PDE8B (phosphodiesterase 8B) - Rat Genome Database

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Gene: PDE8B (phosphodiesterase 8B) Sus scrofa
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Symbol: PDE8B
Name: phosphodiesterase 8B
RGD ID: 14258468
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred); metal ion binding (inferred); INVOLVED IN behavioral fear response (ortholog); negative regulation of insulin secretion (ortholog); negative regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH basal ganglia disease (ortholog); congenital adrenal hyperplasia (ortholog); Dysarthria (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1286,007,190 - 86,323,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,703,295 - 87,929,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Genomics

Comparative Map Data
PDE8B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1286,007,190 - 86,323,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,703,295 - 87,929,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE8B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl577,210,449 - 77,428,256 (+)EnsemblGRCh38hg38GRCh38
GRCh38577,180,304 - 77,428,256 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37576,476,129 - 76,724,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,542,462 - 76,758,999 (+)NCBINCBI36hg18NCBI36
Build 34576,542,461 - 76,758,982NCBI
Celera572,400,947 - 72,618,614 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef571,713,174 - 71,930,868 (+)NCBIHuRef
CHM1_1575,940,448 - 76,157,815 (+)NCBICHM1_1
Pde8b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,160,613 - 95,386,904 (-)NCBIGRCm39mm39
GRCm39 Ensembl1395,160,962 - 95,386,844 (-)Ensembl
GRCm381395,024,105 - 95,250,401 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,024,454 - 95,250,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv371395,794,060 - 96,020,259 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,125,209 - 96,356,676 (-)NCBImm8
Celera1398,642,301 - 98,869,729 (-)NCBICelera
Cytogenetic Map13D1NCBI
Pde8b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,275,117 - 26,479,725 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl226,276,635 - 26,509,209 (-)Ensembl
Rnor_6.0224,718,548 - 24,955,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl224,719,976 - 24,923,128 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0243,877,817 - 44,112,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,352,725 - 25,469,209 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1225,273,093 - 25,389,578 (-)NCBI
Celera222,346,017 - 22,449,253 (-)NCBICelera
Cytogenetic Map2q12NCBI
Pde8b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542523,512,865 - 23,614,326 (-)NCBIChiLan1.0ChiLan1.0
PDE8B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1538,401,194 - 38,617,737 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0537,874,089 - 38,121,322 (-)NCBIMhudiblu_PPA_v0panPan3
PDE8B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,289,867 - 29,432,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,291,549 - 29,432,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha330,529,732 - 30,795,035 (-)NCBI
ROS_Cfam_1.0329,211,247 - 29,477,045 (-)NCBI
UMICH_Zoey_3.1329,145,547 - 29,411,320 (-)NCBI
UNSW_CanFamBas_1.0329,126,263 - 29,366,339 (-)NCBI
UU_Cfam_GSD_1.0329,457,265 - 29,761,295 (-)NCBI
Pde8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213185,408,778 - 185,646,290 (-)NCBI
SpeTri2.0NW_0049365495,212,693 - 5,450,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE8B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,425,722 - 71,668,747 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604920,170,235 - 20,506,517 (+)NCBIVero_WHO_p1.0
Pde8b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248691,695,362 - 1,936,097 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 7
Low 9 2 3 5 1 16 2 3 1
Below cutoff 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: XM_013994908   ⟹   XP_013850362
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,087,147 - 86,323,752 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084465   ⟹   XP_020940124
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,087,066 - 86,323,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084466   ⟹   XP_020940125
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,087,066 - 86,323,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084467   ⟹   XP_020940126
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,087,147 - 86,322,479 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084468   ⟹   XP_020940127
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,007,190 - 86,323,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084469   ⟹   XP_020940128
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,007,191 - 86,323,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084470   ⟹   XP_020940129
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,046,158 - 86,323,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084471   ⟹   XP_020940130
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,046,158 - 86,323,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084472   ⟹   XP_020940131
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1286,046,118 - 86,323,738 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020940127   ⟸   XM_021084468
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020940128   ⟸   XM_021084469
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_020940131   ⟸   XM_021084472
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_020940129   ⟸   XM_021084470
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_020940130   ⟸   XM_021084471
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_020940124   ⟸   XM_021084465
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020940125   ⟸   XM_021084466
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013850362   ⟸   XM_013994908
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020940126   ⟸   XM_021084467
- Peptide Label: isoform X4
- Sequence:
Protein Domains
PAS   PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014097 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014990 UniProtKB/TrEMBL
  ENSSSCP00000036186 UniProtKB/TrEMBL
  ENSSSCP00000043371 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000060141 UniProtKB/TrEMBL
  ENSSSCP00000068009 UniProtKB/TrEMBL
  ENSSSCP00000068619 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015399 UniProtKB/TrEMBL
  ENSSSCT00000038239 UniProtKB/TrEMBL
  ENSSSCT00000051115 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000073788 UniProtKB/TrEMBL
  ENSSSCT00000078031 UniProtKB/TrEMBL
  ENSSSCT00000080168 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
  PDEase_PDE8 UniProtKB/TrEMBL
NCBI Gene PDE8B ENTREZGENE
Pfam PAS_9 UniProtKB/TrEMBL
  PDE8 UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PAS UniProtKB/TrEMBL
  PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF55785 UniProtKB/TrEMBL
TIGRFAMs sensory_box UniProtKB/TrEMBL
UniProt A0A286ZWX2_PIG UniProtKB/TrEMBL
  A0A287AHK6_PIG UniProtKB/TrEMBL
  A0A5G2Q8E4_PIG UniProtKB/TrEMBL
  A0A5G2RBL7_PIG UniProtKB/TrEMBL
  A0A5G2RD51_PIG UniProtKB/TrEMBL
  F1S2G7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:100321 ENTREZGENE