RGD Reference Report - The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.

General

The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.
Authors:	Cleveland, HH Schlomer, GL Vandenbergh, DJ Feinberg, M Greenberg, M Spoth, R Redmond, C Shriver, MD Zaidi, AA Hair, KL
Citation:	Cleveland HH, etal., Dev Psychopathol. 2015 Feb;27(1):51-67. doi: 10.1017/S0954579414001291.
RGD ID:	11064848
Pubmed:	PMID:25640830 (View Abstract at PubMed)
PMCID:	PMC4450765 (View Article at PubMed Central)
DOI:	DOI:10.1017/S0954579414001291 (Journal Full-text)
Data drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4). Variation in this gene and maternal involvement were hypothesized to moderate the influence of intervention status on alcohol use. The PROSPER data used were drawn from 28 communities randomly assigned to intervention or comparison conditions. Participating youth were assessed in five in-home interviews from sixth to ninth grades. A main effect of sixth-grade pretest maternal involvement on ninth-grade alcohol use was found. Neither intervention status nor DRD4 variation was unconditionally linked to ninth-grade drinking. However, moderation analyses revealed a significant three-way interaction among DRD4 status, maternal involvement, and intervention condition. Follow-up analyses revealed that prevention reduced drinking risk, but only for youth with at least one DRD4 seven-repeat allele who reported average or greater pretest levels of maternal involvement. To determine if this conditional pattern was limited to the DRD4 gene, we repeated analyses using the serotonin transporter linked polymorphic region site near the serotonin transporter gene. The results for this supplemental analysis revealed a significant three-way interaction similar but not identical to that found for DRD4.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
DRD4	Human	alcohol use disorder	treatment	IAGP		DNA:repeats:exon:	RGD
Drd4	Rat	alcohol use disorder	treatment	ISO	DRD4 (Homo sapiens)	DNA:repeats:exon:	RGD
Drd4	Mouse	alcohol use disorder	treatment	ISO	DRD4 (Homo sapiens)	DNA:repeats:exon:	RGD

Objects Annotated

Genes (Rattus norvegicus)

Drd4 (dopamine receptor D4)

Genes (Mus musculus)

Drd4 (dopamine receptor D4)

Genes (Homo sapiens)

DRD4 (dopamine receptor D4)

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The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.