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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GW 7647
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Accession:CHEBI:70778 term browser browse the term
Definition:A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.
Synonyms:exact_synonym: 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid
 related_synonym: 2-((4-(2-(1-cyclohexylbutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-(4-(2-(1-(4-cyclohexylbutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-(4-(2-(1-(cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-({4-{2-{{(cyclohexylamino)carbonyl}(4-cyclohexylbutyl)amino}ethyl}phenyl}thio)-2-methylpropanoic acid;   Formula=C29H46N2O3S;   GW7647;   InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33);   InChIKey=PKNYXWMTHFMHKD-UHFFFAOYSA-N;   SMILES=CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O
 xref: CAS:265129-71-3;   KEGG:C15622;   LINCS:LSM-4172
 xref_mesh: MESH:C453899
 xref: PMID:14654352;   PMID:16839165;   PMID:17434479;   PMID:21443859;   PMID:21742490;   PMID:22465071;   PMID:23008696;   Reaxys:8955332


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GW 7647 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases expression		 ISO
EXP		 GW 7647 results in increased expression of ABCB1 mRNA
GW 7647 results in decreased expression of ABCB1A mRNA		 CTD PMID:31628012 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression
multiple interactions		 ISO GW 7647 results in increased expression of ACAA1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACAA1 mRNA		 CTD PMID:30611723 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of ACAA2 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACAA2 mRNA		 CTD PMID:30611723 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of ACADL mRNA CTD PMID:30611723 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO
EXP		 GW 7647 results in increased expression of ACADM mRNA CTD PMID:30611723 PMID:31628012 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of ACADS mRNA
GW 7647 results in increased expression of ACADS mRNA		 CTD PMID:30611723 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression
multiple interactions		 ISO GW 7647 results in increased expression of ACADVL mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACADVL mRNA		 CTD PMID:30611723 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO GW 7647 results in increased expression of ACOT1 mRNA CTD PMID:30611723 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acot12 acyl-CoA thioesterase 12 multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of ACOT12 mRNA
GW 7647 results in increased expression of ACOT12 mRNA		 CTD PMID:30611723 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of ACOT4 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACOT4 mRNA		 CTD PMID:30611723 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of ACOX1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA
GW 6471 inhibits the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of ACOX1 mRNA]		 CTD PMID:21324916 PMID:23014847 PMID:30611723 PMID:31437187 PMID:34081128 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acox2 acyl-CoA oxidase 2 multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of ACOX2 mRNA
GW 7647 results in increased expression of ACOX2 mRNA		 CTD PMID:30611723 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP GW 7647 results in increased expression of ACSL1 mRNA CTD PMID:31628012 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression ISO GW 7647 results in increased expression of ACSL3 mRNA CTD PMID:30611723 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of ACSL4 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACSL4 mRNA		 CTD PMID:30611723 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions
decreases expression
increases expression		 ISO
EXP		 [GW 7647 co-treated with Oleic Acid] results in increased expression of ACSL5 mRNA
GW 7647 results in decreased expression of ACSL5 mRNA
GW 7647 results in increased expression of ACSL5 mRNA		 CTD PMID:30611723 PMID:31628012 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO GW 6471 inhibits the reaction [[GW 7647 co-treated with PPARA protein] results in increased expression of ADIPOQ mRNA] CTD PMID:21324916 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 increases expression ISO GW 7647 results in increased expression of AGPAT1 mRNA CTD PMID:30611723 NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of AGPAT2 mRNA
GW 7647 results in increased expression of AGPAT2 mRNA		 CTD PMID:30611723 NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371 		JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO GW 7647 results in increased expression of APOA1 mRNA; GW 7647 results in increased expression of APOA1 protein CTD PMID:19445040 PMID:31676336 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa5 apolipoprotein A5 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of APOA5 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of APOA5 mRNA		 CTD PMID:30611723 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816 		JBrowse link
G Apob apolipoprotein B multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of APOB mRNA CTD PMID:30611723 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc4 apolipoprotein C4 decreases expression
multiple interactions		 ISO GW 7647 results in decreased expression of APOC4 mRNA
[GW 7647 co-treated with Oleic Acid] results in decreased expression of APOC4 mRNA		 CTD PMID:30611723 NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of APOE mRNA CTD PMID:30611723 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression
increases expression		 EXP
ISO		 GW 7647 results in decreased expression of AVPR1A mRNA
GW 7647 results in increased expression of AVPR1A mRNA		 CTD PMID:31628012 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO GW 7647 inhibits the reaction [IFNG results in increased expression of CCL2 mRNA] CTD PMID:21268089 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of CD36 mRNA
GW 7647 results in increased expression of CD36 mRNA		 CTD PMID:30611723 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 increases expression ISO GW 7647 results in increased expression of COX10 mRNA CTD PMID:30611723 NCBI chr10:48,630,993...48,742,805
Ensembl chr10:48,630,676...48,746,667 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions		 EXP
ISO		 GW 7647 results in increased expression of CPT1A mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of CPT1A mRNA		 CTD PMID:19631232 PMID:27226639 PMID:30611723 PMID:31676336 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
increases expression		 ISO GW 6471 inhibits the reaction [GW 7647 results in increased expression of CPT1B mRNA]; GW 7647 promotes the reaction [PPARA protein binds to CPT1B promoter]; PPARA protein promotes the reaction [GW 7647 results in increased expression of CPT1B mRNA] CTD PMID:21324916 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of CPT2 mRNA
GW 7647 results in increased expression of CPT2 mRNA		 CTD PMID:30611723 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP GW 7647 promotes the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:19631232 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of CYP2B6 mRNA
GW 7647 results in increased expression of CYP2B6 mRNA		 CTD PMID:30611723 PMID:31676336 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP GW 7647 results in increased expression of CYP4A1 mRNA CTD PMID:23315828 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression ISO GW 7647 results in increased expression of DGAT2 mRNA CTD PMID:30611723 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Dhdds dehydrodolichyl diphosphate synthase subunit multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of DHDDS mRNA
GW 7647 results in increased expression of DHDDS mRNA		 CTD PMID:30611723 NCBI chr 5:146,198,359...146,224,479
Ensembl chr 5:146,197,457...146,224,454 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
multiple interactions		 ISO GW 7647 results in increased activity of DIO2 protein
PPARG protein promotes the reaction [GW 7647 results in increased activity of DIO2 protein]		 CTD PMID:19036883 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G E2f5 E2F transcription factor 5 decreases expression EXP GW 7647 results in decreased expression of E2F5 mRNA CTD PMID:31628012 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO GW 7647 results in increased expression of ECH1 mRNA CTD PMID:30611723 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression ISO GW 7647 results in increased expression of ECHS1 mRNA CTD PMID:30611723 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO GW 7647 results in increased expression of EHHADH mRNA CTD PMID:30611723 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 increases expression ISO GW 7647 results in increased expression of ELOVL1 mRNA CTD PMID:30611723 NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression ISO GW 7647 results in increased expression of ELOVL5 mRNA CTD PMID:30611723 NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases activity ISO GW 7647 results in decreased activity of EPHX2 protein CTD PMID:15798002 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression EXP GW 7647 results in decreased expression of ETS1 mRNA CTD PMID:31628012 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Fa2h fatty acid 2-hydroxylase increases expression ISO GW 7647 results in increased expression of FA2H mRNA CTD PMID:23535410 NCBI chr19:39,312,904...39,364,153
Ensembl chr19:39,312,906...39,364,153 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO
EXP		 GW 7647 results in increased expression of FABP1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of FABP1 mRNA		 CTD PMID:30611723 PMID:31628012 PMID:31676336 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression		 ISO GW 6471 inhibits the reaction [PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA]]; GW 7647 promotes the reaction [PPARA protein binds to FABP4 promoter]; PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA] CTD PMID:21324916 PMID:31437187 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of FASN mRNA
GW 7647 results in increased expression of FASN mRNA		 CTD PMID:30611723 PMID:31437187 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
increases expression		 ISO indolo(3,2-b)carbazole inhibits the reaction [GW 7647 results in increased expression of FGF21 mRNA] CTD PMID:27226639 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fhl3 four and a half LIM domains 3 decreases expression EXP GW 7647 results in decreased expression of FHL3 mRNA CTD PMID:31628012 NCBI chr 5:136,953,947...136,961,317
Ensembl chr 5:136,950,411...136,961,317 		JBrowse link
G Fnta farnesyltransferase, CAAX box, subunit alpha increases expression ISO GW 7647 results in increased expression of FNTA mRNA CTD PMID:30611723 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460 		JBrowse link
G Gng12 G protein subunit gamma 12 increases expression
decreases expression		 ISO
EXP		 GW 7647 results in increased expression of GNG12 mRNA
GW 7647 results in decreased expression of GNG12 mRNA		 CTD PMID:31628012 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of GPAT3 mRNA
GW 7647 results in increased expression of GPAT3 mRNA		 CTD PMID:30611723 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP GW 7647 results in increased expression of GPT protein CTD PMID:31628012 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
decreases expression		 ISO
EXP		 GW 7647 results in increased expression of GPX3 mRNA
GW 7647 results in decreased expression of GPX3 mRNA		 CTD PMID:31628012 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
decreases expression		 EXP
ISO		 GW 7647 results in increased expression of GSTA1 mRNA
GW 7647 results in decreased expression of GSTA1 mRNA		 CTD PMID:31628012 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression ISO GW 7647 results in increased expression of HADH mRNA CTD PMID:30611723 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
multiple interactions		 ISO GW 7647 results in increased expression of HADHA mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of HADHA mRNA; GW 7647 promotes the reaction [Oleic Acid results in increased expression of HADHA mRNA]		 CTD PMID:30611723 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of HADHB mRNA; GW 7647 promotes the reaction [Oleic Acid results in increased expression of HADHB mRNA]; Oleic Acid promotes the reaction [GW 7647 results in increased expression of HADHB mRNA] CTD PMID:30611723 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression EXP GW 7647 results in decreased expression of HES6 mRNA CTD PMID:31628012 NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of HMGCR mRNA CTD PMID:30611723 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP
ISO		 GW 7647 results in increased expression of HMGCS2 mRNA CTD PMID:23315828 PMID:31437187 PMID:31628012 PMID:31676336 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Ifng interferon gamma multiple interactions ISO GW 7647 inhibits the reaction [IFNG results in increased expression of CCL2 mRNA] CTD PMID:21268089 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO GW 7647 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B protein] CTD PMID:28673093 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of IL6 mRNA
GW 7647 results in decreased expression of IL6 mRNA		 CTD PMID:30611723 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]
PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]]		 CTD PMID:21324916 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO GW 7647 results in increased expression of INSIG1 mRNA CTD PMID:31437187 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO GW 7647 results in increased expression of LPL mRNA CTD PMID:31437187 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase increases expression ISO GW 7647 results in increased expression of MECR mRNA CTD PMID:30611723 NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863 		JBrowse link
G Mid1 midline 1 decreases expression
increases expression		 EXP
ISO		 GW 7647 results in decreased expression of MID1 mRNA
GW 7647 results in increased expression of MID1 mRNA		 CTD PMID:31628012 NCBI chr  X:24,116,674...24,491,205
Ensembl chr  X:24,120,293...24,248,353 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA CTD PMID:30611723 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of MTTP mRNA CTD PMID:30611723 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Mxd4 Max dimerization protein 4 decreases expression EXP GW 7647 results in decreased expression of MXD4 mRNA CTD PMID:31628012 NCBI chr14:76,562,105...76,576,224
Ensembl chr14:76,561,774...76,576,221 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 ISO PPARA gene mutant form inhibits the reaction [GW 7647 results in increased expression of MYC protein] CTD PMID:34081128 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; lactacystin inhibits the reaction [GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:17891158 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of NR0B2 mRNA
GW 7647 results in decreased expression of NR0B2 mRNA		 CTD PMID:30611723 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO GW 7647 results in decreased expression of NR1H4 mRNA CTD PMID:30611723 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
multiple interactions		 EXP
ISO		 GW 7647 results in increased expression of NR1I3 mRNA
[GW 7647 co-treated with Oleic Acid] results in decreased expression of NR1I3 mRNA
GW 7647 promotes the reaction [Phenobarbital results in increased expression of NR1I3 mRNA]		 CTD PMID:19631232 PMID:30611723 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nrip3 nuclear receptor interacting protein 3 decreases expression EXP GW 7647 results in decreased expression of NRIP3 mRNA CTD PMID:31628012 NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600 		JBrowse link
G Onecut1 one cut homeobox 1 decreases expression EXP GW 7647 results in decreased expression of ONECUT1 mRNA CTD PMID:31628012 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of PCK1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of PCK1 mRNA		 CTD PMID:30611723 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO GW 7647 results in increased expression of PDK4 mRNA CTD PMID:31437187 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of PECR mRNA CTD PMID:30611723 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 decreases expression EXP GW 7647 results in decreased expression of PIAS3 mRNA CTD PMID:31628012 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480 		JBrowse link
G Pla1a phospholipase A1 member A decreases expression
increases expression		 EXP
ISO		 GW 7647 results in decreased expression of PLA1A mRNA
GW 7647 results in increased expression of PLA1A mRNA		 CTD PMID:31628012 NCBI chr11:62,320,112...62,357,779
Ensembl chr11:62,320,493...62,357,779 		JBrowse link
G Pla2g15 phospholipase A2, group XV decreases expression EXP GW 7647 results in decreased expression of PLA2G15 mRNA CTD PMID:31628012 NCBI chr19:34,050,685...34,068,070
Ensembl chr19:34,050,694...34,068,063 		JBrowse link
G Plin2 perilipin 2 multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of PLIN2 mRNA
GW 7647 results in increased expression of PLIN2 mRNA		 CTD PMID:30611723 PMID:31676336 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Plpp6 phospholipid phosphatase 6 multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of PLPP6 mRNA CTD PMID:30611723 NCBI chr 1:226,679,100...226,681,952
Ensembl chr 1:226,679,100...226,681,949 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases response to substance
affects binding
increases expression
increases activity		 ISO
EXP		 Acetaldehyde inhibits the reaction [GW 7647 results in increased activity of PPARA protein]; Ethanol inhibits the reaction [GW 7647 results in increased activity of PPARA protein]; GW 7647 binds to and results in increased activity of PPARA protein; norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein]; Quercetin inhibits the reaction [GW 7647 results in increased activity of PPARA protein]
PPARA gene mutant form results in decreased susceptibility to GW 7647
GW 7647 binds to PPARA protein
[GW 7647 results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; GW 7647 binds to and results in increased activity of PPARA protein
GW 7647 results in increased expression of PPARA mRNA
[GW 7647 binds to and results in increased activity of PPARA protein] affects the reaction [Glucose affects the abundance of Calcium]; [GW 7647 binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; [GW 7647 co-treated with PPARA protein] results in increased expression of PPARA mRNA; [PPARA protein co-treated with GW 7647] results in increased expression of PPARG mRNA; GW 6471 inhibits the reaction [[GW 7647 co-treated with PPARA protein] results in increased expression of ADIPOQ mRNA]; GW 6471 inhibits the reaction [[GW 7647 co-treated with PPARA protein] results in increased expression of PPARA mRNA]; GW 6471 inhibits the reaction [PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA]]; GW 7647 binds to and results in increased activity of PPARA protein; GW 7647 promotes the reaction [PPARA protein binds to CPT1B promoter]; GW 7647 promotes the reaction [PPARA protein binds to FABP4 promoter]; PPARA gene mutant form inhibits the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [GW 7647 results in increased expression of CYP4A10 mRNA]; PPARA gene mutant form inhibits the reaction [GW 7647 results in increased expression of MYC protein]; PPARA protein inhibits the reaction [GW 7647 results in increased abundance of Triglycerides]; PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Carbon Dioxide]; PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Fatty Acids metabolite]; PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]]; PPARA protein promotes the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of CPT1B mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of UCP3 mRNA]		 CTD PMID:17891158 PMID:18003597 PMID:18393431 PMID:19017711 PMID:19445040 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity ISO GW 7647 results in increased activity of PPARD protein CTD PMID:20143881 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity		 ISO GW 7647 binds to and results in increased activity of PPARG protein; PPARG protein promotes the reaction [GW 7647 results in increased activity of DIO2 protein]
[PPARA protein co-treated with GW 7647] results in increased expression of PPARG mRNA
GW 7647 results in increased activity of PPARG protein		 CTD PMID:19036883 PMID:20143881 PMID:21324916 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression ISO
EXP		 GW 7647 results in decreased expression of PTPRK mRNA CTD PMID:31628012 NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:16,850,576...17,103,605 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression		 ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of SCD mRNA
GW 7647 results in increased expression of SCD mRNA		 CTD PMID:30611723 PMID:31437187 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sec16b SEC16 homolog B, endoplasmic reticulum export factor increases expression
decreases expression		 ISO
EXP		 GW 7647 results in increased expression of SEC16B mRNA
GW 7647 results in decreased expression of SEC16B mRNA		 CTD PMID:31628012 NCBI chr13:69,665,757...69,727,199
Ensembl chr13:69,684,291...69,727,196 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of SLC25A20 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of SLC25A20 mRNA		 CTD PMID:30611723 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of SLC27A1 mRNA CTD PMID:30611723 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression
multiple interactions		 ISO GW 7647 results in increased expression of SLC27A2 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of SLC27A2 mRNA		 CTD PMID:30611723 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate decreases expression
increases expression		 EXP
ISO		 GW 7647 results in decreased expression of SPNS2 mRNA
GW 7647 results in increased expression of SPNS2 mRNA		 CTD PMID:31628012 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of SREBF1 mRNA CTD PMID:30611723 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tbx15 T-box transcription factor 15 decreases expression EXP GW 7647 results in decreased expression of TBX15 mRNA CTD PMID:31628012 NCBI chr 2:186,576,650...186,687,748
Ensembl chr 2:186,576,676...186,687,663 		JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions
increases expression		 ISO PPARA protein promotes the reaction [GW 7647 results in increased expression of UCP3 mRNA] CTD PMID:21324916 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions		 EXP GW 7647 results in increased expression of UGT1A3 mRNA
GW 7647 promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA]		 CTD PMID:19631232 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          agonist 18570
            PPARalpha agonist 3146
              GW 7647 103
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                urea 5571
                                                  ureas 5569
                                                    GW 7647 103
paths to the root