CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | sesquiterpene lactone |
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Accession: | CHEBI:37667
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browse the term
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Definition: | Any member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring. |
Synonyms: | related_synonym: | sesquiterpene lactones |
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression decreases activity |
ISO |
artemisinin results in increased expression of ABCB1 mRNA artemisinin results in decreased activity of ABCB1 protein |
CTD |
PMID:15761118 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] |
CTD |
PMID:18463201 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Casp3 |
caspase 3 |
increases activity |
EXP |
artemisinin results in increased activity of CASP3 protein |
CTD |
PMID:17948936 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] |
CTD |
PMID:18463201 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity increases expression |
ISO EXP |
artemisinin results in decreased activity of CYP1A2 protein artemisinin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:11124226 PMID:16919048 PMID:17962186 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
increases activity increases expression |
ISO |
artemisinin results in increased activity of CYP2A5 protein artemisinin results in increased expression of CYP2A5 mRNA |
CTD |
PMID:16919048 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression increases activity |
EXP ISO |
artemisinin results in increased expression of CYP2B1 mRNA artemisinin results in increased expression of CYP2B10 mRNA artemisinin results in increased activity of CYP2B10 protein |
CTD |
PMID:16919048 PMID:17962186 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions affects metabolic processing increases expression |
ISO |
[artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CYP2B6 protein affects the metabolism of artemisinin artemisinin results in increased expression of CYP2B6 mRNA |
CTD |
PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
artemisinin results in decreased activity of CYP2C19 protein |
CTD |
PMID:11124226 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
ISO |
artemisinin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:17962186 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions affects metabolic processing increases expression |
ISO |
[artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CYP3A4 protein affects the metabolism of artemisinin artemisinin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Esrra |
estrogen related receptor, alpha |
multiple interactions |
ISO |
artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; artemisinin inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] |
CTD |
PMID:30818834 |
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NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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Gsta1 |
glutathione S-transferase alpha 1 |
decreases activity |
ISO |
artemisinin results in decreased activity of GSTA1 protein |
CTD |
PMID:11807801 |
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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Gstp1 |
glutathione S-transferase pi 1 |
decreases activity |
ISO |
artemisinin results in decreased activity of GSTP1 protein |
CTD |
PMID:11807801 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Idh3a |
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha |
decreases expression |
ISO |
artemisinin results in decreased expression of IDH3A mRNA |
CTD |
PMID:30818834 |
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NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
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Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:18463201 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Lyz2 |
lysozyme 2 |
multiple interactions |
ISO |
[parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] |
CTD |
PMID:23355332 |
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NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein] |
CTD |
PMID:18463201 PMID:23355332 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18463201 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
[artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; artemisinin binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:15761118 PMID:17041008 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions increases expression affects expression affects localization increases activity |
ISO EXP |
[artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; artemisinin binds to and results in increased activity of NR1I3 protein; artemisinin binds to and results in increased activity of NR1I3 protein mutant form artemisinin binds to and results in increased activity of NR1I3 protein; fenvalerate inhibits the reaction [artemisinin binds to and results in increased activity of NR1I3 protein] artemisinin results in increased expression of NR1I3 mRNA artemisinin affects the expression of NR1I3 mRNA alternative form artemisinin affects the localization of NR1I3 protein artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein mutant form |
CTD |
PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 PMID:20686338 PMID:21778469 PMID:24721719 PMID:27665777 PMID:27732639 PMID:31472229 PMID:31538121 More...
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] |
CTD |
PMID:30818834 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of RELA protein] |
CTD |
PMID:18463201 PMID:23355332 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:27504015 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:27504015 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:27504015 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Tp53 |
tumor protein p53 |
increases activity |
ISO |
artemisinin results in increased activity of TP53 protein |
CTD |
PMID:30818834 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
alantolactone results in increased expression of BAK1 protein |
CTD |
PMID:22721982 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax |
BCL2 associated X, apoptosis regulator |
decreases expression increases expression |
ISO |
alantolactone results in decreased expression of BAX protein alantolactone results in increased expression of BAX protein |
CTD |
PMID:22721982 PMID:24252419 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
increases expression decreases expression |
ISO |
alantolactone results in increased expression of BCL2 protein alantolactone results in decreased expression of BCL2 protein |
CTD |
PMID:22721982 PMID:24252419 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bid |
BH3 interacting domain death agonist |
increases cleavage |
ISO |
alantolactone results in increased cleavage of BID protein |
CTD |
PMID:22721982 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Casp3 |
caspase 3 |
increases cleavage |
ISO |
alantolactone results in increased cleavage of CASP3 protein |
CTD |
PMID:22721982 PMID:24252419 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8 |
caspase 8 |
increases cleavage |
ISO |
alantolactone results in increased cleavage of CASP8 protein |
CTD |
PMID:22721982 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9 |
caspase 9 |
increases cleavage increases activity |
ISO |
alantolactone results in increased cleavage of CASP9 protein alantolactone results in increased activity of CASP9 protein |
CTD |
PMID:22721982 PMID:24252419 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
alantolactone results in increased cleavage of PARP1 protein |
CTD |
PMID:22721982 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Prss50 |
serine protease 50 |
decreases expression |
ISO |
alantolactone results in decreased expression of PRSS50 mRNA; alantolactone results in decreased expression of PRSS50 protein |
CTD |
PMID:24252419 |
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NCBI chr 8:110,842,525...110,848,855
Ensembl chr 8:110,842,671...110,848,802
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Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression |
ISO |
alantolactone results in decreased expression of RELA protein |
CTD |
PMID:22721982 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tp53 |
tumor protein p53 |
increases expression |
ISO |
alantolactone results in increased expression of TP53 protein |
CTD |
PMID:22721982 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25455453 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
[Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25455453 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA |
CTD |
PMID:31312845 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects expression multiple interactions |
ISO |
artemether affects the expression of NR1I3 mRNA alternative form [Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; Artemether binds to and results in increased activity of NR1I3 protein alternative form |
CTD |
PMID:24721719 PMID:31312845 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects expression |
ISO |
artemotil affects the expression of NR1I3 mRNA alternative form |
CTD |
PMID:24721719 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA] Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:30551460 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization |
ISO |
artesunate affects the localization of AIFM1 protein |
CTD |
PMID:24704559 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Ar |
androgen receptor |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of AR protein |
CTD |
PMID:25752796 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atg12 |
autophagy related 12 |
increases expression |
ISO |
Artesunate results in increased expression of ATG12 mRNA |
CTD |
PMID:30551460 |
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NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atg3 |
autophagy related 3 |
increases expression |
ISO |
Artesunate results in increased expression of ATG3 mRNA |
CTD |
PMID:30551460 |
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NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
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Atg5 |
autophagy related 5 |
increases expression |
ISO |
Artesunate results in increased expression of ATG5 mRNA |
CTD |
PMID:30551460 |
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NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
Artesunate results in increased expression of BAX protein [1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein |
CTD |
PMID:24704559 PMID:29031619 PMID:33002460 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Artesunate results in decreased expression of BCL2 protein 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein] [1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein |
CTD |
PMID:24704559 PMID:29031619 PMID:33002460 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bst1 |
bone marrow stromal cell antigen 1 |
increases response to substance |
ISO |
BST1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
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Casp3 |
caspase 3 |
increases activity increases cleavage multiple interactions |
ISO |
artesunate results in increased activity of CASP3 protein Artesunate results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein] |
CTD |
PMID:19513562 PMID:24704559 PMID:33002460 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9 |
caspase 9 |
affects expression |
ISO |
artesunate affects the expression of CASP9 protein |
CTD |
PMID:24704559 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat |
catalase |
increases expression decreases response to substance |
ISO |
artesunate results in increased expression of CAT protein CAT protein results in decreased susceptibility to artesunate |
CTD |
PMID:19513562 PMID:20144594 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cct2 |
chaperonin containing TCP1 subunit 2 |
decreases response to substance |
ISO |
CCT2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
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Chek1 |
checkpoint kinase 1 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] |
CTD |
PMID:31664825 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2 |
checkpoint kinase 2 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:31664825 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Clip4 |
CAP-GLY domain containing linker protein family, member 4 |
increases response to substance |
ISO |
CLIP4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
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G |
Coq8a |
coenzyme Q8A |
decreases response to substance |
ISO |
COQ8A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] |
CTD |
PMID:29031619 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Dbh |
dopamine beta-hydroxylase |
increases response to substance |
ISO |
DBH mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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G |
Des |
desmin |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA] Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein |
CTD |
PMID:30551460 |
|
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:25752796 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
artesunate results in increased expression of FAS protein |
CTD |
PMID:19513562 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Flna |
filamin A |
increases response to substance |
ISO |
FLNA mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
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G |
Fn1 |
fibronectin 1 |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA] Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein |
CTD |
PMID:30551460 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression multiple interactions |
ISO |
Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA] |
CTD |
PMID:30551460 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Fzd7 |
frizzled class receptor 7 |
increases response to substance |
ISO |
FZD7 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
affects response to substance decreases response to substance |
ISO |
GCLC mRNA affects the susceptibility to artesunate GCLC mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
decreases response to substance |
ISO |
GCLM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases activity multiple interactions |
ISO |
Artesunate results in decreased activity of GPX4 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein] |
CTD |
PMID:30551460 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gstm4 |
glutathione S-transferase mu 4 |
affects response to substance |
ISO |
GSTM4 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
artesunate results in decreased expression of GSTP1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gstt2 |
glutathione S-transferase, theta 2 |
affects response to substance |
ISO |
GSTT2 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects response to substance |
ISO |
GSTZ1 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] |
CTD |
PMID:31664825 |
|
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgb1 |
integrin subunit beta 1 |
increases response to substance |
ISO |
ITGB1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases lipidation |
ISO |
3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:33002460 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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|
G |
Mgst3 |
microsomal glutathione S-transferase 3 |
affects response to substance |
ISO |
MGST3 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
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|
G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] |
CTD |
PMID:29031619 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
EXP ISO |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA] |
CTD |
PMID:29031619 PMID:30551460 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:27474069 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
decreases response to substance |
ISO |
MTHFD2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO |
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] |
CTD |
PMID:33002460 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] |
CTD |
PMID:30031708 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Naca |
nascent polypeptide associated complex subunit alpha |
decreases response to substance |
ISO |
NACA mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
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|
G |
Nckap1 |
NCK-associated protein 1 |
increases response to substance |
ISO |
NCKAP1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
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G |
Ncoa4 |
nuclear receptor coactivator 4 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA] Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein |
CTD |
PMID:30551460 |
|
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
ISO |
artesunate affects the localization of NFE2L2 protein |
CTD |
PMID:26340163 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] |
CTD |
PMID:30031708 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
Artesunate results in increased cleavage of PARP1 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein] |
CTD |
PMID:24704559 PMID:33002460 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] |
CTD |
PMID:29031619 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
artesunate binds to and results in increased activity of PGR protein |
CTD |
PMID:25752796 |
|
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein |
CTD |
PMID:30551460 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rpa2 |
replication protein A2 |
increases phosphorylation |
ISO |
Artesunate results in increased phosphorylation of RPA2 protein |
CTD |
PMID:31664825 |
|
NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
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G |
Rpl41 |
ribosomal protein L41 |
decreases response to substance |
ISO |
RPL41 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 7:977,885...978,965
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G |
Rpl6 |
ribosomal protein L6 |
decreases response to substance |
ISO |
RPL6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
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G |
Rpl7 |
ribosomal protein L7 |
decreases response to substance |
ISO |
RPL7 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 5:3,217,184...3,220,192
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G |
Rps12 |
ribosomal protein S12 |
decreases response to substance |
ISO |
RPS12 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
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G |
Rps15a |
ribosomal protein S15a |
decreases response to substance |
ISO |
RPS15A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
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G |
Rps6 |
ribosomal protein S6 |
decreases response to substance |
ISO |
RPS6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Slc25a19 |
solute carrier family 25 member 19 |
decreases response to substance |
ISO |
SLC25A19 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
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G |
Sp1 |
Sp1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of SP1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein] Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein |
CTD |
PMID:30551460 |
|
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Srsf2 |
serine and arginine rich splicing factor 2 |
decreases response to substance |
ISO |
SRSF2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression multiple interactions |
ISO |
Artesunate results in increased expression of TIMP1 mRNA Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] |
CTD |
PMID:30551460 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] |
CTD |
PMID:30031708 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
Artesunate results in increased expression of TP53 protein Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein] |
CTD |
PMID:33259807 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpt1 |
tumor protein, translationally-controlled 1 |
affects response to substance multiple interactions |
ISO |
TPT1 protein affects the susceptibility to artesunate Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein] |
CTD |
PMID:15878303 PMID:33259807 |
|
NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
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G |
Tufm |
Tu translation elongation factor, mitochondrial |
decreases response to substance |
ISO |
TUFM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
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G |
Ulk1 |
unc-51 like autophagy activating kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Artesunate results in increased phosphorylation of ULK1 protein acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein] |
CTD |
PMID:33002460 |
|
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] |
CTD |
PMID:29031619 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Yy1 |
YY1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of YY1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747
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G |
Zbtb4 |
zinc finger and BTB domain containing 4 |
increases response to substance |
ISO |
ZBTB4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:18001288 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:18001288 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:21329749 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases expression |
EXP |
bilobalide results in increased expression of and results in increased activity of CYP1A2 protein bilobalide results in increased expression of CYP1A2 mRNA |
CTD |
PMID:18421621 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
bilobalide results in increased expression of CYP2B1 mRNA; bilobalide results in increased expression of CYP2B1 protein |
CTD |
PMID:16258077 PMID:18421621 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
increases expression |
EXP |
bilobalide results in increased expression of CYP2B2 protein |
CTD |
PMID:18421621 |
|
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases activity |
EXP |
bilobalide results in increased activity of CYP2E1 protein |
CTD |
PMID:18421621 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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|
G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions increases expression |
EXP |
bilobalide results in increased expression of and results in increased activity of CYP3A23-3A1 protein bilobalide results in increased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:18421621 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
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|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]] |
CTD |
PMID:32319158 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]] |
CTD |
PMID:32319158 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:32319158 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Cat |
catalase |
increases activity |
EXP |
costunolide results in increased activity of CAT protein |
CTD |
PMID:20709041 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
costunolide inhibits the reaction [Ethanol results in decreased expression of IL10 protein] |
CTD |
PMID:26970604 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
costunolide inhibits the reaction [Ethanol results in increased expression of NOS2 protein] |
CTD |
PMID:26970604 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
costunolide inhibits the reaction [Ethanol results in decreased expression of PCNA protein] |
CTD |
PMID:26970604 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
costunolide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] |
CTD |
PMID:26970604 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
costunolide inhibits the reaction [Ethanol results in increased expression of TNF protein] |
CTD |
PMID:26970604 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects localization |
ISO |
AHR mutant form inhibits the reaction [cynaropicrin affects the localization of NFE2L2 protein]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NFE2L2 mRNA]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA] cynaropicrin affects the localization of AHR protein |
CTD |
PMID:25680693 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:25680693 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression affects localization |
ISO |
AHR mutant form inhibits the reaction [cynaropicrin affects the localization of NFE2L2 protein]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NFE2L2 mRNA]; NFE2L2 mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA] |
CTD |
PMID:25680693 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
ISO |
AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA] |
CTD |
PMID:25680693 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
dehydrocostus lactone results in increased expression of HMOX1 protein |
CTD |
PMID:23942037 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein] |
CTD |
PMID:19457452 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of NOS2 protein] |
CTD |
PMID:26970604 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] |
CTD |
PMID:26970604 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of TNF protein] |
CTD |
PMID:26970604 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein] |
CTD |
PMID:19457452 |
|
NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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G |
Cat |
catalase |
increases activity |
EXP |
eremanthin results in increased activity of CAT protein |
CTD |
PMID:20709041 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
helenalin results in increased expression of ATF4 protein |
CTD |
PMID:23123298 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
helenalin inhibits the reaction [CD 437 results in increased activity of CASP3 protein] |
CTD |
PMID:16024638 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
helenalin inhibits the reaction [CD 437 results in increased activity of CASP8 protein] |
CTD |
PMID:16024638 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] |
CTD |
PMID:23688403 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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|
G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD40 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD40 protein] |
CTD |
PMID:15894585 |
|
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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|
G |
Cd80 |
Cd80 molecule |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD80 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD80 protein] |
CTD |
PMID:15894585 |
|
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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|
G |
Cd83 |
CD83 molecule |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD83 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD83 protein] |
CTD |
PMID:15894585 |
|
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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|
G |
Cd86 |
CD86 molecule |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD86 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD86 protein] |
CTD |
PMID:15894585 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
helenalin results in increased expression of DDIT3 protein |
CTD |
PMID:23123298 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Ddit4 |
DNA-damage-inducible transcript 4 |
increases expression |
ISO |
helenalin results in increased expression of DDIT4 protein |
CTD |
PMID:23123298 |
|
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of ICAM1 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of ICAM1 protein] helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:15894585 PMID:19608869 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL10 protein]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of IL10 protein] |
CTD |
PMID:15894585 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:15894585 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL12B protein]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of IL12B protein] |
CTD |
PMID:15894585 |
|
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] |
CTD |
PMID:23688403 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
helenalin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:17532054 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
helenalin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein] |
CTD |
PMID:16678799 |
|
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
helenalin inhibits the reaction [CD 437 results in decreased expression of NFKBIA protein] |
CTD |
PMID:16024638 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
helenalin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; helenalin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein] |
CTD |
PMID:28495310 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases activity |
ISO |
helenalin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; helenalin inhibits the reaction [CD 437 results in increased localization of RELA protein]; helenalin inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein] helenalin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] helenalin results in decreased activity of RELA protein |
CTD |
PMID:15930313 PMID:16024638 PMID:18413660 PMID:19608869 PMID:28495310 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
helenalin inhibits the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein] |
CTD |
PMID:16540396 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
helenalin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]] |
CTD |
PMID:16678799 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; helenalin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] |
CTD |
PMID:19608869 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions |
ISO |
helenalin inhibits the reaction [CD 437 results in increased expression of TNFRSF10A protein] |
CTD |
PMID:16024638 |
|
NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
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|
G |
Tslp |
thymic stromal lymphopoietin |
multiple interactions |
ISO |
helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] |
CTD |
PMID:23688403 |
|
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:19608869 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
inuviscolide results in decreased expression of BIRC5 protein |
CTD |
PMID:17919456 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
inuviscolide results in increased activity of CASP3 protein |
CTD |
PMID:17919456 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccnb1 |
cyclin B1 |
affects expression |
ISO |
inuviscolide affects the expression of CCNB1 protein |
CTD |
PMID:17919456 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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|
G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
ISO |
inuviscolide results in decreased expression of and affects the phosphorylation of CDK1 protein |
CTD |
PMID:17919456 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
inuviscolide results in increased expression of CDKN1A protein |
CTD |
PMID:17919456 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression |
ISO |
inuviscolide results in decreased expression of RELA protein |
CTD |
PMID:17919456 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [inuviscolide results in increased phosphorylation of TP53 protein]; inuviscolide results in increased expression of and results in increased phosphorylation of TP53 protein |
CTD |
PMID:17919456 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Casp3 |
caspase 3 |
increases expression |
ISO |
isoalantolactone results in increased expression of CASP3 protein modified form |
CTD |
PMID:29800641 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp7 |
caspase 7 |
increases cleavage increases expression multiple interactions |
ISO |
isoalantolactone results in increased cleavage of CASP7 protein isoalantolactone results in increased expression of CASP7 protein modified form Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of CASP7 protein modified form] |
CTD |
PMID:29800641 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression multiple interactions increases cleavage |
ISO |
isoalantolactone results in increased expression of PARP1 protein modified form Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of PARP1 protein modified form] isoalantolactone results in increased cleavage of PARP1 protein |
CTD |
PMID:29800641 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
parthenin analog results in decreased phosphorylation of AKT1 protein benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [parthenin analog results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:25196075 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
affects localization |
ISO |
parthenin analog affects the localization of BAX protein |
CTD |
PMID:25196075 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Casp3 |
caspase 3 |
increases activity |
ISO |
parthenin analog results in increased activity of CASP3 protein |
CTD |
PMID:25196075 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
parthenin analog results in increased activity of CASP8 protein |
CTD |
PMID:25196075 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
parthenin analog results in increased activity of CASP9 protein |
CTD |
PMID:25196075 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Dffa |
DNA fragmentation factor subunit alpha |
increases cleavage |
ISO |
parthenin analog results in increased cleavage of DFFA protein |
CTD |
PMID:25196075 |
|
NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
parthenin analog results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:25196075 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
parthenin analog results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:25196075 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
parthenin analog results in increased cleavage of PARP1 protein |
CTD |
PMID:25196075 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases phosphorylation |
ISO |
parthenin analog results in decreased phosphorylation of RAF1 protein |
CTD |
PMID:25196075 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions decreases phosphorylation |
ISO |
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [parthenin analog results in decreased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:25196075 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] |
CTD |
PMID:18463201 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
parthenolide results in increased expression of BAK1 protein |
CTD |
PMID:16024633 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
parthenolide results in increased expression of BAX protein |
CTD |
PMID:16024633 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
[[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 protein] parthenolide results in decreased expression of BCL2 mRNA; parthenolide results in decreased expression of BCL2 protein |
CTD |
PMID:20154269 PMID:21928377 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases response to substance |
ISO |
BCL2L1 protein results in decreased susceptibility to parthenolide |
CTD |
PMID:16024633 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bid |
BH3 interacting domain death agonist |
increases cleavage |
ISO |
parthenolide results in increased cleavage of BID protein |
CTD |
PMID:16024633 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
C5 |
complement C5 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein] |
CTD |
PMID:19284563 |
|
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA] |
CTD |
PMID:30259999 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein |
CTD |
PMID:20154269 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of CCL2 mRNA] parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA] parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA] |
CTD |
PMID:15728586 PMID:22748497 PMID:23958496 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] |
CTD |
PMID:23958496 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 protein] parthenolide results in decreased expression of CCND1 mRNA; parthenolide results in decreased expression of CCND1 protein |
CTD |
PMID:21928377 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cd14 |
CD14 molecule |
multiple interactions |
ISO |
parthenolide promotes the reaction [Calcitriol results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] |
CTD |
PMID:20089671 |
|
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cfb |
complement factor B |
decreases expression |
ISO |
parthenolide results in decreased expression of CFB mRNA |
CTD |
PMID:16921510 |
|
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] |
CTD |
PMID:18463201 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] |
CTD |
PMID:21507677 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions increases expression |
ISO |
parthenolide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA] parthenolide results in increased expression of CXCL1 mRNA |
CTD |
PMID:17320037 |
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NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
parthenolide promotes the reaction [Calcimycin results in increased expression of DDIT3 mRNA] parthenolide results in increased expression of DDIT3 mRNA |
CTD |
PMID:11360202 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Fas |
Fas cell surface death receptor |
decreases expression |
ISO |
parthenolide results in decreased expression of FAS mRNA |
CTD |
PMID:16024633 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
decreases expression |
ISO |
parthenolide results in decreased expression of FASLG mRNA |
CTD |
PMID:16024633 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA] |
CTD |
PMID:16921510 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Flt3 |
Fms related receptor tyrosine kinase 3 |
multiple interactions |
ISO |
parthenolide promotes the reaction [SC-203048 results in decreased expression of FLT3 mRNA] |
CTD |
PMID:21928377 |
|
NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
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G |
Hpgds |
hematopoietic prostaglandin D synthase |
multiple interactions |
ISO |
[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein |
CTD |
PMID:21669866 |
|
NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
parthenolide results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [resveratrol results in increased expression of ICAM1 mRNA] |
CTD |
PMID:22748497 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifna1 |
interferon, alpha 1 |
decreases expression |
ISO |
parthenolide results in decreased expression of IFNA1 mRNA |
CTD |
PMID:16921510 |
|
NCBI chr 5:103,095,767...103,098,260
Ensembl chr 5:103,097,356...103,097,925
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:18463201 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il12b |
interleukin 12B |
decreases expression |
ISO |
parthenolide results in decreased expression of IL12B mRNA |
CTD |
PMID:16921510 |
|
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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G |
Il1a |
interleukin 1 alpha |
decreases expression |
ISO |
parthenolide results in decreased expression of IL1A mRNA |
CTD |
PMID:16921510 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL1B protein] |
CTD |
PMID:24444433 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
parthenolide inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL6 protein]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of IL6 mRNA] parthenolide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA] parthenolide inhibits the reaction [Cyclosporine results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA] |
CTD |
PMID:22748497 PMID:23958496 PMID:24444433 PMID:30259999 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
parthenolide promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] |
CTD |
PMID:20089671 |
|
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
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G |
Ltc4s |
leukotriene C4 synthase |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA] |
CTD |
PMID:12574384 |
|
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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G |
Lyz2 |
lysozyme 2 |
multiple interactions |
ISO |
[parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; parthenolide inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] |
CTD |
PMID:23355332 |
|
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases expression multiple interactions |
ISO EXP |
parthenolide results in increased expression of MAPK8 mRNA parthenolide inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA] parthenolide results in increased phosphorylation of and results in increased activity of MAPK8 protein |
CTD |
PMID:16921510 PMID:30259999 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases expression |
ISO |
parthenolide results in increased expression of MAPK9 mRNA |
CTD |
PMID:16921510 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter] |
CTD |
PMID:20093109 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Ncor2 |
nuclear receptor co-repressor 2 |
affects localization multiple interactions |
ISO |
parthenolide affects the localization of NCOR2 protein SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein] |
CTD |
PMID:21928377 |
|
NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO EXP |
parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]] parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA] |
CTD |
PMID:16921510 PMID:18463201 PMID:30259999 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:18413660 PMID:18463201 PMID:19303104 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] |
CTD |
PMID:30259999 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] |
CTD |
PMID:30259999 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
parthenolide results in increased activity of NR1I2 protein |
CTD |
PMID:25455453 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
multiple interactions |
EXP |
parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] |
CTD |
PMID:15728586 |
|
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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G |
Ptges |
prostaglandin E synthase |
multiple interactions |
ISO |
[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein |
CTD |
PMID:21669866 |
|
NCBI chr 3:14,177,892...14,189,236
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein] parthenolide inhibits the reaction [JP8 aviation fuel results in increased expression of PTGS2 mRNA] |
CTD |
PMID:19095747 PMID:19303104 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization multiple interactions decreases activity |
ISO EXP |
parthenolide affects the localization of RELA protein parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein modified form] parthenolide inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein] parthenolide results in decreased activity of RELA protein [[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein]; parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; SC-203048 promotes the reaction [parthenolide affects the localization of RELA protein] |
CTD |
PMID:16921510 PMID:18413660 PMID:18463201 PMID:19095747 PMID:19284563 PMID:19303104 PMID:20093109 PMID:20154269 PMID:21928377 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rtkn |
rhotekin |
multiple interactions |
ISO |
parthenolide inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates] |
CTD |
PMID:15480428 |
|
NCBI chr 4:115,640,801...115,657,952
Ensembl chr 4:115,640,774...115,657,952
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G |
Sele |
selectin E |
decreases expression |
ISO |
parthenolide results in decreased expression of SELE mRNA |
CTD |
PMID:16921510 |
|
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Selp |
selectin P |
decreases expression |
ISO |
parthenolide results in decreased expression of SELP mRNA |
CTD |
PMID:16921510 |
|
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
parthenolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Sts |
steroid sulfatase |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein] |
CTD |
PMID:16178010 |
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NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G |
Tbxas1 |
thromboxane A synthase 1 |
multiple interactions |
ISO |
[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein |
CTD |
PMID:21669866 |
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NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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G |
Tlr5 |
toll-like receptor 5 |
decreases expression |
ISO |
parthenolide results in decreased expression of TLR5 mRNA |
CTD |
PMID:16921510 |
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NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
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G |
Tlr6 |
toll-like receptor 6 |
decreases expression |
ISO |
parthenolide results in decreased expression of TLR6 mRNA |
CTD |
PMID:16921510 |
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NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO EXP |
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of TNF mRNA]]; parthenolide inhibits the reaction [Resveratrol results in increased expression of TNF mRNA]; parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] parthenolide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA] parthenolide results in decreased activity of TNF protein |
CTD |
PMID:19303104 PMID:20093109 PMID:22748497 PMID:30259999 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
parthenolide results in increased expression of TP53 protein |
CTD |
PMID:16024633 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tradd |
TNFRSF1A-associated via death domain |
increases expression |
ISO |
parthenolide results in increased expression of TRADD mRNA |
CTD |
PMID:16921510 |
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NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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G |
Traf1 |
TNF receptor-associated factor 1 |
multiple interactions decreases expression |
ISO |
parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA] parthenolide results in decreased expression of TRAF1 mRNA; parthenolide results in decreased expression of TRAF1 protein |
CTD |
PMID:16921510 |
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NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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G |
Traf2 |
Tnf receptor-associated factor 2 |
multiple interactions decreases expression |
ISO |
parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA] parthenolide results in decreased expression of TRAF2 mRNA; parthenolide results in decreased expression of TRAF2 protein |
CTD |
PMID:16921510 |
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NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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G |
Tslp |
thymic stromal lymphopoietin |
multiple interactions |
ISO |
parthenolide inhibits the reaction [Glupearl 19S results in increased expression of TSLP mRNA] |
CTD |
PMID:32493875 |
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NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
parthenolide results in decreased expression of VCAM1 mRNA |
CTD |
PMID:16921510 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA] |
CTD |
PMID:16921510 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of AARS protein |
CTD |
PMID:24648495 |
|
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression multiple interactions |
ISO |
Thapsigargin results in decreased expression of ABCB1 mRNA; Thapsigargin results in decreased expression of ABCB1 protein 1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Thapsigargin results in decreased expression of ABCB1 protein] |
CTD |
PMID:34915026 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acad11 |
acyl-CoA dehydrogenase family, member 11 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACAD11 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560
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G |
Acad9 |
acyl-CoA dehydrogenase family, member 9 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACAD9 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
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G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
increases expression |
ISO |
Thapsigargin results in increased expression of ACADVL mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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G |
Acat2 |
acetyl-CoA acetyltransferase 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACAT2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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G |
Acbd3 |
acyl-CoA binding domain containing 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACBD3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380
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G |
Ackr1 |
atypical chemokine receptor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACKR1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr13:85,782,396...85,786,002
Ensembl chr13:85,782,398...85,783,983
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G |
Acly |
ATP citrate lyase |
increases expression |
ISO |
Thapsigargin results in increased expression of ACLY protein |
CTD |
PMID:24648495 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Aco2 |
aconitase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACO2 protein |
CTD |
PMID:24648495 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G |
Acot13 |
acyl-CoA thioesterase 13 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACOT13 mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851
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G |
Acot7 |
acyl-CoA thioesterase 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACOT7 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309
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G |
Acta2 |
actin alpha 2, smooth muscle |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of ACTA2 mRNA Thapsigargin results in decreased expression of ACTA2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Actg1 |
actin, gamma 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACTG1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
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G |
Actn1 |
actinin, alpha 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACTN1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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G |
Acvr1 |
activin A receptor type 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACVR1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
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G |
Adamts4 |
ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ADAMTS4 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
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G |
Adamts9 |
ADAM metallopeptidase with thrombospondin type 1 motif, 9 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ADAMTS9 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929
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G |
Adhfe1 |
alcohol dehydrogenase, iron containing, 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ADHFE1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
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G |
Adi1 |
acireductone dioxygenase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ADI1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842
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G |
Adm |
adrenomedullin |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of ADM mRNA Thapsigargin results in increased expression of ADM mRNA |
CTD |
PMID:20682585 PMID:22378314 |
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NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Adm2 |
adrenomedullin 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ADM2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:120,393,219...120,394,965
Ensembl chr 7:120,393,179...120,396,331
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G |
Adra2a |
adrenoceptor alpha 2A |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] |
CTD |
PMID:10742289 |
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NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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G |
Afap1 |
actin filament associated protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of AFAP1 protein |
CTD |
PMID:24648495 |
|
NCBI chr14:74,743,322...74,856,295
Ensembl chr14:74,743,320...74,856,263
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G |
Afdn |
afadin, adherens junction formation factor |
increases expression |
ISO |
Thapsigargin results in increased expression of AFDN protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:53,884,711...54,034,216
Ensembl chr 1:53,905,373...54,034,216
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G |
Ago3 |
argonaute RISC catalytic component 3 |
multiple interactions affects localization |
ISO |
Cycloheximide inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] |
CTD |
PMID:29576526 |
|
NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
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G |
Ahnak |
AHNAK nucleoprotein |
increases expression |
ISO |
Thapsigargin results in increased expression of AHNAK mRNA |
CTD |
PMID:19442820 |
|
NCBI chr 1:205,882,223...205,970,934
Ensembl chr 1:205,882,273...205,970,926
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:15364539 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ak2 |
adenylate kinase 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AK2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632
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G |
Ak3 |
adenylate kinase 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AK3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
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G |
Ak4 |
adenylate kinase 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AK4 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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G |
Akap17a |
A-kinase anchoring protein 17A |
increases expression |
ISO |
Thapsigargin results in increased expression of AKAP17A mRNA |
CTD |
PMID:22378314 |
|
NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479
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G |
Akap8l |
A-kinase anchoring protein 8 like |
increases expression |
ISO |
Thapsigargin results in increased expression of AKAP8L protein |
CTD |
PMID:24648495 |
|
NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275
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G |
Akirin1 |
akirin 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AKIRIN1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 5:135,989,378...136,004,782
Ensembl chr 5:135,989,465...136,004,762
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G |
Akna |
AT-hook transcription factor |
increases expression |
ISO |
Thapsigargin results in increased expression of AKNA mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation decreases phosphorylation decreases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; NRF1 protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein]; TFAM protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein] [Thapsigargin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein Thapsigargin results in decreased expression of AKT1 protein modified form |
CTD |
PMID:15339911 PMID:16338971 PMID:22378314 PMID:24898257 PMID:25398788 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aktip |
AKT interacting protein |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AKTIP protein |
CTD |
PMID:24648495 |
|
NCBI chr19:15,866,811...15,877,123
Ensembl chr19:15,866,928...15,886,663
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G |
Alcam |
activated leukocyte cell adhesion molecule |
increases expression |
ISO |
Thapsigargin results in increased expression of ALCAM mRNA |
CTD |
PMID:22378314 |
|
NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
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G |
Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ALDH18A1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
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G |
Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDH1A2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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G |
Aldh1a3 |
aldehyde dehydrogenase 1 family, member A3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDH1A3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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G |
Aldh5a1 |
aldehyde dehydrogenase 5 family, member A1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDH5A1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
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G |
Aldh6a1 |
aldehyde dehydrogenase 6 family, member A1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ALDH6A1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDOC mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alg5 |
ALG5, dolichyl-phosphate beta-glucosyltransferase |
increases expression |
ISO |
Thapsigargin results in increased expression of ALG5 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
|
NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]; 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]]; SB 203580 inhibits the reaction [Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein; Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein |
CTD |
PMID:10779545 PMID:18218859 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Alpp |
alkaline phosphatase, placental |
increases expression |
ISO |
Thapsigargin results in increased expression of ALPP mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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G |
Amot |
angiomotin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AMOT mRNA |
CTD |
PMID:29453283 |
|
NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272
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G |
Amt |
aminomethyltransferase |
increases expression |
ISO |
Thapsigargin results in increased expression of AMT mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126
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G |
Angptl2 |
angiopoietin-like 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ANGPTL2 protein |
CTD |
PMID:24648495 |
|
NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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G |
Angptl3 |
angiopoietin-like 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ANGPTL3 mRNA |
CTD |
PMID:32535746 |
|
NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
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G |
Ankrd10 |
ankyrin repeat domain 10 |
increases expression |
ISO |
Thapsigargin results in increased expression of ANKRD10 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr16:77,866,489...77,889,745
Ensembl chr16:77,864,261...77,889,745
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G |
Ankrd17 |
ankyrin repeat domain 17 |
increases expression |
ISO |
Thapsigargin results in increased expression of ANKRD17 protein |
CTD |
PMID:24648495 |
|
NCBI chr14:17,723,239...17,862,625
Ensembl chr14:17,721,932...17,862,617
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G |
Antxr2 |
ANTXR cell adhesion molecule 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ANTXR2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr14:11,542,266...11,682,112
Ensembl chr14:11,541,772...11,682,094
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G |
Anxa5 |
annexin A5 |
increases expression |
ISO |
Thapsigargin results in increased expression of ANXA5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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G |
Ap2m1 |
adaptor related protein complex 2 subunit mu 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AP2M1 protein |
CTD |
PMID:24648495 |
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NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
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G |
Ap3b1 |
adaptor related protein complex 3 subunit beta 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of AP3B1 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
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Apob |
apolipoprotein B |
decreases secretion decreases expression |
ISO |
Thapsigargin results in decreased secretion of APOB protein Thapsigargin results in decreased expression of APOB mRNA |
CTD |
PMID:32535746 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Apoc3 |
apolipoprotein C3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of APOC3 mRNA |
CTD |
PMID:32535746 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
Aqr |
aquarius intron-binding spliceosomal factor |
increases expression |
ISO |
Thapsigargin results in increased expression of AQR protein |
CTD |
PMID:24648495 |
|
NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Thapsigargin results in increased degradation of and results in decreased expression of AR protein |
CTD |
PMID:30280407 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arcn1 |
archain 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARCN1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:45,057,617...45,082,224
Ensembl chr 8:45,057,619...45,082,247
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G |
Arf3 |
ADP-ribosylation factor 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ARF3 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002
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G |
Arf4 |
ADP-ribosylation factor 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARF4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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G |
Arfgap3 |
ADP-ribosylation factor GTPase activating protein 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARFGAP3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208
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Arg2 |
arginase 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ARG2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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G |
Arhgef2 |
Rho/Rac guanine nucleotide exchange factor 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARHGEF2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
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G |
Arid4a |
AT-rich interaction domain 4A |
increases expression |
ISO |
Thapsigargin results in increased expression of ARID4A protein |
CTD |
PMID:24648495 |
|
NCBI chr 6:89,522,463...89,593,868
Ensembl chr 6:89,522,442...89,593,510
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G |
Arid4b |
AT-rich interaction domain 4B |
increases expression |
ISO |
Thapsigargin results in increased expression of ARID4B protein |
CTD |
PMID:24648495 |
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NCBI chr17:51,138,419...51,262,956
Ensembl chr17:51,138,535...51,262,906
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G |
Arl1 |
ADP-ribosylation factor like GTPase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARL1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
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G |
Armcx1 |
armadillo repeat containing, X-linked 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARMCX1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299
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G |
Armcx3 |
armadillo repeat containing, X-linked 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARMCX3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:97,937,115...97,942,098
Ensembl chr X:97,936,999...97,942,098
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G |
Arpc3 |
actin related protein 2/3 complex, subunit 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARPC3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651
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G |
Asb5 |
ankyrin repeat and SOCS box-containing 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ASB5 protein |
CTD |
PMID:24648495 |
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NCBI chr16:37,237,869...37,305,207
Ensembl chr16:37,235,405...37,278,109
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G |
Ascl1 |
achaete-scute family bHLH transcription factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ASCL1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993
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G |
Asf1b |
anti-silencing function 1B histone chaperone |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ASF1B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
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G |
Asgr1 |
asialoglycoprotein receptor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ASGR1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Thapsigargin results in increased expression of ASNS mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Asph |
aspartate-beta-hydroxylase |
increases expression |
ISO |
Thapsigargin results in increased expression of ASPH protein |
CTD |
PMID:24648495 |
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NCBI chr 5:22,603,879...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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G |
Atad2 |
ATPase family, AAA domain containing 2 |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of ATAD2 mRNA Thapsigargin results in increased expression of ATAD2 protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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G |
Atf3 |
activating transcription factor 3 |
multiple interactions increases expression |
ISO EXP |
ATF3 mutant form promotes the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA] Thapsigargin results in increased expression of ATF3 mRNA Thapsigargin results in increased expression of ATF3 mRNA; Thapsigargin results in increased expression of ATF3 protein |
CTD |
PMID:17332266 PMID:20022965 PMID:21694771 PMID:22641616 PMID:22935518 PMID:29453283 PMID:33770205 More...
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression increases activity decreases response to substance |
ISO EXP |
ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]; ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; NUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Thapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter] 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein] Thapsigargin results in increased expression of ATF4 mRNA; Thapsigargin results in increased expression of ATF4 protein 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; ATF4 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; GSK2656157 inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein] Thapsigargin results in increased activity of ATF4 protein ATF4 results in decreased susceptibility to Thapsigargin |
CTD |
PMID:16298333 PMID:17283163 PMID:20022965 PMID:20589738 PMID:22378314 PMID:23383089 PMID:24648495 PMID:24865413 PMID:27226639 PMID:27358234 PMID:27587023 PMID:28223344 PMID:28844859 PMID:29109149 PMID:32357311 PMID:32578922 More...
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf5 |
activating transcription factor 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATF5 mRNA Thapsigargin results in increased expression of ATF5 mRNA; Thapsigargin results in increased expression of ATF5 protein |
CTD |
PMID:22378314 PMID:24648495 PMID:28942281 |
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NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions increases cleavage increases expression increases activity |
ISO EXP |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein] Thapsigargin results in increased expression of ATF6 mRNA; Thapsigargin results in increased expression of ATF6 protein; Thapsigargin results in increased expression of ATF6 protein modified form 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Thapsigargin results in increased cleavage of and affects the localization of ATF6 protein Thapsigargin results in increased activity of ATF6 protein |
CTD |
PMID:17963750 PMID:18477628 PMID:20493918 PMID:22378314 PMID:23383089 PMID:23576437 PMID:24638036 PMID:26264395 PMID:27358234 PMID:27587023 PMID:28223344 PMID:30796460 PMID:32407927 More...
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atg10 |
autophagy related 10 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATG10 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP1B1 mRNA |
CTD |
PMID:33770205 |
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NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
affects response to substance increases expression decreases activity multiple interactions |
ISO EXP |
ATP2A2 protein affects the susceptibility to Thapsigargin Thapsigargin results in increased expression of ATP2A2 mRNA Thapsigargin results in decreased activity of ATP2A2 protein [Thapsigargin results in decreased activity of ATP2A2 protein] which results in decreased transport of Calcium; Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of ATP2A2 mRNA]; Thapsigargin results in increased expression of and results in decreased activity of ATP2A2 protein |
CTD |
PMID:17287366 PMID:17475205 PMID:19244478 PMID:20816668 |
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NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Atp2a3 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
multiple interactions |
ISO |
[Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein] |
CTD |
PMID:18439569 |
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NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP5F1A mRNA |
CTD |
PMID:22378314 |
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NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5mc1 |
ATP synthase membrane subunit c locus 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATP5MC1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124 Ensembl chr10:81,023,925...81,027,124
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G |
Atp5mc3 |
ATP synthase membrane subunit c locus 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATP5MC3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
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G |
Atp5mf |
ATP synthase membrane subunit f |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATP5MF mRNA |
CTD |
PMID:22378314 |
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NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
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G |
Atp6v0a1 |
ATPase H+ transporting V0 subunit a1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP6V0A1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895
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G |
Atp6v0a2 |
ATPase H+ transporting V0 subunit a2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP6V0A2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr12:31,949,863...31,979,777
Ensembl chr12:31,822,733...32,007,069
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G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
multiple interactions decreases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] |
CTD |
PMID:19442820 |
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NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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G |
Atp8a1 |
ATPase phospholipid transporting 8A1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP8A1 protein |
CTD |
PMID:24648495 |
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NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611
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G |
Atrx |
ATRX, chromatin remodeler |
increases expression |
ISO |
Thapsigargin results in increased expression of ATRX protein |
CTD |
PMID:24648495 |
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NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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G |
Auh |
AU RNA binding methylglutaconyl-CoA hydratase |
increases expression |
ISO |
Thapsigargin results in increased expression of AUH mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:12,329,522...12,424,896
Ensembl chr17:12,329,524...12,424,896
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G |
Aurkb |
aurora kinase B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AURKB mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Aven |
apoptosis and caspase activation inhibitor |
increases expression |
ISO |
Thapsigargin results in increased expression of AVEN mRNA |
CTD |
PMID:29453283 |
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NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634
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G |
B4galt5 |
beta-1,4-galactosyltransferase 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of B4GALT5 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 3:156,018,056...156,033,983
Ensembl chr 3:156,018,053...156,070,074
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G |
Bach2 |
BTB domain and CNC homolog 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of BACH2 mRNA |
CTD |
PMID:24247028 |
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NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877
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Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
Thapsigargin results in increased expression of BAD mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Banf1 |
BAF nuclear assembly factor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BANF1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:202,672,170...202,674,215
Ensembl chr 1:202,671,305...202,674,188
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G |
Basp1 |
brain abundant, membrane attached signal protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BASP1 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases activity increases expression multiple interactions |
ISO |
Thapsigargin results in increased activity of BAX protein Thapsigargin results in increased expression of BAX protein Thapsigargin promotes the reaction [arsenite results in increased expression of BAX protein] |
CTD |
PMID:20130848 PMID:26677073 PMID:35033536 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Baz1a |
bromodomain adjacent to zinc finger domain, 1A |
increases expression |
ISO |
Thapsigargin results in increased expression of BAZ1A protein |
CTD |
PMID:24648495 |
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NCBI chr 6:72,389,701...72,512,516
Ensembl chr 6:72,389,703...72,512,459
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G |
Baz1b |
bromodomain adjacent to zinc finger domain, 1B |
increases expression |
ISO |
Thapsigargin results in increased expression of BAZ1B protein |
CTD |
PMID:24648495 |
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NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of BBC3 mRNA |
CTD |
PMID:16018998 PMID:22378314 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcas2 |
BCAS2, pre-mRNA processing factor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BCAS2 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BCAT1 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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G |
Bcat2 |
branched chain amino acid transaminase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of BCAT2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
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G |
Bckdk |
branched chain ketoacid dehydrogenase kinase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BCKDK mRNA Thapsigargin results in decreased expression of BCKDK protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions decreases expression decreases phosphorylation |
ISO |
Thapsigargin results in increased expression of BCL2 mRNA 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein] Thapsigargin promotes the reaction [arsenite results in decreased expression of BCL2 protein] Thapsigargin results in decreased phosphorylation of BCL2 protein |
CTD |
PMID:22378314 PMID:25611565 PMID:26677073 PMID:30841431 PMID:35033536 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression increases expression affects splicing |
EXP ISO |
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; GW 4869 inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; PLA2G6 mutant form inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA] Thapsigargin results in decreased expression of BCL2L1 protein 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in decreased expression of BCL2L1 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in decreased expression of BCL2L1 protein] BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein alternative form] Thapsigargin results in increased expression of BCL2L1 protein |
CTD |
PMID:23885834 PMID:25762722 PMID:30841431 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bclaf1 |
BCL2-associated transcription factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BCLAF1 protein |
CTD |
PMID:24648495 |
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NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832
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Begain |
brain-enriched guanylate kinase-associated |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BEGAIN mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:127,943,651...127,979,876
Ensembl chr 6:127,943,651...127,979,841
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Bend6 |
BEN domain containing 6 |
increases expression |
ISO |
Thapsigargin results in increased expression of BEND6 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 9:36,081,033...36,135,309
Ensembl chr 9:36,081,484...36,135,228
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Best1 |
bestrophin 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BEST1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063
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G |
Bet1 |
Bet1 golgi vesicular membrane trafficking protein |
decreases expression multiple interactions |
ISO |
Thapsigargin results in decreased expression of BET1 mRNA [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of BET1 mRNA |
CTD |
PMID:19442820 |
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NCBI chr 4:32,116,232...32,126,592
Ensembl chr 4:32,116,235...32,126,617
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G |
Bet1l |
Bet1 golgi vesicular membrane trafficking protein-like |
increases expression |
ISO |
Thapsigargin results in increased expression of BET1L mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:195,930,165...195,935,072
Ensembl chr 1:195,931,411...195,935,040
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Bex2 |
brain expressed X-linked 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of BEX2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr X:99,219,015...99,220,411
Ensembl chr X:99,219,014...99,220,958
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BHLHE40 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Bid |
BH3 interacting domain death agonist |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BID mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BIRC2 protein |
CTD |
PMID:16382148 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 protein] Thapsigargin results in increased expression of BIRC3 mRNA; Thapsigargin results in increased expression of BIRC3 protein |
CTD |
PMID:15339911 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Blm |
BLM RecQ like helicase |
increases expression |
ISO |
Thapsigargin results in increased expression of BLM protein |
CTD |
PMID:24648495 |
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NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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G |
Blnk |
B-cell linker |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BLNK protein |
CTD |
PMID:24648495 |
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NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113
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Bloc1s2 |
biogenesis of lysosomal organelles complex-1, subunit 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of BLOC1S2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653
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G |
Bmf |
Bcl2 modifying factor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BMF mRNA |
CTD |
PMID:33770205 |
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NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bmp2k |
BMP-2 inducible kinase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BMP2K protein |
CTD |
PMID:24648495 |
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NCBI chr14:12,481,194...12,579,411
Ensembl chr14:12,484,729...12,579,134
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G |
Bms1 |
BMS1 ribosome biogenesis factor |
increases expression |
ISO |
Thapsigargin results in increased expression of BMS1 protein |
CTD |
PMID:24648495 |
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NCBI chr 4:151,558,163...151,595,187
Ensembl chr 4:151,558,163...151,595,127
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G |
Bnc2 |
basonuclin 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BNC2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:98,679,071...99,079,742
Ensembl chr 5:98,687,410...99,079,426
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G |
Bnip3 |
BCL2 interacting protein 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BNIP3 mRNA Thapsigargin results in decreased expression of BNIP3 protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bola3 |
bolA family member 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BOLA3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797
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G |
Bphl |
biphenyl hydrolase like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BPHL mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288
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G |
Brca1 |
BRCA1, DNA repair associated |
increases expression multiple interactions affects localization |
ISO |
Thapsigargin results in increased expression of BRCA1 mRNA; Thapsigargin results in increased expression of BRCA1 protein Cycloheximide inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA] |
CTD |
PMID:16434996 PMID:29576526 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Brca2 |
BRCA2, DNA repair associated |
increases expression |
ISO |
Thapsigargin results in increased expression of BRCA2 mRNA; Thapsigargin results in increased expression of BRCA2 protein |
CTD |
PMID:16434996 |
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NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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G |
Brinp1 |
BMP/retinoic acid inducible neural specific 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BRINP1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:82,348,501...82,550,506
Ensembl chr 5:82,348,930...82,493,150
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G |
Brsk1 |
BR serine/threonine kinase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BRSK1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365
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G |
Bub1b |
BUB1 mitotic checkpoint serine/threonine kinase B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BUB1B mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
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G |
C1qbp |
complement C1q binding protein |
decreases expression |
ISO |
Thapsigargin results in decreased expression of C1QBP mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
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G |
C5 |
complement C5 |
increases expression |
ISO |
Thapsigargin results in increased expression of C5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
Cacna1a |
calcium voltage-gated channel subunit alpha1 A |
increases expression |
ISO |
Thapsigargin results in increased expression of CACNA1A mRNA |
CTD |
PMID:19442820 |
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NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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G |
Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CACNA2D1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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G |
Cacna2d2 |
calcium voltage-gated channel auxiliary subunit alpha2delta 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CACNA2D2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
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G |
Cacng4 |
calcium voltage-gated channel auxiliary subunit gamma 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CACNG4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:92,686,100...92,745,601
Ensembl chr10:92,683,761...92,746,126
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G |
Cadm1 |
cell adhesion molecule 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CADM1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [Lipopolysaccharides results in increased expression of CALCA mRNA] |
CTD |
PMID:20682585 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Calcb |
calcitonin-related polypeptide, beta |
increases expression |
ISO |
Thapsigargin results in increased expression of CALCB mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:168,966,465...168,970,125
Ensembl chr 1:168,966,465...168,970,125
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G |
Calr |
calreticulin |
increases expression |
ISO |
Thapsigargin results in increased expression of CALR mRNA; Thapsigargin results in increased expression of CALR protein |
CTD |
PMID:17353921 PMID:22378314 PMID:27587023 PMID:29453283 |
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NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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G |
Calu |
calumenin |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of CALU mRNA; Thapsigargin results in decreased expression of CALU protein Thapsigargin results in increased expression of CALU mRNA |
CTD |
PMID:21692457 PMID:22378314 |
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NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
multiple interactions |
EXP |
Thapsigargin inhibits the reaction [LIF protein results in increased activity of CAMK4 protein] |
CTD |
PMID:11073891 |
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NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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G |
Canx |
calnexin |
increases expression affects localization |
ISO EXP |
Thapsigargin results in increased expression of CANX mRNA; Thapsigargin results in increased expression of CANX protein Thapsigargin affects the localization of CANX protein |
CTD |
PMID:17353921 PMID:22378314 PMID:28315715 PMID:28940366 PMID:29453283 |
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NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Capn1 |
calpain 1 |
increases expression multiple interactions |
EXP |
Thapsigargin results in increased expression of CAPN1 protein Thapsigargin promotes the reaction [cadmium acetate results in increased expression of CAPN1 protein] |
CTD |
PMID:28347754 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Car10 |
carbonic anhydrase 10 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CA10 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:78,055,875...78,556,490
Ensembl chr10:78,054,114...78,555,834
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G |
Car5b |
carbonic anhydrase 5B |
increases expression |
ISO |
Thapsigargin results in increased expression of CA5B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837
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G |
Card9 |
caspase recruitment domain family, member 9 |
increases expression |
ISO |
Thapsigargin results in increased expression of CARD9 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
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G |
Carhsp1 |
calcium regulated heat stable protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CARHSP1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
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G |
Casp1 |
caspase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CASP1 mRNA |
CTD |
PMID:30796460 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
multiple interactions increases expression increases activity increases cleavage |
ISO EXP |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Resveratrol inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased cleavage of CASP12 protein] Thapsigargin results in increased cleavage of CASP12 protein alternative form 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form] |
CTD |
PMID:12198651 PMID:16338971 PMID:18477628 PMID:20493918 PMID:24224909 PMID:26264395 PMID:27638049 PMID:30841431 More...
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp2 |
caspase 2 |
multiple interactions increases activity |
ISO |
Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein] |
CTD |
PMID:16388830 |
|
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases cleavage increases activity increases metabolic processing |
ISO EXP |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of CASP3 protein]; Bortezomib promotes the reaction [Thapsigargin results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] Thapsigargin results in increased cleavage of CASP3 protein 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of CASP3 protein]; 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; HR protein affects the reaction [Thapsigargin results in increased activity of CASP3 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased cleavage of CASP3 protein]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form] Thapsigargin results in increased metabolism of CASP3 protein Thapsigargin results in increased expression of CASP3 protein; Thapsigargin results in increased expression of CASP3 protein alternative form |
CTD |
PMID:12198651 PMID:12871656 PMID:16338971 PMID:16357177 PMID:16382148 PMID:16388830 PMID:17559149 PMID:18178165 PMID:19028522 PMID:20022965 PMID:20130848 PMID:20493918 PMID:20886113 PMID:22800509 PMID:23576437 PMID:25341683 PMID:27638049 PMID:30841431 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP4 protein]; Thapsigargin results in increased cleavage of and results in increased activity of CASP4 protein |
CTD |
PMID:17559149 PMID:25341683 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp6 |
caspase 6 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CASP6 protein |
CTD |
PMID:24648495 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO |
Doxorubicin inhibits the reaction [Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein]; Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP7 protein] |
CTD |
PMID:12198651 PMID:16298333 PMID:17559149 PMID:19139269 PMID:20022965 |
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NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
Thapsigargin results in increased activity of CASP8 protein |
CTD |
PMID:16018998 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases cleavage increases activity |
ISO |
Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP9 protein] Thapsigargin results in increased cleavage of CASP9 protein 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased cleavage of CASP9 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased cleavage of CASP9 protein] |
CTD |
PMID:16018998 PMID:16388830 PMID:20130848 PMID:25341683 PMID:30841431 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Casr |
calcium-sensing receptor |
multiple interactions |
EXP |
Thapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] |
CTD |
PMID:11071898 |
|
NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
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G |
Catsper2 |
cation channel, sperm associated 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CATSPER2 mRNA |
CTD |
PMID:19442820 |
|
NCBI chr 3:108,368,654...108,389,380
Ensembl chr 3:108,368,668...108,388,050
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G |
Cbln2 |
cerebellin 2 precursor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CBLN2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr18:79,940,412...79,948,766
Ensembl chr18:79,942,590...79,947,855
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G |
Ccdc171 |
coiled-coil domain containing 171 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCDC171 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:97,919,965...98,403,853
Ensembl chr 5:97,920,002...98,282,833
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression multiple interactions decreases expression |
ISO EXP |
Thapsigargin results in increased expression of CCL2 mRNA Thapsigargin inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Thapsigargin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] Thapsigargin results in decreased expression of CCL2 mRNA |
CTD |
PMID:8764118 PMID:18799549 PMID:18951912 PMID:20830808 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression |
EXP |
Thapsigargin results in increased expression of CCL3 mRNA; Thapsigargin results in increased expression of CCL3 protein |
CTD |
PMID:20830808 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccn1 |
cellular communication network factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCN1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNA2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNB1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnb1ip1 |
cyclin B1 interacting protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCNB1IP1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr15:24,014,905...24,031,357
Ensembl chr15:24,014,908...24,028,475
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCND1 mRNA |
CTD |
PMID:17332266 PMID:22378314 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnf |
cyclin F |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNF mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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G |
Ccng2 |
cyclin G2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCNG2 mRNA |
CTD |
PMID:17332266 |
|
NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Ccnq |
cyclin Q |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNQ protein |
CTD |
PMID:24648495 |
|
NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961
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G |
Ccpg1 |
cell cycle progression 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCPG1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
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G |
Cd44 |
CD44 molecule (Indian blood group) |
increases expression |
ISO |
Thapsigargin results in increased expression of CD44 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
increases expression |
ISO |
Thapsigargin results in increased expression of CD55 mRNA |
CTD |
PMID:24247028 |
|
NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cd69 |
Cd69 molecule |
increases expression |
ISO |
Thapsigargin results in increased expression of CD69 mRNA |
CTD |
PMID:24247028 |
|
NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
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G |
Cd70 |
Cd70 molecule |
increases expression |
ISO |
Thapsigargin results in increased expression of CD70 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715
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G |
Cdc20 |
cell division cycle 20 |
multiple interactions increases expression |
ISO |
[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of CDC20 mRNA; [Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA; [Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of CDC20 mRNA Thapsigargin results in increased expression of CDC20 mRNA |
CTD |
PMID:19442820 |
|
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc45 |
cell division cycle 45 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDC45 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
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G |
Cdc5l |
cell division cycle 5-like |
increases expression |
ISO |
Thapsigargin results in increased expression of CDC5L protein |
CTD |
PMID:24648495 |
|
NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450
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G |
Cdc7 |
cell division cycle 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDC7 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
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G |
Cdca2 |
cell division cycle associated 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDCA2 protein |
CTD |
PMID:24648495 |
|
NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
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G |
Cdca7 |
cell division cycle associated 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDCA7 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353
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G |
Cdca7l |
cell division cycle associated 7 like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDCA7L mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 6:138,793,953...138,839,889
Ensembl chr 6:138,794,228...138,839,888
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G |
Cdh15 |
cadherin 15 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDH15 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr19:50,903,757...50,927,151
Ensembl chr19:50,903,638...50,927,105
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G |
Cdipt |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDIPT protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDK1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions decreases expression increases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA] Thapsigargin results in decreased expression of CDK2 mRNA |
CTD |
PMID:19442820 PMID:22378314 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk2ap2 |
cyclin-dependent kinase 2 associated protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDK2AP2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137
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G |
Cdk5rap2 |
CDK5 regulatory subunit associated protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDK5RAP2 protein |
CTD |
PMID:24648495 |
|
NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782
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G |
Cdk5rap3 |
CDK5 regulatory subunit associated protein 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDK5RAP3 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
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G |
Cdk7 |
cyclin-dependent kinase 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDK7 protein |
CTD |
PMID:24648495 |
|
NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Thapsigargin results in increased expression of CDKN1A mRNA |
CTD |
PMID:29453283 PMID:33770205 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdr2 |
cerebellar degeneration-related protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDR2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression multiple interactions |
ISO |
Thapsigargin results in increased expression of CEBPB mRNA; Thapsigargin results in increased expression of CEBPB protein alternative form Thapsigargin promotes the reaction [CEBPB protein binds to NR1I2 promoter] |
CTD |
PMID:22378314 PMID:25616597 PMID:29453283 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cebpe |
CCAAT/enhancer binding protein epsilon |
increases expression |
ISO |
Thapsigargin results in increased expression of CEBPE mRNA |
CTD |
PMID:29453283 |
|
NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814
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G |
Cebpg |
CCAAT/enhancer binding protein gamma |
increases expression |
ISO |
Thapsigargin results in increased expression of CEBPG mRNA |
CTD |
PMID:22378314 PMID:29453283 |
|
NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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G |
Cenpa |
centromere protein A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CENPA mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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G |
Cenpf |
centromere protein F |
increases expression |
ISO |
Thapsigargin results in increased expression of CENPF mRNA |
CTD |
PMID:19442820 |
|
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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G |
Cenpu |
centromere protein U |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CENPU mRNA |
CTD |
PMID:22378314 |
|
NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
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G |
Cep290 |
centrosomal protein 290 |
increases expression |
ISO |
Thapsigargin results in increased expression of CEP290 protein |
CTD |
PMID:24648495 |
|
NCBI chr 7:35,310,071...35,399,392
Ensembl chr 7:35,310,199...35,399,392
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G |
Ces5a |
carboxylesterase 5A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CES5A protein |
CTD |
PMID:24648495 |
|
NCBI chr19:11,469,469...11,499,007
Ensembl chr19:11,469,469...11,499,006
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G |
Cetn2 |
centrin 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CETN2 protein |
CTD |
PMID:24648495 |
|
NCBI chr X:150,769,944...150,775,052
Ensembl chr X:150,769,953...150,774,919
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium results in increased activity of CFTR protein mutant form]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] |
CTD |
PMID:18230692 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Cga |
glycoprotein hormones, alpha polypeptide |
increases expression |
ISO |
Thapsigargin results in increased expression of CGA mRNA |
CTD |
PMID:21694771 PMID:29453283 |
|
NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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G |
Cgn |
cingulin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CGN mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645
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G |
Cgnl1 |
cingulin-like 1 |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of CGNL1 protein Thapsigargin results in decreased expression of CGNL1 mRNA |
CTD |
PMID:24648495 PMID:29453283 |
|
NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917
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G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHAC1 mRNA |
CTD |
PMID:19442820 |
|
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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G |
Chaf1a |
chromatin assembly factor 1 subunit A |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of CHAF1A mRNA Thapsigargin results in decreased expression of CHAF1A mRNA |
CTD |
PMID:19442820 PMID:22378314 |
|
NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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G |
Chaf1b |
chromatin assembly factor 1 subunit B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHAF1B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
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G |
Chchd6 |
coiled-coil-helix-coiled-coil-helix domain containing 6 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHCHD6 protein |
CTD |
PMID:24648495 |
|
NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
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G |
Chchd7 |
coiled-coil-helix-coiled-coil-helix domain containing 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHCHD7 protein |
CTD |
PMID:24648495 |
|
NCBI chr 5:16,957,081...16,969,388
Ensembl chr 5:16,957,188...16,961,184
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G |
Chd4 |
chromodomain helicase DNA binding protein 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of CHD4 protein |
CTD |
PMID:24648495 |
|
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHEK1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chga |
chromogranin A |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of CHGA mRNA Thapsigargin results in increased expression of CHGA mRNA |
CTD |
PMID:22378314 PMID:29453283 |
|
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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G |
Chid1 |
chitinase domain containing 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHID1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606
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G |
Chpf |
chondroitin polymerizing factor |
increases expression |
ISO |
Thapsigargin results in increased expression of CHPF mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878
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G |
Chpt1 |
choline phosphotransferase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CHPT1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] |
CTD |
PMID:18316702 |
|
NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHRNA3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
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G |
Chrna5 |
cholinergic receptor nicotinic alpha 5 subunit |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHRNA5 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
|
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G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHRNB4 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
|
|
G |
Chst15 |
carbohydrate sulfotransferase 15 |
increases expression |
ISO |
Thapsigargin results in increased expression of CHST15 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707
|
|
G |
Cirbp |
cold inducible RNA binding protein |
increases expression |
ISO |
Thapsigargin results in increased expression of CIRBP mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
|
|
G |
Ckap5 |
cytoskeleton associated protein 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of CKAP5 protein |
CTD |
PMID:24648495 |
|
NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
|
|
G |
Ckb |
creatine kinase B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CKB mRNA; Thapsigargin results in decreased expression of CKB protein |
CTD |
PMID:21692457 PMID:22378314 |
|
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
|
|
G |
Clcc1 |
chloride channel CLIC-like 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CLCC1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913
|
|
G |
Clec11a |
C-type lectin domain containing 11A |
increases expression |
ISO |
Thapsigargin results in increased expression of CLEC11A mRNA |
CTD |
PMID:19442820 |
|
NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633
|
|
G |
Cln8 |
CLN8, transmembrane ER and ERGIC protein |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CLN8 protein |
CTD |
PMID:24648495 |
|
NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774
|
|
G |
Clpp |
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
increases expression |
ISO |
Thapsigargin results in increased expression of CLPP mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693
|
|
G |
Cltc |
clathrin heavy chain |
increases expression |
ISO |
Thapsigargin results in increased expression of CLTC protein |
CTD |
PMID:24648495 |
|
NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
|
|
G |
Cnn3 |
calponin 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CNN3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104
|
|
G |
Cntnap2 |
contactin associated protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CNTNAP2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
|
|
G |
Cog1 |
component of oligomeric golgi complex 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of COG1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:98,695,481...98,708,495
Ensembl chr10:98,695,423...98,709,292
|
|
G |
Cog3 |
component of oligomeric golgi complex 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of COG3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr15:51,020,808...51,071,288
Ensembl chr15:51,020,813...51,070,570
|
|
G |
Cog6 |
component of oligomeric golgi complex 6 |
increases expression |
ISO |
Thapsigargin results in increased expression of COG6 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:137,062,127...137,099,176
Ensembl chr 2:137,061,346...137,099,190
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G |
Col11a1 |
collagen type XI alpha 1 chain |
increases expression |
ISO |
Thapsigargin results in increased expression of COL11A1 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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G |
Col5a1 |
collagen type V alpha 1 chain |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of COL5A1 mRNA Thapsigargin results in decreased expression of COL5A1 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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G |
Col5a2 |
collagen type V alpha 2 chain |
increases expression |
ISO |
Thapsigargin results in increased expression of COL5A2 protein |
CTD |
PMID:24648495 |
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NCBI chr 9:47,448,736...47,598,396
Ensembl chr 9:47,448,736...47,598,154
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G |
Col6a3 |
collagen type VI alpha 3 chain |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] |
CTD |
PMID:18435905 |
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NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
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G |
Colec12 |
collectin sub-family member 12 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COLEC12 protein |
CTD |
PMID:24648495 |
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NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
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G |
Copa |
COPI coat complex subunit alpha |
increases expression |
ISO |
Thapsigargin results in increased expression of COPA mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874
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G |
Copg1 |
COPI coat complex subunit gamma 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of COPG1 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616
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G |
Cops4 |
COP9 signalosome subunit 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COPS4 protein |
CTD |
PMID:21692457 |
|
NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
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G |
Cops7a |
COP9 signalosome subunit 7A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COPS7A protein |
CTD |
PMID:24648495 |
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NCBI chr 4:157,766,626...157,792,632
Ensembl chr 4:157,766,588...157,773,948
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G |
Coq3 |
coenzyme Q3 methyltransferase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COQ3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
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G |
Coq8a |
coenzyme Q8A |
increases expression |
ISO |
Thapsigargin results in increased expression of COQ8A mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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G |
Coro1a |
coronin 1A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CORO1A mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
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G |
Cotl1 |
coactosin-like F-actin binding protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COTL1 protein |
CTD |
PMID:24648495 |
|
NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
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G |
Cox10 |
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 |
increases expression |
ISO |
Thapsigargin results in increased expression of COX10 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:48,630,993...48,742,835
Ensembl chr10:48,630,676...48,746,667
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G |
Cox11 |
cytochrome c oxidase copper chaperone COX11 |
increases expression |
ISO |
Thapsigargin results in increased expression of COX11 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
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G |
Cox17 |
cytochrome c oxidase copper chaperone COX17 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COX17 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr11:62,400,733...62,406,507
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G |
Cox6b1 |
cytochrome c oxidase subunit 6B1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COX6B1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
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G |
Cox6c |
cytochrome c oxidase subunit 6C |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COX6C mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
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G |
Cox7b |
cytochrome c oxidase subunit 7B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COX7B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732
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G |
Cpne1 |
copine 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CPNE1 protein |
CTD |
PMID:21692457 |
|
NCBI chr 3:144,587,548...144,629,603
Ensembl chr 3:144,588,995...144,598,636
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G |
Cpsf1 |
cleavage and polyadenylation specific factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CPSF1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 7:108,319,429...108,330,023
Ensembl chr 7:108,319,434...108,329,934
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G |
Cpt1c |
carnitine palmitoyltransferase 1c |
increases expression |
ISO |
Thapsigargin results in increased expression of CPT1C mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
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G |
Crabp1 |
cellular retinoic acid binding protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CRABP1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360
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G |
Crabp2 |
cellular retinoic acid binding protein 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CRABP2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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G |
Crat |
carnitine O-acetyltransferase |
increases expression |
ISO |
Thapsigargin results in increased expression of CRAT mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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G |
Creb1 |
cAMP responsive element binding protein 1 |
affects localization multiple interactions |
ISO |
Thapsigargin affects the localization of CREB1 mRNA Cycloheximide inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA] |
CTD |
PMID:29576526 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Creb3l1 |
cAMP responsive element binding protein 3-like 1 |
increases activity multiple interactions |
ISO |
Thapsigargin results in increased activity of CREB3L1 protein [Thapsigargin results in increased activity of CREB3L1 protein] which results in increased expression of VEGFA mRNA |
CTD |
PMID:23383089 |
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NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456
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G |
Creb3l2 |
cAMP responsive element binding protein 3-like 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CREB3L2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
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G |
Crebbp |
CREB binding protein |
increases expression |
ISO |
Thapsigargin results in increased expression of CREBBP mRNA |
CTD |
PMID:24247028 |
|
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Creg1 |
cellular repressor of E1A-stimulated genes 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CREG1 protein |
CTD |
PMID:24648495 |
|
NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
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G |
Creld1 |
cysteine-rich with EGF-like domains 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRELD1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499
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G |
Creld2 |
cysteine-rich with EGF-like domains 2 |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of CRELD2 mRNA; Thapsigargin results in increased expression of CRELD2 protein Thapsigargin results in decreased expression of CRELD2 protein |
CTD |
PMID:22378314 PMID:24648495 PMID:29453283 |
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NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
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G |
Crk |
CRK proto-oncogene, adaptor protein |
multiple interactions |
EXP |
Thapsigargin inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein] |
CTD |
PMID:16187300 |
|
NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
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G |
Crtac1 |
cartilage acidic protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRTAC1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 1:241,091,679...241,233,677
Ensembl chr 1:241,078,864...241,233,421
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G |
Cry1 |
cryptochrome circadian regulator 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CRY1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
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G |
Crybb2 |
crystallin, beta B2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRYBB2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr12:43,569,747...43,579,671
Ensembl chr12:43,569,747...43,579,671
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G |
Crybg3 |
crystallin beta-gamma domain containing 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRYBG3 protein |
CTD |
PMID:24648495 |
|
NCBI chr11:40,749,198...40,861,753
Ensembl chr11:40,749,214...40,861,752
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G |
Cryz |
crystallin zeta |
multiple interactions decreases expression increases expression |
ISO |
Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CRYZ mRNA] Thapsigargin results in decreased expression of CRYZ mRNA |
CTD |
PMID:19442820 PMID:22378314 |
|
NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
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G |
Cs |
citrate synthase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CS mRNA |
CTD |
PMID:28223344 |
|
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csnk2a2 |
casein kinase 2 alpha 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CSNK2A2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
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G |
Cspg5 |
chondroitin sulfate proteoglycan 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CSPG5 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:110,220,653...110,234,750
Ensembl chr 8:110,220,653...110,234,758
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G |
Csrnp1 |
cysteine and serine rich nuclear protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CSRNP1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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G |
Csrp2 |
cysteine and glycine-rich protein 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CSRP2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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G |
Cstf2 |
cleavage stimulation factor subunit 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CSTF2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
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G |
Ctf1 |
cardiotrophin 1 |
multiple interactions |
ISO |
[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of CTF1 mRNA; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA] |
CTD |
PMID:19442820 |
|
NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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G |
Cth |
cystathionine gamma-lyase |
increases expression |
ISO |
Thapsigargin results in increased expression of CTH mRNA; Thapsigargin results in increased expression of CTH protein |
CTD |
PMID:29453283 |
|
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Ctps1 |
CTP synthase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CTPS mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
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G |
Ctr9 |
CTR9 homolog, Paf1/RNA polymerase II complex component |
increases expression |
ISO |
Thapsigargin results in increased expression of CTR9 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303
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G |
Ctsl |
cathepsin L |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein] |
CTD |
PMID:25639782 |
|
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Ctxn1 |
cortexin 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CTXN1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr12:2,610,465...2,612,076
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] |
CTD |
PMID:19442820 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of CXCL1 mRNA |
CTD |
PMID:8764118 |
|
NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
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G |
Cyb561d2 |
cytochrome b561 family, member D2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYB561D2 protein |
CTD |
PMID:24648495 |
|
NCBI chr 8:108,213,201...108,215,778
Ensembl chr 8:108,213,205...108,215,759
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G |
Cyb5a |
cytochrome b5 type A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYB5A mRNA |
CTD |
PMID:22378314 |
|
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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G |
Cyb5b |
cytochrome b5 type B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYB5B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249
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G |
Cyb5r1 |
cytochrome b5 reductase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYB5R1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
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G |
Cyba |
cytochrome b-245 alpha chain |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYBA mRNA |
CTD |
PMID:29453283 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cycs |
cytochrome c, somatic |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYCS mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Cyfip1 |
cytoplasmic FMR1 interacting protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYFIP1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386
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G |
Cygb |
cytoglobin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYGB mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:25616597 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp4f18 |
cytochrome P450, family 4, subfamily f, polypeptide 18 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYP4F3 mRNA |
CTD |
PMID:19442820 |
|
NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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G |
Cyp4v3 |
cytochrome P450, family 4, subfamily v, polypeptide 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYP4V2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
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G |
Cyp4x1 |
cytochrome P450, family 4, subfamily x, polypeptide 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYP4X1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 5:128,652,844...128,683,338
Ensembl chr 5:128,651,776...128,682,779
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G |
Dap |
death-associated protein |
multiple interactions increases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA] Thapsigargin results in increased expression of DAP mRNA |
CTD |
PMID:19442820 PMID:22378314 |
|
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Dbi |
diazepam binding inhibitor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DBI mRNA |
CTD |
PMID:22378314 |
|
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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G |
Dbnl |
drebrin-like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DBNL mRNA |
CTD |
PMID:22378314 |
|
NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155
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G |
Dctpp1 |
dCTP pyrophosphatase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DCTPP1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839
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|
G |
Ddah1 |
dimethylarginine dimethylaminohydrolase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DDAH1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
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G |
Ddb1 |
damage-specific DNA binding protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DDB1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
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G |
Ddc |
dopa decarboxylase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DDC mRNA |
CTD |
PMID:22378314 |
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NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Ddias |
DNA damage-induced apoptosis suppressor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DDIAS mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
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Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression increases activity decreases response to substance |
ISO EXP |
ATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Quercetin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Thapsigargin promotes the reaction [DDIT3 protein binds to LCN2 promoter]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 protein Thapsigargin results in increased expression of DDIT3 mRNA; Thapsigargin results in increased expression of DDIT3 protein 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; GW 506033X inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 protein Thapsigargin results in increased activity of DDIT3 protein 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 protein]]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Vaticanol B inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] DDIT3 results in decreased susceptibility to Thapsigargin |
CTD |
PMID:16298333 PMID:16330322 PMID:16338971 PMID:17283163 PMID:17332266 PMID:17353921 PMID:17475668 PMID:19028522 PMID:19135031 PMID:19139269 PMID:19285962 PMID:19428936 PMID:20022965 PMID:20493918 PMID:20589738 PMID:20626587 PMID:21525004 PMID:21694771 PMID:22378314 PMID:22509299 PMID:22641616 PMID:22800509 PMID:22843330 PMID:22935518 PMID:24648495 PMID:24668805 PMID:24865413 PMID:25289770 PMID:25324550 PMID:25341683 PMID:25611565 PMID:26264395 PMID:26513129 PMID:27226639 PMID:27358234 PMID:27587023 PMID:27638049 PMID:28223344 PMID:28315715 PMID:28844859 PMID:28940366 PMID:28942281 PMID:29109149 PMID:29414781 PMID:29453283 PMID:30508555 PMID:32407927 PMID:32535746 PMID:32574669 PMID:32578922 PMID:34915026 PMID:35033536 More...
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ddost |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
increases expression |
ISO |
Thapsigargin results in increased expression of DDOST mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
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Ddr2 |
discoidin domain receptor tyrosine kinase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of DDR2 protein |
CTD |
PMID:24648495 |
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NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
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Ddrgk1 |
DDRGK domain containing 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DDRGK1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680
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Dennd4c |
DENN domain containing 4C |
increases expression |
ISO |
Thapsigargin results in increased expression of DENND4C protein |
CTD |
PMID:24648495 |
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NCBI chr 5:101,272,298...101,369,529
Ensembl chr 5:101,272,005...101,368,118
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Depdc1b |
DEP domain containing 1B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DEPDC1B mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
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Deptor |
DEP domain containing MTOR-interacting protein |
increases expression |
ISO |
Thapsigargin results in increased expression of DEPTOR mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
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Derl2 |
derlin 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of DERL2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518
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Dglucy |
D-glutamate cyclase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DGLUCY mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:120,055,480...120,130,910
Ensembl chr 6:120,055,460...120,130,910
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Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DHCR24 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
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Dhcr7 |
7-dehydrocholesterol reductase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DHCR7 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Dhrs13 |
dehydrogenase/reductase 13 |
increases expression |
ISO |
Thapsigargin results in increased expression of DHRS13 mRNA |
CTD |
PMID:29453283 |
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NCBI chr10:62,920,743...62,925,952
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Dhrs3 |
dehydrogenase/reductase 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of DHRS3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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Dhx36 |
DEAH-box helicase 36 |
increases expression |
ISO |
Thapsigargin results in increased expression of DHX36 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572
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Dhx9 |
DExH-box helicase 9 |
increases expression |
ISO |
Thapsigargin results in increased expression of DHX9 protein |
CTD |
PMID:24648495 |
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NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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Diablo |
diablo, IAP-binding mitochondrial protein |
affects response to substance increases expression affects localization |
ISO |
DIABLO protein affects the susceptibility to Thapsigargin Thapsigargin results in increased expression of DIABLO mRNA Thapsigargin affects the localization of DIABLO protein |
CTD |
PMID:15339911 PMID:16382148 PMID:22378314 |
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NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
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G |
Diaph2 |
diaphanous-related formin 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of DIAP2 protein |
CTD |
PMID:24648495 |
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NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869
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G |
Diaph3 |
diaphanous-related formin 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of DIAPH3 protein |
CTD |
PMID:24648495 |
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NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
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Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DKK1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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Dld |
dihydrolipoamide dehydrogenase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DLD mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
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Dlg4 |
discs large MAGUK scaffold protein 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of DLG4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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Dlgap5 |
DLG associated protein 5 |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of DLGAP5 mRNA Thapsigargin results in increased expression of DLGAP5 protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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Dlk1 |
delta like non-canonical Notch ligand 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DLK1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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G |
Dlx5 |
distal-less homeobox 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DLX5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407
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Dmac2l |
distal membrane arm assembly component 2 like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DMAC2L mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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G |
Dnaja1 |
DnaJ heat shock protein family (Hsp40) member A1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DNAJA1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNAJA3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161
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Dnajb11 |
DnaJ heat shock protein family (Hsp40) member B11 |
multiple interactions increases expression decreases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]; [DNAJB11 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA] Thapsigargin results in increased expression of DNAJB11 mRNA; Thapsigargin results in increased expression of DNAJB11 protein |
CTD |
PMID:19442820 PMID:22378314 PMID:26085089 PMID:29453283 |
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NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNAJB9 mRNA |
CTD |
PMID:19135031 PMID:22378314 PMID:29453283 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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Dnajc1 |
DnaJ heat shock protein family (Hsp40) member C1 |
affects expression |
ISO |
Thapsigargin affects the expression of DNAJC1 mRNA |
CTD |
PMID:24247028 |
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NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988
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G |
Dnajc10 |
DnaJ heat shock protein family (Hsp40) member C10 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNAJC10 mRNA; Thapsigargin results in increased expression of DNAJC10 protein |
CTD |
PMID:17353921 PMID:29453283 |
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NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
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Dnajc3 |
DnaJ heat shock protein family (Hsp40) member C3 |
increases expression multiple interactions |
ISO |
Thapsigargin results in increased expression of DNAJC3 mRNA; Thapsigargin results in increased expression of DNAJC3 protein [DNAJC3 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin |
CTD |
PMID:19135031 PMID:26085089 PMID:29453283 |
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NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
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Dnase2 |
deoxyribonuclease 2, lysosomal |
increases expression |
ISO |
Thapsigargin results in increased expression of DNASE2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr19:23,244,661...23,247,329
Ensembl chr19:23,244,664...23,247,376
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G |
Dnhd1 |
dynein heavy chain domain 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNHD1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858
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G |
Dnm1l |
dynamin 1-like |
increases expression |
ISO |
Thapsigargin results in increased expression of DNM1L mRNA |
CTD |
PMID:28940366 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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Dnmt1 |
DNA methyltransferase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNMT1 protein |
CTD |
PMID:24648495 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Dock7 |
dedicator of cytokinesis 7 |
increases expression |
ISO |
Thapsigargin results in increased expression of DOCK7 protein |
CTD |
PMID:24648495 |
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NCBI chr 5:113,599,371...113,782,871
Ensembl chr 5:113,600,198...113,782,813
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G |
Dpf1 |
double PHD fingers 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DPF1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950
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G |
Dph5 |
diphthamide biosynthesis 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of DPH5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433
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G |
Dpysl3 |
dihydropyrimidinase-like 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DPYSL3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr18:35,374,429...35,480,462
Ensembl chr18:35,377,181...35,480,157
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G |
Dpysl4 |
dihydropyrimidinase-like 4 |
multiple interactions increases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] |
CTD |
PMID:19442820 |
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NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
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G |
Dscc1 |
DNA replication and sister chromatid cohesion 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DSCC1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
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G |
Dse |
dermatan sulfate epimerase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DSE protein |
CTD |
PMID:24648495 |
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NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
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Dtl |
denticleless E3 ubiquitin protein ligase homolog |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DTL mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
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Dtna |
dystrobrevin, alpha |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DTNA mRNA |
CTD |
PMID:22378314 |
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NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
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Dusp1 |
dual specificity phosphatase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DUSP1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr10:16,680,489...16,683,276
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Dusp26 |
dual specificity phosphatase 26 |
increases expression |
ISO |
Thapsigargin results in increased expression of DUSP26 mRNA |
CTD |
PMID:22378314 |
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NCBI chr16:61,041,784...61,049,319
Ensembl chr16:61,041,792...61,049,051
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Dusp5 |
dual specificity phosphatase 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DUSP5 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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Dusp6 |
dual specificity phosphatase 6 |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of DUSP6 mRNA Thapsigargin results in decreased expression of DUSP6 mRNA |
CTD |
PMID:22378314 PMID:24247028 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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Dut |
deoxyuridine triphosphatase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DUT mRNA Thapsigargin results in decreased expression of DUT protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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Dym |
dymeclin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DYM protein |
CTD |
PMID:24648495 |
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NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903
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Dync1i1 |
dynein cytoplasmic 1 intermediate chain 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DYNC1I1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
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Dync2i2 |
dynein 2 intermediate chain 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DYNC2I2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:13,306,039...13,322,121
Ensembl chr 3:13,306,039...13,322,121
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G |
Dyrk4 |
dual specificity tyrosine phosphorylation regulated kinase 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of DYRK4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:159,715,658...159,757,660
Ensembl chr 4:159,715,417...159,757,627
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of E2F1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f2 |
E2F transcription factor 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of E2F2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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E2f7 |
E2F transcription factor 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of E2F7 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
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Ears2 |
glutamyl-tRNA synthetase 2, mitochondrial |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EARS2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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G |
Ebf1 |
EBF transcription factor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EBF1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
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G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ECH1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Edc4 |
enhancer of mRNA decapping 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of EDC4 protein |
CTD |
PMID:24648495 |
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NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of EDEM1 mRNA |
CTD |
PMID:22378314 PMID:27587023 |
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NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Eef1akmt1 |
EEF1A lysine methyltransferase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EEF1AKMT1 protein |
CTD |
PMID:24648495 |
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NCBI chr15:31,694,289...31,711,959
Ensembl chr15:31,694,292...31,711,336
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G |
Eepd1 |
endonuclease/exonuclease/phosphatase family domain containing 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EEPD1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340
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G |
Efr3a |
EFR3 homolog A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EFR3A protein |
CTD |
PMID:24648495 |
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NCBI chr 7:97,552,677...97,633,369
Ensembl chr 7:97,552,677...97,633,369
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein] |
CTD |
PMID:17991733 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
increases expression |
ISO |
Thapsigargin results in increased expression of EGFR protein |
CTD |
PMID:24648495 |
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NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of EGR1 mRNA Thapsigargin results in decreased expression of EGR1 mRNA |
CTD |
PMID:8764118 PMID:21694771 PMID:22378314 |
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NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of EGR2 mRNA |
CTD |
PMID:20830808 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
increases expression |
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