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Gene: Pde8b (phosphodiesterase 8B) Rattus norvegicus
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Symbol: Pde8b
Name: phosphodiesterase 8B
Description: Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cAMP-specific cyclic nucleotide phosphodiesterase PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; RNPDE8B
Orthologs:
Homo sapiens (human) : PDE8B (phosphodiesterase 8B)  HGNC  Alliance
Mus musculus (house mouse) : Pde8b (phosphodiesterase 8B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde8b (phosphodiesterase 8B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE8B (phosphodiesterase 8B)
Canis lupus familiaris (dog) : PDE8B (phosphodiesterase 8B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde8b (phosphodiesterase 8B)
Sus scrofa (pig) : PDE8B (phosphodiesterase 8B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0224,718,548 - 24,955,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0243,877,817 - 44,112,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,352,725 - 25,469,209 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1225,273,093 - 25,389,578 (-)NCBI
Celera222,346,017 - 22,449,253 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pde8b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735041
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.