Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PFDN4 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Pfdn4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PFDN4 mRNA | CTD | PMID:36331819 | 1H-pyrazole | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | pyrazole results in increased expression of PFDN4 mRNA | CTD | PMID:17945193 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Pfdn4 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PFDN4 mRNA | CTD | PMID:21570461 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PFDN4 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PFDN4 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Fenretinide results in increased expression of PFDN4 mRNA | CTD | PMID:28973697 | aflatoxin M1 | decreases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Aflatoxin M1 results in decreased expression of PFDN4 mRNA | CTD | PMID:30928695 | all-trans-retinoic acid | decreases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PFDN4 mRNA | CTD | PMID:33167477 | Aroclor 1254 | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of PFDN4 mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to PFDN4 mRNA] | CTD | PMID:32406909 | avobenzone | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | avobenzone results in increased expression of PFDN4 mRNA | CTD | PMID:31016361 | benzo[a]pyrene | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PFDN4 mRNA | CTD | PMID:19770486 | bisphenol A | increases methylation | ISO | Pfdn4 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of PFDN4 promoter | CTD | PMID:27312807 | bisphenol A | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PFDN4 protein | CTD | PMID:34186270 | bisphenol A | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PFDN4 mRNA | CTD | PMID:32156529 and PMID:38074096 | Bisphenol B | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of PFDN4 protein | CTD | PMID:34186270 | bisphenol F | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of PFDN4 protein | CTD | PMID:34186270 | bortezomib | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of PFDN4 mRNA | CTD | PMID:20977926 | carbon nanotube | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PFDN4 mRNA | CTD | PMID:25554681 | choline | multiple interactions | ISO | Pfdn4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PFDN4 gene | CTD | PMID:20938992 | copper(II) sulfate | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PFDN4 mRNA | CTD | PMID:19549813 | crocidolite asbestos | decreases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PFDN4 mRNA | CTD | PMID:29279043 | cyclosporin A | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PFDN4 mRNA | CTD | PMID:20106945 | dexamethasone | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PFDN4 mRNA | CTD | PMID:28628672 | dibutyl phthalate | decreases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PFDN4 mRNA | CTD | PMID:17361019 | dicrotophos | decreases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of PFDN4 mRNA | CTD | PMID:28302478 | doxorubicin | decreases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PFDN4 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PFDN4 protein | CTD | PMID:23301498 | ethanol | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Ethanol results in increased expression of PFDN4 mRNA | CTD | PMID:30319688 | fenthion | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Fenthion results in increased expression of PFDN4 mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Pfdn4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PFDN4 gene | CTD | PMID:20938992 | folic acid | decreases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PFDN4 mRNA | CTD | PMID:25629700 | FR900359 | increases phosphorylation | ISO | PFDN4 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PFDN4 protein | CTD | PMID:37730182 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PFDN4 mRNA | CTD | PMID:33387578 | hydrogen peroxide | decreases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Hydrogen Peroxide results in decreased expression of PFDN4 mRNA | CTD | PMID:12419474 | indometacin | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PFDN4 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PFDN4 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Pfdn4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PFDN4 gene | CTD | PMID:20938992 | mercury atom | decreases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Mercury analog results in decreased expression of PFDN4 mRNA | CTD | PMID:25056781 | mercury(0) | decreases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Mercury analog results in decreased expression of PFDN4 mRNA | CTD | PMID:25056781 | ozone | multiple interactions | ISO | Pfdn4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of PFDN4 mRNA | CTD | PMID:34911549 | ozone | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PFDN4 mRNA | CTD | PMID:35430440 | paracetamol | affects expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PFDN4 mRNA | CTD | PMID:17562736 | pentachlorophenol | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of PFDN4 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Pfdn4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PFDN4 mRNA | CTD | PMID:36331819 | pirinixic acid | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PFDN4 mRNA | CTD | PMID:18301758 | resveratrol | multiple interactions | ISO | PFDN4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PFDN4 mRNA | CTD | PMID:23557933 | sodium arsenite | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of PFDN4 mRNA | CTD | PMID:12016162 | tetrachloromethane | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PFDN4 mRNA | CTD | PMID:27339419 and PMID:31919559 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PFDN4 mRNA | CTD | PMID:33387578 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PFDN4 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PFDN4 mRNA] | CTD | PMID:31150632 | thimerosal | increases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of PFDN4 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PFDN4 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PFDN4 mRNA | CTD | PMID:29264374 | tungsten | increases expression | ISO | Pfdn4 (Mus musculus) | 6480464 | Tungsten results in increased expression of PFDN4 mRNA | CTD | PMID:30912803 | valproic acid | decreases expression | ISO | PFDN4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PFDN4 mRNA | CTD | PMID:23179753 and PMID:27188386 | |