Scin (scinderin) - Rat Genome Database

Name: Scin
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Scin (scinderin) Rattus norvegicus

Analyze

Symbol:

Scin

Name:

scinderin

RGD ID:

735034

Description:

Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Part of protein-containing complex. Orthologous to human SCIN (scinderin); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adseverin; Scind

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SCIN (scinderin)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Scin (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Scin (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SCIN (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SCIN (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Scin (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SCIN (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SCIN (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Scin (scinderin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SCIN (scinderin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Scin (scinderin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	scin (scinderin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gel	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gsnl-1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	qua	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	scin	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	57,109,500 - 57,188,123 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	57,109,403 - 57,188,242 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	57,380,003 - 57,480,452 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	57,694,940 - 57,795,392 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	57,179,603 - 57,270,868 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	59,975,375 - 60,055,075 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	59,976,003 - 60,054,279 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	69,564,441 - 69,641,704 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	59,237,930 - 59,357,001 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	59,241,055 - 59,360,127 (-)	NCBI
Celera	6	56,160,567 - 56,251,246 (-)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aldrin (ISO)

aristolochic acid A (EXP,ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cannabidiol (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

copper atom (ISO)

copper(0) (ISO)

decabromodiphenyl ether (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

glycidol (EXP)

irinotecan (EXP)

ivermectin (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

nickel atom (ISO)

paracetamol (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulforaphane (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

trovafloxacin (ISO)

tungsten (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament capping (ISO)

actin filament severing (IBA,ISO)

actin polymerization or depolymerization (IBA)

barbed-end actin filament capping (IBA)

cell projection assembly (IBA)

central nervous system development (IBA)

negative regulation of cell population proliferation (ISO)

positive regulation of actin nucleation (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of megakaryocyte differentiation (ISO)

sequestering of actin monomers (ISO)

Cellular Component

actin cytoskeleton (IBA)

brush border (ISO)

cytoplasm (IBA)

protein-containing complex (IDA)

Molecular Function

actin filament binding (IBA)

phosphatidylinositol-4,5-bisphosphate binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Fc gamma receptor mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Identification of a multiprotein "motor" complex binding to water channel aquaporin-2.	Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor.	Svensson C, etal., Biochem Biophys Res Commun 2002 Mar 15;291(5):1194-200.

Additional References at PubMed

PMID:11568009	PMID:19056867	PMID:19666531	PMID:22114352	PMID:23376485	PMID:28823945

Genomics

Comparative Map Data

Scin
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	57,109,500 - 57,188,123 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	57,109,403 - 57,188,242 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	57,380,003 - 57,480,452 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	57,694,940 - 57,795,392 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	57,179,603 - 57,270,868 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	59,975,375 - 60,055,075 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	59,976,003 - 60,054,279 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	69,564,441 - 69,641,704 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	59,237,930 - 59,357,001 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	59,241,055 - 59,360,127 (-)	NCBI
Celera	6	56,160,567 - 56,251,246 (-)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI

SCIN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	12,570,720 - 12,660,182 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	12,570,577 - 12,660,182 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	12,610,346 - 12,699,807 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	12,595,673 - 12,659,752 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	12,402,387 - 12,466,467	NCBI
Celera	7	12,587,891 - 12,670,905 (+)	NCBI		Celera
Cytogenetic Map	7	p21.3	NCBI
HuRef	7	12,488,818 - 12,571,812 (+)	NCBI		HuRef
CHM1_1	7	12,610,380 - 12,693,312 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	12,701,807 - 12,791,257 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	12,661,354 - 12,744,363 (+)	NCBI

Scin
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	40,109,768 - 40,184,227 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	40,109,768 - 40,184,227 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	40,059,769 - 40,134,228 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	40,059,769 - 40,134,228 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	40,786,356 - 40,860,815 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	40,570,192 - 40,644,606 (-)	NCBI		MGSCv36	mm8
Celera	12	41,488,078 - 41,562,781 (-)	NCBI		Celera
Cytogenetic Map	12	B1	NCBI
cM Map	12	18.06	NCBI

Scin
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	16,285,217 - 16,358,280 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	16,286,131 - 16,358,286 (+)	NCBI	ChiLan1.0	ChiLan1.0

SCIN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	7	65,766,665 - 65,851,350 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	13,269,361 - 13,351,854 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	12,613,996 - 12,696,244 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	12,613,996 - 12,696,244 (+)	Ensembl	panpan1.1		panPan2

SCIN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	27,429,476 - 27,477,805 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	27,412,351 - 27,477,283 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	26,912,136 - 26,989,694 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	27,226,368 - 27,303,850 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	27,226,395 - 27,306,606 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	27,396,521 - 27,473,978 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	27,127,055 - 27,204,635 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	27,495,113 - 27,521,348 (+)	NCBI		UU_Cfam_GSD_1.0
UU_Cfam_GSD_1.0	14	27,385,153 - 27,462,823 (+)	NCBI		UU_Cfam_GSD_1.0

Scin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	71,891,966 - 71,969,069 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936795	418,436 - 495,936 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936795	418,874 - 495,990 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCIN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	82,103,087 - 82,185,283 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	82,103,271 - 82,185,254 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	90,266,490 - 90,348,474 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCIN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	45,453,034 - 45,537,733 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	45,452,659 - 45,537,323 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	58,931,149 - 59,016,257 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Scin
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	17,304,486 - 17,384,050 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624739	17,303,805 - 17,384,105 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Scin
484 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	44
Count of miRNA genes:	42
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000005988
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	32074428	72227641	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	33309549	57730294	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
1354632	Scl29	Serum cholesterol level QTL 29	3.74		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	6	35098709	71636405	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	35691618	57730540	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
4889848	Pur25	Proteinuria QTL 25	14	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	56728562	90198260	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3				2					35	4	3
Low		10	22	7	17	7	2	2	11		31	8	2
Below cutoff		17	33	32		32	6	8	35		6		6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_198748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY324394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005988 ⟹ ENSRNOP00000005988

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	57,109,403 - 57,188,242 (-)	Ensembl
Rnor_6.0 Ensembl	6	59,976,003 - 60,054,279 (-)	Ensembl

RefSeq Acc Id:

NM_198748 ⟹ NP_942043

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	57,109,500 - 57,188,123 (-)	NCBI
Rnor_6.0	6	59,976,003 - 60,054,279 (-)	NCBI
Rnor_5.0	6	69,564,441 - 69,641,704 (-)	NCBI
RGSC_v3.4	6	59,237,930 - 59,357,001 (-)	RGD
Celera	6	56,160,567 - 56,251,246 (-)	RGD

Sequence:

show sequence

ATGGCGCAGGAGCTGCAGCACCCCGAGTTCGCGCGCGCAGGAAAACAGGCGGGGCTGCAAGTGT
GGAGGGTCGAGAAGCTGGAACTGGTACCGGTGCCCCAGGGTGCCTATGGTGACTTTTACGTCGG
AGACGCCTACCTGGTGTTGCACACCACCAAGTCGAGCAGGGGCTTCTCCTACCGCCTGCACTTC
TGGCTGGGAAAGGAGTGTTCCCAGGATGAGAGCACGGCAGCGGCCATCTTCACGGTCCAGATGG
ACGACTATTTGGGCGGCAAGCCGGTGCAGAGCAGAGAGCTTCAAGGCTATGAGTCGACTGATTT
TGTGGGCTATTTCAAAGGCGGTCTGAAGTACAAGGCCGGAGGTGTGGCTTCTGGACTAAACCAT
GTCCTCACCAATGACCTGACGGCGAAAAGGCTTCTGCATGTGAAGGGTCGGAGAGTGGTCAGGG
CCACAGAAGTTCCCCTCAGCTGGCAGAGCTTCAACAAGGGCGACTGCTTCATCATTGACCTTGG
CACCGAAATTTACCAGTGGTGTGGTTCCTCCTGCAACAAATATGAGCGTCTGAAAGCAAGTCAG
GTGGCCACTGGCATCCGGGACAATGAGAGGAAGGGAAGATCTCAACTCATTGTGGTGGAAGAAG
GAAGTGAACCACCAGAGCTCATGAAGGTTTTAGGGAGAAAGCCTGAACTTCCAGATGGGGACAA
TGATGATGATGTCATAGCAGACATAAGTAACAGGAAGATGGCGAAACTCTACATGGTTTCAGAT
GCCAGTGGGTCCATGAAAGTGACTCTGGTGGCTGAAGAAAACCCGTTCTCCATGGGCATGTTGC
TTCCTGAAGAATGCTTCATTTTGGACCATGGTGCTGCAAAACAAATCTTTGTGTGGAAAGGTAA
AAATGCTAACCCGCAGGAAAGGAAGACTGCCATGAAGACAGCTGAGGAGTTTCTACACAAAATG
AATTATTCTGCCAATACTCAAATTCAGGTACTTCCAGAAGGCGGCGAGACACCAATTTTCAAAC
AGTTCTTTAAGGATTGGAAGGATAAAGACCAGAGTGACGGCTTTGGGAAGGTGTACATCACAGA
GAAAGTGGCTCAAATAAAGCAGATTCCATTTGATGCATCAAAACTGCACAGTTCTCCGCAGATG
GCAGCCCAGCACAACATGGTGGATGATGGCTCTGGAGGGGTGGAGATCTGGCGTGTGGAGAACA
GTGGTAGGGTCCAGATTGACCCAAGCTCTTATGGTGAGTTCTATGGCGGTGACTGCTACATCAT
CCTCTACACTTATCCCAGAGGACAGATCATCTACACGTGGCAAGGGGCAGATGCTACCAGAGAC
GAGCTGACGATGTCTGCGTTTCTGACTGTTCAGTTGGATCGGTCTCTCGGAGGGCAGGCTGTGC
AGGTTCGTGTGTCTCAAGGCAAAGAGCCTGCTCACCTGCTGAGTTTGTTCAAAGACAAACCACT
CATTATTTATAAGAACGGGACATCTAAGAAAGGAGGGCAGGCACCGGCTCCCCCTACACGCCTC
TTTCAAGTCCGGAGGAACCTGGCATCTATCACTAGAATCGTGGAGGTTGATGTGGATACAAATT
CATTGAATTCTAATGACACTTTTGTCCTGAAACTGCCACGAAACAATGGCTTCATCTGGATAGG
AAAAGGGGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTGGCTGATGTCCTCAAATGCAAA
ACCACAAGAATTCAAGAAGGCAAGGAACCAGATGAATTCTGGAACTCTCTTGGAGGAAGAGGAG
ACTACCAGACTTCACCATTGCTGGAAACACAGGCTGAAGATCATCCTCCTCGGCTTTATGGCTG
CTCTAACAAAACTGGAAGATTCATTATTGAAGAAGTTCCGGGAGAGTTCACCCAGGATGACTTG
GCCGAAGATGATGTCATGCTACTTGATGCGTGGGAACAGATCTTCATTTGGATTGGCAAAGATG
CCAATGAAGTTGAGAAAAAGGAATCAGTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTC
TGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAAGGCCATGAGCCCCCCACATTCACA
GGCTGGTTTCTGGGCTGGGACTCCAGCAGGTGGTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_942043	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP85593	(Get FASTA)	NCBI Sequence Viewer
	EDM03335	(Get FASTA)	NCBI Sequence Viewer
	EDM03336	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_942043 ⟸ NM_198748

- UniProtKB:

E9PU64 (UniProtKB/TrEMBL), Q7TQ08 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQELQHPEFARAGKQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHTTKSSRGFSYRLHF
WLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNH
VLTNDLTAKRLLHVKGRRVVRATEVPLSWQSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQ
VATGIRDNERKGRSQLIVVEEGSEPPELMKVLGRKPELPDGDNDDDVIADISNRKMAKLYMVSD
ASGSMKVTLVAEENPFSMGMLLPEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLHKM
NYSANTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQM
AAQHNMVDDGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYIILYTYPRGQIIYTWQGADATRD
ELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRL
FQVRRNLASITRIVEVDVDTNSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGAEYVADVLKCK
TTRIQEGKEPDEFWNSLGGRGDYQTSPLLETQAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDL
AEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFT
GWFLGWDSSRW

hide sequence

RefSeq Acc Id:

ENSRNOP00000005988 ⟸ ENSRNOT00000005988

Protein Domains

Gelsolin-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PU64-F1-model_v2	AlphaFold	E9PU64	1-715	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735034	AgrOrtholog
BioCyc Gene	G2FUF-37745	BioCyc
Ensembl Genes	ENSRNOG00000004498	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005988	ENTREZGENE
	ENSRNOP00000005988.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005988	ENTREZGENE
	ENSRNOT00000005988.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.20.10	UniProtKB/TrEMBL
InterPro	ADF-H/Gelsolin-like_dom	UniProtKB/TrEMBL
	Gelsolin	UniProtKB/TrEMBL
	Gelsolin-like_dom_sf	UniProtKB/TrEMBL
	Gelsolin_dom	UniProtKB/TrEMBL
KEGG Report	rno:298975	UniProtKB/TrEMBL
NCBI Gene	298975	ENTREZGENE
PANTHER	Gelsolin	UniProtKB/TrEMBL
	PTHR11977:SF78	UniProtKB/TrEMBL
Pfam	Gelsolin	UniProtKB/TrEMBL
PhenoGen	Scin	PhenoGen
PRINTS	GELSOLIN	UniProtKB/TrEMBL
SMART	GEL	UniProtKB/TrEMBL
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/TrEMBL
	SSF82754	UniProtKB/TrEMBL
UniProt	A6HBD0_RAT	UniProtKB/TrEMBL
	A6HBD1_RAT	UniProtKB/TrEMBL
	E9PU64	ENTREZGENE, UniProtKB/TrEMBL
	Q7TQ08	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Scin	scinderin			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)