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gingerol - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gingerol
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Accession:CHEBI:10136 term browser browse the term
Definition:A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.
Synonyms:exact_synonym: (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
 related_synonym: (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone;   (S)-(6)-Gingerol;   6-Gingerol;   Formula=C17H26O4;   InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1;   InChIKey=NLDDIKRKFXEWBK-AWEZNQCLSA-N;   SMILES=CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1
 xref: CAS:23513-14-6;   HMDB:HMDB0005783;   KEGG:C10462;   KNApSAcK:C00002748;   LINCS:LSM-2569
 xref_mesh: MESH:C007845
 xref: MetaCyc:CPD-13494;   PMID:22719783;   PMID:23369342;   PMID:23437345;   PMID:23519881;   Reaxys:5287467;   Wikipedia:Gingerol

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gingerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:18385293 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 PMID:21851089 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:27451028 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein CTD PMID:19481070 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein] CTD PMID:37121058 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein] CTD PMID:18577375 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]
gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]; gingerol inhibits the reaction [TNF protein results in increased expression of BAX protein]
gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Bax protein in neural crest-derived cells] 		CTD
RGD		 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 PMID:37121058 More... RGD:155882488 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]
gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bcl2 protein in neural crest-derived cells] 		CTD
RGD		 PMID:18030663 PMID:19481070 PMID:25034532 PMID:27451028 PMID:28249781 More... RGD:155882488 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bdnf protein in neural crest-derived cells] RGD PMID:34962339 RGD:155882488 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein CTD PMID:27451028 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein] CTD PMID:25034532 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein] CTD PMID:18030663 PMID:25034532 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
affects activity
increases cleavage 		ISO
EXP 		gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]
gingerol affects the activity of CASP3 protein
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of CASP3 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]
gingerol results in increased cleavage of CASP3 protein 		CTD PMID:17454143 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
affects activity
increases cleavage 		ISO [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]
gingerol affects the activity of CASP8 protein
gingerol results in increased cleavage of CASP8 protein 		CTD PMID:17454143 PMID:25034532 PMID:28249781 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
affects activity
multiple interactions
increases cleavage 		ISO gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein
gingerol affects the activity of CASP9 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein]
gingerol results in increased cleavage of CASP9 protein 		CTD PMID:17454143 PMID:18030663 PMID:19481070 PMID:28249781 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions ISO
EXP 		gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein] 		CTD PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein CTD PMID:28249781 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
increases expression 		ISO [gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein
gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein
gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein 		CTD PMID:18058799 PMID:26498061 PMID:28249781 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein CTD PMID:28249781 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO gingerol results in decreased expression of CDK1 mRNA CTD PMID:28249781 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO gingerol results in decreased expression of CDK4 protein CTD PMID:18058799 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO gingerol results in decreased expression of CDKN1A mRNA CTD PMID:28249781 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO gingerol results in decreased expression of CDKN1B mRNA CTD PMID:28249781 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions 		ISO gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein] 		CTD PMID:26498061 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein] CTD PMID:25034532 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] CTD PMID:28988496 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization
multiple interactions
increases expression 		ISO gingerol affects the localization of CTNNB1 protein
gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
gingerol results in increased expression of and affects the localization of CTNNB1 protein
gingerol results in increased expression of CTNNB1 mRNA 		CTD PMID:18058799 PMID:26498061 PMID:27645308 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases response to substance ISO CYP2C19 mRNA results in increased susceptibility to gingerol CTD PMID:29555536 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO gingerol results in increased expression of DUSP10 mRNA CTD PMID:17151092 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 increases expression ISO gingerol results in increased expression of DVL2 mRNA CTD PMID:26498061 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Fas Fas cell surface death receptor affects activity ISO gingerol affects the activity of FAS protein CTD PMID:17454143 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein CTD PMID:26498061 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:21829520 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] CTD PMID:28421826 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions 		ISO gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein
GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] 		CTD PMID:18058799 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression
increases phosphorylation
increases response to substance 		ISO gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]
gingerol results in increased expression of GSK3B protein
gingerol results in increased phosphorylation of GSK3B protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
GSK3B protein results in increased susceptibility to gingerol 		CTD PMID:18058799 PMID:26498061 PMID:27645308 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A decreases activity ISO gingerol results in decreased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] 		CTD PMID:27645308 PMID:28421826 PMID:31004597 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] CTD PMID:22285432 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO gingerol inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased secretion of INS1 protein] CTD PMID:21851089 PMID:22285432 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:22285432 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] CTD PMID:22285432 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:18577375 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klkb1 kallikrein B1 multiple interactions
decreases expression 		ISO gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]
gingerol results in decreased expression of KLKB1 protein 		CTD PMID:18030663 NCBI chr16:53,690,180...53,714,570
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression ISO gingerol results in increased expression of LATS1 protein CTD PMID:32926756 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein] CTD PMID:28421826 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Lep leptin multiple interactions ISO gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] CTD PMID:28421826 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression ISO gingerol results in increased expression of LRP6 mRNA CTD PMID:26498061 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form CTD PMID:27451028 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:18577375 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mir210 microRNA 210 multiple interactions ISO gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Mir210 miRNA in neural crest-derived cells] RGD PMID:34962339 RGD:155882488 NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases activity
multiple interactions 		ISO gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein
gingerol results in decreased activity of MMP2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein] 		CTD PMID:17683926 PMID:32926756 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity 		ISO gingerol results in decreased expression of MMP9 mRNA
gingerol results in decreased activity of MMP9 protein 		CTD PMID:17683926 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP
ISO 		gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] 		CTD PMID:28373059 PMID:28421826 PMID:31004597 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression 		ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]
gingerol results in decreased expression of MTOR protein modified form 		CTD PMID:27451028 PMID:28249781 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO gingerol affects the phosphorylation of and affects the activity of NFKBIA protein CTD PMID:17454143 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:18683823 PMID:31004597 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] CTD PMID:25034532 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression 		ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein 		CTD PMID:22285432 PMID:26498061 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Ptges prostaglandin E synthase decreases expression
increases expression 		ISO gingerol results in decreased expression of PTGES protein
gingerol results in increased expression of PTGES mRNA 		CTD PMID:27645308 NCBI chr 3:34,575,643...34,586,987 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions 		ISO gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] 		CTD PMID:17454143 PMID:18683823 PMID:31004597 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO gingerol results in decreased phosphorylation of RB1 protein CTD PMID:18058799 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression
affects localization
multiple interactions 		ISO gingerol affects the expression of RELA protein
gingerol affects the localization of RELA protein
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; gingerol inhibits the reaction [TNF protein results in increased expression of RELA protein] 		CTD PMID:17454143 PMID:18683823 PMID:37121058 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO gingerol results in decreased expression of RPS6KB1 protein modified form CTD PMID:28249781 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein] CTD PMID:22285432 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA] CTD PMID:21829520 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression
multiple interactions 		ISO gingerol results in decreased expression of SNAI2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein] 		CTD PMID:32926756 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] CTD PMID:21382473 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of BAX protein]; gingerol inhibits the reaction [TNF protein results in increased expression of CASP3 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of RELA protein]; gingerol inhibits the reaction [TNF protein results in increased expression of TRP53 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein] 		CTD PMID:18577375 PMID:21851089 PMID:22285432 PMID:28373059 PMID:28421826 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance 		ISO [gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] CTD PMID:25034532 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions 		ISO gingerol results in increased expression of TP53 protein
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TP53 protein]; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of TRP53 protein] 		CTD PMID:18030663 PMID:25034532 PMID:28988496 PMID:37121058 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin decreases expression
multiple interactions 		ISO gingerol results in decreased expression of VIM protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein] 		CTD PMID:32926756 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO gingerol results in decreased expression of XIAP protein CTD PMID:25034532 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator affects localization
multiple interactions 		ISO gingerol affects the localization of YAP1 protein
[gingerol co-treated with YAP1 protein] results in increased phosphorylation of YAP1 protein; gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]; gingerol results in decreased expression of and results in increased phosphorylation of YAP1 protein 		CTD PMID:32926756 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        pharmaceutical 20413
          drug 20413
            antineoplastic agent 18066
              gingerol 80
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                carbocyclic compound 18977
                                  benzenoid aromatic compound 18460
                                    benzenes 18331
                                      methoxybenzenes 2959
                                        monomethoxybenzene 1947
                                          guaiacols 1396
                                            gingerol 80
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