MTOR-interacting protein increases expression ISO Thapsigargin results in increased expression of DEPTOR mRNA CTD PMID:22378314 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773 		JBrowse link
G Derl2 derlin 2 increases expression ISO Thapsigargin results in increased expression of DERL2 mRNA CTD PMID:22378314 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Dglucy D-glutamate cyclase decreases expression ISO Thapsigargin results in decreased expression of DGLUCY mRNA CTD PMID:22378314 NCBI chr 6:120,055,480...120,130,910
Ensembl chr 6:120,055,460...120,130,910 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Thapsigargin results in decreased expression of DHCR24 mRNA CTD PMID:22378314 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO Thapsigargin results in decreased expression of DHCR7 mRNA CTD PMID:22378314 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dhrs13 dehydrogenase/reductase 13 increases expression ISO Thapsigargin results in increased expression of DHRS13 mRNA CTD PMID:29453283 NCBI chr10:62,920,743...62,925,952 JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Thapsigargin results in increased expression of DHRS3 mRNA CTD PMID:22378314 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Thapsigargin results in increased expression of DHX36 protein CTD PMID:24648495 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572 		JBrowse link
G Dhx9 DExH-box helicase 9 increases expression ISO Thapsigargin results in increased expression of DHX9 protein CTD PMID:24648495 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects response to substance
increases expression
affects localization		 ISO DIABLO protein affects the susceptibility to Thapsigargin
Thapsigargin results in increased expression of DIABLO mRNA
Thapsigargin affects the localization of DIABLO protein		 CTD PMID:15339911 PMID:16382148 PMID:22378314 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Diaph2 diaphanous-related formin 2 increases expression ISO Thapsigargin results in increased expression of DIAP2 protein CTD PMID:24648495 NCBI chr  X:92,395,189...93,234,521
Ensembl chr  X:92,395,251...93,229,869 		JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression ISO Thapsigargin results in increased expression of DIAPH3 protein CTD PMID:24648495 NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression ISO Thapsigargin results in decreased expression of DKK1 mRNA CTD PMID:22378314 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression ISO Thapsigargin results in decreased expression of DLD mRNA CTD PMID:22378314 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 increases expression ISO Thapsigargin results in increased expression of DLG4 mRNA CTD PMID:22378314 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression
increases expression		 ISO Thapsigargin results in decreased expression of DLGAP5 mRNA
Thapsigargin results in increased expression of DLGAP5 protein		 CTD PMID:22378314 PMID:24648495 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Thapsigargin results in decreased expression of DLK1 mRNA CTD PMID:22378314 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Dlx5 distal-less homeobox 5 decreases expression ISO Thapsigargin results in decreased expression of DLX5 mRNA CTD PMID:22378314 NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407 		JBrowse link
G Dmac2l distal membrane arm assembly component 2 like decreases expression ISO Thapsigargin results in decreased expression of DMAC2L mRNA CTD PMID:22378314 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression ISO Thapsigargin results in decreased expression of DNAJA1 mRNA CTD PMID:22378314 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases expression ISO Thapsigargin results in increased expression of DNAJA3 mRNA CTD PMID:22378314 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 multiple interactions
increases expression
decreases expression		 ISO 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]; [DNAJB11 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]
Thapsigargin results in increased expression of DNAJB11 mRNA; Thapsigargin results in increased expression of DNAJB11 protein		 CTD PMID:19442820 PMID:22378314 PMID:26085089 PMID:29453283 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Thapsigargin results in increased expression of DNAJB9 mRNA CTD PMID:19135031 PMID:22378314 PMID:29453283 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 affects expression ISO Thapsigargin affects the expression of DNAJC1 mRNA CTD PMID:24247028 NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 increases expression ISO Thapsigargin results in increased expression of DNAJC10 mRNA; Thapsigargin results in increased expression of DNAJC10 protein CTD PMID:17353921 PMID:29453283 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression
multiple interactions		 ISO Thapsigargin results in increased expression of DNAJC3 mRNA; Thapsigargin results in increased expression of DNAJC3 protein
[DNAJC3 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin		 CTD PMID:19135031 PMID:26085089 PMID:29453283 NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal increases expression ISO Thapsigargin results in increased expression of DNASE2 mRNA CTD PMID:22378314 NCBI chr19:23,244,661...23,247,329
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Dnhd1 dynein heavy chain domain 1 increases expression ISO Thapsigargin results in increased expression of DNHD1 mRNA CTD PMID:22378314 NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858 		JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Thapsigargin results in increased expression of DNM1L mRNA CTD PMID:28940366 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Thapsigargin results in increased expression of DNMT1 protein CTD PMID:24648495 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression ISO Thapsigargin results in increased expression of DOCK7 protein CTD PMID:24648495 NCBI chr 5:113,599,371...113,782,871
Ensembl chr 5:113,600,198...113,782,813 		JBrowse link
G Dpf1 double PHD fingers 1 decreases expression ISO Thapsigargin results in decreased expression of DPF1 mRNA CTD PMID:22378314 NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950 		JBrowse link
G Dph5 diphthamide biosynthesis 5 increases expression ISO Thapsigargin results in increased expression of DPH5 mRNA CTD PMID:22378314 NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression ISO Thapsigargin results in decreased expression of DPYSL3 mRNA CTD PMID:22378314 NCBI chr18:35,374,429...35,480,462
Ensembl chr18:35,377,181...35,480,157 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 multiple interactions
increases expression		 ISO 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] CTD PMID:19442820 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 decreases expression ISO Thapsigargin results in decreased expression of DSCC1 mRNA CTD PMID:22378314 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212 		JBrowse link
G Dse dermatan sulfate epimerase decreases expression ISO Thapsigargin results in decreased expression of DSE protein CTD PMID:24648495 NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog decreases expression ISO Thapsigargin results in decreased expression of DTL mRNA CTD PMID:22378314 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890 		JBrowse link
G Dtna dystrobrevin, alpha decreases expression ISO Thapsigargin results in decreased expression of DTNA mRNA CTD PMID:22378314 NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Thapsigargin results in increased expression of DUSP1 mRNA CTD PMID:29453283 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp26 dual specificity phosphatase 26 increases expression ISO Thapsigargin results in increased expression of DUSP26 mRNA CTD PMID:22378314 NCBI chr16:61,041,784...61,049,319
Ensembl chr16:61,041,792...61,049,051 		JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression ISO Thapsigargin results in decreased expression of DUSP5 mRNA CTD PMID:29453283 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression
decreases expression		 ISO Thapsigargin results in increased expression of DUSP6 mRNA
Thapsigargin results in decreased expression of DUSP6 mRNA		 CTD PMID:22378314 PMID:24247028 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Dut deoxyuridine triphosphatase decreases expression ISO Thapsigargin results in decreased expression of DUT mRNA
Thapsigargin results in decreased expression of DUT protein		 CTD PMID:22378314 PMID:24648495 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771 		JBrowse link
G Dym dymeclin decreases expression ISO Thapsigargin results in decreased expression of DYM protein CTD PMID:24648495 NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903 		JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 decreases expression ISO Thapsigargin results in decreased expression of DYNC1I1 mRNA CTD PMID:22378314 NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149 		JBrowse link
G Dync2i2 dynein 2 intermediate chain 2 decreases expression ISO Thapsigargin results in decreased expression of DYNC2I2 mRNA CTD PMID:22378314 NCBI chr 3:13,306,039...13,322,121
Ensembl chr 3:13,306,039...13,322,121 		JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 increases expression ISO Thapsigargin results in increased expression of DYRK4 mRNA CTD PMID:22378314 NCBI chr 4:159,715,658...159,757,660
Ensembl chr 4:159,715,417...159,757,627 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Thapsigargin results in decreased expression of E2F1 mRNA CTD PMID:22378314 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Thapsigargin results in decreased expression of E2F2 mRNA CTD PMID:22378314 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G E2f7 E2F transcription factor 7 decreases expression ISO Thapsigargin results in decreased expression of E2F7 mRNA CTD PMID:22378314 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734 		JBrowse link
G Ears2 glutamyl-tRNA synthetase 2, mitochondrial decreases expression ISO Thapsigargin results in decreased expression of EARS2 mRNA CTD PMID:29453283 NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836 		JBrowse link
G Ebf1 EBF transcription factor 1 decreases expression ISO Thapsigargin results in decreased expression of EBF1 mRNA CTD PMID:22378314 NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Thapsigargin results in increased expression of ECH1 mRNA CTD PMID:22378314 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Edc4 enhancer of mRNA decapping 4 increases expression ISO Thapsigargin results in increased expression of EDC4 protein CTD PMID:24648495 NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Thapsigargin results in increased expression of EDEM1 mRNA CTD PMID:22378314 PMID:27587023 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Eef1akmt1 EEF1A lysine methyltransferase 1 decreases expression ISO Thapsigargin results in decreased expression of EEF1AKMT1 protein CTD PMID:24648495 NCBI chr15:31,694,289...31,711,959
Ensembl chr15:31,694,292...31,711,336 		JBrowse link
G Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 decreases expression ISO Thapsigargin results in decreased expression of EEPD1 mRNA CTD PMID:22378314 NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340 		JBrowse link
G Efr3a EFR3 homolog A decreases expression ISO Thapsigargin results in decreased expression of EFR3A protein CTD PMID:24648495 NCBI chr 7:97,552,677...97,633,369
Ensembl chr 7:97,552,677...97,633,369 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein] CTD PMID:17991733 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Thapsigargin results in increased expression of EGFR protein CTD PMID:24648495 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression		 ISO Thapsigargin results in increased expression of EGR1 mRNA
Thapsigargin results in decreased expression of EGR1 mRNA		 CTD PMID:8764118 PMID:21694771 PMID:22378314 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 decreases expression EXP Thapsigargin results in decreased expression of EGR2 mRNA CTD PMID:20830808 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression