mercury(0) - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	mercury(0)	go back to main search page
Accession:	CHEBI:16170	browse the term
Definition:	Elemental mercury of oxidation state zero.
Synonyms:	related_synonym:	Elemental mercury; Formula=Hg; Hg; Hg(0); Hgn; InChI=1S/Hg; InChIKey=QSHDDOUJBYECFT-UHFFFAOYSA-N; Mercury; SMILES=[Hg]; metallic mercury
	alt_id:	CHEBI:13369; CHEBI:29319; CHEBI:5713
	xref:	CAS:7439-97-6; KEGG:C01319
	xref_mesh:	MESH:D008628
	xref:	UM-BBD_compID:c0387; Wikipedia:Mercury_(element)

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Rat (558) Mouse (563) Human (579) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (4) Green Monkey (0) Naked Mole-rat (0) All
Genes (558)

mercury(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

affects expression

Mercury affects the expression of A1BG protein

NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097

G

alpha-2-macroglobulin

decreases expression

Mercury results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily A member 1

affects expression

Mercury affects the expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

multiple interactions

[ABCB1 gene SNP affects the susceptibility to Mercury] which affects the abundance of Mercury; ABCB1 gene SNP affects the susceptibility to and affects the abundance of Mercury

PMID:27262785 PMID:32946573

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

Mercury results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

increases expression
multiple interactions

Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein
ABCC1 gene SNP affects the susceptibility to and affects the abundance of Mercury

PMID:12730625 PMID:27262785

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions
affects response to substance
increases export
increases transport
affects transport

ABCC2 gene SNP affects the susceptibility to and affects the abundance of Mercury; ABCC2 protein affects the transport of [Mercury co-treated with Cysteine]; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]
ABCC2 gene mutant form affects the susceptibility to Mercury
ABCC2 protein results in increased export of Mercury
ABCC2 protein affects the transport of Mercury

PMID:21134393 PMID:23052037 PMID:23059061 PMID:24039982 PMID:25145654 More...

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 1

increases expression

Mercury results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

increases expression

Mercury results in increased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

increases expression

Mercury results in increased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetylcholinesterase

increases activity
multiple interactions

Mercury results in increased activity of ACHE protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein

PMID:10798623 PMID:37415728

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acid phosphatase 2, lysosomal

decreases expression

Mercury results in decreased expression of ACP2 mRNA

NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680

G

acyl-CoA synthetase long-chain family member 1

decreases expression

Mercury results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

actin, beta

increases expression

Mercury results in increased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

aarF domain containing kinase 5

decreases expression

Mercury analog results in decreased expression of ADCK5 mRNA

NCBI chr 7:108,301,623...108,319,439
Ensembl chr 7:108,301,415...108,319,436

G

adrenomedullin

increases expression

Mercury results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

aryl hydrocarbon receptor

multiple interactions

Mercury results in increased activity of [AHR protein binds to ARNT protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member B1

decreases expression

Mercury results in decreased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 7 member A3

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of AKR7A3 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of AKR7A3 protein

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

AKT1 substrate 1

decreases expression

Mercury results in decreased expression of AKT1S1 mRNA

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

AKT serine/threonine kinase 2

decreases expression

Mercury results in decreased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

aminolevulinate dehydratase

multiple interactions
decreases activity
affects abundance

[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury; Sodium Selenite inhibits the reaction [Mercury results in decreased activity of ALAD protein]
ALAD gene polymorphism affects the abundance of Mercury

PMID:12499120 PMID:14615064 PMID:25728017

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

albumin

increases export
multiple interactions

Mercury results in increased export of ALB protein
[Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of ALB protein

PMID:30090589 PMID:37137463

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 5 family, member A1

decreases expression

Mercury analog results in decreased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

Mercury results in decreased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

ALG3, alpha-1,3- mannosyltransferase

increases expression

Mercury results in increased expression of ALG3 mRNA

NCBI chr11:80,300,487...80,306,014
Ensembl chr11:80,300,498...80,307,912

G

alsin Rho guanine nucleotide exchange factor ALS2

increases expression

Mercury results in increased expression of ALS2 mRNA

NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737

G

ankyrin 1

decreases expression

Mercury results in decreased expression of ANK1 mRNA

NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759

G

ankyrin repeat and KH domain containing 1

increases expression

Mercury results in increased expression of ANKHD1 mRNA

NCBI chr18:28,161,882...28,260,917
Ensembl chr18:28,162,311...28,268,024

G

annexin A2

increases expression

Mercury results in increased expression of ANXA2 mRNA

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

adaptor related protein complex 2 subunit alpha 2

decreases expression

Mercury results in decreased expression of AP2A2 mRNA

NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603

G

apolipoprotein A2

affects expression

Mercury affects the expression of APOA2 protein

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein E

affects response to substance

APOE gene polymorphism affects the susceptibility to Mercury; APOE polymorphism affects the susceptibility to Mercury

PMID:12897404 PMID:23603214

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

multiple interactions
increases secretion

Estradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form]
Mercury results in increased secretion of APP protein alternative form; Mercury results in increased secretion of APP protein modified form

PMID:12182891 PMID:25673500

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 1

multiple interactions
decreases activity

Mercury inhibits the reaction [AQP1 protein results in increased transport of Water]
Mercaptoethanol inhibits the reaction [Mercury results in decreased activity of AQP1 protein]

PMID:21259319 PMID:24028651

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 10

decreases activity
affects activity

Mercury results in decreased activity of AQP10 protein
Mercury affects the activity of AQP10 protein

PMID:11573934 PMID:12084581

NCBI chr 2:175,402,609...175,407,677
Ensembl chr 2:175,403,263...175,406,815

G

aquaporin 8

multiple interactions

Mercury affects the reaction [AQP8 protein affects the transport of Water]

NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158

G

aquaporin 9

multiple interactions

Mercury inhibits the reaction [AQP9 protein results in increased transport of Water]

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

ADP-ribosylation factor 4

decreases expression

Mercury results in decreased expression of ARF4 mRNA

NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261

G

arginase 1

decreases activity

Mercury results in decreased activity of ARG1 protein

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

arginase 2

decreases activity

Mercury results in decreased activity of ARG2 protein

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho guanine nucleotide exchange factor 28

decreases expression

Mercury results in decreased expression of ARHGEF28 mRNA

NCBI chr 2:29,263,888...29,560,595
Ensembl chr 2:29,263,886...29,560,672

G

AT-rich interaction domain 1A

increases expression

Mercury results in increased expression of ARID1A mRNA

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

AT-rich interaction domain 4A

affects expression

Mercury affects the expression of ARID4A mRNA

NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

Mercury results in increased activity of [AHR protein binds to ARNT protein]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

ATPase Na+/K+ transporting subunit beta 3

increases expression

Mercury results in increased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATPase H+ transporting V1 subunit A

decreases expression

Mercury results in decreased expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ataxin 3

decreases expression

Mercury analog results in decreased expression of ATXN3 mRNA

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

ataxin 7-like 3

decreases expression

Mercury analog results in decreased expression of ATXN7L3 mRNA

NCBI chr10:87,242,843...87,250,186
Ensembl chr10:87,243,587...87,250,620

G

alpha-2-glycoprotein 1, zinc-binding

decreases expression

Mercury results in decreased expression of AZGP1 mRNA

NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091

G

BCL2-associated agonist of cell death

decreases expression

Mercury results in decreased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 6

decreases expression

Mercury results in decreased expression of BAG6 mRNA

NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657

G

B-cell scaffold protein with ankyrin repeats 1

increases expression

Mercury results in increased expression of BANK1 mRNA

NCBI chr 2:224,530,475...224,800,420
Ensembl chr 2:224,530,475...224,800,405

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Mercury results in increased expression of BAX protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]

PMID:21186712 PMID:29115570

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Mercury results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

decreases expression

Mercury results in decreased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL6 co-repressor

increases expression

Mercury results in increased expression of BCOR mRNA

NCBI chr X:10,609,756...10,729,613
Ensembl chr X:10,687,732...10,729,613

G

brain-derived neurotrophic factor

decreases expression
affects response to substance

Mercury results in decreased expression of BDNF mRNA
BDNF polymorphism affects the susceptibility to Mercury

PMID:16301096 PMID:19937285

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

basic helix-loop-helix family, member e40

increases expression

Mercury results in increased expression of BHLHE40 mRNA

PMID:17547211 PMID:19937285

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 3

increases expression

Mercury results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

bone morphogenetic protein receptor type 2

increases expression

Mercury results in increased expression of BMPR2 mRNA

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

B-Raf proto-oncogene, serine/threonine kinase

increases expression

Mercury results in increased expression of BRAF mRNA

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

Mercury results in increased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUB3 mitotic checkpoint protein

decreases expression

Mercury results in decreased expression of BUB3 mRNA

NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036

G

complement C3

affects expression

Mercury affects the expression of C3 protein

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C6

affects expression

Mercury affects the expression of C6 protein

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

cell adhesion molecule 1

decreases expression

Mercury results in decreased expression of CADM1 mRNA

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

cell adhesion molecule 2

decreases expression

Mercury analog results in decreased expression of CADM2 mRNA

NCBI chr11:4,548,367...5,525,420
Ensembl chr11:4,555,159...5,525,400

G

calmodulin 3

decreases expression

Mercury results in decreased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calpain, small subunit 1

decreases expression

Mercury analog results in decreased expression of CAPNS1 mRNA

NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795

G

capping actin protein of muscle Z-line subunit beta

increases expression

Mercury results in increased expression of CAPZB mRNA

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

carbonic anhydrase 1

decreases activity

Mercury results in decreased activity of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

decreases activity

Mercury results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

increases expression

Mercury results in increased expression of CA3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

carnosine synthase 1

decreases expression

Mercury analog results in decreased expression of CARNS1 mRNA

NCBI chr 1:201,459,061...201,470,019
Ensembl chr 1:201,459,076...201,469,845

G

caspase 1

multiple interactions

CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
increases expression
multiple interactions

Mercury results in increased activity of CASP3 protein
Mercury results in increased expression of CASP3 protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein]

PMID:16823075 PMID:21186712 PMID:29115570 PMID:37415728

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases expression
multiple interactions

Mercury results in increased expression of CASP9 protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein]

PMID:21186712 PMID:29115570

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity
multiple interactions

Mercury results in decreased activity of CAT protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; Selenium affects the reaction [Mercury results in decreased activity of CAT protein]

PMID:17176674 PMID:20143455 PMID:37415728

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cation channel, sperm associated 2

decreases expression

Mercury results in decreased expression of CATSPER2 mRNA

NCBI chr 3:108,368,654...108,389,380
Ensembl chr 3:108,368,668...108,388,050

G

caveolae associated protein 2

decreases expression

Mercury analog results in decreased expression of CAVIN2 mRNA

NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147

G

chromobox 7

decreases expression

Mercury analog results in decreased expression of CBX7 mRNA

NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973

G

C-C motif chemokine ligand 12

increases expression

Mercury results in increased expression of CCL12 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 3

increases expression
multiple interactions

Mercury results in increased expression of CCL3 mRNA
MT3 protein affects the reaction [Mercury results in increased expression of CCL3 mRNA]

PMID:12730625 PMID:30103553

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 7

multiple interactions

[MT3 protein affects the susceptibility to Mercury] which affects the expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin B2

increases expression

Mercury results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

C-C motif chemokine receptor 2

decreases expression

Mercury results in decreased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD226 molecule

increases expression

Mercury results in increased expression of CD226 mRNA

NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051

G

CD40 molecule

increases expression

Mercury results in increased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD84 molecule

decreases expression

Mercury results in decreased expression of CD84 mRNA

NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076

G

cadherin 1

decreases expression

Mercury results in decreased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Mercury results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin dependent kinase like 2

decreases expression

Mercury analog results in decreased expression of CDKL2 mRNA

NCBI chr14:16,027,381...16,063,257
Ensembl chr14:16,028,363...16,063,252

G

cyclin-dependent kinase inhibitor 3

increases expression

Mercury results in increased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein delta

decreases expression

Mercury results in decreased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

complement factor B

decreases expression
affects expression

Mercury results in decreased expression of CFB mRNA
Mercury affects the expression of CFB protein

PMID:17547211 PMID:22030286

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

complement factor D

increases expression

Mercury results in increased expression of CFD mRNA

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

decreases expression

Mercury analog results in decreased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

choline O-acetyltransferase

decreases expression

Mercury results in decreased expression of CHAT mRNA

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

cell death-inducing DFFA-like effector b

decreases expression

Mercury results in decreased expression of CIDEB mRNA

NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605

G

CDC28 protein kinase regulatory subunit 2

increases expression

Mercury results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

cytoplasmic linker associated protein 2

increases expression

Mercury results in increased expression of CLASP2 mRNA

NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731

G

calmegin

decreases expression

Mercury results in decreased expression of CLGN mRNA

NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758

G

CDC-like kinase 1

affects expression

Mercury affects the expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

CLPTM1 regulator of GABA type A receptor forward trafficking

decreases expression
increases expression

Mercury results in decreased expression of CLPTM1 mRNA
Mercury results in increased expression of CLPTM1 mRNA

PMID:16823088 PMID:17547211

NCBI chr 1:79,289,478...79,321,079
Ensembl chr 1:79,289,477...79,321,092

G

clathrin heavy chain

decreases expression

Mercury results in decreased expression of CLTC mRNA

NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737

G

carboxymethylenebutenolidase homolog

decreases expression

Mercury analog results in decreased expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

CCR4-NOT transcription complex, subunit 3

increases expression

Mercury results in increased expression of CNOT3 mRNA

NCBI chr 1:65,555,924...65,572,167
Ensembl chr 1:65,555,924...65,572,167

G

collagen type XXVI alpha 1 chain

decreases methylation

Mercury results in decreased methylation of COL26A1 gene

NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556

G

collagen type IV alpha 3 chain

increases expression

Mercury results in increased expression of COL4A3 mRNA

NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895

G

catechol-O-methyltransferase

affects response to substance

COMT gene polymorphism affects the susceptibility to Mercury; COMT gene SNP affects the susceptibility to Mercury

PMID:19296409 PMID:24593143

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

affects expression

Mercury affects the expression of CP protein

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carboxypeptidase N subunit 2

affects expression

Mercury affects the expression of CPN2 protein

NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472

G

coproporphyrinogen oxidase

affects response to substance
multiple interactions
decreases activity

CPOX polymorphism affects the susceptibility to Mercury; CPOX protein affects the susceptibility to Mercury; CPOX protein polymorphism affects the susceptibility to Mercury
[Mercury results in decreased activity of CPOX protein] which results in increased abundance of Coproporphyrins; Mercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III]; Mercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]

PMID:16214298 PMID:16343843 PMID:19339664

NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746

G

carboxypeptidase Z

increases expression

Mercury results in increased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945

G

cysteine rich protein 1

decreases expression

Mercury analog results in decreased expression of CRIP1 mRNA

NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620

G

crystallin, alpha A

decreases expression

Mercury results in decreased expression of CRYAA mRNA

NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349

G

crystallin, alpha B

multiple interactions
decreases response to substance
increases expression

[arsenite co-treated with Cadmium] promotes the reaction [Mercury results in increased expression of CRYAB protein]; [arsenite co-treated with Mercury] promotes the reaction [Cadmium results in increased expression of CRYAB protein]; [Mercury co-treated with Cadmium] promotes the reaction [arsenite results in increased expression of CRYAB protein]
CRYAB protein results in decreased susceptibility to Mercury

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

crystallin zeta

multiple interactions
increases activity

Mercury promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA]
Mercury results in increased activity of CRYZ protein

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

chondroitin sulfate proteoglycan 5

increases expression

Mercury results in increased expression of CSPG5 mRNA

NCBI chr 8:110,220,506...110,234,766
Ensembl chr 8:110,220,653...110,234,758

G

cysteine and serine rich nuclear protein 2

increases expression

Mercury results in increased expression of CSRNP2 mRNA

NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075

G

C-terminal binding protein 1

increases expression

Mercury results in increased expression of CTBP1 mRNA

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

G

cathepsin B

increases activity

Mercury results in increased activity of CTSB protein

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cullin 4B

decreases expression

Mercury analog results in decreased expression of CUL4B mRNA

NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688

G

cytochrome b-561

decreases expression

Mercury results in decreased expression of CYB561 mRNA

NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases stability
increases activity
increases expression

[Mercury co-treated with methylmercuric chloride] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Cycloheximide promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; pyrazolanthrone promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 inhibits the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]
Mercury results in increased stability of CYP1A1 protein
Mercury results in increased activity of CYP1A1 protein

PMID:15297030 PMID:16093525 PMID:18078826 PMID:22579925 PMID:23231920 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases activity

[Mercury co-treated with methylmercuric chloride] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A2 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
Mercury results in increased activity of CYP1A2 protein

PMID:22579925 PMID:23231920 PMID:36245390

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1B1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Mercury results in increased expression of CYP1B1 protein

PMID:22579925 PMID:23231920

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily u, polypeptide 1

increases expression

Mercury results in increased expression of CYP2U1 mRNA

NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882

G

cytochrome P450 family 7 subfamily A member 1

decreases activity

Mercury results in decreased activity of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DAB adaptor protein 1

increases expression

Mercury results in increased expression of DAB1 mRNA

NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552

G

differentially expressed in FDCP 8 homolog

decreases expression

Mercury results in decreased expression of DEF8 mRNA

NCBI chr19:51,474,783...51,495,638
Ensembl chr19:51,474,878...51,495,638

G

DIRAS family GTPase 1

decreases expression

Mercury results in decreased expression of DIRAS1 mRNA

NCBI chr 7:8,687,964...8,692,828
Ensembl chr 7:8,687,942...8,693,831

G

dynein, axonemal, heavy chain 1

decreases expression

Mercury results in decreased expression of DNAH1 mRNA

NCBI chr16:6,455,514...6,517,103
Ensembl chr16:6,456,002...6,518,350

G

DnaJ heat shock protein family (Hsp40) member A2

increases expression

Mercury results in increased expression of DNAJA2 mRNA

NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901

G

dedicator of cytokinesis 10

increases expression

Mercury results in increased expression of DOCK10 mRNA

NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525

G

dihydropyrimidinase-like 4

increases expression

Mercury results in increased expression of DPYSL4 mRNA

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

dopamine receptor D3

multiple interactions

Mercury inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

multiple interactions

Mercury inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

dystrobrevin, alpha

increases expression

Mercury results in increased expression of DTNA mRNA

NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261

G

early endosome antigen 1

increases expression

Mercury results in increased expression of EEA1 mRNA

NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487

G

ephrin B1

increases expression

Mercury results in increased expression of EFNB1 mRNA

NCBI chr X:64,257,351...64,270,158
Ensembl chr X:64,257,351...64,270,157

G

eukaryotic translation initiation factor 2 alpha kinase 1

decreases activity
multiple interactions

Mercury results in decreased activity of EIF2AK1 protein
Nitric Oxide inhibits the reaction [Mercury results in decreased activity of EIF2AK1 protein]

NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573

G

eukaryotic translation initiation factor 3, subunit F

decreases expression

Mercury results in decreased expression of EIF3F mRNA

NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204

G

eukaryotic translation initiation factor 4 gamma 1

decreases expression

Mercury analog results in decreased expression of EIF4G1 mRNA

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

elongator acetyltransferase complex subunit 1

decreases expression

Mercury results in decreased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

empty spiracles homeobox 2

increases expression

Mercury results in increased expression of EMX2 mRNA

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

engrailed homeobox 1

increases expression

Mercury results in increased expression of EN1 mRNA

NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

increases expression

Mercury results in increased expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

estrogen receptor 2

increases expression

Mercury results in increased expression of ESR2 mRNA

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

electron transfer flavoprotein subunit beta

increases expression

Mercury results in increased expression of ETFB mRNA

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

ETS proto-oncogene 2, transcription factor

increases expression

Mercury results in increased expression of ETS2 mRNA

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

enhancer of zeste 1 polycomb repressive complex 2 subunit

increases expression

Mercury results in increased expression of EZH1 mRNA

NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921

G

coagulation factor X

decreases expression

Mercury results in decreased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor V

decreases expression

Mercury results in decreased expression of F5 mRNA

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

G

fatty acid binding protein 5

increases expression

Mercury results in increased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

fatty acid binding protein 7

increases expression

Mercury results in increased expression of FABP7 mRNA

NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880

G

family with sequence similarity 184, member B

decreases expression

Mercury analog results in decreased expression of FAM184B mRNA

NCBI chr14:65,475,489...65,591,388
Ensembl chr14:65,475,489...65,591,388

G

Fas cell surface death receptor

multiple interactions

Mercury inhibits the reaction [FAS protein binds to FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fc epsilon receptor Ig

affects response to substance

FCER1G protein affects the susceptibility to Mercury

NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443

G

Fc gamma receptor 1A

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

Fc gamma receptor 3A

decreases expression

Mercury results in decreased expression of FCGR3A mRNA

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

Fc receptor-like A

decreases expression

Mercury results in decreased expression of FCRLA mRNA

NCBI chr13:83,160,453...83,170,170
Ensembl chr13:83,160,398...83,170,762

G

ferrochelatase

decreases activity

Mercury results in decreased activity of FECH protein

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

Fer3-like bHLH transcription factor

decreases expression

Mercury results in decreased expression of FERD3L mRNA

NCBI chr 6:50,645,379...50,646,268
Ensembl chr 6:50,645,379...50,646,268

G

fibroblast growth factor 2

increases expression

Mercury results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

filamin B

increases expression

Mercury results in increased expression of FLNB mRNA

NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006

G

fibronectin 1

decreases expression

Mercury results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Mercury promotes the reaction [HSPA5 protein binds to FOS enhancer]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Mercury results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box I1

decreases expression

Mercury results in decreased expression of FOXI1 mRNA

NCBI chr10:18,806,292...18,810,231
Ensembl chr10:18,806,308...18,810,231

G

forkhead box K1

increases expression

Mercury results in increased expression of FOXK1 mRNA

NCBI chr12:12,110,119...12,175,089
Ensembl chr12:12,115,950...12,175,089

G

FERM domain containing 6

decreases expression

Mercury analog results in decreased expression of FRMD6 mRNA

NCBI chr 6:89,345,983...89,419,579
Ensembl chr 6:89,346,035...89,419,579

G

furin (paired basic amino acid cleaving enzyme)

decreases expression

Mercury results in decreased expression of FURIN mRNA

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

glucose-6-phosphate dehydrogenase

decreases activity

Mercury results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

gamma-aminobutyric acid type A receptor subunit alpha6

increases expression

Mercury results in increased expression of GABRA6 mRNA

NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769

G

growth arrest specific 7

increases expression

Mercury results in increased expression of GAS7 mRNA

NCBI chr10:52,152,718...52,383,283
Ensembl chr10:52,152,493...52,383,276

G

GATA zinc finger domain containing 2B

decreases expression

Mercury analog results in decreased expression of GATAD2B mRNA

NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542

G

glutamate-cysteine ligase, catalytic subunit

increases expression
affects response to substance
multiple interactions

Mercury results in increased expression of GCLC mRNA
GCLC gene SNP affects the susceptibility to Mercury
[Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein; GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]

PMID:17547211 PMID:19515364 PMID:22236634 PMID:27837179 PMID:30359721

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

decreases expression
affects abundance
affects metabolic processing

Mercury results in decreased expression of GCLM mRNA
GCLM gene polymorphism affects the abundance of Mercury; GCLM protein affects the abundance of Mercury
GCLM polymorphism affects the metabolism of Mercury

PMID:16961004 PMID:18560528 PMID:19937285 PMID:21925580

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

gamma-glutamyl carboxylase

decreases expression

Mercury results in decreased expression of GGCX mRNA

NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063

G

gamma-glutamyltransferase 1

decreases expression
multiple interactions

Mercury results in decreased expression of GGT1 mRNA
[Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of GGT1 protein

PMID:19937285 PMID:30090589

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

galactosidase, alpha

increases expression

Mercury results in increased expression of GLA mRNA

NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664

G

glycine receptor, alpha 3

increases expression

Mercury results in increased expression of GLRA3 mRNA

NCBI chr16:34,199,937...34,848,773
Ensembl chr16:34,204,811...34,848,753

G

GDP-mannose pyrophosphorylase B

decreases expression

Mercury analog results in decreased expression of GMPPB mRNA

NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286

G

G protein subunit gamma transducin 1

increases expression

Mercury results in increased expression of GNGT1 mRNA

NCBI chr 4:32,006,267...32,009,252
Ensembl chr 4:32,006,267...32,009,252

G

gonadotropin releasing hormone 1

increases expression

Mercury results in increased expression of GNRH1 mRNA

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

golgin A1

decreases expression

Mercury analog results in decreased expression of GOLGA1 mRNA

NCBI chr 3:22,765,690...22,812,637
Ensembl chr 3:22,767,761...22,812,585

G

golgin A3

decreases expression

Mercury analog results in decreased expression of GOLGA3 mRNA

NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509

G

golgi reassembly stacking protein 1

decreases expression

Mercury analog results in decreased expression of GORASP1 mRNA

NCBI chr 8:119,655,267...119,667,022
Ensembl chr 8:119,655,268...119,666,972

G

G protein-coupled estrogen receptor 1

decreases expression

Mercury results in decreased expression of GPER1 mRNA

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

glutathione peroxidase 1

affects response to substance
increases expression

GPX1 gene SNP affects the susceptibility to Mercury
Mercury results in increased expression of GPX1 protein

PMID:16451871 PMID:22236634

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

gelsolin

decreases expression
affects expression

Mercury results in decreased expression of GSN mRNA
Mercury affects the expression of GSN protein

PMID:17547211 PMID:22030286

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Mercury results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein

PMID:10798623 PMID:17176674

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

affects abundance

GSS gene polymorphism affects the abundance of Mercury

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

affects abundance

GSTA1 gene polymorphism affects the abundance of Mercury

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

increases expression

Mercury results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 1

affects response to substance
multiple interactions
affects abundance

GSTM1 gene polymorphism affects the susceptibility to Mercury; GSTM1 polymorphism affects the susceptibility to Mercury
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury; [GSTP1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of Mercury; [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GSTM1 protein
GSTM1 gene polymorphism affects the abundance of Mercury

PMID:17716707 PMID:19515364 PMID:20194072 PMID:24319713 PMID:25728017 More...

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

increases expression
affects abundance
multiple interactions

Mercury results in increased expression of GSTP1 mRNA; Mercury results in increased expression of GSTP1 protein
GSTP1 gene affects the abundance of Mercury; GSTP1 gene polymorphism affects the abundance of Mercury
[GSTP1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of Mercury; GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]; GSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 protein

PMID:12167210 PMID:12730625 PMID:18560528 PMID:19515364 PMID:21967774 More...

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

affects abundance
multiple interactions
affects response to substance

GSTT1 gene polymorphism affects the abundance of Mercury
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury; GSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]
GSTT1 gene polymorphism affects the susceptibility to Mercury; GSTT1 polymorphism affects the susceptibility to Mercury

PMID:17716707 PMID:19515364 PMID:20194072 PMID:21967774 PMID:24319713

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

GTP-binding protein 8 (putative)

decreases expression

Mercury analog results in decreased expression of GTPBP8 mRNA

NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635

G

glucoside xylosyltransferase 2

decreases expression

Mercury analog results in decreased expression of GXYLT2 mRNA

NCBI chr 4:133,347,230...133,449,708
Ensembl chr 4:133,347,499...133,449,454

G

hyaluronan binding protein 4

increases expression

Mercury results in increased expression of HABP4 mRNA

NCBI chr17:934,931...957,604
Ensembl chr17:935,654...957,565

G

hepcidin antimicrobial peptide

multiple interactions

[HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hepatitis A virus cellular receptor 1

increases expression

Mercury results in increased expression of HAVCR1 mRNA; Mercury results in increased expression of HAVCR1 protein

PMID:17934191 PMID:25145654

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hephaestin

increases expression

Mercury results in increased expression of HEPH mRNA

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

G

hypoxia inducible factor 3 subunit alpha

decreases expression

Mercury results in decreased expression of HIF3A mRNA

NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758

G

histidine triad nucleotide binding protein 3

decreases expression

Mercury analog results in decreased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721

G

histone cluster 1 H2A family member H

increases expression

Mercury results in increased expression of H2AC11 mRNA

NCBI chr17:41,384,521...41,385,018

G

high mobility group nucleosomal binding domain 2

increases expression

Mercury results in increased expression of HMGN2 mRNA

NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521
Ensembl chr16:146,192,126...146,195,521

G

heme oxygenase 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter]
[Benzo(a)pyrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [beta-Naphthoflavone co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Mercury co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 protein; [Methylcholanthrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Tetrachlorodibenzodioxin co-treated with Mercury] results in increased expression of HMOX1 mRNA; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HMOX1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA]; Mercury results in increased expression of and results in increased activity of HMOX1 protein; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Mercury results in increased expression of HMOX mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; U 0126 promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]

PMID:12730625 PMID:15297030 PMID:16093525 PMID:17244614 PMID:17547211 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox A

increases expression

Mercury results in increased expression of HNF1A mRNA

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

heterogeneous nuclear ribonucleoprotein H3

increases expression

Mercury results in increased expression of HNRNPH3 mRNA

NCBI chr20:25,616,400...25,625,814
Ensembl chr20:25,614,733...25,625,750

G

homeo box B4

increases expression

Mercury results in increased expression of HOXB4 mRNA

NCBI chr10:81,284,552...81,287,134
Ensembl chr10:81,284,552...81,287,128

G

homeo box B6

increases expression

Mercury results in increased expression of HOXB6 mRNA

NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449

G

hemopexin

affects expression

Mercury affects the expression of HPX protein

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

G

HRas proto-oncogene, GTPase

multiple interactions

Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

HCLS1 binding protein 3

decreases expression

Mercury results in decreased expression of HS1BP3 mRNA

NCBI chr 6:31,192,568...31,222,835
Ensembl chr 6:31,192,568...31,222,835

G

heat shock transcription factor 1

multiple interactions
increases activity

Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter]; Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter]
Mercury results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock transcription factor 2

decreases expression

Mercury results in decreased expression of HSF2 mRNA

NCBI chr20:36,819,864...36,847,490
Ensembl chr20:36,819,864...36,850,174

G

heat shock protein 90 alpha family class A member 1

increases expression

Mercury results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter]
Mercury results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

affects response to substance

HSPA1B gene polymorphism affects the susceptibility to Mercury

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 1 like

affects response to substance

HSPA1L gene polymorphism affects the susceptibility to Mercury

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 5

affects expression
multiple interactions

Mercury affects the expression of HSPA5 mRNA
Mercury promotes the reaction [HSPA5 protein binds to FOS enhancer]; Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]; Mercury results in increased expression of and results in increased activity of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

increases expression

Mercury results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

5-hydroxytryptamine receptor 7

increases expression

Mercury results in increased expression of HTR7 mRNA

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

interferon-induced protein 44

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon gamma

affects expression
decreases secretion
increases expression
multiple interactions

Mercury affects the expression of IFNG mRNA; Mercury affects the expression of IFNG protein
Mercury results in decreased secretion of IFNG protein
Mercury results in increased expression of IFNG protein
Mercury results in increased expression of IFNG mRNA
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG protein; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG mRNA]; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of IFNG mRNA]

PMID:12928768 PMID:15910788 PMID:20176347 PMID:25237059 PMID:28453771

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

affects response to substance

IFNGR1 affects the susceptibility to Mercury

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

interferon-related developmental regulator 1

decreases expression

Mercury results in decreased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

insulin-like growth factor 1

multiple interactions

Mercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

increases expression

Mercury results in increased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

increases expression

Mercury results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 17 receptor B

decreases expression

Mercury results in decreased expression of IL17RB mRNA

NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125

G

interleukin 1 beta

increases expression
multiple interactions

Mercury results in increased expression of IL1B protein
Mercury promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Mercury results in increased expression of IL1B mRNA; Mercury results in increased expression of IL1B protein
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL1B mRNA; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of IL1B mRNA]

PMID:20176347 PMID:20600710 PMID:25237059 PMID:28453771 PMID:37137463

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

Mercury results in increased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 33

decreases expression

Mercury analog results in decreased expression of IL33 mRNA

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 3 receptor subunit alpha

decreases expression

Mercury results in decreased expression of IL3RA mRNA

NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484

G

interleukin 4

decreases secretion
multiple interactions

Mercury results in decreased secretion of IL4 protein
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]

PMID:15910788 PMID:28453771

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
multiple interactions

Mercury results in increased expression of IL6 protein
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL6 mRNA; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; Salicylic Acid inhibits the reaction [Mercury results in increased expression of IL6]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein

PMID:18393961 PMID:23742082 PMID:28453771 PMID:37415728

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interphotoreceptor matrix proteoglycan 1

increases expression

Mercury results in increased expression of IMPG1 mRNA

NCBI chr 8:81,243,624...81,389,722
Ensembl chr 8:81,243,624...81,389,722

G

insulin 1

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] inhibits the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

interferon regulatory factor 1

affects response to substance
multiple interactions

IRF1 affects the susceptibility to Mercury
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]

PMID:22578563 PMID:28453771

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

interferon regulatory factor 8

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

insulin receptor substrate 1

multiple interactions

[Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

ISG15 ubiquitin-like modifier

decreases expression

Mercury analog results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit beta 1

increases activity

Mercury results in increased activity of ITGB1 protein

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 3 binding protein

increases expression

Mercury results in increased expression of ITGB3BP mRNA

NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704

G

inter-alpha trypsin inhibitor, heavy chain 1

affects expression

Mercury affects the expression of ITIH1 protein

NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363

G

inter-alpha trypsin inhibitor, heavy chain 3

decreases expression

Mercury results in decreased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

inter-alpha-trypsin inhibitor heavy chain 4

affects expression

Mercury affects the expression of ITIH4 protein

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

influenza virus NS1A binding protein

decreases expression

Mercury results in decreased expression of IVNS1ABP mRNA

NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701

G

Janus kinase 2

affects expression

Mercury affects the expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Mercury results in decreased expression of JUN mRNA
[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of JUN protein

PMID:12730625 PMID:28035397

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily H member 2

increases expression

Mercury results in increased expression of KCNH2 mRNA

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

KDEL endoplasmic reticulum protein retention receptor 2

decreases expression

Mercury analog results in decreased expression of KDELR2 mRNA

NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153

G

KLF transcription factor 12

decreases expression

Mercury results in decreased expression of KLF12 mRNA

NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056

G

KLF transcription factor 2

decreases expression

Mercury results in decreased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

lysine methyltransferase 2B

increases expression

Mercury results in increased expression of KMT2B mRNA

NCBI chr 1:85,821,700...85,840,987
Ensembl chr 1:85,821,753...85,841,326

G

keratin 1

increases expression

Mercury results in increased expression of KRT1 mRNA

NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844

G

laminin subunit gamma 1

decreases expression

Mercury analog results in decreased expression of LAMC1 mRNA

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

G

LanC like glutathione S-transferase 1

decreases expression

Mercury results in decreased expression of LANCL1 mRNA

NCBI chr 9:68,515,052...68,548,646
Ensembl chr 9:68,518,574...68,548,628

G

LanC like glutathione S-transferase 2

decreases expression

Mercury results in decreased expression of LANCL2 mRNA

NCBI chr 4:87,441,821...87,483,707
Ensembl chr 4:87,441,823...87,482,800

G

lipocalin 2

increases expression

Mercury results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

leukocyte receptor cluster member 9

decreases expression

Mercury analog results in decreased expression of LENG9 mRNA

NCBI chr 1:70,039,099...70,041,559
Ensembl chr 1:70,035,791...70,044,509

G

leptin receptor

decreases expression

Mercury results in decreased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

LIM domain containing 1

decreases expression

Mercury analog results in decreased expression of LIMD1 mRNA

NCBI chr 8:123,121,363...123,168,476
Ensembl chr 8:123,122,460...123,167,714

G

LIM zinc finger domain containing 2

decreases expression

Mercury analog results in decreased expression of LIMS2 mRNA

NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137

G

lipase A, lysosomal acid type

decreases expression

Mercury results in decreased expression of LIPA mRNA

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

limb development membrane protein 1

decreases expression

Mercury analog results in decreased expression of LMBR1 mRNA

NCBI chr 4:5,974,687...6,146,348
Ensembl chr 4:5,974,750...6,146,368

G

lamin A/C

decreases expression

Mercury results in decreased expression of LMNA mRNA

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

LRR binding FLII interacting protein 1

increases expression

Mercury results in increased expression of LRRFIP1 mRNA

NCBI chr 9:91,592,032...91,720,250
Ensembl chr 9:91,643,197...91,720,250

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Mercury analog results in decreased expression of LSM5 mRNA

NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

G

lactotransferrin

increases expression

Mercury results in increased expression of LTF protein

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

Mercury results in increased phosphorylation of and results in increased activity of LYN protein

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

leucine zipper tumor suppressor 2

decreases expression

Mercury analog results in decreased expression of LZTS2 mRNA

NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423

G

microtubule-actin crosslinking factor 1

increases expression

Mercury results in increased expression of MACF1 mRNA

NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905

G

MAF bZIP transcription factor F

increases expression

Mercury results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAGE family member B1

increases expression

Mercury results in increased expression of MAGEB4 mRNA

NCBI chr X:50,915,789...50,921,863

G

mannosidase, alpha, class 1B, member 1

affects expression

Mercury affects the expression of MAN1B1 mRNA

NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006

G

mitogen activated protein kinase kinase 2

increases expression

Mercury results in increased expression of MAP2K2 mRNA

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

microtubule-associated protein 9

increases expression

Mercury results in increased expression of MAP9 mRNA

NCBI chr 2:167,708,661...167,743,927
Ensembl chr 2:167,708,765...167,740,736

G

mitogen activated protein kinase 1

increases phosphorylation

Mercury results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Mercury results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

minichromosome maintenance complex component 2

increases expression

Mercury results in increased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

mediator complex subunit 16

increases expression

Mercury results in increased expression of MED16 mRNA

NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172

G

mesenchyme homeobox 2

increases expression

Mercury results in increased expression of MEOX2 mRNA

NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467

G

microfibril associated protein 5

increases expression

Mercury results in increased expression of MFAP5 mRNA

NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458

G

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

decreases expression

Mercury results in decreased expression of MGAT2 mRNA

NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177

G

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase

increases expression

Mercury results in increased expression of MGAT5 mRNA

NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513

G

microRNA 10a

decreases expression

Mercury results in decreased expression of MIR10A mRNA

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

G

microRNA 151

decreases expression

Mercury results in decreased expression of MIR151A mRNA

NCBI chr 7:105,172,377...105,172,473

G

microRNA 190b

decreases expression

Mercury results in decreased expression of MIR190B mRNA

NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877

G

microRNA 193b

decreases expression

Mercury results in decreased expression of MIR193B mRNA

NCBI chr10:1,317,742...1,317,824
Ensembl chr10:1,317,742...1,317,824

G

microRNA 423

decreases expression

Mercury results in decreased expression of MIR423 mRNA

NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226

G

microRNA 96

decreases expression

Mercury results in decreased expression of MIR96 mRNA

NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516

G

microRNA let-7b

decreases expression

Mercury results in decreased expression of MIRLET7B mRNA

NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270

G

microRNA let-7c-1

decreases expression

Mercury results in decreased expression of MIRLET7C mRNA

NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265

G

microRNA let-7d

decreases expression

Mercury results in decreased expression of MIRLET7D mRNA

NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990

G

microRNA let-7g

decreases expression

Mercury results in decreased expression of MIRLET7G mRNA

NCBI chr 8:106,822,293...106,822,380
Ensembl chr 8:106,822,280...106,822,388

G

microRNA let-7i

decreases expression

Mercury results in decreased expression of MIRLET7I mRNA

NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571

G

membrane metallo-endopeptidase

increases expression
multiple interactions

Mercury results in increased expression of MME protein
Mercury affects the folding of and results in decreased activity of MME protein

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 2

multiple interactions

Mercury affects the reaction [MMP2 promoter polymorphism results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

affects response to substance

MMP9 promoter polymorphism affects the susceptibility to Mercury

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mortality factor 4 like 2

decreases expression

Mercury results in decreased expression of MORF4L2 mRNA

NCBI chr X:100,082,562...100,093,658
Ensembl chr X:100,082,404...100,093,728

G

myeloperoxidase

decreases activity

Mercury results in decreased activity of MPO protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosomal protein S23

decreases expression

Mercury analog results in decreased expression of MRPS23 mRNA

NCBI chr10:72,999,033...73,006,791
Ensembl chr10:72,998,497...73,006,264

G

mutS homolog 6

increases expression

Mercury results in increased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

MSL complex subunit 3

decreases expression

Mercury analog results in decreased expression of MSL3 mRNA

NCBI chr X:25,638,029...25,655,698
Ensembl chr X:25,637,804...25,655,697

G

macrophage scavenger receptor 1

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of MSR1 mRNA

NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676

G

metallothionein 1

increases expression
affects abundance

Mercury results in increased expression of MT1A mRNA
MT1A gene polymorphism affects the abundance of Mercury; MT1A gene SNP affects the abundance of Mercury

PMID:9462895 PMID:9587011 PMID:12167210 PMID:12730625 PMID:19515364 More...

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

affects response to substance

MT1E gene SNP affects the susceptibility to Mercury

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

affects abundance
affects binding
increases expression
increases response to substance
multiple interactions
affects response to substance

MT2A gene SNP affects the abundance of Mercury
Mercury binds to MT2 protein
Mercury results in increased expression of MT2 mRNA; Mercury results in increased expression of MT2 protein
MT2 gene mutant form results in increased susceptibility to Mercury
[MT1 co-treated with MT2] affects the susceptibility to Mercury; [MT3 protein affects the susceptibility to Mercury] which affects the expression of MT2 mRNA
[MT1M gene polymorphism co-treated with MT2A gene polymorphism] affects the susceptibility to Mercury
MT2A gene polymorphism affects the susceptibility to Mercury
Mercury results in increased expression of MT2A mRNA

PMID:2771874 PMID:8917669 PMID:9462895 PMID:9587011 PMID:15138662 More...

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 3

affects binding
increases expression
multiple interactions
affects response to substance

Mercury binds to MT3 protein
Mercury results in increased expression of MT3 mRNA; Mercury results in increased expression of MT3 protein
[MT3 protein affects the susceptibility to Mercury] which affects the expression of CCL7 mRNA; [MT3 protein affects the susceptibility to Mercury] which affects the expression of MT2 mRNA; MT3 protein affects the reaction [Mercury results in increased expression of CCL3 mRNA]

PMID:8917669 PMID:9587011 PMID:15138662 PMID:15782327 PMID:17018868 More...

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

metallothionein 4

affects abundance

MT4 gene polymorphism affects the abundance of Mercury

NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909

G

metal-regulatory transcription factor 1

increases expression

Mercury results in increased expression of MTF1 mRNA

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

myotubularin related protein 11

decreases expression

Mercury results in decreased expression of MTMR11 mRNA

NCBI chr 2:183,721,983...183,732,148
Ensembl chr 2:183,723,530...183,732,148

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Mercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]

PMID:14745455 PMID:26989453

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

mitochondrial translation release factor 1

decreases expression

Mercury results in decreased expression of MTRF1 mRNA

NCBI chr15:54,776,885...54,804,699
Ensembl chr15:54,776,937...54,804,704

G

mucin 2, oligomeric mucus/gel-forming

increases expression

Mercury results in increased expression of MUC2 mRNA

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

multivesicular body subunit 12B

increases expression

Mercury results in increased expression of MVB12B mRNA

NCBI chr 3:17,034,002...17,192,658
Ensembl chr 3:17,034,003...17,193,202

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
affects expression

Mercury results in decreased expression of MYC mRNA
Mercury affects the expression of MYC mRNA

PMID:12928768 PMID:16823088

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin Ib

increases expression
decreases expression

Mercury results in increased expression of MYO1B mRNA
Mercury analog results in decreased expression of MYO1B mRNA

PMID:16823088 PMID:25056781

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

myeloid zinc finger 1

decreases expression

Mercury analog results in decreased expression of MZF1 mRNA

NCBI chr 1:73,670,522...73,682,885
Ensembl chr 1:73,670,541...73,681,635

G

nucleosome assembly protein 1-like 1

increases expression

Mercury results in increased expression of NAP1L1 mRNA

NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593

G

N-acetyltransferase 1

multiple interactions

Mercury binds to and results in decreased activity of NAT1 protein

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

neuron navigator 3

increases expression

Mercury results in increased expression of NAV3 mRNA

NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698

G

non-SMC condensin II complex, subunit D3

increases expression
decreases expression

Mercury results in increased expression of NCAPD3 mRNA
Mercury analog results in decreased expression of NCAPD3 mRNA

PMID:19937285 PMID:25056781

NCBI chr 8:25,437,067...25,506,375
Ensembl chr 8:25,437,123...25,506,373

G

nuclear receptor coactivator 3

increases expression

Mercury results in increased expression of NCOA3 mRNA

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

Mercury results in decreased expression of NDUFS2 mRNA

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

G

nuclear factor of activated T-cells 4

increases expression

Mercury results in increased expression of NFATC4 mRNA

NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
increases activity

NFE2L2 protein affects the reaction [Mercury results in increased expression of GSTA1 mRNA]; NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA]
Mercury results in increased expression of NFE2L2 mRNA
Mercury results in increased activity of NFE2L2 promoter
[Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of NFE2L2 protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]

PMID:16243960 PMID:21643505 PMID:27837179 PMID:30359721 PMID:37415728

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of NFKB1 protein]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein; Mercury inhibits the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]

PMID:11437639 PMID:15282405 PMID:37415728

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

increases expression
decreases expression

Mercury results in increased expression of NGF mRNA
Mercury results in decreased expression of NGF mRNA

PMID:7781173 PMID:16823088

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

decreases expression

Mercury results in decreased expression of NGFR mRNA

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

NHERF family PDZ scaffold protein 2

increases expression

Mercury results in increased expression of NHERF2 mRNA

NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049

G

NLR family, pyrin domain containing 1A

decreases expression

Mercury results in decreased expression of NLRP1 mRNA

NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180

G

NLR family, pyrin domain containing 3

increases expression
multiple interactions

Mercury results in increased expression of NLRP3 mRNA
N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of NLRP3 mRNA]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

N-myristoyltransferase 2

increases expression

Mercury results in increased expression of NMT2 mRNA

NCBI chr17:74,917,833...74,964,788
Ensembl chr17:74,917,833...74,961,080

G

nucleotide-binding oligomerization domain containing 1

decreases expression

Mercury results in decreased expression of NOD1 mRNA

NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404

G

NADPH oxidase 4

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NOX4 protein

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases activity
increases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 protein]; Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 protein]; Mercury results in increased expression of and results in increased activity of NQO1 protein; NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA]; prolinedithiocarbamate promotes the reaction [Mercury results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 protein]; U 0126 promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; U 0126 promotes the reaction [Mercury results in increased expression of NQO1 protein]
Mercury results in increased activity of NQO1 protein
Mercury results in increased expression of NQO1 mRNA; Mercury results in increased expression of NQO1 protein
Acetylcysteine inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]

PMID:16243960 PMID:18752316 PMID:22579925 PMID:26600472

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

Mercury results in decreased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear speckle splicing regulatory protein 1

decreases expression

Mercury analog results in decreased expression of NSRP1 mRNA

NCBI chr10:61,880,807...61,914,471
Ensembl chr10:61,880,825...61,914,471

G

neurotrophic receptor tyrosine kinase 3

increases expression

Mercury results in increased expression of NTRK3 mRNA

NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286

G

nucleoporin 107

increases expression

Mercury results in increased expression of NUP107 mRNA

NCBI chr 7:53,353,740...53,398,345
Ensembl chr 7:53,353,743...53,398,370

G

occludin

decreases expression

Mercury results in decreased expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

8-oxoguanine DNA glycosylase

decreases expression

Mercury results in decreased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

opioid receptor, delta 1

multiple interactions

Mercury inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

multiple interactions

Mercury inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

multiple interactions

Mercury inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

OS9, endoplasmic reticulum lectin

decreases expression

Mercury results in decreased expression of OS9 mRNA

NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745

G

purinergic receptor P2X 2

multiple interactions

Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]

NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891

G

purinergic receptor P2X 4

multiple interactions

[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

PMID:10737610 PMID:15629187 PMID:19793987

NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253

G

Parkinsonism associated deglycase

increases expression
affects binding

Mercury results in increased expression of PARK7 mRNA
Mercury binds to PARK7 protein

PMID:16823088 PMID:23792957

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protocadherin beta 5

decreases expression

Mercury results in decreased expression of PCDHB4 mRNA

NCBI chr18:29,024,315...29,032,183
Ensembl chr18:29,028,382...29,053,259

G

phosphodiesterase 1A

decreases expression

Mercury results in decreased expression of PDE1A mRNA

NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874

G

phosphodiesterase 4D interacting protein

increases expression

Mercury results in increased expression of PDE4DIP mRNA

NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379

G

protein disulfide isomerase family A, member 4

decreases expression

Mercury results in decreased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

PDS5 cohesin associated factor B

decreases expression

Mercury results in decreased expression of PDS5B mRNA

NCBI chr12:202,481...345,596
Ensembl chr12:255,313...345,596

G

peroxisomal biogenesis factor 14

increases expression

Mercury results in increased expression of PEX14 mRNA

NCBI chr 5:159,399,776...159,536,260
Ensembl chr 5:159,399,776...159,536,272

G

prefoldin subunit 4

decreases expression

Mercury analog results in decreased expression of PFDN4 mRNA

NCBI chr 3:159,303,173...159,311,221
Ensembl chr 3:159,303,071...159,311,219

G

progastricsin

decreases expression

Mercury results in decreased expression of PGC mRNA

NCBI chr 9:13,257,462...13,265,682
Ensembl chr 9:13,257,462...13,265,682

G

paired-like homeobox 2b

increases expression

Mercury results in increased expression of PHOX2B mRNA

NCBI chr14:41,066,012...41,069,202
Ensembl chr14:41,066,264...41,068,978

G

protein inhibitor of activated STAT, 2

affects expression

Mercury affects the expression of PIAS2 mRNA

NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033

G

protein inhibitor of activated STAT, 4

decreases expression

Mercury results in decreased expression of PIAS4 mRNA

NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

Mercury results in decreased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

phosphoinositide-3-kinase, regulatory subunit 4

increases expression

Mercury results in increased expression of PIK3R4 mRNA

NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584

G

phosphoinositide kinase, FYVE-type zinc finger containing

decreases expression

Mercury results in decreased expression of PIKFYVE mRNA

NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868

G

phospholipase D1

increases phosphorylation

Mercury results in increased phosphorylation of PLD1 protein

NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692

G

phospholipid phosphatase related 4

increases expression

Mercury results in increased expression of PLPPR4 mRNA

NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302

G

plexin B3

decreases expression

Mercury analog results in decreased expression of PLXNB3 mRNA

NCBI chr X:151,493,832...151,508,688
Ensembl chr X:151,494,207...151,508,674

G

pro-melanin-concentrating hormone

decreases expression

Mercury results in decreased expression of PMCH mRNA

NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250

G

PMS1 homolog 1, mismatch repair system component

decreases expression

Mercury analog results in decreased expression of PMS1 mRNA

NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237

G

PNMA family member 1

decreases expression

Mercury results in decreased expression of PNMA1 mRNA

NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567

G

pogo transposable element derived with KRAB domain

affects expression

Mercury affects the expression of POGK mRNA

NCBI chr13:78,647,447...78,663,363
Ensembl chr13:78,647,447...78,663,363

G

DNA polymerase delta 2, accessory subunit

affects expression

Mercury affects the expression of POLD2 mRNA

NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160

G

paraoxonase 1

decreases activity
multiple interactions

Mercury results in decreased activity of PON1 protein
Selenium inhibits the reaction [Mercury results in decreased activity of PON1 protein]

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

POU class 2 homeobox 3

increases expression

Mercury results in increased expression of POU2F3 mRNA

NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795

G

peptidylprolyl isomerase A

increases expression

Mercury results in increased expression of PPIA mRNA

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

peptidylprolyl isomerase H

increases expression

Mercury results in increased expression of PPIH mRNA

NCBI chr 5:132,906,324...132,924,341
Ensembl chr 5:132,906,328...132,924,267

G

protein phosphatase 1, regulatory subunit 12A

increases expression

Mercury results in increased expression of PPP1R12A mRNA

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

protein phosphatase 1, regulatory subunit 15A

decreases expression

Mercury results in decreased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 3 catalytic subunit beta

decreases expression

Mercury results in decreased expression of PPP3CB mRNA

NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981

G

PPARG related coactivator 1

affects response to substance

PPRC1 protein affects the susceptibility to Mercury

NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587

G

palmitoyl-protein thioesterase 2

decreases expression

Mercury results in decreased expression of PPT2 mRNA

NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774

G

peroxiredoxin 2

increases expression

Mercury results in increased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

peroxiredoxin 6

decreases expression
increases expression

Mercury results in decreased expression of PRDX6 mRNA
Mercury analog results in increased expression of PRDX6 mRNA

PMID:16823088 PMID:25056781

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

protein kinase C, alpha

increases expression

Mercury results in increased expression of PRKCA mRNA

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, gamma

increases expression

Mercury results in increased expression of PRKCG mRNA

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

protein kinase C, theta

decreases expression

Mercury analog results in decreased expression of PRKCQ mRNA

NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704

G

pre-mRNA processing factor 31

decreases expression

Mercury analog results in decreased expression of PRPF31 mRNA

NCBI chr 1:65,575,887...65,587,561
Ensembl chr 1:65,575,887...65,587,873

G

pre-mRNA processing factor 40 homolog A

decreases expression

Mercury analog results in decreased expression of PRPF40A mRNA

NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886

G

phosphoserine phosphatase

decreases expression

Mercury results in decreased expression of PSPH mRNA

NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074

G

polypyrimidine tract binding protein 1

decreases expression

Mercury analog results in decreased expression of PTBP1 mRNA

NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397

G

prostaglandin E receptor 2

increases expression

Mercury results in increased expression of PTGER2 mRNA

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

PTOV1, extended AT-hook containing adaptor protein

decreases expression

Mercury analog results in decreased expression of PTOV1 mRNA

NCBI chr 1:95,347,065...95,354,514
Ensembl chr 1:95,347,068...95,353,613

G

PTTG1 regulator of sister chromatid separation, securin

increases expression

Mercury results in increased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

purine rich element binding protein B

increases expression

Mercury analog results in increased expression of PURB mRNA

NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432

G

parvalbumin

decreases expression

Mercury analog results in decreased expression of PVALB mRNA

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

G

peroxidasin

decreases expression

Mercury results in decreased expression of PXDN mRNA

NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345

G

paxillin

affects localization

Mercury affects the localization of PXN protein

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

Rac family small GTPase 1

increases expression

Mercury results in increased expression of RAC1 mRNA

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Rac GTPase-activating protein 1

increases expression

Mercury results in increased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RAD18 E3 ubiquitin protein ligase

decreases expression

Mercury results in decreased expression of RAD18 mRNA

NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069

G

Ral GTPase activating protein catalytic subunit alpha 1

decreases expression

Mercury results in decreased expression of RALGAPA1 mRNA

NCBI chr 6:72,977,432...73,252,378
Ensembl chr 6:72,977,432...73,252,378

G

retinoic acid receptor, alpha

decreases expression

Mercury results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RNA binding motif protein 22

decreases expression

Mercury analog results in decreased expression of RBM22 mRNA

NCBI chr18:54,013,374...54,024,182
Ensembl chr18:54,013,351...54,024,569

G

RNA binding protein, mRNA processing factor

increases expression

Mercury results in increased expression of RBPMS mRNA

NCBI chr16:58,239,370...58,395,424
Ensembl chr16:58,239,474...58,395,426

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased localization of RELA protein]
Mercury inhibits the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]
[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of RELA protein

PMID:11437639 PMID:15282405 PMID:28035397

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

decreases expression

Mercury results in decreased expression of RELN mRNA

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

G

Rho-related BTB domain containing 2

increases expression

Mercury results in increased expression of RHOBTB2 mRNA

NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651

G

ribonuclease H1

decreases expression

Mercury results in decreased expression of RNASEH1 mRNA

NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236

G

ribonuclease H2, subunit A

decreases expression
increases expression

Mercury results in decreased expression of RNASEH2A mRNA
Mercury results in increased expression of RNASEH2A mRNA

PMID:16823088 PMID:17547211

NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041

G

Rho family GTPase 2

increases methylation

Mercury results in increased methylation of RND2 gene

NCBI chr10:86,399,151...86,402,750
Ensembl chr10:86,399,148...86,402,742

G

ring finger protein 138

increases expression

Mercury results in increased expression of RNF138 mRNA

NCBI chr18:12,291,557...12,315,931
Ensembl chr18:12,291,590...12,315,930

G

ring finger protein 141

decreases expression

Mercury results in decreased expression of RNF141 mRNA

NCBI chr 1:164,933,972...164,957,081
Ensembl chr 1:164,931,077...164,957,118

G

RNA guanylyltransferase and 5'-phosphatase

affects expression

Mercury affects the expression of RNGTT mRNA

NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295

G

ribosomal protein L19

decreases expression

Mercury results in decreased expression of RPL19 mRNA

NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112

G

ribosomal protein L28

decreases expression

Mercury results in decreased expression of RPL28 mRNA

NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032

G

ribonuclease P/MRP subunit p21

decreases expression

Mercury analog results in decreased expression of RPP21 mRNA

NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106

G

ribosomal protein S5

decreases expression

Mercury results in decreased expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S6 kinase C1

decreases expression

Mercury analog results in decreased expression of RPS6KC1 mRNA

NCBI chr13:102,346,160...102,491,000
Ensembl chr13:102,346,160...102,490,303

G

ribosome binding protein 1

decreases expression

Mercury results in decreased expression of RRBP1 mRNA

NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981

G

radical S-adenosyl methionine domain containing 2

multiple interactions

[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class II, locus Ba

decreases expression

Mercury results in decreased expression of HLA-DQA1 mRNA

PMID:16823088 PMID:19937285

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

increases expression
decreases expression

Mercury results in increased expression of RT1-BB mRNA
Mercury results in increased expression of HLA-DQB1 mRNA
Mercury results in decreased expression of HLA-DQB1 mRNA

PMID:16823088 PMID:19937285 PMID:22688007

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

reticulon 4

decreases expression

Mercury results in decreased expression of RTN4 mRNA

NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686

G

receptor (chemosensory) transporter protein 3

decreases expression

Mercury results in decreased expression of RTP3 mRNA

NCBI chr 8:110,970,154...110,975,000
Ensembl chr 8:110,970,160...110,974,699

G

rubicon like autophagy enhancer

increases expression

Mercury results in increased expression of RUBCNL mRNA

NCBI chr15:50,332,458...50,377,494
Ensembl chr15:50,332,418...50,400,849

G

S100 calcium-binding protein A4

decreases expression

Mercury analog results in decreased expression of S100A4 mRNA

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

S100 calcium binding protein B

increases secretion

Mercury results in increased secretion of S100B mRNA

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

Sin3A associated protein 30

increases expression

Mercury results in increased expression of SAP30 mRNA

NCBI chr16:32,747,777...32,753,114
Ensembl chr16:32,747,734...32,753,112

G

SR-related CTD-associated factor 4

increases expression

Mercury results in increased expression of SCAF4 mRNA

NCBI chr11:29,460,479...29,521,153
Ensembl chr11:29,465,106...29,521,153

G

scavenger receptor class B, member 1

increases expression

Mercury results in increased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

secretogranin III

increases expression

Mercury results in increased expression of SCG3 mRNA

NCBI chr 8:76,399,777...76,442,015
Ensembl chr 8:76,399,777...76,442,015

G

SEC24 homolog C, COPII coat complex component

increases expression

Mercury results in increased expression of SEC24C mRNA

NCBI chr15:3,602,460...3,624,524
Ensembl chr15:3,602,460...3,624,422

G

selenoprotein P

affects abundance
increases expression
multiple interactions

SELENOP gene polymorphism affects the abundance of Mercury
Mercury results in increased expression of SELENOP protein
[Mercury results in increased expression of SELENOP protein] which results in increased abundance of Selenium; SELENOP protein binds to and results in decreased susceptibility to Mercury

PMID:16451871 PMID:21967774 PMID:27989593

NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852

G

SUMO specific peptidase 6

increases expression

Mercury results in increased expression of SENP6 mRNA

NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170

G

serine (or cysteine) peptidase inhibitor, clade A, member 3N

affects expression

Mercury affects the expression of SERPINA3 protein

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family B member 1A

decreases expression

Mercury results in decreased expression of SERPINB1 mRNA

NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102

G

serpin family C member 1

decreases expression

Mercury results in decreased expression of SERPINC1 mRNA

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family G member 1

affects expression

Mercury affects the expression of SERPING1 protein

NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034

G

secreted frizzled-related protein 1

decreases expression

Mercury results in decreased expression of SFRP1 mRNA

NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286

G

SH3-domain binding protein 2

increases expression

Mercury results in increased expression of SH3BP2 mRNA

NCBI chr14:76,176,097...76,213,300
Ensembl chr14:76,176,101...76,213,251

G

SH3 domain-containing GRB2-like endophilin B2

increases expression

Mercury results in increased expression of SH3GLB2 mRNA

NCBI chr 3:13,616,936...13,631,785
Ensembl chr 3:13,616,938...13,631,757

G

SH3 and PX domains 2A

increases expression

Mercury results in increased expression of SH3PXD2A mRNA

NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166

G

SHC adaptor protein 1

decreases expression

Mercury results in decreased expression of SHC1 mRNA

NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536

G

sirtuin 5

decreases expression

Mercury analog results in decreased expression of SIRT5 mRNA

NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101

G

solute carrier family 11 member 1

increases expression

Mercury results in increased expression of SLC11A1 mRNA

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

G

solute carrier family 11 member 2

decreases expression
multiple interactions
increases uptake

Mercury results in decreased expression of SLC11A2 mRNA
[HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury
SLC11A2 mRNA results in increased uptake of Mercury
SLC11A2 results in increased uptake of Mercury

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 12 member 2

affects transport

SLC12A2 protein mutant form affects the transport of Mercury

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 18 member A2

decreases expression

Mercury analog results in decreased expression of SLC18A2 mRNA

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 22 member 1

increases expression

Mercury results in increased expression of SLC22A1 mRNA

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 4

multiple interactions

Acetylcysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Cysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Mercury binds to and results in decreased activity of SLC22A4 protein

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 6

multiple interactions
affects response to substance

SLC22A6 gene SNP affects the susceptibility to and affects the abundance of Mercury; SLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Mercury]
SLC22A6 gene SNP affects the susceptibility to Mercury

PMID:15908511 PMID:23052037 PMID:32946573

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

multiple interactions

[SLC22A8 gene SNP affects the susceptibility to Mercury] which affects the abundance of Mercury; SLC22A8 gene SNP affects the susceptibility to and affects the abundance of Mercury

PMID:23052037 PMID:32946573

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 25 member 22

decreases expression

Mercury results in decreased expression of SLC25A22 mRNA

NCBI chr 1:196,528,471...196,536,398
Ensembl chr 1:196,528,472...196,536,331

G

solute carrier family 2 member 4

decreases expression

Mercury results in decreased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 30 member 1

increases expression

Mercury results in increased expression of SLC30A1 mRNA

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 39 member 8

multiple interactions

Mercury inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]

NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129

G

solute carrier family 3 member 2

affects import

SLC3A2 protein affects the import of Mercury

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 6 member 4

affects response to substance

SLC6A4 promoter polymorphism affects the susceptibility to Mercury

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

solute carrier family 7 member 2

decreases expression

Mercury results in decreased expression of SLC7A2 mRNA

NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784

G

solute carrier family 7 member 5

multiple interactions

SLC7A5 gene SNP affects the susceptibility to and affects the abundance of Mercury

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

slit guidance ligand 3

decreases expression

Mercury results in decreased expression of SLIT3 mRNA

NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634

G

SMAD family member 2

increases expression

Mercury results in increased expression of SMAD2 mRNA

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

structural maintenance of chromosomes 4

increases expression

Mercury results in increased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

small integral membrane protein 14

increases expression

Mercury results in increased expression of SMIM14 mRNA

NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760

G

small nuclear ribonucleoprotein polypeptide A

increases expression

Mercury results in increased expression of SNRPA mRNA

NCBI chr 1:82,481,770...82,490,540
Ensembl chr 1:82,481,770...82,490,538

G

superoxide dismutase 1

increases expression
multiple interactions

Mercury results in increased expression of SOD1 mRNA
[Mercury co-treated with Hydrogen Peroxide] results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

Mercury analog results in decreased expression of SOS1 mRNA

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SRY-box transcription factor 18

increases expression

Mercury results in increased expression of SOX18 mRNA

NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290

G

serine peptidase inhibitor, Kazal type 1

decreases expression

Mercury results in decreased expression of SPINK1 mRNA

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

secreted phosphoprotein 1

increases expression

Mercury results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

spectrin, beta, non-erythrocytic 1

increases expression

Mercury results in increased expression of SPTBN1 mRNA

NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507

G

serum response factor

decreases expression

Mercury results in decreased expression of SRF mRNA

NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733

G

SRSF protein kinase 3

decreases expression

Mercury analog results in decreased expression of SRPK3 mRNA

NCBI chr X:151,510,452...151,515,208
Ensembl chr X:151,510,539...151,515,198

G

serine and arginine rich splicing factor 2

increases expression

Mercury results in increased expression of SRSF2 mRNA

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine and arginine rich splicing factor 7

increases expression

Mercury results in increased expression of SRSF7 mRNA

NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965

G

single stranded DNA binding protein 1

increases expression

Mercury results in increased expression of SSBP1 mRNA

NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135

G

signal sequence receptor subunit 2

decreases expression

Mercury results in decreased expression of SSR2 mRNA

NCBI chr 2:174,048,291...174,057,043
Ensembl chr 2:174,048,460...174,057,042

G

somatostatin receptor 3

decreases expression

Mercury results in decreased expression of SSTR3 mRNA

NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769

G

serine/threonine kinase 24

decreases expression

Mercury analog results in decreased expression of STK24 mRNA

NCBI chr15:98,363,707...98,458,940
Ensembl chr15:98,365,791...98,460,553

G

STIP1 homology and U-box containing protein 1

decreases expression

Mercury results in decreased expression of STUB1 mRNA

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

SUB1 regulator of transcription

decreases expression

Mercury results in decreased expression of SUB1 mRNA

NCBI chr 2:61,005,646...61,020,486
Ensembl chr 2:61,005,666...61,020,436
Ensembl chr 2:61,005,666...61,020,436

G

SUZ RNA binding domain containing 1

affects expression

Mercury affects the expression of SZRD1 mRNA

NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252

G

tachykinin, precursor 1

increases expression

Mercury results in increased expression of TAC1 mRNA

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transporter 1, ATP binding cassette subfamily B member

decreases expression

Mercury results in decreased expression of TAP1 mRNA

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

TAR DNA binding protein

multiple interactions

[methylmercuric chloride results in increased abundance of Mercury] which affects the localization of TARDBP protein

NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055

G

tyrosine aminotransferase

increases activity
multiple interactions

Mercury results in increased activity of TAT protein
Mercury inhibits the reaction [Dexamethasone results in increased activity of TAT protein]

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

transcription factor 3

decreases expression

Mercury results in decreased expression of TCF3 mRNA

NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314

G

testin LIM domain protein

decreases expression

Mercury results in decreased expression of TES mRNA

NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829

G

transferrin

increases secretion

Mercury results in increased secretion of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 2

increases expression

Mercury results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

thioesterase superfamily member 6

decreases expression

Mercury analog results in decreased expression of THEM6 mRNA

NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746

G

THUMP domain containing 2

decreases expression

Mercury analog results in decreased expression of THUMPD2 mRNA

NCBI chr 6:13,924,742...13,976,657
Ensembl chr 6:13,924,765...13,976,657

G

THUMP domain containing 3

decreases expression

Mercury results in decreased expression of THUMPD3 mRNA

NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246

G

translocase of inner mitochondrial membrane 13

decreases expression

Mercury results in decreased expression of TIMM13 mRNA

NCBI chr 7:8,809,069...8,810,172
Ensembl chr 7:8,809,058...8,809,910

G

translocase of inner mitochondrial membrane 23

increases expression

Mercury results in increased expression of TIMM23 mRNA

NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379

G

tight junction protein 1

decreases expression

Mercury results in decreased expression of TJP1 mRNA

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

thymidine kinase 2

affects expression

Mercury affects the expression of TK2 mRNA

NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924

G

TM2 domain containing 1

increases expression

Mercury results in increased expression of TM2D1 mRNA

NCBI chr 5:113,020,793...113,062,134
Ensembl chr 5:113,020,760...113,050,933

G

TATA element modulatory factor 1

decreases expression

Mercury results in decreased expression of TMF1 mRNA

NCBI chr 4:129,759,952...129,785,705
Ensembl chr 4:129,763,114...129,785,629

G

tumor necrosis factor

increases expression
multiple interactions
affects expression

Mercury results in increased expression of TNF mRNA
Mercury promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Mercury results in increased expression of TNF protein
Mercury affects the expression of TNF mRNA
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of TNF mRNA]
Mercury results in increased expression of TNF mRNA; Mercury results in increased expression of TNF protein

PMID:12730625 PMID:12928768 PMID:15282405 PMID:20176347 PMID:20600710 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

increases expression

Mercury results in increased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 8

increases expression
decreases expression

Mercury results in increased expression of TNFAIP8 mRNA
Mercury results in decreased expression of TNFAIP8 mRNA

PMID:17547211 PMID:22688007

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 1A

increases expression

Mercury results in increased expression of TNFRSF1A mRNA; Mercury results in increased expression of TNFRSF1A protein

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

decreases expression

Mercury results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tensin 2

decreases expression

Mercury analog results in decreased expression of TNS2 mRNA

NCBI chr 7:133,229,746...133,247,889
Ensembl chr 7:133,206,364...133,247,888

G

TOX high mobility group box family member 3

increases expression

Mercury results in increased expression of TOX3 mRNA

NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148

G

tumor protein p53

affects folding

Mercury affects the folding of TRP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 2

increases expression

Mercury results in increased expression of TPM2 mRNA

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

TNFRSF1A-associated via death domain

increases expression

Mercury results in increased expression of TRADD protein

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

tribbles pseudokinase 3

decreases expression

Mercury results in decreased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

thyroid hormone receptor interactor 13

increases expression

Mercury results in increased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

G

tetraspanin 7

decreases expression

Mercury results in decreased expression of TSPAN7 mRNA

NCBI chr X:12,208,783...12,306,092
Ensembl chr X:12,208,783...12,306,131

G

thiosulfate sulfurtransferase

decreases expression

Mercury results in decreased expression of TST mRNA

NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216

G

tubulin, alpha 8

decreases expression

Mercury analog results in decreased expression of TUBA8 mRNA

NCBI chr 4:154,440,045...154,456,918
Ensembl chr 4:154,440,074...154,456,917

G

twinfilin actin-binding protein 2

decreases expression

Mercury results in decreased expression of TWF2 mRNA

NCBI chr 8:106,845,253...106,858,298
Ensembl chr 8:106,845,253...106,858,298

G

thioredoxin 1

affects binding

Mercury binds to TXN protein

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin domain containing 11

decreases expression

Mercury analog results in decreased expression of TXNDC11 mRNA

NCBI chr10:4,515,457...4,572,999
Ensembl chr10:4,515,478...4,572,989

G

thioredoxin reductase 1

increases expression

Mercury results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

decreases activity

Mercury results in decreased activity of TXNRD2 protein

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

thymidylate synthetase

increases expression

Mercury results in increased expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin-conjugating enzyme E2C

increases expression

Mercury results in increased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2L 3

decreases expression

Mercury analog results in decreased expression of UBE2L3 mRNA

NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862

G

ubiquitin-conjugating enzyme E2N

decreases expression

Mercury results in decreased expression of UBE2N mRNA

NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355

G

UDP-glucose ceramide glucosyltransferase

increases expression

Mercury results in increased expression of UGCG mRNA

NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393

G

ubiquinol-cytochrome c reductase binding protein

increases expression

Mercury results in increased expression of UQCRB mRNA

NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150

G

uroporphyrinogen decarboxylase

decreases activity

Mercury results in decreased activity of UROD protein

NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808

G

ubiquitin specific peptidase 39

increases expression

Mercury results in increased expression of USP39 mRNA

NCBI chr 4:104,373,948...104,406,359
Ensembl chr 4:104,373,955...104,406,359

G

ubiquitin specific peptidase 53

decreases expression

Mercury analog results in decreased expression of USP53 mRNA

NCBI chr 2:211,059,512...211,120,942
Ensembl chr 2:211,059,520...211,120,943

G

ubiquitin specific peptidase like 1

increases expression

Mercury results in increased expression of USPL1 mRNA

NCBI chr12:5,823,460...5,850,470
Ensembl chr12:5,823,359...5,850,366

G

vasodilator-stimulated phosphoprotein

decreases expression

Mercury analog results in decreased expression of VASP mRNA

NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061

G

vitamin D receptor

affects abundance

VDR gene polymorphism affects the abundance of Mercury

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vimentin

increases expression

Mercury results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vacuolar protein sorting 36 homolog

decreases expression

Mercury analog results in decreased expression of VPS36 mRNA

NCBI chr16:69,810,404...69,834,789
Ensembl chr16:69,808,193...69,834,810

G

vitronectin

decreases expression

Mercury results in decreased expression of VTN mRNA

NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810

G

von Willebrand factor A domain containing 1

increases expression

Mercury results in increased expression of VWA1 mRNA

NCBI chr 5:166,377,451...166,382,784
Ensembl chr 5:166,377,455...166,382,637

G

WD repeat domain 12

decreases expression

Mercury results in decreased expression of WDR12 mRNA

NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469

G

WD repeat domain, phosphoinositide interacting 1

decreases expression

Mercury results in decreased expression of WIPI1 mRNA

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

G

X inactive specific transcript

increases expression

Mercury results in increased expression of XIST mRNA

NCBI chr X:68,474,987...68,492,500

G

Y box binding protein 1

increases expression

Mercury results in increased expression of YBX1 mRNA

NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

decreases expression

Mercury analog results in decreased expression of YWHAQ mRNA

NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreases expression

Mercury results in decreased expression of YWHAZ mRNA

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

G

zinc finger and BTB domain containing 1

increases expression

Mercury results in increased expression of ZBTB1 mRNA

NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996

G

zinc finger and BTB domain containing 10

increases expression

Mercury results in increased expression of ZBTB10 mRNA

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

G

zinc finger and BTB domain containing 16

increases expression

Mercury results in increased expression of ZBTB16 mRNA

NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011

G

zinc finger and BTB domain containing 38

increases expression

Mercury results in increased expression of ZBTB38 mRNA

NCBI chr 8:97,284,617...97,288,518
Ensembl chr 8:97,280,993...97,485,625

G

zinc finger AN1-type containing 3

decreases expression

Mercury analog results in decreased expression of ZFAND3 mRNA

NCBI chr20:8,083,407...8,279,617
Ensembl chr20:8,082,200...8,279,616

G

zinc finger homeobox 4

decreases expression

Mercury analog results in decreased expression of ZFHX4 mRNA

NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228

G

zinc finger protein 174

decreases expression

Mercury results in decreased expression of ZNF174 mRNA

NCBI chr10:11,666,580...11,676,328
Ensembl chr10:11,669,913...11,676,312

G

zinc finger protein 866

increases expression

Mercury results in increased expression of CXCL5 mRNA

NCBI chr16:19,653,966...19,675,968
Ensembl chr16:19,668,258...19,675,932

G

zinc finger protein 950

increases expression

Mercury results in increased expression of ZNF80 mRNA

NCBI chr 1:260,248,231...260,265,211
Ensembl chr 1:260,236,599...260,265,254

G

ZW10 interacting kinetochore protein

increases expression

Mercury results in increased expression of ZWINT mRNA

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
biological role	19785
aetiopathogenetic role	19163
neurotoxin	18154
mercury(0)	558
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
metal atom	17706
transition element atom	17076
d-block element atom	17069
d-block molecular entity	16824
zinc group molecular entity	11765
mercury molecular entity	6766
elemental mercury	558
mercury(0)	558

paths to the root