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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-amanitin
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Accession:CHEBI:37415 term browser browse the term
Definition:A heterodetic cyclic peptide consisting of eight amino acid residues and containing a thioether bridge between a cysteine and a tryptophan residue. It is found in a number of poisonous mushrooms, including Amanita phalloides (the death cap), Galerina marginata, and and Conocybe filaris.
Synonyms:exact_synonym: 1,8-anhydro-S(1),C(2.5)-cyclo[L-cysteinyl-L-asparaginyl-trans-4-hydroxy-L-prolyl-(R)-4,5-dihydroxy-L-isoleucyl-6-hydroxy-L-tryptophylglycyl-L-isoleucylglycine] (R)-S(1)-oxide
 related_synonym: Formula=C39H54N10O14S;   InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)/t16-,17-,19+,23-,24-,25-,26-,27-,31-,32-,64+/m0/s1;   InChIKey=CIORWBWIBBPXCG-SXZCQOKQSA-N;   SMILES=[H][C@]12Cc3c([nH]c4cc(O)ccc34)[S@](=O)C[C@]([H])(NC(=O)CNC(=O)[C@@]([H])(NC(=O)CNC1=O)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N1C[C@H](O)C[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)[C@@H](O)CO)C(=O)N2;   alpha-Amanitine;   alpha-Amatoxin
 alt_id: CHEBI:10207;   CHEBI:37414
 xref: Beilstein:1071138;   CAS:23109-05-9;   KEGG:C08438;   KNApSAcK:C00001516
 xref_mesh: MESH:D053959
 xref: PMID:109306;   PMID:17525082;   PMID:19556115;   PMID:20529816;   PMID:23763309;   PMID:6208374;   PMID:6630208;   PMID:9093889;   Reaxys:1071138;   Wikipedia:Alpha-amanitin


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alpha-amanitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA] CTD PMID:10377250 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Aicda activation-induced cytidine deaminase multiple interactions ISO [Dactinomycin co-treated with Alpha-Amanitin] inhibits the reaction [Estradiol results in increased expression of AICDA mRNA] CTD PMID:19139166 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Alb albumin decreases secretion ISO Alpha-Amanitin results in decreased secretion of ALB protein CTD PMID:35384471 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 ISO
EXP		 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG5 protein] CTD PMID:37329965 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO
EXP		 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG7 protein] CTD PMID:37329965 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Alpha-Amanitin results in increased expression of BAX protein CTD PMID:35175747 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Alpha-Amanitin results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Alpha-Amanitin results in decreased expression of BCL2 protein]		 CTD PMID:35175747 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO
EXP		 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of BECN1 protein]; Alpha-Amanitin inhibits the reaction [dorsomorphin results in decreased expression of BECN1 protein] CTD PMID:37329965 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO Alpha-Amanitin results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]		 CTD PMID:35175747 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
decreases expression		 ISO Polymyxin B inhibits the reaction [Alpha-Amanitin results in decreased expression of GAPDH mRNA] CTD PMID:26385100 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO
EXP		 Alpha-Amanitin results in increased expression of GPT protein
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]		 CTD PMID:30891624 PMID:37329965 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Alpha-Amanitin inhibits the reaction [LHB protein results in increased expression of NR4A1 mRNA] CTD PMID:11416027 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
affects lipidation		 EXP
ISO		 Alpha-Amanitin results in increased expression of and results in increased lipidation of MAP1LC3B protein
3-methyladenine affects the reaction [Alpha-Amanitin affects the lipidation of MAP1LC3B protein]; Alpha-Amanitin inhibits the reaction [dorsomorphin results in decreased lipidation of MAP1LC3B protein]		 CTD PMID:37329965 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions		 ISO Alpha-Amanitin results in increased activity of MPO protein
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]		 CTD PMID:30891624 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP
ISO		 Alpha-Amanitin results in decreased expression of and results in decreased phosphorylation of MTOR protein
Alpha-Amanitin inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of MTOR protein]
Alpha-Amanitin results in decreased expression of and results in decreased phosphorylation of MTOR protein; Sirolimus promotes the reaction [Alpha-Amanitin results in decreased expression of and results in decreased phosphorylation of MTOR protein]		 CTD PMID:37329965 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Alpha-Amanitin affects the localization of NFKB1 protein CTD PMID:26385100 PMID:30891624 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP Alpha-Amanitin inhibits the reaction [LHB protein results in increased expression of NR4A1 mRNA] CTD PMID:11416027 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Alpha-Amanitin inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein] CTD PMID:21533478 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Polr2a RNA polymerase II subunit A increases degradation ISO Alpha-Amanitin results in increased degradation of POLR2A protein CTD PMID:32193566 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO Sirolimus promotes the reaction [Alpha-Amanitin results in decreased expression of SQSTM1 protein] CTD PMID:35175747 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression
multiple interactions		 ISO
EXP		 Alpha-Amanitin results in increased expression of ULK1 protein
Alpha-Amanitin inhibits the reaction [3-methyladenine results in decreased expression of ULK1 protein]; Alpha-Amanitin inhibits the reaction [dorsomorphin results in decreased expression of ULK1 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in increased expression of ULK1 protein]		 CTD PMID:37329965 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        poison 18590
          toxin 15966
            mycotoxin 12009
              alpha-amanitin 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              peptide 11122
                                                cyclic peptide 8873
                                                  heterodetic cyclic peptide 1644
                                                    alpha-amanitin 21
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