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Gene: Acox2 (acyl-CoA oxidase 2) Rattus norvegicus
Symbol: Acox2
Name: acyl-CoA oxidase 2
RGD ID: 628684
Description: Exhibits 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Involved in fatty acid beta-oxidation. Localizes to peroxisome. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; acyl-CoA oxidase 2, branched chain; acyl-Coenzyme A oxidase 2; acyl-Coenzyme A oxidase 2, branched chain; peroxisomal acyl-coenzyme A oxidase 2; THCA-CoA oxidase; THCCox; trihydroxycoprostanoyl-CoA oxidase
Homo sapiens (human) : ACOX2 (acyl-CoA oxidase 2)  HGNC  Alliance
Mus musculus (house mouse) : Acox2 (acyl-Coenzyme A oxidase 2, branched chain)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acox2 (acyl-CoA oxidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACOX2 (acyl-CoA oxidase 2)
Canis lupus familiaris (dog) : ACOX2 (acyl-CoA oxidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acox2 (acyl-CoA oxidase 2)
Sus scrofa (pig) : ACOX2 (acyl-CoA oxidase 2)
Chlorocebus sabaeus (African green monkey) : ACOX2 (acyl-CoA oxidase 2)
Heterocephalus glaber (naked mole-rat) : Acox2 (acyl-CoA oxidase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01518,449,304 - 18,481,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,451,144 - 18,481,470 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,418,099 - 22,449,500 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,645,349 - 18,677,855 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11518,645,348 - 18,677,855 (+)NCBI
Celera1516,620,632 - 16,652,578 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Acox2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628684
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.