Spn (sialophorin) - Rat Genome Database

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Gene: Spn (sialophorin) Mus musculus
Analyze
Symbol: Spn
Name: sialophorin
RGD ID: 11339
MGI Page MGI
Description: Exhibits heat shock protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of defense response. Localizes to several cellular components, including basement membrane; external side of plasma membrane; and uropod. Orthologous to human SPN (sialophorin); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; Cd43; Ga; Galgp; leu; leukocyte sialoglycoprotein; leukosialin; Ly-4; Ly-48; Ly4; Ly48; lymphocyte antigen 48
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Spn-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,731,404 - 126,743,785 (-)NCBIGRCm39mm39
GRCm39 Ensembl7126,731,404 - 126,736,995 (-)Ensembl
GRCm387127,123,637 - 127,145,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,132,232 - 127,137,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,276,978 - 134,281,331 (-)NCBIGRCm37mm9NCBIm37
MGSCv367126,924,612 - 126,928,965 (-)NCBImm8
Celera7126,982,004 - 126,986,358 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1431091   PMID:1533277   PMID:1973410   PMID:2144340   PMID:2347365   PMID:7477353   PMID:7514104   PMID:7523443   PMID:7566153   PMID:7790813   PMID:7795661   PMID:7831340  
PMID:7959747   PMID:8617496   PMID:8920854   PMID:8986768   PMID:9529154   PMID:9645617   PMID:9988767   PMID:10349636   PMID:10429671   PMID:10899905   PMID:10922068   PMID:10943842  
PMID:11042159   PMID:11076861   PMID:11078605   PMID:11123300   PMID:11217851   PMID:11238599   PMID:11380685   PMID:11728336   PMID:11739501   PMID:11828253   PMID:11829488   PMID:11937524  
PMID:11994475   PMID:12055210   PMID:12068294   PMID:12466851   PMID:12477932   PMID:14607908   PMID:14610273   PMID:14635057   PMID:14662853   PMID:15117976   PMID:15528368   PMID:15699109  
PMID:15778363   PMID:15843532   PMID:16034122   PMID:16141072   PMID:16141073   PMID:16246302   PMID:16339541   PMID:16602821   PMID:16805789   PMID:16890924   PMID:17015718   PMID:17056577  
PMID:17101770   PMID:17277158   PMID:17392823   PMID:17401367   PMID:17638845   PMID:17982027   PMID:18490738   PMID:18614175   PMID:18637079   PMID:18714037   PMID:19299737   PMID:19401394  
PMID:19696198   PMID:19890058   PMID:20360400   PMID:20439727   PMID:20633027   PMID:21267068   PMID:21289089   PMID:21598252   PMID:21677750   PMID:21873635   PMID:22345665   PMID:23408841  
PMID:23555902   PMID:23585675   PMID:24250818   PMID:25524774   PMID:26426795   PMID:26700769   PMID:27011118   PMID:29113976   PMID:30226896   PMID:31197200   PMID:31757864  


Genomics

Comparative Map Data
Spn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,731,404 - 126,743,785 (-)NCBIGRCm39mm39
GRCm39 Ensembl7126,731,404 - 126,736,995 (-)Ensembl
GRCm387127,123,637 - 127,145,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,132,232 - 127,137,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,276,978 - 134,281,331 (-)NCBIGRCm37mm9NCBIm37
MGSCv367126,924,612 - 126,928,965 (-)NCBImm8
Celera7126,982,004 - 126,986,358 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.35NCBI
SPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1629,662,979 - 29,670,876 (+)EnsemblGRCh38hg38GRCh38
GRCh381629,662,963 - 29,670,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371629,674,284 - 29,682,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,581,801 - 29,589,329 (+)NCBINCBI36hg18NCBI36
Build 34864,262,738 - 64,263,150NCBI
Celera1673,114,178 - 73,121,702 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1627,335,753 - 27,343,116 (+)NCBIHuRef
CHM1_11630,890,050 - 30,897,603 (+)NCBICHM1_1
Spn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21181,746,937 - 181,759,564 (-)NCBI
Rnor_6.0 Ensembl1198,572,999 - 198,577,226 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01198,572,999 - 198,585,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01205,563,659 - 205,576,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,388,120 - 186,391,887 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,538,248 - 186,541,733 (-)NCBI
Celera1179,399,985 - 179,404,212 (-)NCBICelera
Cytogenetic Map1q37NCBI
Spn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,256,505 - 7,258,607 (-)NCBIChiLan1.0ChiLan1.0
SPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11630,034,739 - 30,037,033 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,035,243 - 30,036,445 (+)Ensemblpanpan1.1panPan2
SPN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,770,303 - 17,774,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,347,439 - 19,352,997 (+)NCBI
ROS_Cfam_1.0617,904,551 - 17,908,967 (+)NCBI
UMICH_Zoey_3.1617,704,496 - 17,710,054 (+)NCBI
UNSW_CanFamBas_1.0617,619,970 - 17,625,528 (+)NCBI
UU_Cfam_GSD_1.0617,935,701 - 17,941,231 (+)NCBI
Spn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,676,088 - 124,678,845 (-)NCBI
SpeTri2.0NW_00493650112,773,967 - 12,776,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1317,978,731 - 17,982,222 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,608,470 - 18,612,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,987,810 - 26,990,214 (-)NCBI
Spn
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,471,083 - 13,483,712 (-)NCBI

Position Markers
UniSTS:489105  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387127,136,068 - 127,137,336UniSTSGRCm38
MGSCv377134,279,582 - 134,280,850UniSTSGRCm37
Celera7126,984,609 - 126,985,877UniSTS
Cytogenetic Map7F3-F4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105651440139651588Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105750785139750785Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7116100000128900000Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117600000134500000Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7118151499128365612Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
38501070Tip5_mtuberculosis immunophenotype 5, IFN-g level (mouse)7121000000130700000Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122651440129217600Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122651440135569172Mouse
38501066Tip2_mtuberculosis immunophenotype 2, spleen CFU (mouse)7124700000127300000Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124914439129217600Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1547
Count of miRNA genes:696
Interacting mature miRNAs:901
Transcripts:ENSMUST00000049931, ENSMUST00000143713
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_110337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006507522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW540100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB850887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX633083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S70677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000049931   ⟹   ENSMUSP00000049534
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,133,702 - 127,137,823 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143713   ⟹   ENSMUSP00000122787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,132,232 - 127,137,814 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205483   ⟹   ENSMUSP00000145637
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,133,470 - 127,136,566 (-)Ensembl
RefSeq Acc Id: NM_001037810   ⟹   NP_001032899
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,732,636 - 126,736,995 (-)NCBI
GRCm387127,133,464 - 127,137,823 (-)NCBI
MGSCv377134,276,978 - 134,281,331 (-)RGD
Celera7126,980,772 - 126,986,364 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009259   ⟹   NP_033285
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,732,866 - 126,736,995 (-)NCBI
GRCm387127,133,694 - 127,137,823 (-)NCBI
MGSCv377134,276,978 - 134,281,331 (-)RGD
Celera7126,980,772 - 126,986,364 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_110337
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,731,404 - 126,736,995 (-)NCBI
GRCm387127,132,232 - 127,137,823 (-)NCBI
Celera7126,980,772 - 126,986,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006507522   ⟹   XP_006507585
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,732,878 - 126,743,653 (-)NCBI
GRCm387127,133,706 - 127,145,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241716   ⟹   XP_011240018
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,732,878 - 126,743,785 (-)NCBI
GRCm387127,133,706 - 127,144,614 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001032899   ⟸   NM_001037810
- Peptide Label: precursor
- UniProtKB: P15702 (UniProtKB/Swiss-Prot),   Q544C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_033285   ⟸   NM_009259
- Peptide Label: precursor
- UniProtKB: P15702 (UniProtKB/Swiss-Prot),   Q544C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006507585   ⟸   XM_006507522
- Peptide Label: isoform X2
- UniProtKB: P15702 (UniProtKB/Swiss-Prot),   Q544C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240018   ⟸   XM_011241716
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000122787   ⟸   ENSMUST00000143713
RefSeq Acc Id: ENSMUSP00000145637   ⟸   ENSMUST00000205483
RefSeq Acc Id: ENSMUSP00000049534   ⟸   ENSMUST00000049931

Promoters
RGD ID:8665639
Promoter ID:EPDNEW_M10851
Type:multiple initiation site
Name:Spn_1
Description:Mus musculus sialophorin , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387127,137,814 - 127,137,874EPDNEW
RGD ID:6842095
Promoter ID:MM_KWN:52750
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:NM_001037810,   OTTMUST00000072890,   OTTMUST00000072891
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367134,280,906 - 134,281,406 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98384 AgrOrtholog
Ensembl Genes ENSMUSG00000051457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000049534 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122787 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145637 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049931 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000143713 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000205483 UniProtKB/TrEMBL
InterPro Leukosialin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98384 ENTREZGENE
NCBI Gene 20737 ENTREZGENE
PANTHER PTHR35265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spn PhenoGen
UniProt A0A0U1RNN5_MOUSE UniProtKB/TrEMBL
  LEUK_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544C5 ENTREZGENE, UniProtKB/TrEMBL