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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sildenafil
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Accession:CHEBI:9139 term browser browse the term
Definition:A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.
Synonyms:exact_synonym: 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
 related_synonym: 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine;   Formula=C22H30N6O4S;   InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);   InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N;   SMILES=CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
 alt_id: CHEBI:46436;   CHEBI:600437
 xref: Beilstein:7673458;   CAS:139755-83-2;   DrugBank:DB00203;   Drug_Central:2441;   FooDB:FDB023606;   HMDB:HMDB0005039;   KEGG:C07259;   KEGG:D08514;   LINCS:LSM-3797
 xref_mesh: MESH:C101426
 xref: PDBeChem:VIA;   Patent:EP463756;   Patent:US5250534;   Wikipedia:Sildenafil


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sildenafil citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of ABCB1 mRNA] CTD PMID:35608386 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of ABCG2 mRNA] CTD PMID:35608386 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Sildenafil Citrate results in decreased expression of ACTA2 protein CTD PMID:14996430 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions		 ISO
EXP		 Sildenafil Citrate results in increased expression of ADIPOQ mRNA
Sildenafil Citrate inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein]		 CTD PMID:20471953 PMID:29233027 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agt angiotensinogen increases expression
multiple interactions		 ISO Sildenafil Citrate results in increased expression of AGT protein modified form
PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]		 CTD PMID:15613622 PMID:25139994 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein] CTD PMID:32479886 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP Sildenafil Citrate results in increased phosphorylation of AKT1 protein
Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of AKT1 mRNA]; Sildenafil Citrate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]		 CTD PMID:18373738 PMID:35608386 PMID:36940862 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Angpt1 angiopoietin 1 increases expression EXP Sildenafil Citrate results in increased expression of ANGPT1 mRNA; Sildenafil Citrate results in increased expression of ANGPT1 protein CTD PMID:18373738 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Arg1 arginase 1 decreases expression ISO Sildenafil Citrate results in decreased expression of ARG1 protein CTD PMID:17101732 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Sildenafil Citrate promotes the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:20884855 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Sildenafil Citrate inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]] CTD PMID:19152827 PMID:20574430 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression		 ISO
EXP		 Sildenafil Citrate inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]
Sildenafil Citrate results in increased expression of BCL2
Sildenafil Citrate results in decreased expression of BCL2 protein		 CTD PMID:15811867 PMID:18373738 PMID:20574430 PMID:38059649 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
affects response to substance		 ISO BCL2L1 protein inhibits the reaction [Sildenafil Citrate results in increased activity of Doxorubicin]; Sildenafil Citrate promotes the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]
BCL2L1 protein affects the susceptibility to Sildenafil Citrate		 CTD PMID:20884855 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 CASP3 protein promotes the reaction [Sildenafil Citrate results in increased susceptibility to Doxorubicin]; Sildenafil Citrate promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
Sildenafil Citrate inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Sildenafil Citrate inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]
5-hydroxydecanoic acid inhibits the reaction [Sildenafil Citrate inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; Cisplatin promotes the reaction [Sildenafil Citrate results in increased cleavage of CASP3 protein]; Sildenafil Citrate inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Sildenafil Citrate promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Sildenafil Citrate results in decreased expression of and results in increased cleavage of CASP3 protein		 CTD PMID:15811867 PMID:19152827 PMID:20155316 PMID:20884855 PMID:29233027 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 affects response to substance
multiple interactions		 ISO CASP9 protein affects the susceptibility to Sildenafil Citrate
CASP9 protein mutant form inhibits the reaction [Sildenafil Citrate results in increased activity of Doxorubicin]; Sildenafil Citrate promotes the reaction [Doxorubicin results in increased activity of CASP9 protein]		 CTD PMID:20884855 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression
multiple interactions
decreases expression		 EXP
ISO		 Sildenafil Citrate results in increased expression of CAT protein
Sildenafil Citrate inhibits the reaction [Paroxetine results in decreased activity of CAT protein]
Sildenafil Citrate results in decreased expression of CAT protein		 CTD PMID:18265987 PMID:36740106 PMID:38059649 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA] CTD PMID:25139994 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP Sildenafil Citrate inhibits the reaction [Oxygen deficiency results in increased expression of CCNA2 protein] CTD PMID:36940862 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Sildenafil Citrate inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein] CTD PMID:36940862 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO Sildenafil Citrate results in increased expression of CEBPA mRNA; Sildenafil Citrate results in increased expression of CEBPA protein CTD PMID:20471953 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression		 ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [Sildenafil Citrate results in increased expression of CEBPB protein]
Sildenafil Citrate results in increased expression of CEBPB mRNA; Sildenafil Citrate results in increased expression of CEBPB protein		 CTD PMID:20471953 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cftr CF transmembrane conductance regulator affects localization
increases activity
multiple interactions		 ISO Sildenafil Citrate affects the localization of CFTR protein mutant form
Sildenafil Citrate results in increased activity of CFTR protein
Sildenafil Citrate promotes the reaction [CFTR protein affects the secretion of Chlorides]		 CTD PMID:12714375 PMID:15618584 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA] CTD PMID:25139994 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO atosiban inhibits the reaction [Sildenafil Citrate results in increased phosphorylation of CREB1 protein] CTD PMID:27220266 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein] CTD PMID:32479886 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Sildenafil Citrate results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Des desmin multiple interactions ISO Sildenafil Citrate inhibits the reaction [Doxorubicin affects the localization of DES protein] CTD PMID:15811867 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Sildenafil Citrate inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA] CTD PMID:18818482 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression		 ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [Sildenafil Citrate results in increased expression of FABP4 protein]
Sildenafil Citrate results in increased expression of FABP4 mRNA; Sildenafil Citrate results in increased expression of FABP4 protein		 CTD PMID:20471953 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Sildenafil Citrate results in increased expression of FASN mRNA CTD PMID:20471953 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP Sildenafil Citrate results in increased expression of FGF1 mRNA CTD PMID:20583517 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression EXP Sildenafil Citrate results in increased expression of FGFR3 mRNA CTD PMID:20583517 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA] CTD PMID:25139994 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] CTD PMID:30365938 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Sildenafil Citrate inhibits the reaction [Aflatoxin B1 results in increased activity of GOT1 protein] CTD PMID:35608386 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 Sildenafil Citrate inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]
Sildenafil Citrate inhibits the reaction [Paroxetine results in increased activity of GPT protein]		 CTD PMID:35608386 PMID:36740106 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 EXP
ISO		 Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of HIF1A protein]
Sildenafil Citrate results in decreased expression of HIF1A mRNA		 CTD PMID:35608386 PMID:38059649 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]
Sildenafil Citrate results in increased expression of HMOX1; Sildenafil Citrate results in increased expression of HMOX1 mRNA; Sildenafil Citrate results in increased expression of HMOX1 protein		 CTD PMID:17627722 PMID:18373738 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Sildenafil Citrate inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor decreases expression ISO Sildenafil Citrate results in decreased expression of IL4RA protein CTD PMID:17101732 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Sildenafil Citrate inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL5 protein] CTD PMID:15169552 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [Sildenafil Citrate promotes the reaction [INS1 protein results in increased import of Blood Glucose]]; Sildenafil Citrate promotes the reaction [INS1 protein results in increased import of Glucose] CTD PMID:20471953 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
decreases expression		 EXP
ISO		 Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of LDHA mRNA]
Sildenafil Citrate results in decreased expression of LDHA mRNA		 CTD PMID:35608386 PMID:38059649 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of LHB protein] CTD PMID:30365938 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Sildenafil Citrate promotes the reaction [Atorvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]] CTD PMID:26614570 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Sildenafil Citrate inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16113693 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of MYC mRNA] CTD PMID:35608386 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nes nestin multiple interactions EXP Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of NES protein] CTD PMID:32959702 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression		 EXP [Sildenafil Citrate co-treated with Resveratrol] inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein]; [Sildenafil Citrate co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNA; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA] CTD PMID:17627722 PMID:26006044 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO
EXP		 Sildenafil Citrate results in decreased expression of NOS2 protein
[Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS2 mRNA; [Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS2 protein		 CTD PMID:17101732 PMID:19152827 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases activity
multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 Sildenafil Citrate results in increased activity of NOS3 protein
[Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS3 mRNA; [Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS3 protein; [Sildenafil Citrate co-treated with Resveratrol] inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein]; [Sildenafil Citrate results in increased expression of NOS3 protein] which results in increased secretion of Nitric Oxide; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 protein]; Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]
Sildenafil Citrate results in increased phosphorylation of NOS3 protein		 CTD PMID:18373738 PMID:19152827 PMID:19845545 PMID:23650378 PMID:26006044 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18790048 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B affects expression
multiple interactions		 ISO
EXP		 Sildenafil Citrate affects the expression of NPPB protein
Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]		 CTD PMID:18790048 PMID:19179780 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Sildenafil Citrate inhibits the reaction [Oxygen deficiency results in increased expression of PCNA mRNA]; Sildenafil Citrate inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein] CTD PMID:36940862 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pde5a phosphodiesterase 5A decreases activity
multiple interactions		 ISO
EXP		 Sildenafil Citrate results in decreased activity of PDE5A protein
[Sildenafil Citrate co-treated with resveratrol] inhibits the reaction [Streptozocin results in increased expression of PDE5A protein]		 CTD PMID:8858389 PMID:10422958 PMID:15934858 PMID:16368379 PMID:17138653 More... NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde8b phosphodiesterase 8B multiple interactions ISO Sildenafil Citrate inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP] CTD PMID:12681444 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 multiple interactions EXP Sildenafil Citrate inhibits the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of PFKFB3 mRNA] CTD PMID:35608386 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [Sildenafil Citrate results in increased expression of PPARG protein]
Sildenafil Citrate results in increased expression of PPARG mRNA; Sildenafil Citrate results in increased expression of PPARG protein		 CTD PMID:20471953 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases response to substance		 ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]
PRKG1 protein results in increased susceptibility to Sildenafil Citrate		 CTD PMID:25139994 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Ren renin increases activity ISO Sildenafil Citrate results in increased activity of REN protein CTD PMID:15613622 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Sildenafil Citrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions EXP Sildenafil Citrate inhibits the reaction [Aflatoxin B1 results in increased expression of SLC2A1 mRNA] CTD PMID:35608386 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Sildenafil Citrate results in increased expression of SLC2A4 mRNA; Sildenafil Citrate results in increased expression of SLC2A4 protein CTD PMID:20471953 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Snca synuclein alpha multiple interactions EXP Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNCA protein] CTD PMID:32959702 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Sildenafil Citrate results in decreased expression of SOD1 protein CTD PMID:38059649 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] CTD PMID:32479886 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]
Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of TGFB1 mRNA]		 CTD PMID:25139994 PMID:35608386 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Sildenafil Citrate inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of TNF protein]
Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TNF protein]		 CTD PMID:15169552 PMID:32959702 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [Sildenafil Citrate results in increased susceptibility to Doxorubicin]
Sildenafil Citrate results in increased expression of TP53 protein		 CTD PMID:20155316 PMID:38059649 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO Sildenafil Citrate inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA] CTD PMID:18818482 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases phosphorylation ISO Sildenafil Citrate results in increased phosphorylation of TRPC6 protein CTD PMID:20177073 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Sildenafil Citrate results in increased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Sildenafil Citrate results in increased expression of TXN1 CTD PMID:18373738 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VCAM1 protein] CTD PMID:32959702 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 EXP Sildenafil Citrate results in increased expression of VEGFA mRNA; Sildenafil Citrate results in increased expression of VEGFA protein
Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein]; Sildenafil Citrate inhibits the reaction [Aflatoxin B1 results in increased expression of VEGFA mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA protein]		 CTD PMID:18373738 PMID:20583517 PMID:30974023 PMID:32959702 PMID:35608386 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfb vascular endothelial growth factor B increases expression EXP Sildenafil Citrate results in increased expression of VEGFB mRNA CTD PMID:20583517 NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944 		JBrowse link
G Vegfc vascular endothelial growth factor C increases expression EXP Sildenafil Citrate results in increased expression of VEGFC mRNA CTD PMID:20583517 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pharmaceutical 19518
          drug 19538
            cardiovascular drug 8649
              vasodilator agent 6030
                sildenafil 77
                  sildenafil citrate 77
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      chalcogen 19577
                        oxygen atom 19549
                          oxygen molecular entity 19529
                            hydroxides 19334
                              oxoacid 18791
                                chalcogen oxoacid 13796
                                  sulfur oxoacid 13585
                                    sulfonic acid 11613
                                      sulfonic acid derivative 11634
                                        sulfonamide 5322
                                          sildenafil 77
                                            sildenafil citrate 77
paths to the root