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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-amanitin
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Accession:CHEBI:37415 term browser browse the term
Definition:A heterodetic cyclic peptide consisting of eight amino acid residues and containing a thioether bridge between a cysteine and a tryptophan residue. It is found in a number of poisonous mushrooms, including Amanita phalloides (the death cap), Galerina marginata, and and Conocybe filaris.
Synonyms:exact_synonym: 1,8-anhydro-S(1),C(2.5)-cyclo[L-cysteinyl-L-asparaginyl-trans-4-hydroxy-L-prolyl-(R)-4,5-dihydroxy-L-isoleucyl-6-hydroxy-L-tryptophylglycyl-L-isoleucylglycine] (R)-S(1)-oxide
 related_synonym: Formula=C39H54N10O14S;   InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)/t16-,17-,19+,23-,24-,25-,26-,27-,31-,32-,64+/m0/s1;   InChIKey=CIORWBWIBBPXCG-SXZCQOKQSA-N;   SMILES=[H][C@]12Cc3c([nH]c4cc(O)ccc34)[S@](=O)C[C@]([H])(NC(=O)CNC(=O)[C@@]([H])(NC(=O)CNC1=O)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N1C[C@H](O)C[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)[C@@H](O)CO)C(=O)N2;   alpha-Amanitine;   alpha-Amatoxin
 alt_id: CHEBI:10207;   CHEBI:37414
 xref: CAS:23109-05-9;   KEGG:C08438;   KNApSAcK:C00001516
 xref_mesh: MESH:D053959
 xref: PMID:109306;   PMID:17525082;   PMID:19556115;   PMID:20529816;   PMID:23763309;   PMID:6208374;   PMID:6630208;   PMID:9093889;   Reaxys:1071138;   Wikipedia:Alpha-amanitin


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alpha-amanitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA] CTD PMID:10377250 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Adcy2 adenylate cyclase 2 affects expression ISO Alpha-Amanitin affects the expression of ADCY2 mRNA CTD PMID:38531469 NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236 		JBrowse link
G Adcy7 adenylate cyclase 7 affects expression ISO Alpha-Amanitin affects the expression of ADCY7 mRNA CTD PMID:38531469 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311 		JBrowse link
G Aicda activation-induced cytidine deaminase multiple interactions ISO [Dactinomycin co-treated with Alpha-Amanitin] inhibits the reaction [Estradiol results in increased expression of AICDA mRNA] CTD PMID:19139166 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Alb albumin decreases secretion ISO Alpha-Amanitin results in decreased secretion of ALB protein CTD PMID:35384471 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases secretion ISO Alpha-Amanitin results in increased secretion of ALPL protein CTD PMID:38531469 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein affects expression ISO Alpha-Amanitin affects the expression of APBB1IP mRNA CTD PMID:38531469 NCBI chr17:84,941,404...85,033,020
Ensembl chr17:84,982,243...85,033,010 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 ISO
EXP		 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG5 protein] CTD PMID:37329965 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO
EXP		 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG7 protein] CTD PMID:37329965 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Alpha-Amanitin results in increased expression of BAX protein CTD PMID:35175747 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Alpha-Amanitin results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Alpha-Amanitin results in decreased expression of BCL2 protein]		 CTD PMID:35175747 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO
EXP		 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of BECN1 protein]; Alpha-Amanitin inhibits the reaction [dorsomorphin results in decreased expression of BECN1 protein] CTD PMID:37329965 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression ISO Alpha-Amanitin affects the expression of BIRC3 mRNA CTD PMID:38531469 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Btk Bruton tyrosine kinase affects expression ISO Alpha-Amanitin affects the expression of BTK mRNA CTD PMID:38531469 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B affects expression ISO Alpha-Amanitin affects the expression of BUB1B mRNA CTD PMID:38531469 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F affects expression ISO Alpha-Amanitin affects the expression of CACNA1F mRNA CTD PMID:38531469 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413 		JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 affects expression ISO Alpha-Amanitin affects the expression of CACNA2D3 mRNA CTD PMID:38531469 NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO Alpha-Amanitin results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]		 CTD PMID:35175747 PMID:38641045 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 affects expression ISO Alpha-Amanitin affects the expression of CCL7 mRNA CTD PMID:38531469 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccne1 cyclin E1 affects expression ISO Alpha-Amanitin affects the expression of CCNE1 mRNA CTD PMID:38531469 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 affects expression ISO Alpha-Amanitin affects the expression of CCR3 mRNA CTD PMID:38531469 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression ISO Alpha-Amanitin affects the expression of CCR4 mRNA CTD PMID:38531469 NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Cd276 Cd276 molecule affects expression ISO Alpha-Amanitin affects the expression of CD276 mRNA CTD PMID:38531469 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Cd80 Cd80 molecule affects expression ISO Alpha-Amanitin affects the expression of CD80 mRNA CTD PMID:38531469 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd8b CD8 subunit beta affects expression ISO Alpha-Amanitin affects the expression of CD8B1 mRNA CTD PMID:38531469 NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553 		JBrowse link
G Cdc25c cell division cycle 25C affects expression ISO Alpha-Amanitin affects the expression of CDC25C mRNA CTD PMID:38531469 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdc6 cell division cycle 6 affects expression ISO Alpha-Amanitin affects the expression of CDC6 mRNA CTD PMID:38531469 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression ISO Alpha-Amanitin affects the expression of CDKN2A mRNA CTD PMID:38531469 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO Alpha-Amanitin affects the expression of CNR1 mRNA CTD PMID:38531469 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cntn2 contactin 2 affects expression ISO Alpha-Amanitin affects the expression of CNTN2 mRNA CTD PMID:38531469 NCBI chr13:43,942,868...43,975,973
Ensembl chr13:43,947,265...43,975,887 		JBrowse link
G Col2a1 collagen type II alpha 1 chain affects expression ISO Alpha-Amanitin affects the expression of COL2A1 mRNA CTD PMID:38531469 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Csf2 colony stimulating factor 2 affects expression ISO Alpha-Amanitin affects the expression of CSF2 mRNA CTD PMID:38531469 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 affects expression ISO Alpha-Amanitin affects the expression of CSF3 mRNA CTD PMID:38531469 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression ISO Alpha-Amanitin affects the expression of CXCL2 mRNA CTD PMID:38531469 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO Alpha-Amanitin affects the expression of CXCL3 mRNA CTD PMID:38531469 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Dock2 dedicator of cytokinesis 2 affects expression ISO Alpha-Amanitin affects the expression of DOCK2 mRNA CTD PMID:38531469 NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808 		JBrowse link
G Dusp2 dual specificity phosphatase 2 affects expression ISO Alpha-Amanitin affects the expression of DUSP2 mRNA CTD PMID:38531469 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499 		JBrowse link
G Epha3 Eph receptor A3 affects expression ISO Alpha-Amanitin affects the expression of EPHA3 mRNA CTD PMID:38531469 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900 		JBrowse link
G Ephb6 Eph receptor B6 affects expression ISO Alpha-Amanitin affects the expression of EPHB6 mRNA CTD PMID:38531469 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Espl1 extra spindle pole bodies like 1, separase affects expression ISO Alpha-Amanitin affects the expression of ESPL1 mRNA CTD PMID:38531469 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984 		JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 affects expression ISO Alpha-Amanitin affects the expression of F2RL2 mRNA CTD PMID:38531469 NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098 		JBrowse link
G Fcer1g Fc epsilon receptor Ig affects expression ISO Alpha-Amanitin affects the expression of FCER1G mRNA CTD PMID:38531469 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Fgf16 fibroblast growth factor 16 affects expression ISO Alpha-Amanitin affects the expression of FGF16 mRNA CTD PMID:38531469 NCBI chr  X:70,816,658...70,828,028
Ensembl chr  X:70,817,433...70,878,717 		JBrowse link
G Fpr1 formyl peptide receptor 1 affects expression ISO Alpha-Amanitin affects the expression of FPR1 mRNA CTD PMID:38531469 NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559 		JBrowse link
G G6pc2 glucose-6-phosphatase catalytic subunit 2 affects expression ISO Alpha-Amanitin affects the expression of G6PC2 mRNA CTD PMID:38531469 NCBI chr 3:53,999,821...54,005,539 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
decreases expression		 ISO Polymyxin B inhibits the reaction [Alpha-Amanitin results in decreased expression of GAPDH mRNA] CTD PMID:26385100 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gng13 G protein subunit gamma 13 affects expression ISO Alpha-Amanitin affects the expression of GNG13 mRNA CTD PMID:38531469 NCBI chr10:14,741,179...14,743,083
Ensembl chr10:14,741,239...14,743,083 		JBrowse link
G Gng8 G protein subunit gamma 8 affects expression ISO Alpha-Amanitin affects the expression of GNG8 mRNA CTD PMID:38531469 NCBI chr 1:77,564,512...77,568,371
Ensembl chr 1:77,564,515...77,568,371 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO
EXP		 Alpha-Amanitin results in increased expression of GPT protein
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]		 CTD PMID:30891624 PMID:37329965 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression ISO Alpha-Amanitin affects the expression of GRIN1 mRNA CTD PMID:38531469 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression ISO Alpha-Amanitin affects the expression of HCK mRNA CTD PMID:38531469 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects expression ISO Alpha-Amanitin affects the expression of HTR7 mRNA CTD PMID:38531469 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Il17a interleukin 17A affects expression ISO Alpha-Amanitin affects the expression of IL17A mRNA CTD PMID:38531469 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Itga2 integrin subunit alpha 2 affects expression ISO Alpha-Amanitin affects the expression of ITGA2 mRNA CTD PMID:38531469 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Klrc3 killer cell lectin like receptor C3 affects expression ISO Alpha-Amanitin affects the expression of KLRC3 mRNA CTD PMID:38531469 NCBI chr 4:163,105,081...163,112,737
Ensembl chr 4:163,106,024...163,112,336 		JBrowse link
G Lbp lipopolysaccharide binding protein affects expression ISO Alpha-Amanitin affects the expression of LBP mRNA CTD PMID:38531469 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Alpha-Amanitin inhibits the reaction [LHB protein results in increased expression of NR4A1 mRNA] CTD PMID:11416027 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lrrc4c leucine rich repeat containing 4C affects expression ISO Alpha-Amanitin affects the expression of LRRC4C mRNA CTD PMID:38531469 NCBI chr 3:82,305,495...83,684,039
Ensembl chr 3:83,483,851...83,687,774 		JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 affects expression ISO Alpha-Amanitin affects the expression of MADCAM1 mRNA CTD PMID:38531469 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
affects lipidation		 EXP
ISO		 Alpha-Amanitin results in increased expression of and results in increased lipidation of MAP1LC3B protein
3-methyladenine affects the reaction [Alpha-Amanitin affects the lipidation of MAP1LC3B protein]; Alpha-Amanitin inhibits the reaction [dorsomorphin results in decreased lipidation of MAP1LC3B protein]		 CTD PMID:37329965 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO Alpha-Amanitin affects the expression of MCM3 mRNA CTD PMID:38531469 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 affects expression ISO Alpha-Amanitin affects the expression of MCM5 mRNA CTD PMID:38531469 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions		 ISO Alpha-Amanitin results in increased activity of MPO protein
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]		 CTD PMID:30891624 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP
ISO		 Alpha-Amanitin results in decreased expression of and results in decreased phosphorylation of MTOR protein
Alpha-Amanitin inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of MTOR protein]
Alpha-Amanitin results in decreased expression of and results in decreased phosphorylation of MTOR protein; Sirolimus promotes the reaction [Alpha-Amanitin results in decreased expression of and results in decreased phosphorylation of MTOR protein]		 CTD PMID:37329965 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects expression ISO Alpha-Amanitin affects the expression of NCF1 mRNA CTD PMID:38531469 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nefh neurofilament heavy chain decreases degradation EXP Alpha-Amanitin results in decreased degradation of NEFH mRNA CTD PMID:1280263 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain decreases degradation EXP Alpha-Amanitin results in decreased degradation of NEFL mRNA CTD PMID:1280263 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain decreases degradation EXP Alpha-Amanitin results in decreased degradation of NEFM mRNA CTD PMID:1280263 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Alpha-Amanitin affects the localization of NFKB1 protein CTD PMID:26385100 PMID:30891624 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlgn3 neuroligin 3 affects expression ISO Alpha-Amanitin affects the expression of NLGN3 mRNA CTD PMID:38531469 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP Alpha-Amanitin inhibits the reaction [LHB protein results in increased expression of NR4A1 mRNA] CTD PMID:11416027 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Osm oncostatin M affects expression ISO Alpha-Amanitin affects the expression of OSM mRNA CTD PMID:38531469 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Alpha-Amanitin inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein] CTD PMID:21533478 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdcd1 programmed cell death 1 affects expression ISO Alpha-Amanitin affects the expression of PDCD1 mRNA CTD PMID:38531469 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 affects expression ISO Alpha-Amanitin affects the expression of PDCD1LG2 mRNA CTD PMID:38531469 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 affects expression ISO Alpha-Amanitin affects the expression of PIK3AP1 mRNA CTD PMID:38531469 NCBI chr 1:240,090,854...240,245,007
Ensembl chr 1:240,093,065...240,204,828 		JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 affects expression ISO Alpha-Amanitin affects the expression of PKMYT1 mRNA CTD PMID:38531469 NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995 		JBrowse link
G Pla2g1b phospholipase A2 group IB affects expression ISO Alpha-Amanitin affects the expression of PLA2G1B mRNA CTD PMID:38531469 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Polr2a RNA polymerase II subunit A increases degradation
increases expression		 ISO Alpha-Amanitin results in increased degradation of POLR2A protein
Alpha-Amanitin results in increased expression of POLR2A mRNA; Alpha-Amanitin results in increased expression of POLR2A protein		 CTD PMID:32193566 PMID:38531469 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Prkcb protein kinase C, beta affects expression ISO Alpha-Amanitin affects the expression of PRKCB mRNA CTD PMID:38531469 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 affects expression ISO Alpha-Amanitin affects the expression of PTPN7 mRNA CTD PMID:38531469 NCBI chr13:46,570,904...46,584,048
Ensembl chr13:46,571,712...46,583,308 		JBrowse link
G Rac2 Rac family small GTPase 2 affects expression ISO Alpha-Amanitin affects the expression of RAC2 mRNA CTD PMID:38531469 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720 		JBrowse link
G Raet1e retinoic acid early transcript 1E affects expression ISO Alpha-Amanitin affects the expression of RAET1E mRNA; Alpha-Amanitin affects the expression of RAET1G mRNA CTD PMID:38531469 NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects phosphorylation ISO Alpha-Amanitin affects the phosphorylation of RELA protein CTD PMID:38531469 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit affects expression ISO Alpha-Amanitin affects the expression of RELB mRNA CTD PMID:38531469 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Rin1 Ras and Rab interactor 1 affects expression ISO Alpha-Amanitin affects the expression of RIN1 mRNA CTD PMID:38531469 NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729 		JBrowse link
G Scin scinderin affects expression ISO Alpha-Amanitin affects the expression of SCIN mRNA CTD PMID:38531469 NCBI chr 6:57,109,500...57,188,123
Ensembl chr 6:57,109,403...57,188,242 		JBrowse link
G Sema3a semaphorin 3A affects expression ISO Alpha-Amanitin affects the expression of SEMA3A mRNA CTD PMID:38531469 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432 		JBrowse link
G Sema4f ssemaphorin 4F affects expression ISO Alpha-Amanitin affects the expression of SEMA4F mRNA CTD PMID:38531469 NCBI chr 4:115,411,411...115,437,721
Ensembl chr 4:115,411,417...115,437,721 		JBrowse link
G Sh2d1a SH2 domain containing 1A affects expression ISO Alpha-Amanitin affects the expression of SH2D1A mRNA CTD PMID:38531469 NCBI chr  X:121,373,693...121,401,923 JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO SLCO1B3 protein results in increased uptake of and results in increased abundance of Alpha-Amanitin CTD PMID:38641045 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO Sirolimus promotes the reaction [Alpha-Amanitin results in decreased expression of SQSTM1 protein] CTD PMID:35175747 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Syk spleen associated tyrosine kinase affects expression ISO Alpha-Amanitin affects the expression of SYK mRNA CTD PMID:38531469 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 affects expression ISO Alpha-Amanitin affects the expression of TGFB3 mRNA CTD PMID:38531469 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO Alpha-Amanitin affects the expression of THBS4 mRNA CTD PMID:38531469 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 affects expression ISO Alpha-Amanitin affects the expression of TICAM2 mRNA CTD PMID:38531469 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Tnf tumor necrosis factor affects expression ISO Alpha-Amanitin affects the expression of TNF mRNA CTD PMID:38531469 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 affects expression ISO Alpha-Amanitin affects the expression of TNFSF11 mRNA CTD PMID:38531469 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnfsf18 TNF superfamily member 18 affects expression ISO Alpha-Amanitin affects the expression of TNFSF18 mRNA CTD PMID:38531469 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
G Tnfsf4 TNF superfamily member 4 affects expression ISO Alpha-Amanitin affects the expression of TNFSF4 mRNA CTD PMID:38531469 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 affects expression ISO Alpha-Amanitin affects the expression of TRPC5 mRNA CTD PMID:38531469 NCBI chr  X:107,946,163...108,230,991
Ensembl chr  X:107,939,131...108,230,991 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp affects expression ISO Alpha-Amanitin affects the expression of TYROBP mRNA CTD PMID:38531469 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression
multiple interactions		 ISO
EXP		 Alpha-Amanitin results in increased expression of ULK1 protein
Alpha-Amanitin inhibits the reaction [3-methyladenine results in decreased expression of ULK1 protein]; Alpha-Amanitin inhibits the reaction [dorsomorphin results in decreased expression of ULK1 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in increased expression of ULK1 protein]		 CTD PMID:37329965 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Unc5d unc-5 netrin receptor D affects expression ISO Alpha-Amanitin affects the expression of UNC5D mRNA CTD PMID:38531469 NCBI chr16:62,860,119...63,406,932
Ensembl chr16:62,860,174...63,401,143 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 affects expression ISO Alpha-Amanitin affects the expression of VAV1 mRNA CTD PMID:38531469 NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937 		JBrowse link
G Was WASP actin nucleation promoting factor affects expression ISO Alpha-Amanitin affects the expression of WAS mRNA CTD PMID:38531469 NCBI chr  X:14,405,105...14,413,850
Ensembl chr  X:14,405,124...14,413,849 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 affects expression ISO Alpha-Amanitin affects the expression of ZAP70 mRNA CTD PMID:38531469 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        poison 18627
          toxin 16008
            mycotoxin 12039
              alpha-amanitin 107
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              peptide 11442
                                                cyclic peptide 8925
                                                  heterodetic cyclic peptide 1722
                                                    alpha-amanitin 107
paths to the root