Stub1 (STIP1 homology and U-box containing protein 1) - Rat Genome Database

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Gene: Stub1 (STIP1 homology and U-box containing protein 1) Rattus norvegicus
Analyze
Symbol: Stub1
Name: STIP1 homology and U-box containing protein 1
RGD ID: 1306167
Description: Enables protein-folding chaperone binding activity. Involved in several processes, including cellular response to hypoxia; chaperone-mediated autophagy; and response to ischemia. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxy terminus of Hsp70-interacting protein; Chip; E3 ubiquitin-protein ligase CHIP; LOC287155; MGC116422; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,355,278 - 15,357,559 (-)NCBIGRCr8
mRatBN7.21014,850,765 - 14,853,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,850,765 - 14,853,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,589,774 - 19,592,055 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,078,650 - 19,080,931 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,578,930 - 14,581,211 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,197,754 - 15,200,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,197,803 - 15,200,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,010,697 - 15,012,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,096,150 - 15,098,431 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,096,147 - 15,098,378 (-)NCBI
Celera1014,519,707 - 14,521,988 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation. Anderson LG, etal., Cell Stress Chaperones. 2010 Sep;15(5):487-95. doi: 10.1007/s12192-009-0162-5. Epub 2009 Dec 2.
2. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. Carrettiero DC, etal., J Neurosci. 2009 Feb 18;29(7):2151-61. doi: 10.1523/JNEUROSCI.4660-08.2009.
3. CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation. Chao CN, etal., J Cell Physiol. 2019 Nov;234(11):20128-20138. doi: 10.1002/jcp.28614. Epub 2019 Apr 13.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. Li F, etal., J Biol Chem. 2009 Jul 24;284(30):20090-8. doi: 10.1074/jbc.M109.017046. Epub 2009 May 29.
6. Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein. Lizama BN, etal., J Neurosci. 2018 Aug 1;38(31):6825-6840. doi: 10.1523/JNEUROSCI.0699-18.2018. Epub 2018 Jun 22.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. Peng X, etal., J Biol Chem. 2005 Apr 1;280(13):13148-52. Epub 2005 Jan 25.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Ulbricht A, etal., Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.
14. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. Woo CH, etal., FASEB J. 2010 Dec;24(12):4917-28. doi: 10.1096/fj.10-162636. Epub 2010 Aug 19.
15. CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation. Xie P, etal., Mol Cell Biol. 2009 May;29(9):2398-408. doi: 10.1128/MCB.01737-08. Epub 2009 Feb 23.
16. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG, etal., Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E617-24. doi: 10.1073/pnas.1104391108. Epub 2011 Aug 1.
Additional References at PubMed
PMID:8889548   PMID:10330192   PMID:11146632   PMID:11435423   PMID:12150907   PMID:12477932   PMID:14610072   PMID:15466472   PMID:15781469   PMID:16207813   PMID:16275660   PMID:16280320  
PMID:16307917   PMID:16809764   PMID:16831871   PMID:17512523   PMID:18042044   PMID:18292230   PMID:18301957   PMID:19103148   PMID:19423554   PMID:19713937   PMID:20060297   PMID:20413784  
PMID:20819951   PMID:21219885   PMID:21855799   PMID:22267842   PMID:22366786   PMID:22456997   PMID:23376485   PMID:23990462   PMID:24186360   PMID:24334056   PMID:24613385   PMID:24664141  
PMID:25773675   PMID:26265139   PMID:26279425   PMID:27323684   PMID:28257878   PMID:28338815   PMID:29883609   PMID:30222779   PMID:35352799   PMID:36400309   PMID:36497031   PMID:36755387  
PMID:37992540   PMID:38085649  


Genomics

Comparative Map Data
Stub1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,355,278 - 15,357,559 (-)NCBIGRCr8
mRatBN7.21014,850,765 - 14,853,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,850,765 - 14,853,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,589,774 - 19,592,055 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,078,650 - 19,080,931 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,578,930 - 14,581,211 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,197,754 - 15,200,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,197,803 - 15,200,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,010,697 - 15,012,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,096,150 - 15,098,431 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,096,147 - 15,098,378 (-)NCBI
Celera1014,519,707 - 14,521,988 (-)NCBICelera
Cytogenetic Map10q12NCBI
STUB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816680,410 - 682,801 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16680,224 - 682,870 (+)EnsemblGRCh38hg38GRCh38
GRCh3716730,410 - 732,801 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616670,116 - 672,769 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416670,115 - 672,768NCBI
Celera16930,272 - 932,925 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16651,974 - 654,645 (+)NCBIHuRef
CHM1_116730,089 - 732,742 (+)NCBICHM1_1
T2T-CHM13v2.016684,485 - 686,876 (+)NCBIT2T-CHM13v2.0
Stub1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,049,608 - 26,051,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,049,479 - 26,052,378 (-)EnsemblGRCm39 Ensembl
GRCm381725,830,634 - 25,832,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,830,505 - 25,833,404 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,967,581 - 25,970,306 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,558,236 - 25,560,961 (-)NCBIMGSCv36mm8
Celera1726,363,459 - 26,366,184 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.93NCBI
Stub1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,521,130 - 16,523,468 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,521,130 - 16,523,733 (-)NCBIChiLan1.0ChiLan1.0
STUB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218921,269 - 923,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,705,136 - 4,707,825 (+)NCBINHGRI_mPanPan1
PanPan1.116694,414 - 696,682 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16694,414 - 696,682 (+)Ensemblpanpan1.1panPan2
STUB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,893,492 - 39,895,385 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,893,670 - 39,897,573 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,157,620 - 41,160,024 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,236,147 - 40,238,551 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,236,151 - 40,238,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,924,709 - 39,927,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,884,918 - 39,887,322 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,364,058 - 40,366,462 (-)NCBIUU_Cfam_GSD_1.0
Stub1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,230,907 - 112,233,127 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501326,451 - 330,983 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501328,767 - 330,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STUB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,092,449 - 41,095,136 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,092,514 - 41,095,181 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,382,439 - 41,385,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STUB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15599,907 - 602,549 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5599,819 - 605,567 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606830,534,608 - 30,537,266 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stub1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,491,991 - 1,494,249 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,491,873 - 1,494,249 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stub1
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:48
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000026921
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat

Markers in Region
AA957388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,850,836 - 14,851,034 (+)MAPPERmRatBN7.2
Rnor_6.01015,197,826 - 15,198,023NCBIRnor6.0
Rnor_5.01015,010,769 - 15,010,966UniSTSRnor5.0
RGSC_v3.41015,096,222 - 15,096,419UniSTSRGSC3.4
Celera1014,519,779 - 14,519,976UniSTS
RH 3.4 Map10154.2UniSTS
Cytogenetic Map10q12UniSTS
RH137115  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,854,094 - 14,854,308 (+)MAPPERmRatBN7.2
Rnor_6.01015,201,084 - 15,201,297NCBIRnor6.0
Rnor_5.01015,014,027 - 15,014,240UniSTSRnor5.0
RGSC_v3.41015,099,480 - 15,099,693UniSTSRGSC3.4
Celera1014,523,037 - 14,523,250UniSTS
RH 3.4 Map10154.1UniSTS
Cytogenetic Map10q12UniSTS
RH137204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,851,593 - 14,851,812 (+)MAPPERmRatBN7.2
Rnor_6.01015,198,583 - 15,198,801NCBIRnor6.0
Rnor_5.01015,011,526 - 15,011,744UniSTSRnor5.0
RGSC_v3.41015,096,979 - 15,097,197UniSTSRGSC3.4
Celera1014,520,536 - 14,520,754UniSTS
RH 3.4 Map10154.5UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026921   ⟹   ENSRNOP00000026921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,850,765 - 14,853,046 (-)Ensembl
Rnor_6.0 Ensembl1015,197,803 - 15,200,117 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119797   ⟹   ENSRNOP00000080207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,850,765 - 14,852,738 (-)Ensembl
RefSeq Acc Id: NM_001025625   ⟹   NP_001020796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,355,278 - 15,357,559 (-)NCBI
mRatBN7.21014,850,765 - 14,853,046 (-)NCBI
Rnor_6.01015,197,754 - 15,200,035 (-)NCBI
Rnor_5.01015,010,697 - 15,012,978 (-)NCBI
RGSC_v3.41015,096,150 - 15,098,431 (-)RGD
Celera1014,519,707 - 14,521,988 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020796 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6HD62 (Get FASTA)   NCBI Sequence Viewer  
  AAH99240 (Get FASTA)   NCBI Sequence Viewer  
  EDM03967 (Get FASTA)   NCBI Sequence Viewer  
  EDM03968 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026921
  ENSRNOP00000026921.4
  ENSRNOP00000080207.1
Reference Protein Sequences
RefSeq Acc Id: NP_001020796   ⟸   NM_001025625
- UniProtKB: D4A4T0 (UniProtKB/TrEMBL),   A6HD62 (UniProtKB/TrEMBL),   A0A8I5ZPA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026921   ⟸   ENSRNOT00000026921
RefSeq Acc Id: ENSRNOP00000080207   ⟸   ENSRNOT00000119797
Protein Domains
CHIP N-terminal tetratricopeptide repeat   U-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4T0-F1-model_v2 AlphaFold D4A4T0 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697062
Promoter ID:EPDNEW_R7586
Type:initiation region
Name:Stub1_1
Description:STIP1 homology and U-box containing protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,199,998 - 15,200,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306167 AgrOrtholog
BioCyc Gene G2FUF-25751 BioCyc
Ensembl Genes ENSRNOG00000019798 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026921 ENTREZGENE
  ENSRNOT00000026921.7 UniProtKB/Swiss-Prot
  ENSRNOT00000119797.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  6.10.140.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetratricopeptide repeat domain UniProtKB/Swiss-Prot
  Zinc/RING finger domain, C3HC4 (zinc finger) UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7445727 IMAGE-MGC_LOAD
InterPro CHIP/LubX_RING-Ubox UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  CHIP_TPR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubox_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287155 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116422 IMAGE-MGC_LOAD
NCBI Gene 287155 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE CHIP UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE CHIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46803 UniProtKB/TrEMBL
Pfam ANAPC3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHIP_TPR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stub1 PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019798 RatGTEx
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A8I5ZPA4 ENTREZGENE, UniProtKB/TrEMBL
  A6HD62 ENTREZGENE
  A6HD63_RAT UniProtKB/TrEMBL
  CHIP_RAT UniProtKB/Swiss-Prot
  D4A4T0 ENTREZGENE
  I6L9H8_RAT UniProtKB/TrEMBL
UniProt Secondary D4A4T0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Stub1  STIP1 homology and U-box containing protein 1  Stub1  STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Stub1  STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase  Stub1  STIP1 homology and U-Box containing protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Stub1  STIP1 homology and U-Box containing protein 1  Stub1_predicted  STIP1 homology and U-Box containing protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Stub1_predicted  STIP1 homology and U-Box containing protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED