PDE8B (phosphodiesterase 8B) - Rat Genome Database

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Gene: PDE8B (phosphodiesterase 8B) Pan paniscus
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Symbol: PDE8B
Name: phosphodiesterase 8B
RGD ID: 11676420
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred); hydrolase activity (inferred); INVOLVED IN behavioral fear response (ortholog); negative regulation of insulin secretion (ortholog); negative regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH basal ganglia disease (ortholog); congenital adrenal hyperplasia (ortholog); Dysarthria (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2437,864,204 - 38,117,980 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,024,360 - 36,271,607 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0537,874,089 - 38,121,322 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,401,194 - 38,617,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,402,790 - 38,617,743 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDE8B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2437,864,204 - 38,117,980 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,024,360 - 36,271,607 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0537,874,089 - 38,121,322 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,401,194 - 38,617,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,402,790 - 38,617,743 (-)Ensemblpanpan1.1panPan2
PDE8B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38577,086,715 - 77,428,256 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl577,086,732 - 77,427,124 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl577,210,449 - 77,428,256 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,382,540 - 76,724,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,542,462 - 76,758,999 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,542,461 - 76,758,982NCBI
Celera572,400,947 - 72,618,614 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,713,174 - 71,930,868 (+)NCBIHuRef
CHM1_1575,940,448 - 76,157,815 (+)NCBICHM1_1
T2T-CHM13v2.0577,568,346 - 77,910,865 (+)NCBIT2T-CHM13v2.0
Pde8b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,160,962 - 95,386,904 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,160,962 - 95,386,844 (-)EnsemblGRCm39 Ensembl
GRCm381395,024,105 - 95,250,401 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,024,454 - 95,250,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv371395,794,060 - 96,020,259 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,125,209 - 96,356,676 (-)NCBIMGSCv36mm8
Celera1398,642,301 - 98,869,729 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.22NCBI
Pde8b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,009,841 - 28,244,050 (-)NCBIGRCr8
mRatBN7.2226,275,117 - 26,479,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,276,635 - 26,509,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,312,032 - 33,416,252 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,412,277 - 31,516,497 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,230,581 - 26,334,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0224,718,548 - 24,955,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl224,719,976 - 24,923,128 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0243,877,817 - 44,112,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,352,725 - 25,469,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,273,093 - 25,389,578 (-)NCBI
Celera222,346,017 - 22,449,253 (-)NCBICelera
Cytogenetic Map2q12NCBI
Pde8b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542523,512,151 - 23,635,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542523,512,865 - 23,614,326 (-)NCBIChiLan1.0ChiLan1.0
PDE8B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,289,867 - 29,432,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,291,549 - 29,432,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha330,529,732 - 30,795,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,211,247 - 29,477,045 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,212,086 - 29,476,198 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,145,547 - 29,411,320 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,126,263 - 29,366,339 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,457,265 - 29,761,295 (-)NCBIUU_Cfam_GSD_1.0
Pde8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213185,408,778 - 185,646,290 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365495,212,834 - 5,448,515 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365495,212,693 - 5,450,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE8B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,949,174 - 86,323,795 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1286,007,190 - 86,323,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,703,295 - 87,929,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE8B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,425,722 - 71,668,747 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,456,017 - 71,668,437 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604920,170,235 - 20,506,517 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde8b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,695,480 - 1,936,048 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,695,362 - 1,936,097 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000051337   ⟹   ENSPPAP00000028490
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,790 - 38,617,743 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000051345   ⟹   ENSPPAP00000028498
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,882 - 38,617,741 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000051348   ⟹   ENSPPAP00000028501
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,882 - 38,617,741 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000051349   ⟹   ENSPPAP00000028502
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,882 - 38,617,741 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000051351   ⟹   ENSPPAP00000028504
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,882 - 38,617,741 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000051355   ⟹   ENSPPAP00000028508
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,882 - 38,517,454 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000051356   ⟹   ENSPPAP00000028509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,882 - 38,517,454 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000051357   ⟹   ENSPPAP00000028510
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl538,402,882 - 38,418,973 (-)Ensembl
RefSeq Acc Id: XM_008965078   ⟹   XP_008963326
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,087,999 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,241,617 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,091,239 (-)NCBI
PanPan1.1538,401,194 - 38,617,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014344880   ⟹   XP_014200366
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,087,998 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,241,616 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,091,239 (-)NCBI
PanPan1.1538,401,194 - 38,617,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014344882   ⟹   XP_014200368
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,087,997 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,241,615 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,091,239 (-)NCBI
PanPan1.1538,401,255 - 38,617,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024928744   ⟹   XP_024784512
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,088,001 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,241,618 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,091,324 (-)NCBI
PanPan1.1538,401,194 - 38,617,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034959916   ⟹   XP_034815807
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,088,001 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,241,618 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,091,324 (-)NCBI
RefSeq Acc Id: XM_034959918   ⟹   XP_034815809
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,087,999 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,241,617 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,091,324 (-)NCBI
RefSeq Acc Id: XM_034959919   ⟹   XP_034815810
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,087,998 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,241,616 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,091,239 (-)NCBI
RefSeq Acc Id: XM_034959920   ⟹   XP_034815811
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,117,974 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,271,601 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,121,317 (-)NCBI
RefSeq Acc Id: XM_034959921   ⟹   XP_034815812
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,117,980 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,271,607 (-)NCBI
Mhudiblu_PPA_v0537,874,089 - 38,121,322 (-)NCBI
RefSeq Acc Id: XM_057302282   ⟹   XP_057158265
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 38,117,974 (-)NCBI
NHGRI_mPanPan1536,024,360 - 36,271,601 (-)NCBI
RefSeq Acc Id: XM_063604201   ⟹   XP_063460271
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2437,864,204 - 37,998,829 (-)NCBI
RefSeq Acc Id: XP_014200366   ⟸   XM_014344880
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BGT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008963326   ⟸   XM_008965078
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BGT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014200368   ⟸   XM_014344882
- Peptide Label: isoform X6
- UniProtKB: A0A2R9BFT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024784512   ⟸   XM_024928744
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BGT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034815812   ⟸   XM_034959921
- Peptide Label: isoform X9
- UniProtKB: A0A2R9BGU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034815811   ⟸   XM_034959920
- Peptide Label: isoform X8
- UniProtKB: A0A2R9BGU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034815807   ⟸   XM_034959916
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BGT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034815809   ⟸   XM_034959918
- Peptide Label: isoform X5
- UniProtKB: A0A2R9BFT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034815810   ⟸   XM_034959919
- Peptide Label: isoform X7
- UniProtKB: A0A2R9BFT2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000028510   ⟸   ENSPPAT00000051357
Ensembl Acc Id: ENSPPAP00000028508   ⟸   ENSPPAT00000051355
Ensembl Acc Id: ENSPPAP00000028509   ⟸   ENSPPAT00000051356
Ensembl Acc Id: ENSPPAP00000028498   ⟸   ENSPPAT00000051345
Ensembl Acc Id: ENSPPAP00000028502   ⟸   ENSPPAT00000051349
Ensembl Acc Id: ENSPPAP00000028501   ⟸   ENSPPAT00000051348
Ensembl Acc Id: ENSPPAP00000028504   ⟸   ENSPPAT00000051351
Ensembl Acc Id: ENSPPAP00000028490   ⟸   ENSPPAT00000051337
RefSeq Acc Id: XP_057158265   ⟸   XM_057302282
- Peptide Label: isoform X11
- UniProtKB: A0A2R9BFT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063460271   ⟸   XM_063604201
- Peptide Label: isoform X10
- UniProtKB: A0A2R9BFR9 (UniProtKB/TrEMBL),   A0A2R9BGU1 (UniProtKB/TrEMBL)
Protein Domains
PAS   PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037153 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051337.1 UniProtKB/TrEMBL
  ENSPPAT00000051345.1 UniProtKB/TrEMBL
  ENSPPAT00000051348.1 UniProtKB/TrEMBL
  ENSPPAT00000051349.1 UniProtKB/TrEMBL
  ENSPPAT00000051351.1 UniProtKB/TrEMBL
  ENSPPAT00000051355.1 UniProtKB/TrEMBL
  ENSPPAT00000051356.1 UniProtKB/TrEMBL
  ENSPPAT00000051357.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
KEGG Report pps:100973493 UniProtKB/TrEMBL
NCBI Gene PDE8B ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam PAS_9 UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PAS UniProtKB/TrEMBL
  PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A2R9BFR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BFT2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BFT7_PANPA UniProtKB/TrEMBL
  A0A2R9BFV2_PANPA UniProtKB/TrEMBL
  A0A2R9BGT2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BGU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BJL1_PANPA UniProtKB/TrEMBL
  A0A2R9BPC9_PANPA UniProtKB/TrEMBL