Aicda (activation-induced cytidine deaminase) - Rat Genome Database

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Gene: Aicda (activation-induced cytidine deaminase) Rattus norvegicus
Analyze
Symbol: Aicda
Name: activation-induced cytidine deaminase
RGD ID: 1303222
Description: Predicted to enable several functions, including cytidine deaminase activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including DNA cytosine deamination; cytidine deamination; and regulation of macromolecule metabolic process. Predicted to act upstream of or within cellular response to lipopolysaccharide; defense response to bacterium; and isotype switching. Predicted to be part of protein-containing complex. Predicted to be active in P-body and nucleus. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase); PARTICIPATES IN interleukin-4 signaling pathway; primary immunodeficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AID; single-stranded DNA cytosine deaminase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,446,120 - 157,455,958 (+)NCBIGRCr8
mRatBN7.24155,774,132 - 155,783,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,774,132 - 155,783,972 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,037,288 - 162,047,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,820,509 - 157,830,246 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,467,264 - 156,476,977 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,359,909 - 155,371,104 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,359,921 - 155,369,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,384,433 - 222,395,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,006,328 - 159,017,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,257,307 - 159,260,429 (+)NCBI
Celera4144,595,276 - 144,605,030 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
nucleus  (IBA,ISO)
P-body  (IBA)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Begum NA, etal., Science 2004 Aug 20;305(5687):1160-3.
2. Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. Epeldegui M, etal., AIDS. 2007 Nov 12;21(17):2265-70. doi: 10.1097/QAD.0b013e3282ef9f59.
3. Molecular genetic analysis of Hungarian patients with the hyper-immunoglobulin M syndrome. Erdos M, etal., Mol Immunol. 2008 Jan;45(1):278-82. Epub 2007 Jun 5.
4. A novel activation-induced cytidine deaminase gene mutation in a Tunisian family with hyper IgM syndrome. Fiorini C, etal., Eur J Pediatr. 2004 Dec;163(12):704-8.
5. Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine. Frasca D, etal., Int Immunol. 2012 Mar;24(3):175-82. doi: 10.1093/intimm/dxr123. Epub 2012 Jan 25.
6. A single intranasal immunization with a subunit vaccine formulation induces higher mucosal IgA production than live respiratory syncytial virus. Garg R, etal., Virology. 2016 Dec;499:288-297. doi: 10.1016/j.virol.2016.09.023. Epub 2016 Oct 6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Aberrant activation-induced cytidine deaminase expression is associated with mucosal intestinalization in the early stage of gastric cancer. Goto A, etal., Virchows Arch. 2011 Jun;458(6):717-24. doi: 10.1007/s00428-011-1086-x. Epub 2011 May 3.
10. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Gourzi P, etal., Immunity. 2006 Jun;24(6):779-86. doi: 10.1016/j.immuni.2006.03.021.
11. Activation-induced cytidine deaminase mRNA levels in chronic lymphocytic leukemia. Hancer VS, etal., Leuk Lymphoma. 2011 Jan;52(1):79-84. doi: 10.3109/10428194.2010.531410. Epub 2010 Dec 6.
12. Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease. Hase K, etal., PLoS One. 2008 Aug 21;3(8):e3033. doi: 10.1371/journal.pone.0003033.
13. Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients. Iacobucci I, etal., Leukemia. 2010 Jan;24(1):66-73. doi: 10.1038/leu.2009.197. Epub 2009 Sep 17.
14. Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. Ito M, etal., Clin Immunol. 2010 Jun;135(3):459-65. doi: 10.1016/j.clim.2010.02.002. Epub 2010 Mar 1.
15. Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection. Kato M, etal., J Virol. 2015 Jan 15;89(2):1468-73. doi: 10.1128/JVI.02293-14. Epub 2014 Nov 5.
16. AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans. Khurana S, etal., PLoS Pathog. 2012 Sep;8(9):e1002920. doi: 10.1371/journal.ppat.1002920. Epub 2012 Sep 13.
17. AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Komeno Y, etal., Leukemia. 2010 May;24(5):1018-24. doi: 10.1038/leu.2010.40. Epub 2010 Apr 1.
18. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Kotani A, etal., Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1616-20. Epub 2007 Jan 24.
19. Targeting activation-induced cytidine deaminase overcomes tumor evasion of immunotherapy by CTLs. Liu JQ, etal., J Immunol. 2010 May 15;184(10):5435-43. doi: 10.4049/jimmunol.0903322. Epub 2010 Apr 19.
20. IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection. Matsumoto M, etal., Infect Immun. 2013 Jul;81(7):2518-27. doi: 10.1128/IAI.00285-13. Epub 2013 Apr 29.
21. Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B. Matsumoto T, etal., Antiviral Res. 2017 Mar;139:138-145. doi: 10.1016/j.antiviral.2017.01.004. Epub 2017 Jan 5.
22. Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas. Matsushita M, etal., Yonago Acta Med. 2017 Sep 15;60(3):145-153. eCollection 2017 Sep.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome. Minegishi Y, etal., Clin Immunol. 2000 Dec;97(3):203-10.
25. Enhanced expression of activation-induced cytidine deaminase in human gastric mucosa infected by Helicobacter pylori and its decrease following eradication. Nagata N, etal., J Gastroenterol. 2014 Mar;49(3):427-35. doi: 10.1007/s00535-013-0808-z. Epub 2013 Apr 18.
26. Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection. Nakamura M, etal., Eur J Dermatol. 2011 Sep-Oct;21(5):780-2. doi: 10.1684/ejd.2011.1433.
27. Effective B cell activation in vitro during viremic HIV-1 infection with surrogate T cell stimulation. Nicholson LK, etal., Immunobiology. 2018 Dec;223(12):839-849. doi: 10.1016/j.imbio.2018.08.007. Epub 2018 Sep 7.
28. Germ Line IgM Is Sufficient, but Not Required, for Antibody-Mediated Alphavirus Clearance from the Central Nervous System. Nilaratanakul V, etal., J Virol. 2018 Mar 14;92(7). pii: JVI.02081-17. doi: 10.1128/JVI.02081-17. Print 2018 Apr 1.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. An Unmutated IgM Response to the Vi Polysaccharide of Salmonella Typhi Contributes to Protective Immunity in a Murine Model of Typhoid. Pandya KD, etal., J Immunol. 2018 Jun 15;200(12):4078-4084. doi: 10.4049/jimmunol.1701348. Epub 2018 May 9.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Revy P, etal., Cell. 2000 Sep 1;102(5):565-75.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Comprehensive gene review and curation RGD comprehensive gene curation
38. Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection. Roque Cuéllar MC, etal., J Viral Hepat. 2016 Aug;23(8):606-13. doi: 10.1111/jvh.12526. Epub 2016 Mar 4.
39. Activation-induced cytidine deaminase in B cells of hepatits C virus-related cryoglobulinaemic vasculitis. Russi S, etal., Clin Exp Immunol. 2015 Dec;182(3):323-31. doi: 10.1111/cei.12690. Epub 2015 Sep 17.
40. Hypergammaglobulinemia sustains the development of regulatory responses during chronic Leishmania donovani infection in mice. Silva-Barrios S and Stäger S, Eur J Immunol. 2019 Jul;49(7):1082-1091. doi: 10.1002/eji.201847917. Epub 2019 May 23.
41. A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations. Takai A, etal., Oncogene. 2009 Jan 29;28(4):469-78. doi: 10.1038/onc.2008.415. Epub 2008 Nov 10.
42. Plasmodium chabaudi infection induces AID expression in transitional and marginal zone B cells. Wilmore JR, etal., Immun Inflamm Dis. 2016 Nov 28;4(4):497-505. doi: 10.1002/iid3.134. eCollection 2016 Dec.
43. AID expression in peripheral blood of children living in a malaria holoendemic region is associated with changes in B cell subsets and Epstein-Barr virus. Wilmore JR, etal., Int J Cancer. 2015 Mar 15;136(6):1371-80. doi: 10.1002/ijc.29127. Epub 2014 Aug 19.
44. Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells. Yamamoto N, etal., Immunology. 2016 Jan;147(1):97-113. doi: 10.1111/imm.12544.
Additional References at PubMed
PMID:10373455   PMID:12692563   PMID:14766966   PMID:14769937   PMID:17713479   PMID:18722174   PMID:18762567   PMID:19412186   PMID:19734146   PMID:21255825   PMID:21496894   PMID:21518874  
PMID:23277564  


Genomics

Comparative Map Data
Aicda
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,446,120 - 157,455,958 (+)NCBIGRCr8
mRatBN7.24155,774,132 - 155,783,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,774,132 - 155,783,972 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,037,288 - 162,047,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,820,509 - 157,830,246 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,467,264 - 156,476,977 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,359,909 - 155,371,104 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,359,921 - 155,369,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,384,433 - 222,395,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,006,328 - 159,017,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,257,307 - 159,260,429 (+)NCBI
Celera4144,595,276 - 144,605,030 (+)NCBICelera
Cytogenetic Map4q42NCBI
AICDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,602,170 - 8,612,859 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,602,155 - 8,613,242 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,754,766 - 8,765,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,646,029 - 8,656,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 34128,646,028 - 8,656,706NCBI
Celera1210,292,343 - 10,303,027 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef128,537,559 - 8,548,246 (-)NCBIHuRef
CHM1_1128,723,739 - 8,734,421 (-)NCBICHM1_1
T2T-CHM13v2.0128,585,624 - 8,596,319 (-)NCBIT2T-CHM13v2.0
Aicda
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,530,768 - 122,541,139 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,530,760 - 122,541,139 (+)EnsemblGRCm39 Ensembl
GRCm386122,553,809 - 122,564,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,553,801 - 122,564,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv376122,503,827 - 122,514,198 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,519,428 - 122,529,798 (+)NCBIMGSCv36mm8
Celera6124,348,050 - 124,358,431 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.65NCBI
AICDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21014,130,168 - 14,140,777 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,126,928 - 14,137,537 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,688,392 - 8,699,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,903,288 - 8,913,895 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,904,273 - 8,913,917 (-)Ensemblpanpan1.1panPan2
AICDA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,064,107 - 37,073,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,064,080 - 37,073,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,542,544 - 9,552,236 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,413,568 - 37,423,269 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,413,475 - 37,423,284 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,294,310 - 37,303,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,329,570 - 37,339,245 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,029,099 - 9,038,784 (-)NCBIUU_Cfam_GSD_1.0
Aicda
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,736,851 - 98,746,413 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493687025,039 - 34,601 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493687025,039 - 34,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AICDA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,777,352 - 62,787,369 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,777,236 - 62,787,342 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,607,510 - 65,617,612 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AICDA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,426,920 - 8,438,331 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,428,922 - 8,431,641 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666089515,359 - 525,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aicda
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248604,912,656 - 4,926,634 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248604,912,938 - 4,927,846 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aicda
105 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:59
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000020762
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 13 16 17 3 24 3 41 25 12 6 37 14

Sequence


Ensembl Acc Id: ENSRNOT00000020762   ⟹   ENSRNOP00000020762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,774,132 - 155,783,972 (+)Ensembl
Rnor_6.0 Ensembl4155,359,921 - 155,369,671 (+)Ensembl
RefSeq Acc Id: NM_001100779   ⟹   NP_001094249
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,446,120 - 157,455,958 (+)NCBI
mRatBN7.24155,774,132 - 155,783,972 (+)NCBI
Rnor_6.04155,359,909 - 155,371,104 (+)NCBI
Rnor_5.04222,384,433 - 222,395,569 (+)NCBI
RGSC_v3.44159,006,328 - 159,017,501 (+)RGD
Celera4144,595,276 - 144,605,030 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094249 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE54297 (Get FASTA)   NCBI Sequence Viewer  
  EDM01989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020762
  ENSRNOP00000020762.4
RefSeq Acc Id: NP_001094249   ⟸   NM_001100779
- UniProtKB: G3V7Y8 (UniProtKB/TrEMBL),   A6ILF0 (UniProtKB/TrEMBL),   Q70AG6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020762   ⟸   ENSRNOT00000020762
Protein Domains
CMP/dCMP-type deaminase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7Y8-F1-model_v2 AlphaFold G3V7Y8 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303222 AgrOrtholog
BioCyc Gene G2FUF-43152 BioCyc
Ensembl Genes ENSRNOG00000015478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020762 ENTREZGENE
  ENSRNOT00000020762.8 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
InterPro APOBEC/CMP_deaminase_Zn-bd UniProtKB/TrEMBL
  APOBEC_Cyt_Deaminase UniProtKB/TrEMBL
  APOBEC_N UniProtKB/TrEMBL
  CMP_dCMP_Zn-bd UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/TrEMBL
KEGG Report rno:399679 UniProtKB/TrEMBL
NCBI Gene 399679 ENTREZGENE
PANTHER MRNA EDITING ENZYME UniProtKB/TrEMBL
  SINGLE-STRANDED DNA CYTOSINE DEAMINASE UniProtKB/TrEMBL
Pfam APOBEC_N UniProtKB/TrEMBL
PhenoGen Aicda PhenoGen
PROSITE CYT_DCMP_DEAMINASES UniProtKB/TrEMBL
  CYT_DCMP_DEAMINASES_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015478 RatGTEx
Superfamily-SCOP Cytidine_deaminase-like UniProtKB/TrEMBL
UniProt A6ILF0 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Y8 ENTREZGENE, UniProtKB/TrEMBL
  Q70AG6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-03 Aicda  activation-induced cytidine deaminase  aicda  activation-induced cytidine deaminase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 aicda  activation-induced cytidine deaminase      Symbol and Name status set to provisional 70820 PROVISIONAL