Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Scin | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Scin (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SCIN mRNA | CTD | PMID:22206623 | Scin | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SCIN mRNA | CTD | PMID:22206623 | Scin | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of SCIN mRNA | CTD | PMID:17557909 | Scin | Rat | 17beta-estradiol | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of SCIN mRNA | CTD | PMID:20660070 | Scin | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of SCIN mRNA | CTD | PMID:26496021 | Scin | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SCIN protein] | CTD | PMID:11883943 | Scin | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SCIN mRNA | CTD | PMID:33387578 | Scin | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SCIN mRNA | CTD | PMID:34747641 | Scin | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Scin (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SCIN mRNA and Tetrachlorodibenzodioxin results in increased expression of SCIN protein | CTD | PMID:11883943 more ... | Scin | Rat | 2,4,6-tribromophenol | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Scin | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of SCIN protein | CTD | PMID:31675489 | Scin | Rat | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of SCIN mRNA | CTD | PMID:28522335 | Scin | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SCIN mRNA | CTD | PMID:31881176 | Scin | Rat | aflatoxin B1 | decreases methylation | ISO | SCIN (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SCIN gene | CTD | PMID:27153756 | Scin | Rat | aldrin | increases expression | ISO | Scin (Mus musculus) | 6480464 | Aldrin results in increased expression of SCIN mRNA | CTD | PMID:18579281 | Scin | Rat | all-trans-retinoic acid | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of SCIN mRNA | CTD | PMID:36189433 | Scin | Rat | alpha-amanitin | affects expression | ISO | Scin (Mus musculus) | 6480464 | Alpha-Amanitin affects the expression of SCIN mRNA | CTD | PMID:38531469 | Scin | Rat | aristolochic acid A | multiple interactions | EXP | | 6480464 | [aristolochic acid I co-treated with aristolochic acid II] results in increased expression of SCIN mRNA | CTD | PMID:23912714 | Scin | Rat | aristolochic acid A | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SCIN mRNA | CTD | PMID:33212167 | Scin | Rat | arsenous acid | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SCIN protein] | CTD | PMID:26598702 | Scin | Rat | benzo[a]pyrene | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SCIN mRNA] | CTD | PMID:22228805 | Scin | Rat | benzo[a]pyrene | increases methylation | ISO | SCIN (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SCIN 5' UTR more ... | CTD | PMID:27901495 | Scin | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Scin (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SCIN mRNA | CTD | PMID:28085963 | Scin | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SCIN protein | CTD | PMID:31163220 | Scin | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of SCIN mRNA | CTD | PMID:26496021 | Scin | Rat | bisphenol A | decreases methylation | ISO | SCIN (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SCIN gene | CTD | PMID:31601247 | Scin | Rat | bisphenol A | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SCIN protein | CTD | PMID:31675489 | Scin | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SCIN mRNA | CTD | PMID:25181051 | Scin | Rat | butanal | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of SCIN mRNA | CTD | PMID:26079696 | Scin | Rat | cadmium dichloride | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SCIN mRNA | CTD | PMID:38382870 | Scin | Rat | cannabidiol | affects methylation | EXP | | 6480464 | Cannabidiol affects the methylation of SCIN gene | CTD | PMID:30521419 | Scin | Rat | carbon nanotube | increases expression | ISO | Scin (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:27106021 | Scin | Rat | CGP 52608 | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SCIN gene] | CTD | PMID:28238834 | Scin | Rat | chlordecone | increases expression | ISO | Scin (Mus musculus) | 6480464 | Chlordecone results in increased expression of SCIN mRNA | CTD | PMID:33711761 | Scin | Rat | copper atom | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SCIN mRNA | CTD | PMID:20971185 | Scin | Rat | copper(0) | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SCIN mRNA | CTD | PMID:20971185 | Scin | Rat | decabromodiphenyl ether | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of SCIN protein | CTD | PMID:31675489 | Scin | Rat | dextran sulfate | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SCIN mRNA | CTD | PMID:29950665 | Scin | Rat | diarsenic trioxide | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SCIN protein] | CTD | PMID:26598702 | Scin | Rat | dibutyl phthalate | increases expression | ISO | Scin (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of SCIN mRNA | CTD | PMID:17361019 | Scin | Rat | dorsomorphin | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Scin | Rat | doxorubicin | decreases expression | ISO | Scin (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of SCIN mRNA | CTD | PMID:25896364 | Scin | Rat | ethanol | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | Ethanol results in increased expression of SCIN mRNA | CTD | PMID:31059573 | Scin | Rat | ethyl methanesulfonate | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of SCIN mRNA | CTD | PMID:23649840 | Scin | Rat | folic acid | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SCIN mRNA | CTD | PMID:22206623 | Scin | Rat | genistein | increases expression | ISO | Scin (Mus musculus) | 6480464 | Genistein results in increased expression of SCIN mRNA | CTD | PMID:32186404 | Scin | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SCIN mRNA | CTD | PMID:33387578 | Scin | Rat | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of SCIN mRNA | CTD | PMID:24915197 | Scin | Rat | irinotecan | affects expression | EXP | | 6480464 | Irinotecan affects the expression of SCIN mRNA | CTD | PMID:20097248 | Scin | Rat | ivermectin | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SCIN protein | CTD | PMID:32959892 | Scin | Rat | lipopolysaccharide | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of SCIN mRNA | CTD | PMID:35811015 | Scin | Rat | mercury dibromide | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of SCIN mRNA | CTD | PMID:26272509 | Scin | Rat | mercury dibromide | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCIN mRNA | CTD | PMID:27188386 | Scin | Rat | methyl methanesulfonate | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SCIN mRNA | CTD | PMID:23649840 | Scin | Rat | methylisothiazolinone | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of SCIN mRNA | CTD | PMID:31629900 | Scin | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of SCIN mRNA | CTD | PMID:36189433 | Scin | Rat | nickel atom | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | Nickel results in decreased expression of SCIN mRNA | CTD | PMID:25583101 | Scin | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SCIN mRNA | CTD | PMID:33387578 | Scin | Rat | phenylmercury acetate | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of SCIN mRNA | CTD | PMID:26272509 | Scin | Rat | phenylmercury acetate | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCIN mRNA | CTD | PMID:27188386 | Scin | Rat | pirinixic acid | increases expression | ISO | Scin (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SCIN mRNA | CTD | PMID:20813756 | Scin | Rat | potassium dichromate | increases expression | ISO | Scin (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of SCIN mRNA | CTD | PMID:23608068 | Scin | Rat | progesterone | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of SCIN mRNA | CTD | PMID:20660070 | Scin | Rat | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of SCIN mRNA | CTD | PMID:33725128 | Scin | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of SCIN mRNA | CTD | PMID:35811015 | Scin | Rat | SB 431542 | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Scin | Rat | silicon dioxide | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SCIN mRNA | CTD | PMID:25895662 | Scin | Rat | sodium arsenite | decreases expression | ISO | SCIN (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SCIN mRNA | CTD | PMID:34032870 | Scin | Rat | succimer | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of SCIN mRNA | CTD | PMID:21641980 | Scin | Rat | sulforaphane | increases expression | ISO | Scin (Mus musculus) | 6480464 | sulforaphane results in increased expression of SCIN mRNA | CTD | PMID:30529165 | Scin | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SCIN mRNA | CTD | PMID:31150632 | Scin | Rat | titanium dioxide | decreases expression | ISO | Scin (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of SCIN mRNA | CTD | PMID:23557971 | Scin | Rat | titanium dioxide | increases methylation | ISO | Scin (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of SCIN gene | CTD | PMID:35295148 | Scin | Rat | titanium dioxide | increases expression | ISO | Scin (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SCIN mRNA | CTD | PMID:35295148 | Scin | Rat | titanium dioxide | multiple interactions | ISO | Scin (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SCIN mRNA | CTD | PMID:29950665 | Scin | Rat | trichostatin A | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | trichostatin A results in increased expression of SCIN mRNA | CTD | PMID:24935251 | Scin | Rat | trichostatin A | affects expression | ISO | SCIN (Homo sapiens) | 6480464 | trichostatin A affects the expression of SCIN mRNA | CTD | PMID:28542535 | Scin | Rat | trimellitic anhydride | increases expression | ISO | Scin (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of SCIN mRNA | CTD | PMID:19042947 | Scin | Rat | triptonide | increases expression | ISO | Scin (Mus musculus) | 6480464 | triptonide results in increased expression of SCIN mRNA | CTD | PMID:33045310 | Scin | Rat | trovafloxacin | increases expression | ISO | Scin (Mus musculus) | 6480464 | trovafloxacin results in increased expression of SCIN mRNA | CTD | PMID:35537566 | Scin | Rat | tungsten | increases expression | ISO | Scin (Mus musculus) | 6480464 | Tungsten results in increased expression of SCIN mRNA | CTD | PMID:30912803 | Scin | Rat | valproic acid | decreases methylation | ISO | SCIN (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SCIN gene | CTD | PMID:29154799 | Scin | Rat | valproic acid | multiple interactions | ISO | SCIN (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCIN mRNA | CTD | PMID:27188386 | Scin | Rat | valproic acid | increases expression | ISO | SCIN (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SCIN mRNA | CTD | PMID:23179753 more ... | Scin | Rat | valproic acid | affects expression | ISO | SCIN (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SCIN mRNA | CTD | PMID:25979313 | Scin | Rat | vancomycin | decreases expression | ISO | Scin (Mus musculus) | 6480464 | Vancomycin results in decreased expression of SCIN mRNA | CTD | PMID:18930951 | Scin | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of SCIN mRNA | CTD | PMID:23034163 | |