Mir195a (microRNA 195a) - Rat Genome Database

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Gene: Mir195a (microRNA 195a) Mus musculus
Analyze
Symbol: Mir195a
Name: microRNA 195a
RGD ID: 1608301
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to estrogen stimulus; long-term synaptic potentiation; and sensory perception of sound. Located in extracellular exosome. Part of RISC complex. Is expressed in embryo; gut; lung; and pancreas. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR195 (microRNA 195).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-195a; Mir195; Mirn; Mirn195; mmu-mir-1; mmu-mir-195; mmu-mir-195a
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,125,868 - 70,125,961 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,125,868 - 70,125,961 (+)EnsemblGRCm39 Ensembl
GRCm381170,235,042 - 70,235,135 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,235,042 - 70,235,135 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,048,544 - 70,048,637 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1177,779,516 - 77,779,609 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway. Chang L, etal., Mol Med. 2020 Apr 9;26(1):31. doi: 10.1186/s10020-020-00150-w.
2. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
3. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Ehinger Y, etal., Addict Biol. 2020 Mar 5:e12890. doi: 10.1111/adb.12890.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. MicroRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma. Zheng C, etal., Oncol Rep. 2015 Mar;33(3):1115-22. doi: 10.3892/or.2015.3734. Epub 2015 Jan 19.
Additional References at PubMed
PMID:12554859   PMID:15538371   PMID:16369549   PMID:16381832   PMID:16682203   PMID:17369397   PMID:17604727   PMID:17936263   PMID:18452032   PMID:18594913   PMID:18791161   PMID:19559694  
PMID:19727952   PMID:20215419   PMID:20413612   PMID:20619502   PMID:20668074   PMID:20805985   PMID:21037258   PMID:21267068   PMID:21622680   PMID:21778430   PMID:21983986   PMID:22052914  
PMID:22123611   PMID:22144232   PMID:22367207   PMID:22721728   PMID:22844503   PMID:23349673   PMID:23646144   PMID:24205035   PMID:25119651   PMID:25240198   PMID:25858512   PMID:25903991  
PMID:25994075   PMID:26390028   PMID:26567220   PMID:26637971   PMID:26683705   PMID:26704614   PMID:26837421   PMID:26989874   PMID:27019437   PMID:27693395   PMID:28181691   PMID:29042220  
PMID:29197556   PMID:29330215   PMID:29626503   PMID:31059087   PMID:31204558   PMID:31341888   PMID:32277959   PMID:32468736   PMID:32705746   PMID:33029941   PMID:33686956   PMID:33788631  
PMID:34182078   PMID:34267179   PMID:34337910   PMID:34816499   PMID:36448465   PMID:36515680   PMID:37326937   PMID:38191655  


Genomics

Comparative Map Data
Mir195a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,125,868 - 70,125,961 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,125,868 - 70,125,961 (+)EnsemblGRCm39 Ensembl
GRCm381170,235,042 - 70,235,135 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,235,042 - 70,235,135 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,048,544 - 70,048,637 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1177,779,516 - 77,779,609 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
MIR195
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,017,615 - 7,017,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,017,615 - 7,017,701 (-)EnsemblGRCh38hg38GRCh38
GRCh37176,920,934 - 6,921,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,861,657 - 6,861,743 (-)NCBINCBI36Build 36hg18NCBI36
Celera176,946,439 - 6,946,525 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,814,627 - 6,814,713 (-)NCBIHuRef
CHM1_1176,930,364 - 6,930,450 (-)NCBICHM1_1
T2T-CHM13v2.0176,918,215 - 6,918,301 (-)NCBIT2T-CHM13v2.0
Mir195
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,450,495 - 55,450,581 (+)NCBIGRCr8
mRatBN7.21054,951,838 - 54,951,924 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,951,838 - 54,951,924 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,631,382 - 59,631,468 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,119,981 - 59,120,067 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,619,105 - 54,619,191 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,845,301 - 56,845,387 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,845,301 - 56,845,387 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,589,465 - 56,589,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1054,103,305 - 54,103,391 (+)NCBICelera
Cytogenetic Map10q24NCBI
MIR195
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,045,450 - 32,045,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,045,450 - 32,045,510 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,184,167 - 32,184,227 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,150,422 - 32,150,482 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,150,422 - 32,150,482 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,116,490 - 32,116,550 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,075,734 - 32,075,794 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,252,213 - 32,252,273 (-)NCBIUU_Cfam_GSD_1.0
MIR195
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,422,039 - 52,422,118 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,422,039 - 52,422,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,717,315 - 54,717,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:25017
Count of gene targets:10526
Count of transcripts:17822
Interacting mature miRNAs:mmu-miR-195a-3p, mmu-miR-195a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000083477
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,125,868 - 70,125,961 (+)Ensembl
GRCm38.p6 Ensembl1170,235,042 - 70,235,135 (+)Ensembl
RefSeq Acc Id: NR_029581
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,125,868 - 70,125,961 (+)NCBI
GRCm381170,235,042 - 70,235,135 (+)ENTREZGENE
MGSCv371170,048,544 - 70,048,637 (+)RGD
Celera1177,779,516 - 77,779,609 (+)RGD
cM Map11 ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676859 AgrOrtholog
Ensembl Genes ENSMUSG00000065411 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083477 ENTREZGENE
MGD MGI:2676859 ENTREZGENE
miRBase MI0000237 ENTREZGENE
NCBI Gene 387190 ENTREZGENE
PhenoGen Mir195a PhenoGen
RNAcentral URS0000476C64 RNACentral
  URS00005B3525 RNACentral
  URS000075D9AD RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-27 Mir195a  microRNA 195a  Mir195  microRNA 195  Symbol and/or name change 5135510 APPROVED