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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terpene lactone
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Accession:CHEBI:37668 term browser browse the term
Synonyms:related_synonym: terpene lactones


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(+)-artemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases activity
ISO artemisinine results in increased expression of ABCB1 mRNA
artemisinine results in decreased activity of ABCB1 protein
CTD PMID:15761118 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Casp3 caspase 3 increases activity EXP artemisinine results in increased activity of CASP3 protein CTD PMID:17948936 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression
ISO
EXP
artemisinine results in decreased activity of CYP1A2 protein
artemisinine results in increased expression of CYP1A2 mRNA
CTD PMID:11124226 PMID:16919048 PMID:17962186 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
increases expression
ISO artemisinine results in increased activity of CYP2A5 protein
artemisinine results in increased expression of CYP2A5 mRNA
CTD PMID:16919048 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
increases activity
EXP
ISO
artemisinine results in increased expression of CYP2B1 mRNA
artemisinine results in increased expression of CYP2B10 mRNA
artemisinine results in increased activity of CYP2B10 protein
CTD PMID:16919048 PMID:17962186 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
affects metabolic processing
increases expression
ISO [artemisinine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
CYP2B6 protein affects the metabolism of artemisinine
artemisinine results in increased expression of CYP2B6 mRNA
CTD PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO artemisinine results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO artemisinine results in increased expression of CYP2E1 mRNA CTD PMID:17962186 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO artemisinine inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; artemisinine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO artemisinine results in decreased activity of GSTA1 protein CTD PMID:11807801 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO artemisinine results in decreased activity of GSTP1 protein CTD PMID:11807801 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO artemisinine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinine co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein] CTD PMID:18463201 PMID:23355332 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein] CTD PMID:18463201 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [artemisinine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; artemisinine binds to and results in increased activity of NR1I2 protein CTD PMID:15761118 PMID:17041008 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
affects expression
affects localization
increases activity
ISO
EXP
[artemisinine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; artemisinine binds to and results in increased activity of NR1I3 protein; artemisinine binds to and results in increased activity of NR1I3 protein mutant form
artemisinine binds to and results in increased activity of NR1I3 protein; fenvalerate inhibits the reaction [artemisinine binds to and results in increased activity of NR1I3 protein]
artemisinine results in increased expression of NR1I3 mRNA
artemisinine affects the expression of NR1I3 mRNA alternative form
artemisinine affects the localization of NR1I3 protein
artemisinine results in increased activity of NR1I3 protein; artemisinine results in increased activity of NR1I3 protein alternative form; artemisinine results in increased activity of NR1I3 protein mutant form
artemisinine results in increased activity of NR1I3 protein; artemisinine results in increased activity of NR1I3 protein mutant form
CTD PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 PMID:20686338 PMID:21778469 PMID:24721719 PMID:27665777 PMID:27732639 PMID:31472229 PMID:31538121 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO artemisinine inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of RELA protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of RELA protein] CTD PMID:18463201 PMID:23355332 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO artemisinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO artemisinine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO artemisinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] CTD PMID:27504015 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Tp53 tumor protein p53 increases activity ISO artemisinine results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
14-Deoxy-11,12-didehydroandrographolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of AAAS mRNA CTD PMID:22101062 NCBI chr 7:143,937,198...143,956,668
Ensembl chr 7:143,937,199...143,956,668
JBrowse link
G Acp2 acid phosphatase 2, lysosomal decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ACP2 mRNA CTD PMID:22101062 NCBI chr 3:80,020,346...80,030,365
Ensembl chr 3:80,021,440...80,030,363
JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ADRM1 mRNA CTD PMID:22101062 NCBI chr 3:175,548,181...175,552,943
Ensembl chr 3:175,548,174...175,552,947
JBrowse link
G Ajuba ajuba LIM protein decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of AJUBA mRNA CTD PMID:22101062 NCBI chr15:33,208,210...33,218,456
Ensembl chr15:33,208,216...33,218,456
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of AK1 mRNA CTD PMID:22101062 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Akap1 A-kinase anchoring protein 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of AKAP1 mRNA CTD PMID:22101062 NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of AKR7A2 mRNA CTD PMID:22101062 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ALDOA mRNA CTD PMID:22101062 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Ank3 ankyrin 3 decreases expression
increases expression
ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ANK3 mRNA
14-deoxy-11,12-didehydroandrographolide results in increased expression of ANK3 mRNA
CTD PMID:22101062 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ARHGAP5 mRNA CTD PMID:22101062 NCBI chr 6:73,345,129...73,408,304
Ensembl chr 6:73,345,392...73,405,880
JBrowse link
G Arid4a AT-rich interaction domain 4A increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of ARID4A mRNA CTD PMID:22101062 NCBI chr 6:93,461,713...93,532,901
Ensembl chr 6:93,461,713...93,532,901
JBrowse link
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ARIH2 mRNA CTD PMID:22101062 NCBI chr 8:117,387,004...117,446,085
Ensembl chr 8:117,387,010...117,446,019
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ASXL1 mRNA CTD PMID:22101062 NCBI chr 3:148,832,231...148,902,356
Ensembl chr 3:148,837,814...148,900,452
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ATP5F1D mRNA CTD PMID:22101062 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ATP6V0D1 mRNA CTD PMID:22101062 NCBI chr19:37,481,782...37,525,762
Ensembl chr19:37,481,782...37,525,762
JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ATP6V1C1 mRNA CTD PMID:22101062 NCBI chr 7:77,678,853...77,716,658
Ensembl chr 7:77,678,968...77,716,408
JBrowse link
G Bag1 BAG cochaperone 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of BAG1 mRNA CTD PMID:22101062 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of BCLAF1 mRNA CTD PMID:22101062 NCBI chr 1:15,799,753...15,828,838
Ensembl chr 1:15,782,477...15,860,624
JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of BLOC1S1 mRNA CTD PMID:22101062 NCBI chr 7:3,342,630...3,346,238
Ensembl chr 7:3,342,630...3,346,238
JBrowse link
G Ca12 carbonic anhydrase 12 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of CA12 mRNA CTD PMID:22101062 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Caprin1 cell cycle associated protein 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of CAPRIN1 mRNA CTD PMID:22101062 NCBI chr 3:93,701,830...93,789,580
Ensembl chr 3:93,702,487...93,789,617
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:27089844 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:27089844 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of CCNB1IP1 mRNA CTD PMID:22101062 NCBI chr15:27,720,220...27,736,528
Ensembl chr15:27,720,223...27,733,785
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CCND1 mRNA
14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCND1 protein]; dorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of CCND1 protein]]
CTD PMID:22101062 PMID:30248417 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CCND3 mRNA CTD PMID:22101062 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein] CTD PMID:30248417 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccng2 cyclin G2 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of CCNG2 mRNA CTD PMID:22101062 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CDC37 mRNA CTD PMID:22101062 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]; dorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of CDK2 protein]] CTD PMID:30248417 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK6 protein]; dorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of CDK6 protein]] CTD PMID:30248417 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of CDKN1B mRNA CTD PMID:22101062 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] promotes the reaction [CREB1 protein binds to CEBPB promoter]]; 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPB mRNA]; 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of CEBPB protein] CTD PMID:30248417 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cenps centromere protein S decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CENPS mRNA CTD PMID:22101062 NCBI chr 5:165,946,106...165,955,723 JBrowse link
G Cfl1 cofilin 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CFL1 mRNA CTD PMID:22101062 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of CHD2 mRNA CTD PMID:22101062 NCBI chr 1:134,757,934...134,873,053
Ensembl chr 1:134,757,934...134,871,167
JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CHTF8 mRNA CTD PMID:22101062 NCBI chr19:39,077,580...39,087,880
Ensembl chr19:39,077,580...39,087,880
JBrowse link
G Clptm1 CLPTM1 regulator of GABA type A receptor forward trafficking decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CLPTM1 mRNA CTD PMID:22101062 NCBI chr 1:80,549,051...80,580,665
Ensembl chr 1:80,549,043...80,580,662
JBrowse link
G Cope COPI coat complex subunit epsilon decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of COPE mRNA CTD PMID:22101062 NCBI chr16:20,863,141...20,873,516
Ensembl chr16:20,863,141...20,873,521
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] promotes the reaction [CREB1 protein binds to CEBPB promoter]]; 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of CREB1 protein] CTD PMID:30248417 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of CXCL12 mRNA CTD PMID:22101062 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of CYP1A1 mRNA
beta-Naphthoflavone promotes the reaction [14-deoxy-11,12-didehydroandrographolide results in increased expression of CYP1A1 mRNA]
CTD PMID:21963808 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcaf6 DDB1 and CUL4 associated factor 6 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of DCAF6 mRNA CTD PMID:22101062 NCBI chr13:83,578,730...83,680,330
Ensembl chr13:83,579,036...83,680,207
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of DDIT3 mRNA CTD PMID:22101062 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of DDIT4 mRNA CTD PMID:22101062 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of DHFR mRNA CTD PMID:22101062 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Drg2 developmentally regulated GTP binding protein 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of DRG2 mRNA CTD PMID:22101062 NCBI chr10:46,818,412...46,831,308
Ensembl chr10:46,818,525...46,830,739
JBrowse link
G Dut deoxyuridine triphosphatase decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of DUT mRNA CTD PMID:22101062 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of EIF4EBP1 protein]; dorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of EIF4EBP1 protein]] CTD PMID:30248417 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of ELOVL2 mRNA CTD PMID:22101062 NCBI chr17:21,382,461...21,422,413
Ensembl chr17:21,382,455...21,422,407
JBrowse link
G Eno1 enolase 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ENO1 mRNA CTD PMID:22101062 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ewsr1 EWS RNA-binding protein 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of EWSR1 mRNA CTD PMID:22101062 NCBI chr14:85,322,105...85,350,826
Ensembl chr14:85,322,296...85,350,948
Ensembl chr 4:85,322,296...85,350,948
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein] CTD PMID:30248417 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbxo8 F-box protein 8 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of FBXO8 mRNA CTD PMID:22101062 NCBI chr16:37,131,566...37,177,033
Ensembl chr16:37,131,345...37,177,033
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of FEN1 mRNA CTD PMID:22101062 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fibp FGF1 intracellular binding protein decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of FIBP mRNA CTD PMID:22101062 NCBI chr 1:220,840,078...220,844,412
Ensembl chr 1:220,840,118...220,844,405
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of FKBP1A mRNA CTD PMID:22101062 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Flcn folliculin increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of FLCN mRNA CTD PMID:22101062 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
JBrowse link
G Fnip1 folliculin interacting protein 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of FNIP1 mRNA CTD PMID:22101062 NCBI chr10:39,786,687...39,870,188 JBrowse link
G Folr1 folate receptor alpha increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of FOLR1 mRNA CTD PMID:22101062 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Fus FUS RNA binding protein decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of FUS mRNA CTD PMID:22101062 NCBI chr 1:199,412,805...199,426,705
Ensembl chr 1:199,412,834...199,426,702
JBrowse link
G Fzd7 frizzled class receptor 7 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of FZD7 mRNA CTD PMID:22101062 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of GADD45A mRNA CTD PMID:22101062 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of GAS5 mRNA CTD PMID:22101062 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gfus GDP-L-fucose synthase decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of GFUS mRNA CTD PMID:22101062 NCBI chr 7:116,958,427...116,963,281
Ensembl chr 7:116,958,392...116,963,295
JBrowse link
G Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of GNE mRNA CTD PMID:22101062 NCBI chr 5:59,511,738...59,553,421
Ensembl chr 5:59,512,872...59,553,416
JBrowse link
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of GPAA1 mRNA CTD PMID:22101062 NCBI chr 7:117,394,367...117,397,950
Ensembl chr 7:117,394,372...117,397,956
JBrowse link
G Gps1 G protein pathway suppressor 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of GPS1 mRNA CTD PMID:22101062 NCBI chr10:109,966,875...109,971,912
Ensembl chr10:109,966,904...109,971,911
JBrowse link
G Gps2 G protein pathway suppressor 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of GPS2 mRNA CTD PMID:22101062 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein] CTD PMID:30248417 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of GULP1 mRNA CTD PMID:22101062 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of H1-2 mRNA CTD PMID:22101062 NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387
JBrowse link
G H2bc9 H2B clustered histone 9 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of H2BC9 mRNA CTD PMID:22101062 NCBI chr17:44,519,815...44,520,269
Ensembl chr17:44,519,860...44,520,240
JBrowse link
G Hbp1 HMG-box transcription factor 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of HBP1 mRNA CTD PMID:22101062 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of HELLS mRNA CTD PMID:22101062 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of HERPUD1 mRNA CTD PMID:22101062 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hgsnat heparan-alpha-glucosaminide N-acetyltransferase decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of HGSNAT mRNA CTD PMID:22101062 NCBI chr16:70,876,557...70,909,443 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of HMGCS2 mRNA CTD PMID:22101062 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of HNRNPA1 mRNA CTD PMID:22101062 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of HNRNPD mRNA CTD PMID:22101062 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hoxb3 homeo box B3 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of HOXB3 mRNA CTD PMID:22101062 NCBI chr10:84,170,629...84,196,823
Ensembl chr10:84,182,118...84,195,796
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of IFRD1 mRNA CTD PMID:22101062 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Ifrd2 interferon-related developmental regulator 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of IFRD2 mRNA CTD PMID:22101062 NCBI chr 8:116,343,096...116,348,318
Ensembl chr 8:116,343,096...116,348,314
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of IGFBP5 mRNA CTD PMID:22101062 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] CTD PMID:27089844 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Immp1l inner mitochondrial membrane peptidase subunit 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of IMMP1L mRNA CTD PMID:22101062 NCBI chr 3:95,955,126...96,024,316
Ensembl chr 3:95,959,703...96,024,836
JBrowse link
G Ints11 integrator complex subunit 11 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of INTS11 mRNA CTD PMID:22101062 NCBI chr 5:173,318,435...173,336,930
Ensembl chr 5:173,318,479...173,336,930
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ITGB1BP1 mRNA CTD PMID:22101062 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of ITPK1 mRNA CTD PMID:22101062 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134
JBrowse link
G Jmy junction mediating and regulatory protein, p53 cofactor increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of JMY mRNA CTD PMID:22101062 NCBI chr 2:23,026,506...23,097,702
Ensembl chr 2:23,042,189...23,097,610
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of KCNK2 mRNA CTD PMID:22101062 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of LGR4 mRNA CTD PMID:22101062 NCBI chr 3:101,051,960...101,152,119
Ensembl chr 3:101,051,955...101,152,119
JBrowse link
G Lhx2 LIM homeobox 2 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of LHX2 mRNA CTD PMID:22101062 NCBI chr 3:22,628,674...22,658,447
Ensembl chr 3:22,640,545...22,658,446
JBrowse link
G Lmna lamin A/C decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of LMNA mRNA CTD PMID:22101062 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G LOC103690190 histone H2A type 1-E increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of H2AC6 mRNA CTD PMID:22101062 NCBI chr17:44,747,686...44,748,229
Ensembl chr17:44,747,796...44,748,188
Ensembl chr17:44,747,796...44,748,188
JBrowse link
G Lrrn3 leucine rich repeat neuronal 3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of LRRN3 mRNA CTD PMID:22101062 NCBI chr 6:61,374,328...61,405,195
Ensembl chr 6:61,374,328...61,405,195
JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of LSR mRNA CTD PMID:22101062 NCBI chr 1:89,383,515...89,399,041
Ensembl chr 1:89,383,519...89,399,041
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of MANF mRNA CTD PMID:22101062 NCBI chr 8:115,623,175...115,626,408
Ensembl chr 8:115,623,178...115,626,380
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:30248417 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of MAPK13 mRNA CTD PMID:22101062 NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:30248417 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of MCL1 mRNA CTD PMID:22101062 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of MCM2 mRNA CTD PMID:22101062 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of MCM3 mRNA CTD PMID:22101062 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Msto1 misato mitochondrial distribution and morphology regulator 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of MSTO1 mRNA CTD PMID:22101062 NCBI chr 2:188,212,211...188,216,482
Ensembl chr 2:188,212,211...188,216,482
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of MTSS1 mRNA CTD PMID:22101062 NCBI chr 7:98,820,799...98,960,878
Ensembl chr 7:98,820,812...98,960,837
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of MXI1 mRNA CTD PMID:22101062 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of MYBL2 mRNA CTD PMID:22101062 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of MYC mRNA CTD PMID:22101062 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nabp2 nucleic acid binding protein 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of NABP2 mRNA CTD PMID:22101062 NCBI chr 7:2,820,006...2,825,627
Ensembl chr 7:2,820,007...2,825,608
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of NAMPT mRNA CTD PMID:22101062 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of NBL1 mRNA CTD PMID:22101062 NCBI chr 5:157,524,569...157,535,701
Ensembl chr 5:157,524,513...157,535,664
JBrowse link
G Nck1 NCK adaptor protein 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of NCK1 mRNA CTD PMID:22101062 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of NFAT5 mRNA CTD PMID:22101062 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nmu neuromedin U decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of NMU mRNA CTD PMID:22101062 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of NUPR1 mRNA CTD PMID:22101062 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Olfm1 olfactomedin 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of OLFM1 mRNA CTD PMID:22101062 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PAFAH1B1 mRNA CTD PMID:22101062 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PKM mRNA CTD PMID:22101062 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plxnb2 plexin B2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PLXNB2 mRNA CTD PMID:22101062 NCBI chr 7:130,135,484...130,161,568
Ensembl chr 7:130,135,464...130,151,880
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of POLA1 mRNA CTD PMID:22101062 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG mRNA]; 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein] CTD PMID:30248417 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppfia1 PTPRF interacting protein alpha 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of PPFIA1 mRNA CTD PMID:22101062 NCBI chr 1:217,644,259...217,721,285
Ensembl chr 1:217,644,224...217,721,376
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PPP1CA mRNA CTD PMID:22101062 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Prcp prolylcarboxypeptidase increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of PRCP mRNA CTD PMID:22101062 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of PRKACA protein] CTD PMID:30248417 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkcsh protein kinase C substrate 80K-H decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PRKCSH mRNA CTD PMID:22101062 NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
JBrowse link
G Prlr prolactin receptor increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of PRLR mRNA CTD PMID:22101062 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Prrg4 proline rich and Gla domain 4 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PRRG4 mRNA CTD PMID:22101062 NCBI chr 3:94,783,866...94,808,861
Ensembl chr 3:94,784,008...94,808,861
JBrowse link
G Psen2 presenilin 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PSEN2 mRNA CTD PMID:22101062 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PSMC3 mRNA CTD PMID:22101062 NCBI chr 3:79,876,938...79,882,319
Ensembl chr 3:79,876,938...79,882,319
JBrowse link
G Pspc1 paraspeckle component 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PSPC1 mRNA CTD PMID:22101062 NCBI chr15:36,946,914...37,030,273
Ensembl chr15:36,950,257...37,030,281
JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of PTPRK mRNA CTD PMID:22101062 NCBI chr 1:17,445,052...18,058,266
Ensembl chr 1:17,446,417...18,058,055
JBrowse link
G Rab27b RAB27B, member RAS oncogene family increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of RAB27B mRNA CTD PMID:22101062 NCBI chr18:68,486,006...68,644,595
Ensembl chr18:68,488,942...68,551,558
JBrowse link
G Rangap1 RAN GTPase activating protein 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of RANGAP1 mRNA CTD PMID:22101062 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G Rbm10 RNA binding motif protein 10 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of RBM10 mRNA CTD PMID:22101062 NCBI chr  X:1,754,869...1,786,973
Ensembl chr  X:1,754,861...1,786,978
JBrowse link
G Rbm47 RNA binding motif protein 47 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of RBM47 mRNA CTD PMID:22101062 NCBI chr14:43,701,944...43,839,803
Ensembl chr14:43,810,119...43,837,662
JBrowse link
G Rcbtb1 RCC1 and BTB domain containing protein 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of RCBTB1 mRNA CTD PMID:22101062 NCBI chr15:39,622,572...39,665,335
Ensembl chr15:39,638,510...39,669,473
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased activity of and affects the localization of RELA protein] CTD PMID:27089844 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of RFFL mRNA CTD PMID:22101062 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Rhod ras homolog family member D decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of RHOD mRNA CTD PMID:22101062 NCBI chr 1:219,668,352...219,682,287
Ensembl chr 1:219,668,352...219,682,287
JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of RIT1 mRNA CTD PMID:22101062 NCBI chr 2:188,087,486...188,099,444
Ensembl chr 2:188,087,486...188,099,444
JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of RORC mRNA CTD PMID:22101062 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RPS6KB1 protein]; dorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RPS6KB1 protein]] CTD PMID:30248417 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO [14-deoxy-11,12-didehydroandrographolide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RPTOR protein; dorsomorphin inhibits the reaction [[14-deoxy-11,12-didehydroandrographolide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RPTOR protein] CTD PMID:30248417 NCBI chr10:108,750,620...109,058,691
Ensembl chr10:108,750,620...109,058,691
JBrowse link
G Rsrc2 arginine and serine rich coiled-coil 2 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of RSRC2 mRNA CTD PMID:22101062 NCBI chr12:38,274,290...38,294,294
Ensembl chr12:38,274,297...38,294,292
JBrowse link
G Rtkn rhotekin decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of RTKN mRNA CTD PMID:22101062 NCBI chr 4:114,833,453...114,850,705
Ensembl chr 4:114,835,064...114,850,701
Ensembl chr 4:114,835,064...114,850,701
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of SCARB1 mRNA CTD PMID:22101062 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein] CTD PMID:30248417 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of SEL1L mRNA CTD PMID:22101062 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859
JBrowse link
G Sertad2 SERTA domain containing 2 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of SERTAD2 mRNA CTD PMID:22101062 NCBI chr14:104,786,649...104,890,022
Ensembl chr14:104,821,215...104,886,197
JBrowse link
G Sf1 splicing factor 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SF1 mRNA CTD PMID:22101062 NCBI chr 1:221,735,512...221,749,216
Ensembl chr 1:221,735,517...221,749,086
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SFPQ mRNA CTD PMID:22101062 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sfxn2 sideroflexin 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SFXN2 mRNA CTD PMID:22101062 NCBI chr 1:266,333,440...266,345,736
Ensembl chr 1:266,333,440...266,345,697
JBrowse link
G Sfxn4 sideroflexin 4 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SFXN4 mRNA CTD PMID:22101062 NCBI chr 1:282,213,610...282,236,851
Ensembl chr 1:282,213,675...282,235,974
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SIGMAR1 mRNA CTD PMID:22101062 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Slc35a4 solute carrier family 35, member A4 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SLC35A4 mRNA CTD PMID:22101062 NCBI chr18:29,505,239...29,509,304
Ensembl chr18:29,506,128...29,509,296
JBrowse link
G Slc39a3 solute carrier family 39 member 3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SLC39A3 mRNA CTD PMID:22101062 NCBI chr 7:11,545,073...11,551,074
Ensembl chr 7:11,545,024...11,553,370
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SLC9A3R1 mRNA CTD PMID:22101062 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G Slitrk4 SLIT and NTRK-like family, member 4 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SLITRK4 mRNA CTD PMID:22101062 NCBI chr  X:147,582,195...147,589,529 JBrowse link
G Snf8 SNF8 subunit of ESCRT-II decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SNF8 mRNA CTD PMID:22101062 NCBI chr10:83,856,331...83,868,621
Ensembl chr10:83,856,280...83,868,598
JBrowse link
G Snx16 sorting nexin 16 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of SNX16 mRNA CTD PMID:22101062 NCBI chr 2:93,518,796...93,541,056
Ensembl chr 2:93,518,806...93,540,328
JBrowse link
G Sowahc sosondowah ankyrin repeat domain family member C increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of SOWAHC mRNA CTD PMID:22101062 NCBI chr20:28,815,039...28,819,505
Ensembl chr20:28,815,039...28,819,505
JBrowse link
G Spire1 spire-type actin nucleation factor 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of SPIRE1 mRNA CTD PMID:22101062 NCBI chr18:63,226,557...63,357,420
Ensembl chr18:63,226,557...63,357,298
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SREBF1 mRNA]; 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SREBF1 protein] CTD PMID:30248417 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srm spermidine synthase decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SRM mRNA CTD PMID:22101062 NCBI chr 5:165,405,168...165,408,325
Ensembl chr 5:165,405,168...165,408,320
Ensembl chr 3:165,405,168...165,408,320
JBrowse link
G Srpk2 SRSF protein kinase 2 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of SRPK2 mRNA CTD PMID:22101062 NCBI chr 4:7,994,025...8,187,455
Ensembl chr 4:8,066,737...8,185,935
JBrowse link
G Srrt serrate, RNA effector molecule decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SRRT mRNA CTD PMID:22101062 NCBI chr12:22,457,898...22,471,090 JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SRSF1 mRNA CTD PMID:22101062 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SRSF2 mRNA CTD PMID:22101062 NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of SFRS3 mRNA CTD PMID:22101062 NCBI chr20:6,288,285...6,298,218
Ensembl chr20:6,288,267...6,298,213
JBrowse link
G Stard10 StAR-related lipid transfer domain containing 10 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of STARD10 mRNA CTD PMID:22101062 NCBI chr 1:166,428,780...166,458,413
Ensembl chr 1:166,428,761...166,457,509
JBrowse link
G Stx3 syntaxin 3 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of STX3 mRNA CTD PMID:22101062 NCBI chr 1:228,137,781...228,195,004
Ensembl chr 1:228,149,867...228,194,977
JBrowse link
G Tbrg1 transforming growth factor beta regulator 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of TBRG1 mRNA CTD PMID:22101062 NCBI chr 8:40,114,792...40,122,450
Ensembl chr 8:40,114,792...40,122,450
JBrowse link
G Tcaf1 TRPM8 channel-associated factor 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of TCAF1 mRNA CTD PMID:22101062 NCBI chr 4:72,119,349...72,171,733
Ensembl chr 4:72,124,234...72,143,748
JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of TFAP2A mRNA CTD PMID:22101062 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of TFF1 mRNA CTD PMID:22101062 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Thsd4 thrombospondin type 1 domain containing 4 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of THSD4 mRNA CTD PMID:22101062 NCBI chr 8:64,811,940...65,413,498
Ensembl chr 8:64,817,191...65,003,296
JBrowse link
G Tipin timeless interacting protein decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of TIPIN mRNA CTD PMID:22101062 NCBI chr 8:69,753,363...69,768,640
Ensembl chr 8:69,753,373...69,768,305
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of TK1 mRNA CTD PMID:22101062 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased activity of and affects the localization of RELA protein]; 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; 14-deoxy-11,12-didehydroandrographolide analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] CTD PMID:27089844 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of TP53I3 mRNA CTD PMID:22101062 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Trak2 trafficking kinesin protein 2 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of TRAK2 mRNA CTD PMID:22101062 NCBI chr 9:65,698,706...65,763,351
Ensembl chr 9:65,698,712...65,763,273
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of TYMS mRNA CTD PMID:22101062 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of UFD1 mRNA CTD PMID:22101062 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of VTCN1 mRNA CTD PMID:22101062 NCBI chr 2:203,200,435...203,274,264
Ensembl chr 2:203,200,427...203,276,142
JBrowse link
G Wdr26 WD repeat domain 26 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of WDR26 mRNA CTD PMID:22101062 NCBI chr13:99,493,117...99,532,775
Ensembl chr13:99,493,120...99,531,959
JBrowse link
G Wt1 WT1 transcription factor decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of WT1 mRNA CTD PMID:22101062 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
G Yipf3 Yip1 domain family, member 3 decreases expression ISO 14-deoxy-11,12-didehydroandrographolide results in decreased expression of YIPF3 mRNA CTD PMID:22101062 NCBI chr 9:17,115,308...17,120,659
Ensembl chr 9:17,115,343...17,120,677
JBrowse link
G Yipf5 Yip1 domain family, member 5 increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of YIPF5 mRNA CTD PMID:22101062 NCBI chr18:33,401,103...33,436,885
Ensembl chr18:33,401,106...33,434,775
JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator increases expression ISO 14-deoxy-11,12-didehydroandrographolide results in increased expression of ZYG11B mRNA CTD PMID:22101062 NCBI chr 5:127,844,062...127,878,792
Ensembl chr 5:127,847,129...127,878,792
JBrowse link
17-hydroxyjolkinolide B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 multiple interactions ISO 17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; 17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]] CTD PMID:22080918 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22080918 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22080918 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22080918 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:22080918 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22080918 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22080918 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of RELA protein] CTD PMID:22080918 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:22080918 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
alantolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO alantolactone results in increased expression of BAK1 protein CTD PMID:22721982 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO alantolactone results in decreased expression of BAX protein
alantolactone results in increased expression of BAX protein
CTD PMID:22721982 PMID:24252419 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
ISO alantolactone results in increased expression of BCL2 protein
alantolactone results in decreased expression of BCL2 protein
CTD PMID:22721982 PMID:24252419 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO alantolactone results in increased cleavage of BID protein CTD PMID:22721982 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 increases cleavage ISO alantolactone results in increased cleavage of CASP3 protein CTD PMID:22721982 PMID:24252419 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO alantolactone results in increased cleavage of CASP8 protein CTD PMID:22721982 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
ISO alantolactone results in increased cleavage of CASP9 protein
alantolactone results in increased activity of CASP9 protein
CTD PMID:22721982 PMID:24252419 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alantolactone results in increased cleavage of PARP1 protein CTD PMID:22721982 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prss50 serine protease 50 decreases expression ISO alantolactone results in decreased expression of PRSS50 mRNA; alantolactone results in decreased expression of PRSS50 protein CTD PMID:24252419 NCBI chr 8:119,134,966...119,141,255
Ensembl chr 8:119,135,013...119,141,150
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alantolactone results in decreased expression of RELA protein CTD PMID:22721982 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 increases expression ISO alantolactone results in increased expression of TP53 protein CTD PMID:22721982 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
alpha-santonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
artemether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA CTD PMID:31312845 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression
multiple interactions
ISO artemether affects the expression of NR1I3 mRNA alternative form
[Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; Artemether binds to and results in increased activity of NR1I3 protein alternative form
CTD PMID:24721719 PMID:31312845 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
artemotil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression ISO artemotil affects the expression of NR1I3 mRNA alternative form CTD PMID:24721719 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:30551460 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr14:71,798,218...71,814,540
Ensembl chr14:71,798,651...71,814,523
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression
decreases response to substance
ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate
CTD PMID:19513562 PMID:20144594 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Des desmin multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD PMID:30551460 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Flna filamin A increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD PMID:30551460 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD PMID:30551460 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance
ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate
CTD PMID:15796179 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases activity
multiple interactions
ISO Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD PMID:30551460 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 affects response to substance ISO GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD PMID:29031619 PMID:30551460 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Naca nascent polypeptide associated complex subunit alpha decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:2,458,283...2,470,674
Ensembl chr 7:2,458,264...2,470,674
JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD PMID:30551460 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD PMID:24704559 PMID:33002460 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977
JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:2,633,517...2,636,525
Ensembl chr 5:2,632,712...2,640,021
JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:22,758,214...22,760,370
Ensembl chr 1:22,758,212...22,760,370
JBrowse link
G Rps15a ribosomal protein S15a decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:187,759,865...187,766,734
Ensembl chr 1:187,759,480...187,766,709
JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Slc25a19 solute carrier family 25 member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:104,166,594...104,179,523
Ensembl chr10:104,166,598...104,179,523
JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD PMID:30551460 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Artesunate results in increased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD PMID:30551460 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:33259807 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions
ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:15878303 PMID:33259807 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
multiple interactions
ISO Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD PMID:33002460 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:56,367,586...56,388,296
Ensembl chr10:56,381,813...56,385,960
JBrowse link
bilobalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] CTD PMID:18001288 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] CTD PMID:18001288 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP bilobalide results in increased expression of and results in increased activity of CYP1A2 protein
bilobalide results in increased expression of CYP1A2 mRNA
CTD PMID:18421621 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP bilobalide results in increased expression of CYP2B1 mRNA; bilobalide results in increased expression of CYP2B1 protein CTD PMID:16258077 PMID:18421621 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP bilobalide results in increased expression of CYP2B2 protein CTD PMID:18421621 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity EXP bilobalide results in increased activity of CYP2E1 protein CTD PMID:18421621 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP bilobalide results in increased expression of and results in increased activity of CYP3A23-3A1 protein
bilobalide results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:18421621 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]] CTD PMID:32319158 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]] CTD PMID:32319158 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]] CTD PMID:32319158 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
costunolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity EXP costunolide results in increased activity of CAT protein CTD PMID:20709041 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Il10 interleukin 10 multiple interactions ISO costunolide inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26970604 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO costunolide inhibits the reaction [Ethanol results in increased expression of NOS2 protein] CTD PMID:26970604 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO costunolide inhibits the reaction [Ethanol results in decreased expression of PCNA protein] CTD PMID:26970604 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO costunolide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] CTD PMID:26970604 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO costunolide inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26970604 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
Cynaropicrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO AHR mutant form inhibits the reaction [cynaropicrin affects the localization of NFE2L2 protein]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NFE2L2 mRNA]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA]
cynaropicrin affects the localization of AHR protein
CTD PMID:25680693 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of CYP1A1 mRNA] CTD PMID:25680693 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
affects localization
ISO AHR mutant form inhibits the reaction [cynaropicrin affects the localization of NFE2L2 protein]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NFE2L2 mRNA]; NFE2L2 mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA] CTD PMID:25680693 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA] CTD PMID:25680693 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
dehydrocostus lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO dehydrocostus lactone results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein] CTD PMID:19457452 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of NOS2 protein] CTD PMID:26970604 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] CTD PMID:26970604 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26970604 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein] CTD PMID:19457452 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
Eremanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity EXP eremanthin results in increased activity of CAT protein CTD PMID:20709041 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
Galbanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO galbanic acid results in increased expression of BAX mRNA CTD PMID:31576639 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO galbanic acid results in decreased expression of BCL2 mRNA CTD PMID:31576639 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression ISO galbanic acid results in increased expression of CASP3 mRNA CTD PMID:31576639 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases expression ISO galbanic acid results in increased expression of CAT mRNA CTD PMID:31576639 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO galbanic acid results in increased expression of GPX1 mRNA CTD PMID:31576639 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO galbanic acid results in increased expression of SOD1 mRNA CTD PMID:31576639 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
Ginkgolide A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO ginkgolide A results in increased expression of ABCB1 mRNA CTD PMID:19034627 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ginkgolide A results in increased expression of ABCC2 mRNA CTD PMID:19034627 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:31697926 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alb albumin multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] CTD PMID:31697926 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of CALCA protein] CTD PMID:31697926 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
EXP ginkgolide A results in increased activity of CYP1A2 protein
ginkgolide A results in increased expression of CYP1A2 mRNA
CTD PMID:18421621 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO ginkgolide A results in increased expression of CYP2B6 mRNA CTD PMID:19034627 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP ginkgolide A results in increased expression of CYP3A18 mRNA CTD PMID:16258077 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP ginkgolide A results in increased expression of CYP3A2 mRNA CTD PMID:16258077 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases activity
increases expression
EXP ginkgolide A results in increased activity of CYP3A23-3A1 protein
ginkgolide A results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:16258077 PMID:17045319 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:31697926 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Ifng interferon gamma multiple interactions ISO ginkgolide A affects the reaction [Carbon Tetrachloride results in increased expression of IFNG protein] CTD PMID:31697926 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] CTD PMID:31697926 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of LBP protein] CTD PMID:31697926 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein] CTD PMID:31697926 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO ginkgolide A results in increased activity of NR1I2 protein
ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NR1I2 protein]
CTD PMID:19034627 PMID:31697926 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ocln occludin multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of OCLN protein] CTD PMID:31697926 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] CTD PMID:31697926 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of TJP1 protein] CTD PMID:31697926 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein] CTD PMID:31697926 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:31697926 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ginkgolide A results in increased expression of UGT1A1 mRNA CTD PMID:19034627 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
ginkgolide B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO ginkgolide B results in increased expression of ABCB1 mRNA
NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; sulforaphane inhibits the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]
CTD PMID:19034627 PMID:26775663 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ginkgolide B results in increased expression of ABCC2 mRNA CTD PMID:19034627 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:19464278 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein] CTD PMID:32976958 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased abundance of Reactive Oxygen Species]; ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:19464278 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]
ginkgolide B inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
CTD PMID:19464278 PMID:21704112 PMID:26775663 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP ginkgolide B inhibits the reaction [Ethanol results in increased expression of NOX2 protein] CTD PMID:21704112 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP ginkgolide B results in increased expression of and results in increased activity of CYP1A2 protein
ginkgolide B results in increased expression of CYP1A2 mRNA
CTD PMID:18421621 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO ginkgolide B results in increased expression of CYP2B6 mRNA CTD PMID:19034627 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig decreases expression EXP ginkgolide B results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of FTH1 protein]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]
CTD PMID:32976958 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased activity of GPT protein]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]
CTD PMID:32976958 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GPX4 protein]
CTD PMID:32976958 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of HMOX1 protein]
CTD PMID:32976958 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:19464278 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:19464278 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:19464278 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP ginkgolide B inhibits the reaction [Ethanol results in increased expression of NCF1 protein] CTD PMID:21704112 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of and affects the localization of NFE2L2 protein]
CTD PMID:32976958 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP ginkgolide B inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein] CTD PMID:9006340 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]] CTD PMID:26768586 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
affects localization
ISO ginkgolide B results in increased activity of NR1I2 protein
NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA]
ginkgolide B affects the localization of NR1I2 protein
CTD PMID:19034627 PMID:26775663 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Sele selectin E multiple interactions ISO ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]] CTD PMID:26775663 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]] CTD PMID:26768586 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of TFRC protein]
CTD PMID:32976958 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] CTD PMID:26775663 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]] CTD PMID:26768586 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ginkgolide B results in increased expression of UGT1A1 mRNA CTD PMID:19034627 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] CTD PMID:26775663 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
Ginkgolide C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
Ginkgolide J term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
helenalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression ISO helenalin results in increased expression of ATF4 protein CTD PMID:23123298 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Casp3 caspase 3 multiple interactions ISO helenalin inhibits the reaction [CD 437 results in increased activity of CASP3 protein] CTD PMID:16024638 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO helenalin inhibits the reaction [CD 437 results in increased activity of CASP8 protein] CTD PMID:16024638 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD40 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD40 protein] CTD PMID:15894585 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD80 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD80 protein] CTD PMID:15894585 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd83 CD83 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD83 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD83 protein] CTD PMID:15894585 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD86 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of CD86 protein] CTD PMID:15894585 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO helenalin results in increased expression of DDIT3 protein CTD PMID:23123298 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO helenalin results in increased expression of DDIT4 protein CTD PMID:23123298 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of ICAM1 protein]; helenalin inhibits the reaction [Polysaccharides results in increased expression of ICAM1 protein]
helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
CTD PMID:15894585 PMID:19608869 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL10 protein]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of IL10 protein] CTD PMID:15894585 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:15894585 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL12B protein]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; helenalin inhibits the reaction [Polysaccharides results in increased secretion of IL12B protein] CTD PMID:15894585 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il4 interleukin 4 multiple interactions ISO helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO helenalin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:17532054 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO helenalin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein] CTD PMID:16678799 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO helenalin inhibits the reaction [CD 437 results in decreased expression of NFKBIA protein] CTD PMID:16024638 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO helenalin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; helenalin inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein] CTD PMID:28495310 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO helenalin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; helenalin inhibits the reaction [CD 437 results in increased localization of RELA protein]; helenalin inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein]
helenalin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
helenalin results in decreased activity of RELA protein
CTD PMID:15930313 PMID:16024638 PMID:18413660 PMID:19608869 PMID:28495310 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO helenalin inhibits the reaction [WR 1065 results in increased expression of SOD2 protein] CTD PMID:16540396 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO helenalin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:16678799 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; helenalin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:19608869 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO helenalin inhibits the reaction [CD 437 results in increased expression of TNFRSF10A protein] CTD PMID:16024638 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; helenalin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:19608869 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
inuviscolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO inuviscolide results in decreased expression of BIRC5 protein CTD PMID:17919456 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases activity ISO inuviscolide results in increased activity of CASP3 protein CTD PMID:17919456 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO inuviscolide affects the expression of CCNB1 protein CTD PMID:17919456 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO inuviscolide results in decreased expression of and affects the phosphorylation of CDK1 protein CTD PMID:17919456 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO inuviscolide results in increased expression of CDKN1A protein CTD PMID:17919456 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO inuviscolide results in decreased expression of RELA protein CTD PMID:17919456 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Caffeine inhibits the reaction [inuviscolide results in increased phosphorylation of TP53 protein]; inuviscolide results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:17919456 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
isoalantolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression ISO isoalantolactone results in increased expression of CASP3 protein modified form CTD PMID:29800641 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases cleavage
increases expression
multiple interactions
ISO isoalantolactone results in increased cleavage of CASP7 protein
isoalantolactone results in increased expression of CASP7 protein modified form
Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]
CTD PMID:29800641 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
increases cleavage
ISO isoalantolactone results in increased expression of PARP1 protein modified form
Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]
isoalantolactone results in increased cleavage of PARP1 protein
CTD PMID:29800641 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
Parthenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO parthenin analog results in decreased phosphorylation of AKT1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [parthenin analog results in decreased phosphorylation of AKT1 protein]
CTD PMID:25196075 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO parthenin analog affects the localization of BAX protein CTD PMID:25196075 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 increases activity ISO parthenin analog results in increased activity of CASP3 protein CTD PMID:25196075 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO parthenin analog results in increased activity of CASP8 protein CTD PMID:25196075 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO parthenin analog results in increased activity of CASP9 protein CTD PMID:25196075 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO parthenin analog results in increased cleavage of DFFA protein CTD PMID:25196075 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO parthenin analog results in decreased phosphorylation of MAPK1 protein CTD PMID:25196075 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO parthenin analog results in decreased phosphorylation of MAPK3 protein CTD PMID:25196075 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO parthenin analog results in increased cleavage of PARP1 protein CTD PMID:25196075 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO parthenin analog results in decreased phosphorylation of RAF1 protein CTD PMID:25196075 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [parthenin analog results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:25196075 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
parthenolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO parthenolide results in increased expression of BAK1 protein CTD PMID:16024633 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO parthenolide results in increased expression of BAX protein CTD PMID:16024633 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 protein]
parthenolide results in decreased expression of BCL2 mRNA; parthenolide results in decreased expression of BCL2 protein
CTD PMID:20154269 PMID:21928377 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to parthenolide CTD PMID:16024633 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO parthenolide results in increased cleavage of BID protein CTD PMID:16024633 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G C5 complement C5 multiple interactions ISO parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA] CTD PMID:30259999 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein CTD PMID:20154269 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
CTD PMID:15728586 PMID:22748497 PMID:23958496 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 protein]
parthenolide results in decreased expression of CCND1 mRNA; parthenolide results in decreased expression of CCND1 protein
CTD PMID:21928377 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] CTD PMID:20089671 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cfb complement factor B decreases expression ISO parthenolide results in decreased expression of CFB mRNA CTD PMID:16921510 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO parthenolide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA]
parthenolide results in increased expression of CXCL1 mRNA
CTD PMID:17320037 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO parthenolide promotes the reaction [Calcimycin results in increased expression of DDIT3 mRNA]
parthenolide results in increased expression of DDIT3 mRNA
CTD PMID:11360202 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO parthenolide results in decreased expression of FAS mRNA CTD PMID:16024633 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand decreases expression ISO parthenolide results in decreased expression of FASLG mRNA CTD PMID:16024633 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA] CTD PMID:16921510 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 multiple interactions ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of FLT3 mRNA] CTD PMID:21928377 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein CTD PMID:21669866 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO parthenolide inhibits the reaction [resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [resveratrol results in increased expression of ICAM1 mRNA] CTD PMID:22748497 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il12b interleukin 12B decreases expression ISO parthenolide results in decreased expression of IL12B mRNA CTD PMID:16921510 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO parthenolide results in decreased expression of IL1A mRNA CTD PMID:16921510 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO parthenolide inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL1B protein] CTD PMID:24444433 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL6 protein]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of IL6 mRNA]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]
CTD PMID:22748497 PMID:23958496 PMID:24444433 PMID:30259999 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO parthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA] CTD PMID:12574384 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinine co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; parthenolide inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO
EXP
parthenolide results in increased expression of MAPK8 mRNA
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]
parthenolide results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD PMID:16921510 PMID:30259999 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO parthenolide results in increased expression of MAPK9 mRNA CTD PMID:16921510 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter] CTD PMID:20093109 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects localization
multiple interactions
ISO parthenolide affects the localization of NCOR2 protein
SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein]
CTD PMID:21928377 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
CTD PMID:16921510 PMID:18463201 PMID:30259999 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18413660 PMID:18463201 PMID:19303104 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] CTD PMID:30259999 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO parthenolide results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions EXP parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15728586 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein CTD PMID:21669866 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased expression of PTGS2 mRNA]
CTD PMID:19095747 PMID:19303104 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity
ISO
EXP
parthenolide affects the localization of RELA protein
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein modified form]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein]
parthenolide results in decreased activity of RELA protein
[[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein]; parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; SC-203048 promotes the reaction [parthenolide affects the localization of RELA protein]
CTD PMID:16921510 PMID:18413660 PMID:18463201 PMID:19095747 PMID:19284563 PMID:19303104 PMID:20093109 PMID:20154269 PMID:21928377 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rtkn rhotekin multiple interactions ISO parthenolide inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates] CTD PMID:15480428 NCBI chr 4:114,833,453...114,850,705
Ensembl chr 4:114,835,064...114,850,701
Ensembl chr 4:114,835,064...114,850,701
JBrowse link
G Sele selectin E decreases expression ISO parthenolide results in decreased expression of SELE mRNA CTD PMID:16921510 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selp selectin P decreases expression ISO parthenolide results in decreased expression of SELP mRNA CTD PMID:16921510 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO parthenolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sts steroid sulfatase multiple interactions ISO parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein CTD PMID:21669866 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tlr5 toll-like receptor 5 decreases expression ISO parthenolide results in decreased expression of TLR5 mRNA CTD PMID:16921510 NCBI chr13:101,364,784...101,385,764
Ensembl chr13:101,381,510...101,385,764
JBrowse link
G Tlr6 toll-like receptor 6 decreases expression ISO parthenolide results in decreased expression of TLR6 mRNA CTD PMID:16921510 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of TNF mRNA]]; parthenolide inhibits the reaction [Resveratrol results in increased expression of TNF mRNA]; parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]
parthenolide results in decreased activity of TNF protein
CTD PMID:19303104 PMID:20093109 PMID:22748497 PMID:30259999 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO parthenolide results in increased expression of TP53 protein CTD PMID:16024633 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO parthenolide results in increased expression of TRADD mRNA CTD PMID:16921510 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA]
parthenolide results in decreased expression of TRAF1 mRNA; parthenolide results in decreased expression of TRAF1 protein
CTD PMID:16921510 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA]
parthenolide results in decreased expression of TRAF2 mRNA; parthenolide results in decreased expression of TRAF2 protein
CTD PMID:16921510 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO parthenolide inhibits the reaction [Glupearl 19S results in increased expression of TSLP mRNA] CTD PMID:32493875 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO parthenolide results in decreased expression of VCAM1 mRNA CTD PMID:16921510 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA] CTD PMID:16921510 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
thapsigargin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO Thapsigargin results in increased expression of AARS protein CTD PMID:24648495 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Acad11 acyl-CoA dehydrogenase family, member 11 increases expression ISO Thapsigargin results in increased expression of ACAD11 mRNA CTD PMID:22378314 NCBI chr 8:112,594,758...112,676,275
Ensembl chr 8:112,594,691...112,676,280
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 decreases expression ISO Thapsigargin results in decreased expression of ACAD9 mRNA CTD PMID:22378314 NCBI chr 2:122,782,051...122,806,166
Ensembl chr 2:122,782,060...122,805,768
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression ISO Thapsigargin results in increased expression of ACADVL mRNA CTD PMID:22378314 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression ISO Thapsigargin results in decreased expression of ACAT2 mRNA CTD PMID:22378314 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 increases expression ISO Thapsigargin results in increased expression of ACBD3 mRNA CTD PMID:22378314 NCBI chr13:99,004,942...99,035,520
Ensembl chr13:99,004,942...99,035,519
JBrowse link
G Ackr1 atypical chemokine receptor 1 increases expression ISO Thapsigargin results in increased expression of ACKR1 mRNA CTD PMID:22378314 NCBI chr13:91,827,310...91,828,875 JBrowse link
G Acly ATP citrate lyase increases expression ISO Thapsigargin results in increased expression of ACLY protein CTD PMID:24648495 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aco2 aconitase 2 increases expression ISO Thapsigargin results in increased expression of ACO2 protein CTD PMID:24648495 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO Thapsigargin results in decreased expression of ACOT13 mRNA CTD PMID:22378314 NCBI chr17:42,241,141...42,253,611
Ensembl chr17:42,241,159...42,253,649
JBrowse link
G Acot7 acyl-CoA thioesterase 7 decreases expression ISO Thapsigargin results in decreased expression of ACOT7 mRNA CTD PMID:22378314 NCBI chr 5:169,357,582...169,450,215
Ensembl chr 5:169,357,517...169,450,219
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
decreases expression
ISO Thapsigargin results in increased expression of ACTA2 mRNA
Thapsigargin results in decreased expression of ACTA2 mRNA
CTD PMID:22378314 PMID:29453283 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actg1 actin, gamma 1 decreases expression ISO Thapsigargin results in decreased expression of ACTG1 mRNA CTD PMID:22378314 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO Thapsigargin results in decreased expression of ACTN1 mRNA CTD PMID:22378314 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Acvr1 activin A receptor type 1 increases expression ISO Thapsigargin results in increased expression of ACVR1 mRNA CTD PMID:29453283 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression ISO Thapsigargin results in decreased expression of ADAMTS4 mRNA CTD PMID:22378314 NCBI chr13:89,622,996...89,632,485
Ensembl chr13:89,622,632...89,634,419
JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 decreases expression ISO Thapsigargin results in decreased expression of ADAMTS9 mRNA CTD PMID:22378314 NCBI chr 4:124,660,254...124,860,997
Ensembl chr 4:124,660,262...124,858,250
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 increases expression ISO Thapsigargin results in increased expression of ADHFE1 mRNA CTD PMID:22378314 NCBI chr 5:9,403,194...9,429,783
Ensembl chr 5:9,403,196...9,429,859
JBrowse link
G Adi1 acireductone dioxygenase 1 decreases expression ISO Thapsigargin results in decreased expression of ADI1 protein CTD PMID:24648495 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Adm adrenomedullin decreases expression
increases expression
ISO Thapsigargin results in decreased expression of ADM mRNA
Thapsigargin results in increased expression of ADM mRNA
CTD PMID:20682585 PMID:22378314 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adm2 adrenomedullin 2 increases expression ISO Thapsigargin results in increased expression of ADM2 mRNA CTD PMID:22378314 NCBI chr 7:130,296,895...130,298,641
Ensembl chr 7:130,296,897...130,298,644
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] CTD PMID:10742289 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Afap1 actin filament associated protein 1 increases expression ISO Thapsigargin results in increased expression of AFAP1 protein CTD PMID:24648495 NCBI chr14:79,923,132...80,035,096
Ensembl chr14:79,919,717...79,988,110
JBrowse link
G Afdn afadin, adherens junction formation factor increases expression ISO Thapsigargin results in increased expression of AFDN protein CTD PMID:24648495 NCBI chr 1:53,713,873...53,861,918
Ensembl chr 1:53,715,693...53,802,658
JBrowse link
G Ago3 argonaute RISC catalytic component 3 multiple interactions
affects localization
ISO Cycloheximide inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] CTD PMID:29576526 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Ahnak AHNAK nucleoprotein increases expression ISO Thapsigargin results in increased expression of AHNAK mRNA CTD PMID:19442820 NCBI chr 1:225,184,883...225,429,638
Ensembl chr 1:225,184,939...225,215,015
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Thapsigargin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:15364539 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ak2 adenylate kinase 2 decreases expression ISO Thapsigargin results in decreased expression of AK2 mRNA CTD PMID:22378314 NCBI chr 5:147,185,474...147,204,050
Ensembl chr 5:147,185,474...147,204,050
JBrowse link
G Ak3 adenylate kinase 3 decreases expression ISO Thapsigargin results in decreased expression of AK3 mRNA CTD PMID:22378314 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Ak4 adenylate kinase 4 decreases expression ISO Thapsigargin results in decreased expression of AK4 mRNA CTD PMID:22378314 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akap17a A-kinase anchoring protein 17A increases expression ISO Thapsigargin results in increased expression of AKAP17A mRNA CTD PMID:22378314 NCBI chr12:18,527,116...18,531,780
Ensembl chr12:18,526,422...18,531,161
JBrowse link
G Akap8l A-kinase anchoring protein 8 like increases expression ISO Thapsigargin results in increased expression of AKAP8L protein CTD PMID:24648495 NCBI chr 7:14,340,168...14,369,835
Ensembl chr 7:14,340,170...14,369,821
JBrowse link
G Akirin1 akirin 1 decreases expression ISO Thapsigargin results in decreased expression of AKIRIN1 protein CTD PMID:24648495 NCBI chr 5:141,415,226...141,430,627
Ensembl chr 5:141,415,075...141,430,659
JBrowse link
G Akna AT-hook transcription factor increases expression ISO Thapsigargin results in increased expression of AKNA mRNA CTD PMID:22378314 NCBI chr 5:79,184,087...79,232,370
Ensembl chr 5:79,184,088...79,222,687
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
decreases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; NRF1 protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein]; TFAM protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]
[Thapsigargin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein
Thapsigargin results in decreased expression of AKT1 protein modified form
CTD PMID:15339911 PMID:16338971 PMID:22378314 PMID:24898257 PMID:25398788 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aktip AKT interacting protein decreases expression ISO Thapsigargin results in decreased expression of AKTIP protein CTD PMID:24648495 NCBI chr19:17,290,048...17,300,054
Ensembl chr19:17,290,178...17,300,050
JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO Thapsigargin results in increased expression of ALCAM mRNA CTD PMID:22378314 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression ISO Thapsigargin results in increased expression of ALDH18A1 protein CTD PMID:24648495 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Thapsigargin results in decreased expression of ALDH1A2 mRNA CTD PMID:29453283 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO Thapsigargin results in decreased expression of ALDH1A3 mRNA CTD PMID:22378314 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases expression ISO Thapsigargin results in decreased expression of ALDH5A1 mRNA CTD PMID:22378314 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO Thapsigargin results in increased expression of ALDH6A1 mRNA CTD PMID:22378314 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Thapsigargin results in decreased expression of ALDOC mRNA CTD PMID:22378314 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alg5 ALG5, dolichyl-phosphate beta-glucosyltransferase increases expression ISO Thapsigargin results in increased expression of ALG5 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 2:143,932,242...143,946,472
Ensembl chr 2:143,932,739...143,946,466
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO 1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]; 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]]; SB 203580 inhibits the reaction [Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein; Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein CTD PMID:10779545 PMID:18218859 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alpp alkaline phosphatase, placental increases expression ISO Thapsigargin results in increased expression of ALPP mRNA CTD PMID:29453283 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
JBrowse link
G Amot angiomotin decreases expression ISO Thapsigargin results in decreased expression of AMOT mRNA CTD PMID:29453283 NCBI chr  X:116,751,231...116,810,238
Ensembl chr  X:116,751,230...116,792,864
JBrowse link
G Amt aminomethyltransferase increases expression ISO Thapsigargin results in increased expression of AMT mRNA CTD PMID:22378314 NCBI chr 8:117,068,388...117,078,633
Ensembl chr 8:117,068,582...117,077,913
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression ISO Thapsigargin results in decreased expression of ANGPTL2 protein CTD PMID:24648495 NCBI chr 3:12,262,822...12,292,665
Ensembl chr 3:12,262,822...12,292,663
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Thapsigargin results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:117,698,590...117,706,729
Ensembl chr 5:117,698,764...117,705,808
JBrowse link
G Ankrd10 ankyrin repeat domain 10 increases expression ISO Thapsigargin results in increased expression of ANKRD10 mRNA CTD PMID:29453283 NCBI chr16:83,205,898...83,229,147
Ensembl chr16:83,206,004...83,228,194
JBrowse link
G Ankrd17 ankyrin repeat domain 17 increases expression ISO Thapsigargin results in increased expression of ANKRD17 protein CTD PMID:24648495 NCBI chr14:19,291,025...19,431,521
Ensembl chr14:19,318,565...19,431,515
JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO Thapsigargin results in increased expression of ANTXR2 mRNA CTD PMID:22378314 NCBI chr14:13,191,716...13,331,286
Ensembl chr14:13,192,347...13,274,978
JBrowse link
G Anxa5 annexin A5 increases expression ISO Thapsigargin results in increased expression of ANXA5 mRNA CTD PMID:22378314 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 decreases expression ISO Thapsigargin results in decreased expression of AP2M1 protein CTD PMID:24648495 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Ap3b1 adaptor related protein complex 3 subunit beta 1 increases expression ISO Thapsigargin results in increased expression of AP3B1 protein CTD PMID:24648495 NCBI chr 2:24,022,815...24,227,522
Ensembl chr 2:24,024,791...24,226,224
JBrowse link
G Apob apolipoprotein B decreases secretion
decreases expression
ISO Thapsigargin results in decreased secretion of APOB protein
Thapsigargin results in decreased expression of APOB mRNA
CTD PMID:32535746 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO Thapsigargin results in decreased expression of APOC3 mRNA CTD PMID:32535746 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Aqr aquarius intron-binding spliceosomal factor increases expression ISO Thapsigargin results in increased expression of AQR protein CTD PMID:24648495 NCBI chr 3:105,570,399...105,640,431
Ensembl chr 3:105,570,292...105,640,463
JBrowse link
G Ar androgen receptor multiple interactions ISO Thapsigargin results in increased degradation of and results in decreased expression of AR protein CTD PMID:30280407 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arcn1 archain 1 increases expression ISO Thapsigargin results in increased expression of ARCN1 mRNA CTD PMID:22378314 NCBI chr 8:49,051,257...49,075,861
Ensembl chr 8:49,051,246...49,075,892
JBrowse link
G Arf3 ADP-ribosylation factor 3 decreases expression ISO Thapsigargin results in decreased expression of ARF3 mRNA CTD PMID:29453283 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Arf4 ADP-ribosylation factor 4 increases expression ISO Thapsigargin results in increased expression of ARF4 mRNA CTD PMID:22378314 NCBI chr16:2,338,333...2,354,909
Ensembl chr16:2,338,333...2,354,909
JBrowse link
G Arfgap3 ADP-ribosylation factor GTPase activating protein 3 increases expression ISO Thapsigargin results in increased expression of ARFGAP3 mRNA CTD PMID:22378314 NCBI chr 7:124,149,665...124,198,298
Ensembl chr 7:124,149,751...124,198,200
JBrowse link
G Arg2 arginase 2 decreases expression ISO Thapsigargin results in decreased expression of ARG2 mRNA CTD PMID:22378314 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO Thapsigargin results in increased expression of ARHGEF2 mRNA CTD PMID:22378314 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Arid4a AT-rich interaction domain 4A increases expression ISO Thapsigargin results in increased expression of ARID4A protein CTD PMID:24648495 NCBI chr 6:93,461,713...93,532,901
Ensembl chr 6:93,461,713...93,532,901
JBrowse link
G Arid4b AT-rich interaction domain 4B increases expression ISO Thapsigargin results in increased expression of ARID4B protein CTD PMID:24648495 NCBI chr17:53,831,353...53,955,897
Ensembl chr17:53,833,023...53,915,076
Ensembl chr17:53,833,023...53,915,076
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression ISO Thapsigargin results in increased expression of ARL1 mRNA CTD PMID:22378314 NCBI chr 7:29,282,411...29,293,455
Ensembl chr 7:29,282,305...29,293,399
JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression ISO Thapsigargin results in increased expression of ARMCX1 mRNA CTD PMID:22378314 NCBI chr  X:105,535,670...105,539,575
Ensembl chr  X:105,537,602...105,539,375
Ensembl chr  X:105,537,602...105,539,375
JBrowse link
G Armcx3 armadillo repeat containing, X-linked 3 increases expression ISO Thapsigargin results in increased expression of ARMCX3 mRNA CTD PMID:22378314 NCBI chr  X:105,573,909...105,577,480
Ensembl chr  X:105,573,909...105,580,562
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 increases expression ISO Thapsigargin results in increased expression of ARPC3 mRNA CTD PMID:22378314 NCBI chr12:39,653,951...39,667,817
Ensembl chr12:39,653,953...39,667,849
JBrowse link
G Asb5 ankyrin repeat and SOCS box-containing 5 decreases expression ISO Thapsigargin results in decreased expression of ASB5 protein CTD PMID:24648495 NCBI chr16:39,985,233...40,050,663
Ensembl chr16:39,985,234...40,025,401
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 increases expression ISO Thapsigargin results in increased expression of ASCL1 mRNA CTD PMID:22378314 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO Thapsigargin results in decreased expression of ASF1B mRNA CTD PMID:22378314 NCBI chr19:25,077,918...25,092,491
Ensembl chr19:25,077,918...25,092,491
JBrowse link
G Asgr1 asialoglycoprotein receptor 1 increases expression ISO Thapsigargin results in increased expression of ASGR1 mRNA CTD PMID:29453283 NCBI chr10:56,662,188...56,666,086
Ensembl chr10:56,662,242...56,666,086
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Thapsigargin results in increased expression of ASNS mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Asph aspartate-beta-hydroxylase increases expression ISO Thapsigargin results in increased expression of ASPH protein CTD PMID:24648495 NCBI chr 5:22,577,680...22,799,333
Ensembl chr 5:22,577,675...22,799,349
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 decreases expression
increases expression
ISO Thapsigargin results in decreased expression of ATAD2 mRNA
Thapsigargin results in increased expression of ATAD2 protein
CTD PMID:22378314 PMID:24648495 NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
ISO
EXP
ATF3 mutant form promotes the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]
Thapsigargin results in increased expression of ATF3 mRNA
Thapsigargin results in increased expression of ATF3 mRNA; Thapsigargin results in increased expression of ATF3 protein
CTD PMID:17332266 PMID:20022965 PMID:21694771 PMID:22641616 PMID:22935518 PMID:29453283 PMID:33770205 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
increases activity
decreases response to substance
ISO
EXP
ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]; ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; NUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Thapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter]
4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]
Thapsigargin results in increased expression of ATF4 mRNA; Thapsigargin results in increased expression of ATF4 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; ATF4 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; GSK2656157 inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]
Thapsigargin results in increased activity of ATF4 protein
ATF4 results in decreased susceptibility to Thapsigargin
CTD PMID:16298333 PMID:17283163 PMID:20022965 PMID:20589738 PMID:22378314 PMID:23383089 PMID:24648495 PMID:24865413 PMID:27226639 PMID:27358234 PMID:27587023 PMID:28223344 PMID:28844859 PMID:29109149 PMID:32357311 PMID:32578922 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Thapsigargin results in increased expression of ATF5 mRNA
Thapsigargin results in increased expression of ATF5 mRNA; Thapsigargin results in increased expression of ATF5 protein
CTD PMID:22378314 PMID:24648495 PMID:28942281 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases cleavage
increases expression
increases activity
ISO
EXP
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein]
Thapsigargin results in increased expression of ATF6 mRNA; Thapsigargin results in increased expression of ATF6 protein; Thapsigargin results in increased expression of ATF6 protein modified form
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Thapsigargin results in increased cleavage of and affects the localization of ATF6 protein
Thapsigargin results in increased activity of ATF6 protein
CTD PMID:17963750 PMID:18477628 PMID:20493918 PMID:22378314 PMID:23383089 PMID:23576437 PMID:24638036 PMID:26264395 PMID:27358234 PMID:27587023 PMID:28223344 PMID:30796460 PMID:32407927 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atg10 autophagy related 10 decreases expression ISO Thapsigargin results in decreased expression of ATG10 protein CTD PMID:24648495 NCBI chr 2:19,853,546...20,152,918
Ensembl chr 2:19,853,546...20,152,884
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression ISO Thapsigargin results in increased expression of ATP1B1 mRNA CTD PMID:33770205 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects response to substance
increases expression
decreases activity
multiple interactions
ISO
EXP
ATP2A2 protein affects the susceptibility to Thapsigargin
Thapsigargin results in increased expression of ATP2A2 mRNA
Thapsigargin results in decreased activity of ATP2A2 protein
[Thapsigargin results in decreased activity of ATP2A2 protein] which results in decreased transport of Calcium; Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of ATP2A2 mRNA]; Thapsigargin results in increased expression of and results in decreased activity of ATP2A2 protein
CTD PMID:17287366 PMID:17475205 PMID:19244478 PMID:20816668 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 multiple interactions ISO [Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein] CTD PMID:18439569 NCBI chr10:59,528,849...59,560,440
Ensembl chr10:59,529,785...59,560,433
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO Thapsigargin results in increased expression of ATP5F1A mRNA CTD PMID:22378314 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 decreases expression ISO Thapsigargin results in decreased expression of ATP5MC1 mRNA CTD PMID:22378314 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 decreases expression ISO Thapsigargin results in decreased expression of ATP5MC3 mRNA CTD PMID:22378314 NCBI chr 3:60,811,218...60,813,903
Ensembl chr 3:60,811,210...60,813,869
JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Thapsigargin results in decreased expression of ATP5MF mRNA CTD PMID:22378314 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression ISO Thapsigargin results in increased expression of ATP6V0A1 mRNA CTD PMID:29453283 NCBI chr10:88,914,264...88,967,736
Ensembl chr10:88,914,276...88,967,748
JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 increases expression ISO Thapsigargin results in increased expression of ATP6V0A2 mRNA CTD PMID:29453283 NCBI chr12:37,368,321...37,398,233
Ensembl chr12:37,363,906...37,425,596
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions
decreases expression
ISO 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] CTD PMID:19442820 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 increases expression ISO Thapsigargin results in increased expression of ATP8A1 protein CTD PMID:24648495 NCBI chr14:41,972,398...42,210,555
Ensembl chr14:42,015,347...42,206,311
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Thapsigargin results in increased expression of ATRX protein CTD PMID:24648495 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase increases expression ISO Thapsigargin results in increased expression of AUH mRNA CTD PMID:22378314 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Thapsigargin results in decreased expression of AURKB mRNA CTD PMID:22378314 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Aven apoptosis and caspase activation inhibitor increases expression ISO Thapsigargin results in increased expression of AVEN mRNA CTD PMID:29453283 NCBI chr 3:103,980,612...104,117,193
Ensembl chr 3:104,042,168...104,117,192
JBrowse link
G B4galt5 beta-1,4-galactosyltransferase 5 increases expression ISO Thapsigargin results in increased expression of B4GALT5 mRNA CTD PMID:29453283 NCBI chr 3:164,039,731...164,055,561
Ensembl chr 3:164,039,731...164,095,878
JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO Thapsigargin results in increased expression of BACH2 mRNA CTD PMID:24247028 NCBI chr 5:47,458,891...47,807,176
Ensembl chr 5:47,546,014...47,807,166
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Thapsigargin results in increased expression of BAD mRNA CTD PMID:22378314 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Banf1 BAF nuclear assembly factor 1 decreases expression ISO Thapsigargin results in decreased expression of BANF1 mRNA CTD PMID:22378314 NCBI chr 1:220,744,195...220,746,224
Ensembl chr 1:220,744,195...220,746,224
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO Thapsigargin results in decreased expression of BASP1 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases activity
multiple interactions
ISO Thapsigargin results in increased activity of BAX protein
Thapsigargin promotes the reaction [arsenite results in increased expression of BAX protein]
CTD PMID:20130848 PMID:26677073 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Baz1a bromodomain adjacent to zinc finger domain, 1A increases expression ISO Thapsigargin results in increased expression of BAZ1A protein CTD PMID:24648495 NCBI chr 6:75,793,223...75,873,854
Ensembl chr 6:75,793,960...75,874,235
JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B increases expression ISO Thapsigargin results in increased expression of BAZ1B protein CTD PMID:24648495 NCBI chr12:24,478,882...24,536,851
Ensembl chr12:24,478,898...24,537,313
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Thapsigargin results in increased expression of BBC3 mRNA CTD PMID:16018998 PMID:22378314 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcas2 BCAS2, pre-mRNA processing factor decreases expression ISO Thapsigargin results in decreased expression of BCAS2 protein CTD PMID:24648495 NCBI chr 2:205,662,633...205,670,514
Ensembl chr 2:205,662,588...205,670,511
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression ISO Thapsigargin results in increased expression of BCAT1 mRNA CTD PMID:22378314 PMID:29453283 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 increases expression ISO Thapsigargin results in increased expression of BCAT2 mRNA CTD PMID:22378314 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase decreases expression ISO Thapsigargin results in decreased expression of BCKDK mRNA
Thapsigargin results in decreased expression of BCKDK protein
CTD PMID:22378314 PMID:24648495 NCBI chr 1:199,351,628...199,356,299
Ensembl chr 1:199,351,628...199,356,881
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases phosphorylation
decreases expression
ISO Thapsigargin results in increased expression of BCL2 mRNA
Thapsigargin promotes the reaction [arsenite results in decreased expression of BCL2 protein]
Thapsigargin results in decreased phosphorylation of BCL2 protein
Thapsigargin results in decreased expression of BCL2 protein
CTD PMID:22378314 PMID:25611565 PMID:26677073 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
affects splicing
EXP
ISO
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; GW 4869 inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; PLA2G6 mutant form inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]
BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein alternative form]
Thapsigargin results in increased expression of BCL2L1 protein
CTD PMID:23885834 PMID:25762722 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 increases expression ISO Thapsigargin results in increased expression of BCLAF1 protein CTD PMID:24648495 NCBI chr 1:15,799,753...15,828,838
Ensembl chr 1:15,782,477...15,860,624
JBrowse link
G Begain brain-enriched guanylate kinase-associated decreases expression ISO Thapsigargin results in decreased expression of BEGAIN mRNA CTD PMID:22378314 NCBI chr 6:132,936,964...132,972,569
Ensembl chr 6:132,936,970...132,972,511
JBrowse link
G Bend6 BEN domain containing 6 increases expression ISO Thapsigargin results in increased expression of BEND6 mRNA CTD PMID:22378314 NCBI chr 9:38,297,253...38,351,312
Ensembl chr 9:38,297,322...38,351,024
JBrowse link
G Best1 bestrophin 1 increases expression ISO Thapsigargin results in increased expression of BEST1 mRNA CTD PMID:22378314 NCBI chr 1:226,033,146...226,049,893
Ensembl chr 1:226,030,875...226,049,929