Gene: A2m (alpha-2-macroglobulin) Rattus norvegicus
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Symbol: A2m
Name: alpha-2-macroglobulin
Description: ENCODES a protein that exhibits brain-derived neurotrophic factor binding; endopeptidase inhibitor activity; nerve growth factor binding; INVOLVED IN acute inflammatory response to antigenic stimulus; acute-phase response; embryonic liver development; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; Alzheimer disease pathway; immune response pathway; ASSOCIATED WITH cardiac hypertrophy; ASSOCIATED WITH Adenoma, Liver Cell; Anemia, Hemolytic; Arthritis, Experimental; FOUND IN extracellular space; blood microparticle (ortholog); extracellular exosome (ortholog); INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 1-naphthyl isothiocyanate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A2m1; A2maa; A2MAC1; A2mb; AI893533; alpha-2-M; alpha-2-macroglobulin-P; Mam; MGC114358; RATA2MAC1
Orthologs:
Homo sapiens (human) : A2M (alpha-2-macroglobulin)  HGNC
Mus musculus (house mouse) : A2m (alpha-2-macroglobulin)  MGI
Canis lupus familiaris (dog) : A2m (alpha-2-macroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : A2m (alpha-2-macroglobulin)
more info ...
Is Marker For: QTLs:   Plsm2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBI
Cytogenetic Map4q42NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on A2m
NCBI Gene
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JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 2004
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-05-30
Status: ACTIVE