Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HMGN2 mRNA | CTD | PMID:36331819 | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | o and p'-DDT results in decreased expression of HMGN2 mRNA | CTD | PMID:19371625 | 1,2-dimethylhydrazine | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HMGN2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of HMGN2 mRNA | CTD | PMID:17557909 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HMGN2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HMGN2 mRNA | CTD | PMID:34747641 | 2,3-dimethoxynaphthalene-1,4-dione | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:17547211 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of HMGN2 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of HMGN2 mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of HMGN2 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of HMGN2 mRNA | CTD | PMID:28628672 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of HMGN2 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of HMGN2 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of HMGN2 protein | CTD | PMID:34186270 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Hmgn2 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of HMGN2 promoter | CTD | PMID:33297965 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of HMGN2 mRNA | CTD | PMID:28973697 | 4-hydroxyphenyl retinamide | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Fenretinide results in decreased expression of HMGN2 mRNA | CTD | PMID:16671099 | 5-aza-2'-deoxycytidine | affects expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Decitabine affects the expression of HMGN2 mRNA | CTD | PMID:23300844 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of HMGN2 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of HMGN2 mRNA | CTD | PMID:31881176 | aristolochic acid A | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HMGN2 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of HMGN2 mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to HMGN2 mRNA] | CTD | PMID:32406909 | arsenous acid | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of HMGN2 mRNA | CTD | PMID:17547211 and PMID:20458559 | arsenous acid | increases response to substance | ISO | HMGN2 (Homo sapiens) | 6480464 | HMGN2 protein results in increased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | atrazine | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Atrazine results in increased expression of HMGN2 mRNA | CTD | PMID:22378314 | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of HMGN2 mRNA | CTD | PMID:36841081 | benzo[a]pyrene | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of HMGN2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of HMGN2 protein | CTD | PMID:33278487 | benzo[a]pyrene | affects methylation | ISO | HMGN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HMGN2 3' UTR | CTD | PMID:27901495 | benzo[b]fluoranthene | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of HMGN2 mRNA | CTD | PMID:26377693 | bis(2-chloroethyl) sulfide | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Mustard Gas results in decreased expression of HMGN2 mRNA | CTD | PMID:25102026 | bisphenol A | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of HMGN2 mRNA | CTD | PMID:19371625 | bisphenol A | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of HMGN2 mRNA | CTD | PMID:38074096 | bisphenol A | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of HMGN2 protein | CTD | PMID:34186270 | bisphenol A | decreases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of HMGN2 mRNA | CTD | PMID:33221593 | bisphenol A | affects expression | ISO | HMGN2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of HMGN2 mRNA | CTD | PMID:30903817 | bisphenol A | decreases methylation | ISO | Hmgn2 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of HMGN2 promoter | CTD | PMID:27312807 | Bisphenol B | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of HMGN2 protein | CTD | PMID:34186270 | bisphenol F | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of HMGN2 protein | CTD | PMID:34186270 | Brodifacoum | increases expression | EXP | | 6480464 | bromfenacoum results in increased expression of HMGN2 protein | CTD | PMID:28903499 | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of HMGN2 mRNA | CTD | PMID:24136188 | cadmium atom | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMGN2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMGN2 mRNA | CTD | PMID:35301059 | carbon nanotube | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | carmustine | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Carmustine results in decreased expression of HMGN2 mRNA | CTD | PMID:15980968 | CGP 52608 | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HMGN2 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of HMGN2 mRNA | CTD | PMID:18668222 | chlorpyrifos | decreases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of HMGN2 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of HMGN2 more ... | CTD | PMID:20938992 | chromium atom | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Chromium results in increased expression of HMGN2 mRNA | CTD | PMID:17547211 | ciguatoxin CTX1B | affects expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of HMGN2 mRNA | CTD | PMID:18353800 | cisplatin | affects expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of HMGN2 mRNA | CTD | PMID:23300844 | copper(II) sulfate | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of HMGN2 mRNA | CTD | PMID:19549813 | corticosterone | decreases expression | EXP | | 6480464 | Corticosterone results in decreased expression of HMGN2 mRNA | CTD | PMID:15755911 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of HMGN2 mRNA | CTD | PMID:26577399 | dexamethasone | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of HMGN2 mRNA | CTD | PMID:28628672 | diallyl trisulfide | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | diallyl trisulfide results in decreased expression of HMGN2 mRNA | CTD | PMID:34995734 | diarsenic trioxide | increases response to substance | ISO | HMGN2 (Homo sapiens) | 6480464 | HMGN2 protein results in increased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | diarsenic trioxide | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of HMGN2 mRNA | CTD | PMID:17547211 and PMID:20458559 | diazinon | increases methylation | ISO | HMGN2 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of HMGN2 gene | CTD | PMID:22964155 | dibenz[a,h]anthracene | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of HMGN2 mRNA | CTD | PMID:21551480 | doxorubicin | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HMGN2 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HMGN2 protein | CTD | PMID:23301498 | ethanol | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of HMGN2 mRNA | CTD | PMID:30517762 | ethanol | affects splicing | ISO | Hmgn2 (Mus musculus) | 6480464 | Ethanol affects the splicing of HMGN2 mRNA | CTD | PMID:30319688 | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of HMGN2 mRNA | CTD | PMID:34044035 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of HMGN2 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | genistein | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Genistein results in decreased expression of HMGN2 mRNA | CTD | PMID:18847459 and PMID:19371625 | indometacin | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of HMGN2 mRNA | CTD | PMID:28628672 | L-methionine | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of HMGN2 more ... | CTD | PMID:20938992 | lead(0) | affects expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Lead affects the expression of HMGN2 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of HMGN2 mRNA | CTD | PMID:24136188 | leflunomide | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of HMGN2 mRNA | CTD | PMID:28988120 | levofloxacin | decreases expression | EXP | | 6480464 | Levofloxacin results in decreased expression of HMGN2 mRNA | CTD | PMID:24136188 | lipopolysaccharide | multiple interactions | ISO | HMGN2 (Homo sapiens) | 6480464 | [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of HMGN2 mRNA | CTD | PMID:35877022 | mercury atom | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Mercury results in increased expression of HMGN2 mRNA | CTD | PMID:17547211 | mercury(0) | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Mercury results in increased expression of HMGN2 mRNA | CTD | PMID:17547211 | methidathion | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | methidathion results in increased expression of HMGN2 mRNA | CTD | PMID:34813904 | N-nitrosodiethylamine | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of HMGN2 mRNA | CTD | PMID:17854601 | N-nitrosodiethylamine | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGN2 mRNA] | CTD | PMID:17854601 | ozone | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of HMGN2 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of HMGN2 mRNA | CTD | PMID:34911549 | paracetamol | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of HMGN2 mRNA | CTD | PMID:22230336 | paracetamol | affects expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of HMGN2 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HMGN2 mRNA | CTD | PMID:36331819 | PhIP | increases expression | EXP | | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of HMGN2 mRNA | CTD | PMID:15215175 | pirinixic acid | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of HMGN2 mRNA | CTD | PMID:23811191 | potassium dichromate | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of HMGN2 mRNA and Potassium Dichromate results in increased expression of HMGN2 protein | CTD | PMID:17547211 and PMID:23718831 | propanal | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of HMGN2 mRNA | CTD | PMID:26079696 | rac-lactic acid | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of HMGN2 mRNA | CTD | PMID:30851411 | resveratrol | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | resveratrol results in decreased expression of HMGN2 mRNA | CTD | PMID:19371625 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of HMGN2 mRNA | CTD | PMID:28374803 | sodium arsenite | affects methylation | ISO | HMGN2 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of HMGN2 gene | CTD | PMID:28589171 | sodium arsenite | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of HMGN2 mRNA | CTD | PMID:34032870 | sunitinib | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of HMGN2 mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of HMGN2 mRNA | CTD | PMID:31758290 | tetrachloromethane | affects expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of HMGN2 mRNA | CTD | PMID:17484886 | tetrachloromethane | multiple interactions | ISO | Hmgn2 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of HMGN2 mRNA | CTD | PMID:30517762 | tetraphene | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of HMGN2 mRNA | CTD | PMID:26377693 | trimellitic anhydride | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of HMGN2 mRNA | CTD | PMID:19042947 | triptonide | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | triptonide results in increased expression of HMGN2 mRNA | CTD | PMID:33045310 | tris(2-butoxyethyl) phosphate | affects expression | ISO | HMGN2 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of HMGN2 mRNA | CTD | PMID:29024780 | tungsten | increases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Tungsten results in increased expression of HMGN2 mRNA | CTD | PMID:30912803 | valdecoxib | decreases expression | EXP | | 6480464 | valdecoxib results in decreased expression of HMGN2 mRNA | CTD | PMID:24136188 | valproic acid | increases methylation | ISO | HMGN2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of HMGN2 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of HMGN2 mRNA | CTD | PMID:20546886 | valproic acid | affects expression | ISO | Hmgn2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of HMGN2 mRNA | CTD | PMID:17963808 | zearalenone | decreases expression | ISO | HMGN2 (Homo sapiens) | 6480464 | Zearalenone results in decreased expression of HMGN2 mRNA | CTD | PMID:19371625 | |