Gorasp1 (golgi reassembly stacking protein 1) - Rat Genome Database

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Gene: Gorasp1 (golgi reassembly stacking protein 1) Rattus norvegicus
Analyze
Symbol: Gorasp1
Name: golgi reassembly stacking protein 1
RGD ID: 621122
Description: Predicted to enable metal ion binding activity. Involved in Golgi organization and negative regulation of dendrite morphogenesis. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human GORASP1 (golgi reassembly stacking protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: golgi peripheral membrane protein p65; Golgi reassembly-stacking protein 1; golgi reassembly-stacking protein of 65 kDa; GRASP65
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,532,933 - 128,544,686 (-)NCBIGRCr8
mRatBN7.28119,655,267 - 119,667,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,655,268 - 119,666,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8125,236,740 - 125,248,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,435,787 - 123,447,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,268,521 - 121,280,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,610,290 - 128,622,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,610,291 - 128,622,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,811,973 - 127,824,020 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,883,445 - 124,895,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,903,186 - 124,914,863 (-)NCBI
Celera8118,802,215 - 118,813,913 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi apparatus  (IBA,IEA,ISO,ISS)
Golgi membrane  (TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. Barr FA, etal., J Cell Biol. 2001 Dec 10;155(6):885-91. Epub 2001 Dec 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. Litterman N, etal., PLoS Biol. 2011 May;9(5):e1001060. doi: 10.1371/journal.pbio.1001060. Epub 2011 May 10.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. Short B, etal., J Cell Biol. 2001 Dec 10;155(6):877-83. Epub 2001 Dec 10.
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. A direct role for GRASP65 as a mitotically regulated Golgi stacking factor. Wang Y, etal., EMBO J 2003 Jul 1;22(13):3279-90.
Additional References at PubMed
PMID:9346242   PMID:9628863   PMID:11815631   PMID:12015985   PMID:15678101   PMID:15767678   PMID:15834132   PMID:16396499   PMID:18045989   PMID:18762583   PMID:21884936   PMID:22841714  
PMID:23940043   PMID:24367100   PMID:24795147  


Genomics

Comparative Map Data
Gorasp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,532,933 - 128,544,686 (-)NCBIGRCr8
mRatBN7.28119,655,267 - 119,667,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,655,268 - 119,666,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8125,236,740 - 125,248,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,435,787 - 123,447,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,268,521 - 121,280,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,610,290 - 128,622,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,610,291 - 128,622,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,811,973 - 127,824,020 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,883,445 - 124,895,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,903,186 - 124,914,863 (-)NCBI
Celera8118,802,215 - 118,813,913 (-)NCBICelera
Cytogenetic Map8q32NCBI
GORASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38339,096,599 - 39,107,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl339,095,222 - 39,108,369 (-)EnsemblGRCh38hg38GRCh38
GRCh37339,138,090 - 39,149,118 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,113,095 - 39,124,134 (-)NCBINCBI36Build 36hg18NCBI36
Build 34339,113,094 - 39,124,134NCBI
Celera339,078,594 - 39,089,634 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef339,180,011 - 39,191,775 (-)NCBIHuRef
CHM1_1339,089,163 - 39,100,931 (-)NCBICHM1_1
T2T-CHM13v2.0339,108,763 - 39,119,791 (-)NCBIT2T-CHM13v2.0
Gorasp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,754,739 - 119,766,624 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,754,323 - 119,766,631 (-)EnsemblGRCm39 Ensembl
GRCm389119,925,673 - 119,937,558 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,925,257 - 119,937,565 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,834,791 - 119,846,676 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,774,371 - 119,786,256 (-)NCBIMGSCv36mm8
Celera9120,392,893 - 120,404,786 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.33NCBI
Gorasp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,862,346 - 24,870,651 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,862,253 - 24,873,710 (+)NCBIChiLan1.0ChiLan1.0
GORASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2239,048,191 - 39,059,226 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1339,052,953 - 39,063,985 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,992,863 - 39,004,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,273,272 - 39,285,008 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,273,272 - 39,285,008 (-)Ensemblpanpan1.1panPan2
GORASP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,766,243 - 8,776,278 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,766,243 - 8,776,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,805,904 - 8,816,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0239,054,839 - 9,064,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl239,053,432 - 9,064,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,868,535 - 8,878,620 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,010,792 - 9,020,892 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,004,214 - 9,014,311 (-)NCBIUU_Cfam_GSD_1.0
Gorasp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118195,213,155 - 195,223,471 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,353,485 - 28,361,977 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,351,669 - 28,362,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GORASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,786,248 - 23,797,487 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,786,245 - 23,797,508 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,045,884 - 26,057,044 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GORASP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115308,445 - 319,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15308,649 - 317,728 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,035,490 - 9,046,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gorasp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,873,466 - 1,883,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,873,474 - 1,884,712 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gorasp1
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:109
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000024408
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
RH127721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,655,296 - 119,655,480 (+)MAPPERmRatBN7.2
Rnor_6.08128,610,320 - 128,610,503NCBIRnor6.0
Rnor_5.08127,812,003 - 127,812,186UniSTSRnor5.0
RGSC_v3.48124,883,475 - 124,883,658UniSTSRGSC3.4
Celera8118,802,245 - 118,802,428UniSTS
RH 3.4 Map81285.99UniSTS
Cytogenetic Map8q32UniSTS
MARC_16103-16104:1018028206:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,661,308 - 119,661,871 (+)MAPPERmRatBN7.2
Rnor_6.08128,616,332 - 128,616,894NCBIRnor6.0
Rnor_5.08127,818,015 - 127,818,577UniSTSRnor5.0
RGSC_v3.48124,889,487 - 124,890,049UniSTSRGSC3.4
Celera8118,808,256 - 118,808,818UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 33 29 2 29 3 74 35 41 11
Low 8 24 12 17 12 8 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000024408   ⟹   ENSRNOP00000024408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,655,268 - 119,666,972 (-)Ensembl
Rnor_6.0 Ensembl8128,610,291 - 128,622,337 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084950   ⟹   ENSRNOP00000069907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,656,373 - 119,666,972 (-)Ensembl
Rnor_6.0 Ensembl8128,610,295 - 128,622,314 (-)Ensembl
RefSeq Acc Id: NM_019385   ⟹   NP_062258
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,532,933 - 128,544,636 (-)NCBI
mRatBN7.28119,655,267 - 119,666,972 (-)NCBI
Rnor_6.08128,610,290 - 128,622,337 (-)NCBI
Rnor_5.08127,811,973 - 127,824,020 (-)NCBI
RGSC_v3.48124,883,445 - 124,895,149 (-)RGD
Celera8118,802,215 - 118,813,913 (-)RGD
Sequence:
RefSeq Acc Id: XR_005487911
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,535,037 - 128,544,686 (-)NCBI
mRatBN7.28119,657,371 - 119,667,022 (-)NCBI
RefSeq Acc Id: NP_062258   ⟸   NM_019385
- UniProtKB: O35254 (UniProtKB/Swiss-Prot),   B1WBR1 (UniProtKB/TrEMBL),   F7ERK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069907   ⟸   ENSRNOT00000084950
RefSeq Acc Id: ENSRNOP00000024408   ⟸   ENSRNOT00000024408
Protein Domains
PDZ GRASP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35254-F1-model_v2 AlphaFold O35254 1-451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696378
Promoter ID:EPDNEW_R6901
Type:initiation region
Name:Gorasp1_1
Description:golgi reassembly stacking protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,622,318 - 128,622,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621122 AgrOrtholog
BioCyc Gene G2FUF-28776 BioCyc
Ensembl Genes ENSRNOG00000018047 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024408 ENTREZGENE
  ENSRNOT00000024408.5 UniProtKB/TrEMBL
  ENSRNOT00000084950.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112328 IMAGE-MGC_LOAD
  IMAGE:8369057 IMAGE-MGC_LOAD
InterPro GRASP55/65_PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRASP55_65 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56082 UniProtKB/TrEMBL
MGC_CLONE MGC:187373 IMAGE-MGC_LOAD
  MGC:93484 IMAGE-MGC_LOAD
NCBI Gene 56082 ENTREZGENE
PANTHER GOLGI REASSEMBLY-STACKING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12893 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GRASP55_65 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gorasp1 PhenoGen
PROSITE PDZ_GRASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018047 RatGTEx
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWJ7_RAT UniProtKB/TrEMBL
  A0JN16_RAT UniProtKB/TrEMBL
  B1WBR1 ENTREZGENE, UniProtKB/TrEMBL
  F7ERK9 ENTREZGENE, UniProtKB/TrEMBL
  GORS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gorasp1  golgi reassembly stacking protein 1  GRASP65  golgi peripheral membrane protein p65  Symbol and Name updated 1299863 APPROVED
2002-08-07 GRASP65  golgi peripheral membrane protein p65      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation phosphorylated by mitotic kinases cdc2-cyclin and polo-like kinases 708594