Fmr1 (fragile X messenger ribonucleoprotein 1) - Rat Genome Database

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Gene: Fmr1 (fragile X messenger ribonucleoprotein 1) Mus musculus
Analyze
Symbol: Fmr1
Name: fragile X messenger ribonucleoprotein 1
RGD ID: 735920
MGI Page MGI
Description: Enables several functions, including N6-methyladenosine-containing RNA reader activity; RNA binding activity; and dynein complex binding activity. Involved in several processes, including chemical synaptic transmission; negative regulation of long-term synaptic depression; and post-transcriptional regulation of gene expression. Acts upstream of or within with a positive effect on miRNA-mediated post-transcriptional gene silencing. Acts upstream of or within central nervous system development and dendritic spine development. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; filopodium; and perikaryon. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Used to study autism spectrum disorder; fragile X syndrome; and fragile X-associated tremor/ataxia syndrome. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (fragile X messenger ribonucleoprotein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FM; Fmr-; Fmr-1; FMRP; FMRP translational regulator 1; fragile X mental retardation 1; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; mFmr1p; synaptic functional regulator FMR1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X67,722,144 - 67,761,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX67,722,147 - 67,761,569 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X68,678,536 - 68,717,963 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)Ensemblmm10GRCm38
MGSCv37X65,931,730 - 65,971,138 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X51,835,932 - 51,875,340 (+)NCBIMGSCv36mm8
MGSCv36X64,939,220 - 64,978,628 (+)NCBIMGSCv36mm8
Cytogenetic MapXA7.1NCBI
cM MapX34.83NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2-arachidonoylglycerol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
acamprosate  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminomalonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chlorpyrifos  (ISO)
chrysene  (EXP)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucitol  (ISO)
D-threitol  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
ebselen  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
furan  (ISO)
GSK-J4  (ISO)
hydroxyl  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
linuron  (ISO)
menadione  (EXP)
methidathion  (EXP)
methoxychlor  (EXP)
minocycline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel sulfate  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (ISO)
poly(I:C)  (EXP)
potassium chloride  (ISO)
potassium chromate  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rimonabant  (EXP)
senecionine  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
superoxide  (ISO)
suramin  (EXP)
tamoxifen  (EXP)
tetrahydropalmatine  (ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
threitol  (ISO)
threonic acid  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
urethane  (ISO)
vigabatrin  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IBA)
cellular response to L-glutamate  (ISO)
cellular response to potassium ion  (ISO)
cellular response to virus  (ISO)
central nervous system development  (IMP)
chromatin organization  (IEA)
deadenylation-dependent decapping of nuclear-transcribed mRNA  (ISO)
dendritic spine development  (IGI)
detection of mechanical stimulus involved in sensory perception  (ISO)
DNA damage response  (IEA)
DNA repair  (IDA,IEA,ISO)
evoked excitatory postsynaptic potential  (ISO)
excitatory chemical synaptic transmission  (IMP)
glutamate receptor signaling pathway  (IDA,IEA,IMP,ISO,ISS)
host-mediated perturbation of viral RNA genome replication  (ISO)
inhibitory chemical synaptic transmission  (IMP)
intracellular glutamate homeostasis  (ISO)
locomotory exploration behavior  (ISO)
membraneless organelle assembly  (ISO,ISS)
miRNA-mediated post-transcriptional gene silencing  (IDA)
mRNA export from nucleus  (IDA,IEA,ISO)
mRNA processing  (IEA)
mRNA transport  (IBA,IDA,IEA)
negative regulation of cytoplasmic translation  (IDA)
negative regulation of gene expression  (IMP,ISO)
negative regulation of long-term synaptic depression  (IMP)
negative regulation of miRNA-mediated gene silencing  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of protein processing  (ISO)
negative regulation of receptor internalization  (ISO)
negative regulation of synaptic vesicle exocytosis  (ISO,ISS)
negative regulation of translation  (IDA,IMP,ISO)
negative regulation of translational initiation  (IDA,ISO)
negative regulation of voltage-gated calcium channel activity  (ISO,ISS)
nervous system development  (IEA)
ovarian follicle development  (ISO)
positive regulation of cellular component organization  (IEA)
positive regulation of dendritic spine development  (IDA)
positive regulation of filopodium assembly  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of intracellular transport of viral material  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (IBA,ISO)
positive regulation of long-term synaptic depression  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of miRNA-mediated gene silencing  (ISO,ISS)
positive regulation of proteasomal protein catabolic process  (IDA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor internalization  (ISO,ISS)
positive regulation of synaptic transmission  (IEA,ISO)
positive regulation of translation  (IBA,IEA,IMP,ISO,ISS)
regulation of alternative mRNA splicing, via spliceosome  (IDA,IEA,ISO)
regulation of dendritic spine development  (IEA,IMP,ISO)
regulation of filopodium assembly  (IEA,IMP,ISO)
regulation of long-term synaptic depression  (IEA)
regulation of mRNA stability  (IBA,IMP)
regulation of neuronal action potential  (ISO,ISS)
regulation of neurotransmitter secretion  (ISO,ISS)
regulation of proteolysis  (IEA)
regulation of translation  (IEA)
regulation of translation at postsynapse, modulating synaptic transmission  (IDA,IMP)
regulation of translation at presynapse, modulating synaptic transmission  (IBA,ISO)
regulation of translation at synapse, modulating synaptic transmission  (IEA)
regulatory ncRNA-mediated gene silencing  (IEA)
response to activity  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to gonadotropin  (ISO)
response to interleukin-1  (ISO)
response to interleukin-17  (IMP)
response to light stimulus  (ISO)
RNA splicing  (IEA)
social behavior  (IMP)
stress granule assembly  (ISO,ISS)
transmission of nerve impulse  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anxiety-related response  (IAGP)
abnormal associative learning  (IAGP)
abnormal behavior  (IAGP)
abnormal brain morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal circadian behavior  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal cumulus oophorus morphology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal excitatory synapse morphology  (IAGP)
abnormal eye blink conditioning behavior  (IAGP)
abnormal female germ cell morphology  (IAGP)
abnormal female meiosis  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal hippocampal mossy fiber morphology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal long-term depression  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal nerve fiber response  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal ovarian follicle number  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal postsynaptic density morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal response to novelty  (IAGP)
abnormal response to social novelty  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina rod cell outer segment morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal startle reflex  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal tertiary ovarian follicle morphology  (IAGP)
abnormal vocalization  (IAGP)
audiogenic seizures  (IAGP)
convulsive seizures  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased aggression towards mice  (IAGP)
decreased anxiety-related response  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased corpora lutea number  (IAGP)
decreased grip strength  (IAGP)
decreased locomotor activity  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased social investigation  (IAGP)
decreased startle reflex  (IAGP)
decreased vocalization  (IAGP)
enhanced long-term potentiation  (IAGP)
enlarged testis  (IAGP)
hyperactivity  (IAGP)
hypodipsia  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired coordination  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired passive avoidance behavior  (IAGP)
impaired synaptic plasticity  (IAGP)
increased aggression towards mice  (IAGP)
increased anxiety-related response  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased body weight  (IAGP)
increased dendritic spine density  (IAGP)
increased exploration in new environment  (IAGP)
increased grooming behavior  (IAGP)
increased locomotor activity  (IAGP)
increased miniature excitatory postsynaptic current amplitude  (IAGP)
increased prepulse inhibition  (IAGP)
increased startle reflex  (IAGP)
increased stereotypic behavior  (IAGP)
increased testis weight  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased vertical activity  (IAGP)
neuronal intranuclear inclusions  (IAGP)
ovary atrophy  (IAGP)
ovary cyst  (IAGP)
reduced long-term potentiation  (IAGP)
small ovary  (IAGP)
social withdrawal  (IAGP)
tonic-clonic seizures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome. Asiminas A, etal., Mol Autism. 2022 Dec 20;13(1):49. doi: 10.1186/s13229-022-00528-z.
2. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Bernard PB, etal., Neurobiol Dis. 2013 Nov;59:1-17. doi: 10.1016/j.nbd.2013.06.013. Epub 2013 Jul 2.
3. Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome. Berzhanskaya J, etal., Sci Rep. 2016 Jul 28;6:30769. doi: 10.1038/srep30769.
4. Long-term abstinence from developmental cocaine exposure alters Arc/Arg3.1 modulation in the rat medial prefrontal cortex. Caffino L, etal., Neurotox Res. 2014 Oct;26(3):299-306. doi: 10.1007/s12640-014-9472-1. Epub 2014 May 9.
5. Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up-regulation of Fmr1 gene expression in rat cerebellum. Dulman RS, etal., Alcohol Clin Exp Res. 2021 Oct;45(10):2006-2016. doi: 10.1111/acer.14691. Epub 2021 Aug 28.
6. Degraded speech sound processing in a rat model of fragile X syndrome. Engineer CT, etal., Brain Res. 2014 May 20;1564:72-84. doi: 10.1016/j.brainres.2014.03.049. Epub 2014 Apr 5.
7. Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats. Golden CEM, etal., Cereb Cortex. 2019 May 1;29(5):2228-2244. doi: 10.1093/cercor/bhz029.
8. Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders. Hamilton SM, etal., Behav Neurosci. 2014 Apr;128(2):103-9. doi: 10.1037/a0035988.
9. Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. Hoffman GE, etal., J Histochem Cytochem. 2012 Jun;60(6):439-56. doi: 10.1369/0022155412441002. Epub 2012 Apr 2.
10. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Huber KM, etal., Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50.
11. Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death. Jeon SJ, etal., J Neurochem. 2012 Oct;123(2):226-38. doi: 10.1111/j.1471-4159.2012.07886.x. Epub 2012 Aug 22.
12. Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion. Kim SH, etal., J Neurosci. 2006 Mar 1;26(9):2413-8.
13. Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n. Kremer EJ, etal., Science. 1991 Jun 21;252(5013):1711-4.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. Tian Y, etal., Front Mol Neurosci. 2017 Aug 28;10:269. doi: 10.3389/fnmol.2017.00269. eCollection 2017.
23. Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor/ataxia syndrome (FXTAS). Van Dam D, etal., Behav Brain Res. 2005 Jul 30;162(2):233-9.
24. The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line. Yang GM, etal., Neurotox Res. 2020 Apr;37(4):926-935. doi: 10.1007/s12640-019-00150-7. Epub 2020 Jan 4.
Additional References at PubMed
PMID:1543906   PMID:1572654   PMID:1572655   PMID:3472716   PMID:7633436   PMID:7633450   PMID:8000145   PMID:8033209   PMID:8111372   PMID:8358431   PMID:8358432   PMID:8526888  
PMID:8557260   PMID:8634689   PMID:8844056   PMID:8844057   PMID:8889551   PMID:9015322   PMID:9144249   PMID:9421410   PMID:9512393   PMID:10331607   PMID:10349636   PMID:10439957  
PMID:10556305   PMID:10567518   PMID:10613508   PMID:10643918   PMID:10767339   PMID:10912798   PMID:10922068   PMID:10973830   PMID:11007555   PMID:11008180   PMID:11042159   PMID:11058604  
PMID:11076861   PMID:11099766   PMID:11162447   PMID:11217851   PMID:11301211   PMID:11376146   PMID:11438589   PMID:11438699   PMID:11487573   PMID:11814427   PMID:11860268   PMID:11918286  
PMID:11918288   PMID:12086643   PMID:12112447   PMID:12112451   PMID:12147688   PMID:12160728   PMID:12210340   PMID:12417522   PMID:12427968   PMID:12460560   PMID:12477932   PMID:12575950  
PMID:12581522   PMID:12597853   PMID:12615009   PMID:12691840   PMID:12700164   PMID:12711073   PMID:12763063   PMID:12941608   PMID:14610273   PMID:14613971   PMID:14614133   PMID:14743444  
PMID:14981523   PMID:15020476   PMID:15082225   PMID:15317853   PMID:15329415   PMID:15381419   PMID:15475576   PMID:15530658   PMID:15544577   PMID:15548614   PMID:15574493   PMID:15661377  
PMID:15684045   PMID:15755515   PMID:15782199   PMID:15805463   PMID:15878626   PMID:15901791   PMID:16000371   PMID:16033648   PMID:16054174   PMID:16055059   PMID:16076950   PMID:16093389  
PMID:16135762   PMID:16141072   PMID:16141073   PMID:16154294   PMID:16176388   PMID:16192381   PMID:16199166   PMID:16221856   PMID:16257225   PMID:16319129   PMID:16343653   PMID:16452252  
PMID:16574084   PMID:16602821   PMID:16621323   PMID:16631377   PMID:16675531   PMID:16790844   PMID:16823030   PMID:16887106   PMID:16908410   PMID:16923151   PMID:17007840   PMID:17046729  
PMID:17136426   PMID:17197085   PMID:17254795   PMID:17287348   PMID:17298186   PMID:17350580   PMID:17376973   PMID:17417632   PMID:17428978   PMID:17442505   PMID:17507556   PMID:17521574  
PMID:17548835   PMID:17592139   PMID:17687394   PMID:17699670   PMID:17823967   PMID:17881655   PMID:17899445   PMID:17913902   PMID:18005058   PMID:18028882   PMID:18080753   PMID:18093519  
PMID:18093976   PMID:18094233   PMID:18160412   PMID:18163424   PMID:18184799   PMID:18289890   PMID:18299284   PMID:18329113   PMID:18332424   PMID:18434517   PMID:18452182   PMID:18472227  
PMID:18474609   PMID:18479837   PMID:18480274   PMID:18513141   PMID:18539120   PMID:18571098   PMID:18589395   PMID:18614030   PMID:18638539   PMID:18653529   PMID:18667617   PMID:18760699  
PMID:18782566   PMID:18787232   PMID:18799693   PMID:18805096   PMID:18812493   PMID:18829439   PMID:18830682   PMID:18832330   PMID:18835858   PMID:18840308   PMID:18932249   PMID:18952114  
PMID:19016890   PMID:19056494   PMID:19070606   PMID:19103683   PMID:19138667   PMID:19166269   PMID:19193898   PMID:19244359   PMID:19351745   PMID:19362146   PMID:19464371   PMID:19487368  
PMID:19571810   PMID:19608740   PMID:19640847   PMID:19659572   PMID:19666116   PMID:19710035   PMID:19796132   PMID:19799873   PMID:19846466   PMID:19864489   PMID:19932134   PMID:20001115  
PMID:20011099   PMID:20051238   PMID:20071534   PMID:20159450   PMID:20159451   PMID:20211142   PMID:20300527   PMID:20364100   PMID:20386739   PMID:20398059   PMID:20410124   PMID:20434996  
PMID:20457613   PMID:20470805   PMID:20478339   PMID:20512134   PMID:20534533   PMID:20534828   PMID:20600866   PMID:20660275   PMID:20682298   PMID:20685971   PMID:20702695   PMID:20713728  
PMID:20720104   PMID:20799337   PMID:20817093   PMID:20861447   PMID:20935171   PMID:21047554   PMID:21049485   PMID:21084617   PMID:21092061   PMID:21124905   PMID:21159962   PMID:21215802  
PMID:21220020   PMID:21228181   PMID:21262808   PMID:21267068   PMID:21268289   PMID:21273427   PMID:21307257   PMID:21314987   PMID:21364941   PMID:21371563   PMID:21430043   PMID:21440572  
PMID:21478165   PMID:21490210   PMID:21491426   PMID:21516088   PMID:21517146   PMID:21547530   PMID:21571007   PMID:21596744   PMID:21605597   PMID:21613321   PMID:21645877   PMID:21658607  
PMID:21677750   PMID:21723920   PMID:21734271   PMID:21784246   PMID:21785977   PMID:21795546   PMID:21795626   PMID:21856714   PMID:21873635   PMID:21900387   PMID:21933836   PMID:21957233  
PMID:21976507   PMID:22004265   PMID:22022532   PMID:22046307   PMID:22048960   PMID:22067669   PMID:22099464   PMID:22113615   PMID:22123412   PMID:22128095   PMID:22227453   PMID:22238374  
PMID:22257369   PMID:22265702   PMID:22267161   PMID:22328088   PMID:22384253   PMID:22393026   PMID:22393900   PMID:22405502   PMID:22435671   PMID:22466801   PMID:22500629   PMID:22522472  
PMID:22522693   PMID:22539853   PMID:22561129   PMID:22579290   PMID:22623686   PMID:22640474   PMID:22662315   PMID:22717988   PMID:22737234   PMID:22750206   PMID:22774600   PMID:22796595  
PMID:22796598   PMID:22817866   PMID:22863780   PMID:22867433   PMID:22887750   PMID:22924671   PMID:22984567   PMID:22993295   PMID:23010509   PMID:23011134   PMID:23015112   PMID:23046047  
PMID:23083736   PMID:23119095   PMID:23142366   PMID:23148316   PMID:23211703   PMID:23235829   PMID:23250915   PMID:23260144   PMID:23300470   PMID:23327738   PMID:23390134   PMID:23392687  
PMID:23396537   PMID:23436049   PMID:23439122   PMID:23458504   PMID:23505481   PMID:23509247   PMID:23511190   PMID:23542787   PMID:23553633   PMID:23578490   PMID:23616559   PMID:23630463  
PMID:23640459   PMID:23660195   PMID:23665500   PMID:23727819   PMID:23740941   PMID:23747611   PMID:23891804   PMID:23900139   PMID:23910948   PMID:23968838   PMID:24008143   PMID:24021279  
PMID:24046080   PMID:24050404   PMID:24062571   PMID:24089476   PMID:24141422   PMID:24175909   PMID:24204304   PMID:24205018   PMID:24211451   PMID:24227732   PMID:24312033   PMID:24323121  
PMID:24336711   PMID:24349419   PMID:24352881   PMID:24403144   PMID:24408886   PMID:24418349   PMID:24463622   PMID:24478370   PMID:24493647   PMID:24514761   PMID:24573297   PMID:24646437  
PMID:24657592   PMID:24684608   PMID:24701200   PMID:24709664   PMID:24718368   PMID:24790210   PMID:24793772   PMID:24806451   PMID:24811383   PMID:24813610   PMID:24858908   PMID:24886775  
PMID:24904293   PMID:24906954   PMID:24952961   PMID:24986919   PMID:25015265   PMID:25057190   PMID:25079250   PMID:25115962   PMID:25153086   PMID:25168779   PMID:25181011   PMID:25198012  
PMID:25268320   PMID:25296296   PMID:25332164   PMID:25376939   PMID:25383903   PMID:25402856   PMID:25432536   PMID:25433180   PMID:25446451   PMID:25452762   PMID:25464849   PMID:25466251  
PMID:25521380   PMID:25552647   PMID:25561520   PMID:25562659   PMID:25568123   PMID:25653361   PMID:25679778   PMID:25693964   PMID:25705365   PMID:25726753   PMID:25731748   PMID:25740522  
PMID:25750254   PMID:25809670   PMID:25814945   PMID:25849048   PMID:25859182   PMID:25886163   PMID:25913861   PMID:25921527   PMID:25921541   PMID:25948262   PMID:25950728   PMID:25979787  
PMID:26020477   PMID:26048669   PMID:26051932   PMID:26109663   PMID:26117713   PMID:26182420   PMID:26190969   PMID:26250109   PMID:26298628   PMID:26306459   PMID:26307763   PMID:26308557  
PMID:26372002   PMID:26393806   PMID:26420841   PMID:26511926   PMID:26516618   PMID:26554012   PMID:26558778   PMID:26559723   PMID:26586091   PMID:26601124   PMID:26627235   PMID:26627310  
PMID:26667374   PMID:26670047   PMID:26702437   PMID:26711345   PMID:26719241   PMID:26733386   PMID:26792400   PMID:26794591   PMID:26843652   PMID:26850918   PMID:26888925   PMID:26933487  
PMID:26951674   PMID:26968765   PMID:26993298   PMID:27022628   PMID:27048919   PMID:27050589   PMID:27122614   PMID:27142239   PMID:27147951   PMID:27198123   PMID:27221801   PMID:27233938  
PMID:27242437   PMID:27273096   PMID:27293187   PMID:27294193   PMID:27316341   PMID:27383586   PMID:27427765   PMID:27445731   PMID:27462983   PMID:27485117   PMID:27535496   PMID:27539535  
PMID:27616423   PMID:27643697   PMID:27653682   PMID:27656021   PMID:27659109   PMID:27663742   PMID:27664080   PMID:27666021   PMID:27731798   PMID:27770568   PMID:27797833   PMID:27824730  
PMID:27845329   PMID:27865451   PMID:27889578   PMID:27939692   PMID:27957526   PMID:27979975   PMID:28025327   PMID:28077511   PMID:28082376   PMID:28183735   PMID:28213518   PMID:28218269  
PMID:28218824   PMID:28329674   PMID:28352664   PMID:28444183   PMID:28451631   PMID:28465421   PMID:28504725   PMID:28541473   PMID:28552599   PMID:28607173   PMID:28612854   PMID:28621425  
PMID:28640668   PMID:28649315   PMID:28652410   PMID:28671696   PMID:28674175   PMID:28706196   PMID:28744893   PMID:28772121   PMID:28794184   PMID:28822839   PMID:28823556   PMID:28882193  
PMID:28900386   PMID:28919851   PMID:28931075   PMID:28943283   PMID:29016848   PMID:29019321   PMID:29038238   PMID:29040407   PMID:29062097   PMID:29075560   PMID:29096020   PMID:29104533  
PMID:29112191   PMID:29114037   PMID:29114038   PMID:29116166   PMID:29142209   PMID:29211876   PMID:29274095   PMID:29291238   PMID:29292077   PMID:29330421   PMID:29339535   PMID:29346381  
PMID:29352114   PMID:29358017   PMID:29367010   PMID:29472612   PMID:29486296   PMID:29530978   PMID:29590342   PMID:29605426   PMID:29643767   PMID:29668986   PMID:29681800   PMID:29771335  
PMID:29775702   PMID:29778627   PMID:29859980   PMID:29892074   PMID:29901787   PMID:29950161   PMID:29950602   PMID:29990673   PMID:30056576   PMID:30057755   PMID:30068389   PMID:30093538  
PMID:30107516   PMID:30123107   PMID:30125640   PMID:30132892   PMID:30196744   PMID:30224722   PMID:30237867   PMID:30240639   PMID:30241548   PMID:30242133   PMID:30250263   PMID:30311737  
PMID:30312299   PMID:30319351   PMID:30333723   PMID:30355624   PMID:30373821   PMID:30389838   PMID:30417082   PMID:30503263   PMID:30511641   PMID:30528856   PMID:30566867   PMID:30627633  
PMID:30639292   PMID:30679017   PMID:30686771   PMID:30705620   PMID:30726724   PMID:30742117   PMID:30771487   PMID:30797034   PMID:30804752   PMID:30893603   PMID:30936239   PMID:30953439  
PMID:30958540   PMID:30979884   PMID:31004576   PMID:31040226   PMID:31118285   PMID:31128097   PMID:31130852   PMID:31138677   PMID:31147392   PMID:31189591   PMID:31200759   PMID:31271818  
PMID:31293404   PMID:31326533   PMID:31340148   PMID:31350260   PMID:31364704   PMID:31398341   PMID:31520894   PMID:31539452   PMID:31554841   PMID:31587487   PMID:31616256   PMID:31632352  
PMID:31645553   PMID:31645626   PMID:31666356   PMID:31680833   PMID:31680892   PMID:31685673   PMID:31702995   PMID:31740951   PMID:31753916   PMID:31838149   PMID:31853066   PMID:31860442  
PMID:31882402   PMID:31953317   PMID:32036032   PMID:32184710   PMID:32234480   PMID:32268079   PMID:32286273   PMID:32307754   PMID:32325033   PMID:32374912   PMID:32434143   PMID:32434848  
PMID:32467357   PMID:32488011   PMID:32510328   PMID:32512151   PMID:32558077   PMID:32566916   PMID:32581705   PMID:32612155   PMID:32674111   PMID:32693376   PMID:32719346   PMID:32726631  
PMID:32735823   PMID:32759216   PMID:32760004   PMID:32778145   PMID:32783927   PMID:32795412   PMID:32848552   PMID:32884028   PMID:32894631   PMID:32927026   PMID:32958647   PMID:32970902  
PMID:33077777   PMID:33084871   PMID:33091622   PMID:33093534   PMID:33113347   PMID:33125726   PMID:33154347   PMID:33199649   PMID:33215988   PMID:33243040   PMID:33323119   PMID:33343326  
PMID:33359697   PMID:33374598   PMID:33390902   PMID:33395685   PMID:33401721   PMID:33421563   PMID:33449137   PMID:33523882   PMID:33547274   PMID:33601422   PMID:33674307   PMID:33677132  
PMID:33692361   PMID:33692389   PMID:33775821   PMID:33785420   PMID:33820803   PMID:33856019   PMID:33893168   PMID:33906942   PMID:33931071   PMID:34083256   PMID:34089433   PMID:34093132  
PMID:34121987   PMID:34130255   PMID:34133054   PMID:34138732   PMID:34205274   PMID:34223875   PMID:34238354   PMID:34259631   PMID:34303799   PMID:34321999   PMID:34350185   PMID:34388204  
PMID:34407403   PMID:34411704   PMID:34433831   PMID:34508581   PMID:34617509   PMID:34645383   PMID:34690696   PMID:34695768   PMID:34714519   PMID:34731627   PMID:34758329   PMID:34784943  
PMID:34817267   PMID:34820601   PMID:34847178   PMID:34858133   PMID:34871737   PMID:34924931   PMID:34924936   PMID:34938155   PMID:34939924   PMID:35002623   PMID:35021077   PMID:35043944  
PMID:35058748   PMID:35089938   PMID:35191199   PMID:35259351   PMID:35290907   PMID:35319067   PMID:35373916   PMID:35394871   PMID:35434801   PMID:35438410   PMID:35445787   PMID:35508566  
PMID:35549943   PMID:35584668   PMID:35588990   PMID:35675353   PMID:35675768   PMID:35701158   PMID:35720683   PMID:35728596   PMID:35768828   PMID:35833085   PMID:35863501   PMID:35869039  
PMID:35931081   PMID:35970562   PMID:35977823   PMID:36017614   PMID:36042312   PMID:36057317   PMID:36067267   PMID:36067823   PMID:36167501   PMID:36188480   PMID:36191829   PMID:36222577  
PMID:36375840   PMID:36384114   PMID:36385949   PMID:36410632   PMID:36417873   PMID:36466176   PMID:36470953   PMID:36473166   PMID:36495869   PMID:36584679   PMID:36595706   PMID:36595893  
PMID:36641518   PMID:36646274   PMID:36688132   PMID:36854997   PMID:36898833   PMID:36909303   PMID:36970280   PMID:36996810   PMID:37020302   PMID:37029391   PMID:37035256   PMID:37040696  
PMID:37065917   PMID:37120096   PMID:37142655   PMID:37152432   PMID:37193680   PMID:37255534   PMID:37285615   PMID:37286070   PMID:37305436   PMID:37323585   PMID:37392820   PMID:37407501  
PMID:37442135   PMID:37451263   PMID:37473758   PMID:37505982   PMID:37511156   PMID:37516137   PMID:37516746   PMID:37516865   PMID:37542065   PMID:37551886   PMID:37566006   PMID:37669860  
PMID:37788940   PMID:37816596   PMID:37820724   PMID:37833907   PMID:37852411   PMID:37854624   PMID:37923121   PMID:37936174   PMID:38015349   PMID:38025260   PMID:38036566   PMID:38048226  
PMID:38048343   PMID:38085640   PMID:38124211   PMID:38225196   PMID:38235335   PMID:38257177   PMID:38345852   PMID:38374465   PMID:38376922   PMID:38383408   PMID:38451812   PMID:38510125  
PMID:38614085   PMID:38630591   PMID:38664011   PMID:38720271   PMID:38741709   PMID:38757694   PMID:38787724   PMID:38813469   PMID:38823765   PMID:38830765   PMID:38849354   PMID:38976504  
PMID:39089568   PMID:39107319   PMID:39269925   PMID:39308631   PMID:39510449   PMID:39610285   PMID:39641273   PMID:39848954   PMID:39850357   PMID:39938578   PMID:39961384   PMID:39983718  
PMID:40053578   PMID:40055803   PMID:40174753   PMID:40199322   PMID:40305761   PMID:40467301   PMID:40777047  


Genomics

Comparative Map Data
Fmr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X67,722,144 - 67,761,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX67,722,147 - 67,761,569 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X68,678,536 - 68,717,963 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)Ensemblmm10GRCm38
MGSCv37X65,931,730 - 65,971,138 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X51,835,932 - 51,875,340 (+)NCBIMGSCv36mm8
MGSCv36X64,939,220 - 64,978,628 (+)NCBIMGSCv36mm8
Cytogenetic MapXA7.1NCBI
cM MapX34.83NCBI
FMR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X147,911,919 - 147,951,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX147,911,858 - 147,951,125 (+)Ensemblhg38GRCh38
GRCh37X146,993,437 - 147,032,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X146,801,201 - 146,840,303 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X146,699,054 - 146,738,157NCBI
CeleraX147,345,446 - 147,384,585 (+)NCBICelera
Cytogenetic MapXq27.3NCBI
HuRefX135,963,879 - 135,993,282 (+)NCBIHuRef
CHM1_1X146,904,323 - 146,943,501 (+)NCBICHM1_1
T2T-CHM13v2.0X146,176,547 - 146,215,797 (+)NCBIT2T-CHM13v2.0
Fmr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X152,284,857 - 152,322,686 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX152,284,841 - 152,322,675 (+)EnsemblGRCr8
mRatBN7.2X147,240,239 - 147,278,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX147,240,301 - 147,278,050 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX149,444,285 - 149,482,036 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X152,978,628 - 153,016,381 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X150,519,276 - 150,557,027 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X154,756,031 - 154,793,782 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.1X154,829,463 - 154,867,215 (+)NCBI
Cytogenetic MapXq37NCBI
Fmr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955498566,688 - 595,360 (+)Ensembl
ChiLan1.0NW_004955498566,741 - 594,837 (+)NCBIChiLan1.0ChiLan1.0
FMR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X147,227,441 - 147,266,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X147,231,048 - 147,269,765 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X136,937,889 - 136,976,828 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X147,366,713 - 147,405,327 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX147,365,748 - 147,405,321 (+)EnsemblpanPan2panpan1.1
FMR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X116,249,079 - 116,287,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX116,249,142 - 116,321,439 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX102,141,952 - 102,179,858 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X118,308,237 - 118,346,144 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX118,308,224 - 118,346,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X115,421,122 - 115,459,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X117,632,687 - 117,670,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X117,359,050 - 117,396,958 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fmr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365131,289,558 - 1,327,856 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365131,290,038 - 1,327,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX120,361,367 - 120,399,831 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X120,361,232 - 120,400,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X137,792,642 - 137,831,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X122,635,383 - 122,674,298 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX122,635,439 - 122,674,355 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606560,266,278 - 60,318,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624883645,449 - 682,292 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624883645,524 - 681,705 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fmr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X126,737,972 - 126,775,557 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fmr1
924 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:4549
Count of miRNA genes:676
Interacting mature miRNAs:864
Transcripts:ENSMUST00000088546, ENSMUST00000114653, ENSMUST00000114654, ENSMUST00000114655, ENSMUST00000114656, ENSMUST00000114657, ENSMUST00000127954, ENSMUST00000127993, ENSMUST00000133327, ENSMUST00000141728, ENSMUST00000142584, ENSMUST00000146177, ENSMUST00000148348
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12050071Hstx2_mhybrid sterility, X chromosome 2 (mouse)X6392424768624700Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
1301351Obq6_mobesity QTL 6 (mouse)Not determinedX5077237570434751Mouse
12880401Emlq3_memotional learning QTL 3 (mouse)X5799218370090431Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse

Markers in Region
Fmr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7.1UniSTS
cM MapX24.5UniSTS
px-34b10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X68,683,021 - 68,683,262UniSTSGRCm38
MGSCv37X65,936,196 - 65,936,437UniSTSGRCm37
Cytogenetic MapXA7.1UniSTS
GDB:370773  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X68,700,072 - 68,700,388UniSTSGRCm38
MGSCv37X65,953,247 - 65,953,563UniSTSGRCm37
Cytogenetic MapXA7.1UniSTS
L23971  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X68,716,094 - 68,716,277UniSTSGRCm38
MGSCv37X65,969,269 - 65,969,452UniSTSGRCm37
Cytogenetic MapXA7.1UniSTS
Whitehead_YACX UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001782738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC055766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF170530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF179463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF251347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF461114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY007232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY630338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DS033531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L23971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000088546   ⟹   ENSMUSP00000085906
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,147 - 67,761,569 (+)Ensembl
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114653   ⟹   ENSMUSP00000110301
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,423 - 67,761,569 (+)Ensembl
GRCm38.p6 EnsemblX68,678,817 - 68,717,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114654   ⟹   ENSMUSP00000110302
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,408 - 67,761,569 (+)Ensembl
GRCm38.p6 EnsemblX68,678,802 - 68,717,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114655   ⟹   ENSMUSP00000110303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,408 - 67,761,569 (+)Ensembl
GRCm38.p6 EnsemblX68,678,802 - 68,717,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114656   ⟹   ENSMUSP00000110304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,230 - 67,761,569 (+)Ensembl
GRCm38.p6 EnsemblX68,678,624 - 68,717,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114657   ⟹   ENSMUSP00000110305
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,417 - 67,761,569 (+)Ensembl
GRCm38.p6 EnsemblX68,678,811 - 68,717,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127954
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,188 - 67,736,100 (+)Ensembl
GRCm38.p6 EnsemblX68,678,582 - 68,692,494 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127993
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,755,457 - 67,756,929 (+)Ensembl
GRCm38.p6 EnsemblX68,711,851 - 68,713,323 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,188 - 67,723,691 (+)Ensembl
GRCm38.p6 EnsemblX68,678,582 - 68,680,085 (+)Ensembl
Ensembl Acc Id: ENSMUST00000141728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,741,268 - 67,741,941 (+)Ensembl
GRCm38.p6 EnsemblX68,697,662 - 68,698,335 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,738,404 - 67,749,796 (+)Ensembl
GRCm38.p6 EnsemblX68,694,798 - 68,706,190 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,188 - 67,750,499 (+)Ensembl
GRCm38.p6 EnsemblX68,678,582 - 68,706,893 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148348
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX67,722,188 - 67,752,483 (+)Ensembl
GRCm38.p6 EnsemblX68,678,582 - 68,708,877 (+)Ensembl
RefSeq Acc Id: NM_001290424   ⟹   NP_001277353
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X67,722,188 - 67,761,569 (+)NCBI
GRCm38X68,678,541 - 68,717,963 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001374719   ⟹   NP_001361648
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X67,722,188 - 67,761,569 (+)NCBI
GRCm38X68,678,582 - 68,717,963 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001412089   ⟹   NP_001399018
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X67,722,188 - 67,761,569 (+)NCBI
RefSeq Acc Id: NM_001412090   ⟹   NP_001399019
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X67,722,188 - 67,761,569 (+)NCBI
RefSeq Acc Id: NM_001412091   ⟹   NP_001399020
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X67,722,188 - 67,761,569 (+)NCBI
RefSeq Acc Id: NM_008031   ⟹   NP_032057
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X67,722,188 - 67,761,569 (+)NCBI
GRCm38X68,678,541 - 68,717,963 (+)NCBI
MGSCv37X65,931,730 - 65,971,138 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001782738
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X67,722,144 - 67,761,569 (+)NCBI
GRCm38X68,678,539 - 68,717,963 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032057   ⟸   NM_008031
- Peptide Label: isoform 1
- UniProtKB: P35922 (UniProtKB/Swiss-Prot),   Q6AXB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277353   ⟸   NM_001290424
- Peptide Label: isoform 2
- UniProtKB: E9QAT0 (UniProtKB/TrEMBL),   Q547R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001361648   ⟸   NM_001374719
- Peptide Label: isoform 3
- UniProtKB: E9QNF5 (UniProtKB/TrEMBL),   D3Z6U8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000085906   ⟸   ENSMUST00000088546
Ensembl Acc Id: ENSMUSP00000110302   ⟸   ENSMUST00000114654
Ensembl Acc Id: ENSMUSP00000110303   ⟸   ENSMUST00000114655
Ensembl Acc Id: ENSMUSP00000110301   ⟸   ENSMUST00000114653
Ensembl Acc Id: ENSMUSP00000110304   ⟸   ENSMUST00000114656
Ensembl Acc Id: ENSMUSP00000110305   ⟸   ENSMUST00000114657
RefSeq Acc Id: NP_001399018   ⟸   NM_001412089
- Peptide Label: isoform 4
- UniProtKB: P35922 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001399019   ⟸   NM_001412090
- Peptide Label: isoform 5
- UniProtKB: D3Z6U8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399020   ⟸   NM_001412091
- Peptide Label: isoform 6
- UniProtKB: D3Z6U8 (UniProtKB/TrEMBL)
Protein Domains
Agenet-like   KH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35922-F1-model_v2 AlphaFold P35922 1-614 view protein structure

Promoters
RGD ID:6845754
Promoter ID:MM_KWN:60582
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK148387_GM10474,   ENSMUST00000088541,   ENSMUST00000101518,   ENSMUST00000114649,   ENSMUST00000114651,   ENSMUST00000114654,   ENSMUST00000114655,   ENSMUST00000114656,   OTTMUST00000042964,   OTTMUST00000042969,   OTTMUST00000042974,   UC009TIT.1,   UC009TIU.1,   UC009TIV.1,   UC009TIX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X65,931,251 - 65,931,877 (-)MPROMDB
RGD ID:6845716
Promoter ID:MM_KWN:60584
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3
Transcripts:OTTMUST00000042975
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X65,950,581 - 65,951,081 (+)MPROMDB
RGD ID:6845717
Promoter ID:MM_KWN:60585
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day6
Transcripts:OTTMUST00000042976
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X65,964,291 - 65,965,212 (+)MPROMDB
RGD ID:13680622
Promoter ID:EPDNEW_M24460
Type:initiation region
Name:Fmr1_1
Description:Mus musculus fragile X mental retardation syndrome 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24461  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X68,678,582 - 68,678,642EPDNEW
RGD ID:13680626
Promoter ID:EPDNEW_M24461
Type:initiation region
Name:Fmr1_2
Description:Mus musculus fragile X mental retardation syndrome 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24460  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X68,678,685 - 68,678,745EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95564 AgrOrtholog
Ensembl Genes ENSMUSG00000000838 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000088546 ENTREZGENE
  ENSMUST00000114653 ENTREZGENE
  ENSMUST00000114654 ENTREZGENE
  ENSMUST00000114657 ENTREZGENE
Gene3D-CATH 2.30.30.140 UniProtKB/Swiss-Prot
  3.30.1370.10 UniProtKB/Swiss-Prot
InterPro Agenet-like_dom UniProtKB/Swiss-Prot
  FMR1 UniProtKB/Swiss-Prot
  FMRP_KH0 UniProtKB/Swiss-Prot
  FXMR_C2 UniProtKB/Swiss-Prot
  FXMRP1_C_core UniProtKB/Swiss-Prot
  KH_dom UniProtKB/Swiss-Prot
  KH_dom_type_1 UniProtKB/Swiss-Prot
  KH_dom_type_1_sf UniProtKB/Swiss-Prot
  KH_I_FMR1_rpt1 UniProtKB/Swiss-Prot
  KH_I_FMR1_rpt2 UniProtKB/Swiss-Prot
  Tudor_Agenet_FMR1_rpt1 UniProtKB/Swiss-Prot
  Tudor_Agenet_FMR1_rpt2 UniProtKB/Swiss-Prot
  Tudor_FRX1 UniProtKB/Swiss-Prot
MGD MGI:95564 ENTREZGENE
NCBI Gene 14265 ENTREZGENE
PANTHER PTHR10603 UniProtKB/Swiss-Prot
  SYNAPTIC FUNCTIONAL REGULATOR FMR1 UniProtKB/Swiss-Prot
Pfam Agenet UniProtKB/Swiss-Prot
  FXMR_C2 UniProtKB/Swiss-Prot
  FXMRP1_C_core UniProtKB/Swiss-Prot
  KH_1 UniProtKB/Swiss-Prot
  KH_9 UniProtKB/Swiss-Prot
  Tudor_FRX1 UniProtKB/Swiss-Prot
PhenoGen Fmr1 PhenoGen
PROSITE AGENET_LIKE UniProtKB/Swiss-Prot
  KH_TYPE_1 UniProtKB/Swiss-Prot
SMART SM00322 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot
UniProt D3Z6U8 ENTREZGENE, UniProtKB/TrEMBL
  E9QAS8_MOUSE UniProtKB/TrEMBL
  E9QAS9_MOUSE UniProtKB/TrEMBL
  E9QAT0 ENTREZGENE, UniProtKB/TrEMBL
  E9QNF5 ENTREZGENE, UniProtKB/TrEMBL
  FMR1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q547R0 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXB7 ENTREZGENE, UniProtKB/TrEMBL
  Q8BPK8_MOUSE UniProtKB/TrEMBL
  Q8BPN5_MOUSE UniProtKB/TrEMBL
  Q925S6_MOUSE UniProtKB/TrEMBL
  Q925S7_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-03 Fmr1  fragile X messenger ribonucleoprotein 1  Fmr1  FMRP translational regulator 1  Symbol and/or name change 5135510 APPROVED
2020-02-11 Fmr1  FMRP translational regulator 1  Fmr1  fragile X mental retardation 1  Symbol and/or name change 5135510 APPROVED
2018-06-05 Fmr1  fragile X mental retardation 1    fragile X mental retardation syndrome 1  Symbol and/or name change 5135510 APPROVED
2012-07-10 Fmr1  fragile X mental retardation syndrome 1  Fmr1  fragile X mental retardation syndrome 1 homolog  Symbol and/or name change 5135510 APPROVED