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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:alcohol use disorder
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Accession:DOID:1574 term browser browse the term
Definition:A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. (DO)
Synonyms:exact_synonym: alcohol abuse;   chronic alcoholic intoxication;   ethanol abuse
 related_synonym: Beta-glycopyranoside tasting
 primary_id: MESH:D000437
 xref: ICD10CM:F10.1;   ICD9CM:305.0;   NCI:C20701
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
alcohol use disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acads acyl-Coenzyme A dehydrogenase, short chain susceptibility ISO DNA:SNP:: (rs1799958) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16404797 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide ISO RGD PMID:8462548 RGD:5129091 NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16404797 PMID:17590986 PMID:10780266 RGD:734551 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 severity ISO DNA:polymorphism: :rs1800497(human)
DNA:SNP,haplotype: :rs11604671, rs4938015 (human)		 RGD PMID:32889058 PMID:21936764 RGD:401940151, RGD:401959296 NCBI chr 9:49,326,494...49,338,341
Ensembl chr 9:49,326,494...49,338,321 		JBrowse link
G Arc activity regulated cytoskeletal-associated protein IDA associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO
IEP		 protein:decreased expression:plasma
protein:decreased expression:plasma (human)
mRNA,protein:decreased expression:hippocampus, plasma (rat)
mRNA:decreased expression:hippocampus
protein:altered expression:brain
protein:decreased expression:cerebellum, hippocampus		 RGD PMID:32135570 PMID:30277635 PMID:30277635 PMID:32497709 PMID:15307153 More... RGD:35673317, RGD:401938665, RGD:401938665, RGD:401950485, RGD:401965482, RGD:401976492 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Calb1 calbindin 1 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 IEP mRNA:increased expression:prefrontal cortex RGD PMID:28714806 RGD:18337277 NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV ISO protein:decreased expression:brain, cingulate gyrus RGD PMID:11181917 RGD:401959326 NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281 		JBrowse link
G Cast calpastatin ISO protein:increased expression:gastrocnemius (rat) RGD PMID:28800153 RGD:405100967 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Cat catalase treatment ISO associated with diabetes;protein:decreased activity:liver, kidney (rat)
associated with cognitive disorder; protein:altered activity:hippocampus (rat)
associated with cardiomyopathy
associated with diabetes; protein:decreased activity;testis, epididymis (rat)		 RGD PMID:22596042 PMID:21713042 PMID:27367870 PMID:7195942 PMID:25541261 RGD:405255659, RGD:405255660, RGD:405255662, RGD:405255663, RGD:405255664 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cckar cholecystokinin A receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9922984 NCBI chr 5:53,855,827...53,865,046
Ensembl chr 5:53,855,118...53,865,047 		JBrowse link
G Cdk20 cyclin dependent kinase 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr13:64,580,133...64,587,536
Ensembl chr13:64,580,128...64,589,587 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846 		JBrowse link
G Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 9:54,888,112...54,918,704
Ensembl chr 9:54,888,164...54,915,063 		JBrowse link
G Clock clock circadian regulator susceptibility ISO DNA:SNP:: (rs2412648) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Cnr1 cannabinoid receptor 1 sexual_dimorphism ISO associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Comt catechol-O-methyltransferase disease_progression ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism::
DNA:polymorphism: :rs4680(human)		 CTD
RGD		 PMID:10395222 PMID:10395222 PMID:32889058 RGD:401940114, RGD:401940151 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 sexual_dimorphism ISO mRNA, protein:decreased expression:amygdala
protein:altered expression, altered phosphorylation:liver, nucleus
protein:increased phosphorylation:liver		 RGD PMID:29991681 PMID:22269225 PMID:31262967 RGD:401938626, RGD:401959317, RGD:401959334 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crebbp CREB binding protein ISO mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Crh corticotropin releasing hormone ISO mRNA:increased expression:central amygdaloid nucleus (rat) RGD PMID:20060104 RGD:5508173 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:11988580 RGD:734822 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IMP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma, extracellular exosome		 CTD
RGD		 PMID:20843640 PMID:29404485 PMID:29404485 PMID:23819932 RGD:14700911, RGD:14700911, RGD:14700915 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dbh dopamine beta hydroxylase no_association ISO DNA:polymorphism:cds:g.444G>A (human)
DNA:polymorphism:5' utr:g.-1021C>T (human)		 RGD PMID:16252068 PMID:16133787 RGD:1625571, RGD:1625572 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212 		JBrowse link
G Dcx doublecortin ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr  X:142,638,838...142,716,392
Ensembl chr  X:142,638,838...142,716,307 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 IEP associated with Prenatal Exposure Delayed Effects and anxiety disorder:mRNA,protein:decreased expression:brain (mouse) RGD PMID:30016666 RGD:401959614 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Drd2 dopamine receptor D2 IEA GAD PMID:15118671 RGD:1331525 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd4 dopamine receptor D4 treatment
susceptibility		 ISO DNA:repeats:exon:
associated with peer pressure;DNA:repeats:exon:		 RGD PMID:25640830 PMID:26307243 RGD:11064848, RGD:401959598 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Ep300 E1A binding protein p300 ISO mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 ISO RGD PMID:23095216 RGD:10045658 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 ISO mRNA:increased expression:cerebellum RGD PMID:34453331 RGD:401938639 NCBI chr  X:67,722,144...67,761,569
Ensembl chr  X:67,722,147...67,761,569 		JBrowse link
G Fos FBJ osteosarcoma oncogene treatment ISO
IEP		 protein:increased expression:brain
protein:increased expression:parvocellular oculomotor nucleus 		RGD PMID:14741756 PMID:11164784 PMID:29210146 RGD:405255650, RGD:405255652, RGD:405295495 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosb FBJ osteosarcoma oncogene B treatment ISO
IEP		 protein:increased expression:brain (mouse)
protein:increased expression:dorsal striatum (mouse)		 RGD PMID:22792289 PMID:9835277 PMID:27380261 RGD:401851082, RGD:401901184, RGD:401901287 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976 		JBrowse link
G Fshb follicle stimulating hormone beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr17:37,356,888...37,385,197
Ensembl chr17:37,356,858...37,385,959 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 susceptibility ISO DNA:SNP:intron: (rs2900512) (human) RGD PMID:28118741 RGD:401940105 NCBI chr 4:46,662,318...46,991,714
Ensembl chr 4:46,662,305...46,991,873 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 susceptibility ISO DNA:SNPs:multiple:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22253714 PMID:15024690 RGD:6480257 NCBI chr 5:71,115,735...71,253,192
Ensembl chr 5:71,114,940...71,253,192 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor, subunit gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684 		JBrowse link
G Gata4 GATA binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20585342 NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO protein:increased expression:serum
DNA:hypomethylation:nucleus accumbens		 RGD PMID:25623403 PMID:31710958 RGD:401965480, RGD:405820205 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12747453 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Ghsr growth hormone secretagogue receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23977009 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159 		JBrowse link
G Gphn gephyrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr12:78,264,099...78,731,546
Ensembl chr12:78,273,153...78,731,546 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) IEP
ISO		 protein:increased phosphorylation:lumbar spinal cord (mouse)
protein:increased expression:nucleus accumbens (rat)
protein:increased expression:nucleus accumbens (mouse)
protein:increased expression, increased phosphorylation:cingulate cortex (rat)
protein:decreased expression:neocortex (rat)		 RGD PMID:28585190 PMID:21041654 PMID:21041654 PMID:34280506 PMID:12036520 RGD:405100727, RGD:405650686, RGD:405650686, RGD:405818275, RGD:405820203 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO RGD PMID:14573320 RGD:1642372 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) ISO RGD PMID:14573320 PMID:16911840 RGD:1642372, RGD:1642200 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Hdac2 histone deacetylase 2 ISO RGD PMID:23485013 RGD:9590265 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A treatment ISO RGD PMID:9631953 RGD:401900760 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B sexual_dimorphism
no_association
onset		 ISO associated with attention deficit hyperactivity disorder;DNA:SNP: :rs11568817(human)
DNA:SNPs: :multiples (human)
DNA:SNP: :rs13212041 (human)		 RGD PMID:28923721 PMID:11496363 PMID:30774345 RGD:405650695, RGD:405818272, RGD:405847403 NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A treatment ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:cerebral cortex, liver
protein:increased expression:dorsal raphe, nucleus accumbens		 CTD
RGD		 PMID:20501057 PMID:9347075 PMID:9347073 PMID:9631953 RGD:401900301, RGD:401900740, RGD:401900742, RGD:401900760 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C treatment ISO RGD PMID:24041931 RGD:401900761 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A HDA DNA:hypermethylation, hypomethylation:promoter: (mouse) RGD PMID:22834954 RGD:404976877 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399 		JBrowse link
G Htr3b 5-hydroxytryptamine (serotonin) receptor 3B susceptibility ISO DNA:SNP:cds:rs1176744(human) RGD PMID:20838391 RGD:6480660 NCBI chr 9:48,846,308...48,876,290
Ensembl chr 9:48,846,308...48,876,290 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 ISO DNA:SNP:intron: (rs7916403) (human) RGD PMID:21184583 RGD:150429835 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO protein:decreased expression:plasma (human) RGD PMID:30277635 RGD:401938665 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Il10 interleukin 10 ISO mRNA:increased expression:liver RGD PMID:22269225 RGD:401959317 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO DNA:SNP:promoter:rs2836016 (human) RGD PMID:21307845 RGD:6483053 NCBI chr16:94,545,839...94,798,719
Ensembl chr16:94,549,495...94,798,560 		JBrowse link
G Lhb luteinizing hormone beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Maoa monoamine oxidase A susceptibility ISO RGD PMID:15900229 RGD:1600720 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 IDA protein:increased expression, increased phosphorylation:liver RGD PMID:31262967 RGD:401959334 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO RGD PMID:31262967 RGD:401959334 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 ISO RGD PMID:23095216 RGD:10045658 NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067 		JBrowse link
G Mir191 microRNA 191 onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 9:108,445,518...108,445,591
Ensembl chr 9:108,445,518...108,445,591 		JBrowse link
G Mir195a microRNA 195a onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr11:70,125,868...70,125,961
Ensembl chr11:70,125,868...70,125,961 		JBrowse link
G Mir206 microRNA 206 onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306 		JBrowse link
G Mir30a microRNA 30a onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 1:23,311,350...23,311,420
Ensembl chr 1:23,311,350...23,311,420 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:24966898 RGD:13207311 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:24966898 RGD:13207311 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 treatment
sexual_dimorphism 		ISO mRNA:decreased expression:hippocampus (rat)
associated with chronic stress in female rats		 RGD PMID:30277635 PMID:16207289 PMID:27894930 RGD:401938665, RGD:401959613, RGD:401959751 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225 		JBrowse link
G Ngf nerve growth factor ISO
IEP		 protein:increased expression:serum
protein:decreased expression:brain
protein:decreased expression:cerebral cortex, hippocampus		 RGD PMID:25623403 PMID:15307153 PMID:19100286 RGD:401965480, RGD:401965482, RGD:401976492 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Npy neuropeptide Y ISO DNA:deletion:intron:g.4666_4674del (rat)
DNA:missense mutation: :p.L7P (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17572454 PMID:15749341 PMID:12215082 RGD:1357412, RGD:10430830 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 3:82,445,688...82,455,404
Ensembl chr 3:82,445,690...82,455,391 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 treatment
sexual_dimorphism 		ISO RGD PMID:29437012 PMID:33007359 PMID:30171933 RGD:401965466, RGD:401966865, RGD:401976281 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Nrg1 neuregulin 1 sexual_dimorphism ISO in female, associated with stressful life event;DNA:SNP: :rs6994992(human) RGD PMID:27353026 RGD:405100235 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Ntf3 neurotrophin 3 ISO protein:decreased expression:plasma (human)
mRNA,protein:decreased expression:hippocampus, plasma (rat)
protein:increased expression:brain		 RGD PMID:30277635 PMID:30277635 PMID:15307153 RGD:401938665, RGD:401938665, RGD:401965482 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 IDA
ISO		 associated with Prenatal Exposure Delayed Effects and anxiety disorder:protein:decreased acetylation:brain RGD PMID:30016666 PMID:8840027 RGD:401959614, RGD:401965407 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Oprd1 opioid receptor, delta 1 ISO associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNPs, haplotype:intron 1:multiple (human)		 RGD PMID:28511993 PMID:7501658 PMID:24533225 RGD:401976432, RGD:401976439, RGD:402525443 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797 		JBrowse link
G Oprk1 opioid receptor, kappa 1 severity
no_association
susceptibility		 ISO DNA:SNP, haplotype: :rs6473797 (human)
DNA:SNP: :rs997917 (human)
DNA:SNP: :rs6473797 (human)
associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)		 RGD PMID:31004399 PMID:37177778 PMID:37177778 PMID:28511993 RGD:401831037, RGD:401850581, RGD:401850581, RGD:401976432 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Oprl1 opioid receptor-like 1 ISO RGD PMID:11814626 RGD:9835016 NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778 		JBrowse link
G Oprm1 opioid receptor, mu 1 no_association
treatment		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs510769
DNA:missense mutations, SNP:exon, intron:p.A6V, p.S147C, p.N40D (118A>G) (rs 1799971), IVS2+691G>C (human)
DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)		 CTD
RGD		 PMID:12815747 PMID:26042510 PMID:9399694 PMID:32772383 RGD:401827930, RGD:401827934, RGD:401827947 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pdyn prodynorphin susceptibility
no_association		 ISO CTD Direct Evidence: marker/mechanism
associated with cocaine dependence;DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human)
DNA, mRNA:SNP, decreased expression:promoter, dorsolateral prefrontal cortex:rs1997794 (human)
DNA:SNP: :rs2281285 (human)
DNA:SNPs: :rs2281285, rs2225749, rs910080 (human)
mRNA, protein:decreased expression:hippocampus, granule cell		 CTD
RGD		 PMID:17559549 PMID:18923396 PMID:18923396 PMID:29925858 PMID:36099111 More... RGD:401850550, RGD:401850559, RGD:401850566, RGD:401850581, RGD:401851059 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Penk preproenkephalin ISO mRNA:increased expression:frontal lobe: RGD PMID:22703995 RGD:10003152 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO protein:decreased expression:brain (rat) RGD PMID:18162070 RGD:401976284 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Rpl18a ribosomal protein L18A ISO mRNA:decreased expression:parietal cortex RGD PMID:11244494 RGD:11038708 NCBI chr 8:71,347,366...71,350,087
Ensembl chr 8:71,347,366...71,350,056 		JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 susceptibility ISO protein:decreased activity: :
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15520362 PMID:17000009 PMID:20838391 RGD:6480660 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Snca synuclein, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18055133 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod1 superoxide dismutase 1, soluble ISO associated with diabetes; protein:decreased activity;testis, epididymis (rat) RGD PMID:25541261 RGD:405255664 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Spi1 Spi-1 proto-oncogene treatment ISO protein:decreased expression:alveolar macrophage RGD PMID:16272341 PMID:21447000 RGD:9586723, RGD:9586725 NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101 		JBrowse link
G Spn sialophorin IDA associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995 		JBrowse link
G St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 severity ISO mRNA,protein:decreased expression:liver: RGD PMID:17697868 RGD:10043133 NCBI chr16:23,043,478...23,179,100
Ensembl chr16:23,043,490...23,179,100 		JBrowse link
G Syp synaptophysin sexual_dimorphism ISO associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19204064 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
G Tacr3 tachykinin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18422838 NCBI chr 3:134,534,768...134,640,342
Ensembl chr 3:134,534,768...134,640,340 		JBrowse link
G Tas2r118 taste receptor, type 2, member 118 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16385453 PMID:17250611 NCBI chr 6:23,969,160...23,970,059
Ensembl chr 6:23,969,160...23,970,059 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17250611 NCBI chr 6:40,589,249...40,590,244
Ensembl chr 6:40,589,249...40,590,244 		JBrowse link
G Tbx19 T-box 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 1:164,965,403...164,988,342
Ensembl chr 1:164,965,424...164,988,342 		JBrowse link
G Timeless timeless circadian clock 1 susceptibility ISO DNA:SNP:: (rs2291738) (human) RGD PMID:20554694 RGD:401976551 NCBI chr10:128,067,932...128,088,810
Ensembl chr10:128,067,934...128,088,810 		JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15654285 RGD:1580464 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961 		JBrowse link
G Trf transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11000917 PMID:21792595 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Vip vasoactive intestinal polypeptide susceptibility ISO DNA:SNPs, haplotype:: (rs3823082,rs688136) (human) RGD PMID:20554694 RGD:401976551 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16109
    Chemically-Induced Disorders 1330
      substance-related disorder 634
        substance abuse 192
          alcohol use disorder 108
Path 2
Term Annotations click to browse term
  disease 16109
    disease of anatomical entity 15665
      nervous system disease 13531
        central nervous system disease 12117
          brain disease 11377
            disease of mental health 8213
              substance-related disorder 634
                Alcohol-Related Disorders 331
                  alcohol use disorder 108
paths to the root