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Gene: APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B) Homo sapiens
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Symbol: APOBEC3B
Name: apolipoprotein B mRNA editing enzyme catalytic subunit 3B
Description: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A3B; APOBEC1L; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3B; apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B; ARCD3; ARP4; bK150C2.2; cytidine deaminase; DJ742C19.2; DNA dC->dU-editing enzyme APOBEC-3B; FLJ21201; phorbolin 2; phorbolin 3; phorbolin-1-related protein; phorbolin-2/3; PHRBNL; probable DNA dC->dU-editing enzyme APOBEC-3B
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,982,399 - 38,992,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372239,378,352 - 39,388,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,708,351 - 37,718,729 (+)NCBINCBI36hg18NCBI36
Build 342237,702,904 - 37,713,283NCBI
Celera2223,180,435 - 23,190,818 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2222,346,831 - 22,357,255 (+)NCBIHuRef
CHM1_12239,337,368 - 39,347,749 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on APOBEC3B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347030
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.