Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:733393 | 6480464 | Ethinyl Estradiol results in increased expression of ENPP1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1351327 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ENPP1 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1351327 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ENPP1 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ENPP1 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:733393 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ENPP1 mRNA | CTD | PMID:19933214 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of ENPP1 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ENPP1 mRNA | CTD | PMID:21346803 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | aflatoxin B1 | decreases expression | ISO | RGD:733393 | 6480464 | Aflatoxin B1 results in decreased expression of ENPP1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases expression | ISO | RGD:1351327 | 6480464 | Aflatoxin B1 results in decreased expression of ENPP1 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of ENPP1 mRNA | CTD | PMID:20488242 | amiodarone | affects expression | EXP | | 6480464 | Amiodarone affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ENPP1 mRNA | CTD | PMID:16483693 | benzbromarone | affects expression | EXP | | 6480464 | Benzbromarone affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | benzo[a]pyrene | increases expression | ISO | RGD:733393 | 6480464 | Benzo(a)pyrene results in increased expression of ENPP1 mRNA | CTD | PMID:22228805 | bisphenol A | decreases expression | ISO | RGD:733393 | 6480464 | bisphenol A results in decreased expression of ENPP1 mRNA | CTD | PMID:20739668 | chromium atom | increases expression | ISO | RGD:1351327 | 6480464 | Chromium results in increased expression of ENPP1 mRNA | CTD | PMID:17547211 | clofibrate | affects expression | EXP | | 6480464 | Clofibrate affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of ENPP1 mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of ENPP1 mRNA | CTD | PMID:22465980 | cyclosporin A | decreases expression | ISO | RGD:1351327 | 6480464 | Cyclosporine results in decreased expression of ENPP1 mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:1351327 | 6480464 | Cyclosporine results in increased expression of ENPP1 mRNA | CTD | PMID:21632981 | dasatinib (anhydrous) | decreases expression | ISO | RGD:1351327 | 6480464 | dasatinib results in decreased expression of ENPP1 mRNA | CTD | PMID:20579391 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ENPP1 mRNA | CTD | PMID:21266533 | glycerol 2-phosphate | increases expression | ISO | RGD:1351327 | 6480464 | beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA | CTD | PMID:18500657 | glycerol 2-phosphate | multiple interactions | ISO | RGD:1351327 | 6480464 | Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]; more ... | CTD | PMID:18500657 | glycerol 2-phosphate | increases activity | ISO | RGD:1351327 | 6480464 | beta-glycerophosphoric acid results in increased activity of ENPP1 protein | CTD | PMID:18500657 | hydroquinone O-beta-D-glucopyranoside | decreases expression | ISO | RGD:1351327 | 6480464 | Arbutin results in decreased expression of ENPP1 mRNA | CTD | PMID:17103032 | L-ethionine | affects expression | EXP | | 6480464 | Ethionine affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | mercury atom | increases expression | ISO | RGD:1351327 | 6480464 | Mercury results in increased expression of ENPP1 mRNA | CTD | PMID:17547211 | mercury(0) | increases expression | ISO | RGD:1351327 | 6480464 | Mercury results in increased expression of ENPP1 mRNA | CTD | PMID:17547211 | methotrexate | affects expression | ISO | RGD:733393 | 6480464 | Methotrexate affects the expression of ENPP1 mRNA | CTD | PMID:18502557 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of ENPP1 mRNA | CTD | PMID:19638242 | N-nitrosodimethylamine | increases expression | ISO | RGD:1351327 | 6480464 | Dimethylnitrosamine results in increased expression of ENPP1 mRNA | CTD | PMID:17547211 | omeprazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of ENPP1 mRNA | CTD | PMID:22484513 | potassium dichromate | increases expression | ISO | RGD:1351327 | 6480464 | Potassium Dichromate results in increased expression of ENPP1 mRNA | CTD | PMID:17547211 | quercetin | decreases expression | ISO | RGD:1351327 | 6480464 | Quercetin results in decreased expression of ENPP1 mRNA | CTD | PMID:21632981 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of ENPP1 mRNA | CTD | PMID:19013527 | testosterone enanthate | affects expression | ISO | RGD:1351327 | 6480464 | testosterone enanthate affects the expression of ENPP1 mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | ISO | RGD:733393 | 6480464 | Carbon Tetrachloride results in increased expression of ENPP1 mRNA | CTD | PMID:17484886 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of ENPP1 mRNA | CTD | PMID:19483382 | trimellitic anhydride | increases expression | ISO | RGD:733393 | 6480464 | trimellitic anhydride results in increased expression of ENPP1 mRNA | CTD | PMID:19042947 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Nicotinate and nicotinamide metabolism | |
| Pantothenate and CoA biosynthesis | |
| Purine metabolism | |
| Riboflavin metabolism | |
| Starch and sucrose metabolism | |
Disease Annotations
|
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Nicotinate and nicotinamide metabolism | |
| Pantothenate and CoA biosynthesis | |
| Purine metabolism | |
| Riboflavin metabolism | |
| Starch and sucrose metabolism | |
References - curated| 1. |
Bacci S, etal., Diabetes. 2011 Mar;60(3):1000-7. Epub 2011 Jan 31. |
| 2. |
Banakh I, etal., Eur J Immunogenet 2002 Aug;29(4):307-13. |
| 3. |
Bjelobaba I, etal., Brain Res. 2006 Nov 20;1120(1):54-63. Epub 2006 Oct 16. |
| 4. |
Cheng KS, etal., Am J Med Genet A. 2005 Jul 15;136(2):210-3. |
| 5. |
Fox MA, etal., Mol Cell Neurosci 2003 Jul;23(3):507-19. |
| 6. |
Keene KL, etal., Diabetes. 2008 Apr;57(4):1057-62. Epub 2008 Jan 9. |
| 7. |
KEGG |
| 8. |
Levy-Litan V, etal., Am J Hum Genet. 2010 Feb 12;86(2):273-8. Epub 2010 Feb 4. |
| 9. |
Lorenz-Depiereux B, etal., Am J Hum Genet. 2010 Feb 12;86(2):267-72. Epub 2010 Feb 4. |
| 10. |
Meyre D, etal., Nat Genet. 2005 Aug;37(8):863-7. Epub 2005 Jul 17. |
| 11. |
MGD data from the GO Consortium |
| 12. |
Nakamura I, etal., Hum Genet. 1999 Jun;104(6):492-7. |
| 13. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 14. |
Pizzuti A, etal., Diabetes. 1999 Sep;48(9):1881-4. |
| 15. |
RGD automated import pipeline for gene-chemical interactions |
| 16. |
RGD Automated Pipelines |
| 17. |
RGD comprehensive gene curation |
| 18. |
Rutsch F, etal., Circ Cardiovasc Genet. 2008 Dec;1(2):133-40. |
| 19. |
Rutsch F, etal., Nat Genet 2003 Aug;34(4):379-81. |
| 20. |
Sakoda H, etal., Diabetes 1999 Jul;48(7):1365-71. |
| 21. |
Spoto B, etal., Nephrol Dial Transplant. 2012 Feb;27(2):661-6. Epub 2011 May 19. |
| 22. |
Wu LS, etal., Nephrol Dial Transplant. 2009 Nov;24(11):3360-6. Epub 2009 Jun 8. |
| 23. |
Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91. |
References - uncurated
RGD Disease Portals| Enpp1 has been annotated in the following RGD Disease Portals. |
|||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
Comparative Map Data| Enpp1 (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| ENPP1 (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Enpp1 (Mus musculus) |
|
Position Markers| D1Rat153 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AU048957 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053535 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06001084 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01002007 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002008 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01002009 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB017596 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC127189 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF320054 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF340185 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF340186 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474002 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053535 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_445987 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_445987 | (Get FASTA) |
| GenBank Protein | AAK69653 | (Get FASTA) |
| AAK69654 | (Get FASTA) | |
| AAL26912 | (Get FASTA) | |
| BAA33393 | (Get FASTA) | |
| EDL87772 | (Get FASTA) | |
| EDL87773 | (Get FASTA) | |
| Q924C3 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013994 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000019519 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000019519 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 85496 | ENTREZGENE |
| Gene3D-CATH | Alk_phosphtse | UniProtKB/Swiss-Prot |
| Endonuclease | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000013994 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 38151 | ENTREZGENE |
| InterPro | Alkaline_Pase-like_a/b/a | UniProtKB/Swiss-Prot |
| Alkaline_phosphatase_core | UniProtKB/Swiss-Prot | |
| DNA/RNA_non-sp_Endonuclease | UniProtKB/Swiss-Prot | |
| E-NPP | UniProtKB/Swiss-Prot | |
| Extracellular_endonuc_su_A | UniProtKB/Swiss-Prot | |
| Phosphodiest/P_Trfase | UniProtKB/Swiss-Prot | |
| Somatomedin_B | UniProtKB/Swiss-Prot | |
| Somatomedin_B_chordata | UniProtKB/Swiss-Prot | |
| IPI | IPI00339118 | UniProtKB/Swiss-Prot |
| IPI00390328 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:85496 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR10151 | UniProtKB/Swiss-Prot |
| Pfam | Endonuclease_NS | UniProtKB/Swiss-Prot |
| Phosphodiest | UniProtKB/Swiss-Prot | |
| Somatomedin_B | UniProtKB/Swiss-Prot | |
| PRINTS | SOMATOMEDINB | UniProtKB/Swiss-Prot |
| PROSITE | SMB_1 | UniProtKB/Swiss-Prot |
| SMB_2 | UniProtKB/Swiss-Prot | |
| SMART | Endonuclease_NS | UniProtKB/Swiss-Prot |
| NUC | UniProtKB/Swiss-Prot | |
| SM00201 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Alkaline_phosphatase_core | UniProtKB/Swiss-Prot |
| UniGene | Rn.1199 | ENTREZGENE |
| UniProt | ENPP1_RAT | UniProtKB/Swiss-Prot |
| G3V7V4_RAT | UniProtKB/TrEMBL | |
| O88827_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | Enpp1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2003-02-27 | Enpp1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Enpp1 | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 628825 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




