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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:16170
Term: mercury(0)
Definition: Elemental mercury of oxidation state zero.
Chemical ID: MESH:D008628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1affects abundanceISOGSTM1 (Homo sapiens)6480464CTDGSTM1 gene polymorphism affects the abundance of MercuryPMID:25728017
Gstm1affects response to substanceISOGSTM1 (Homo sapiens)6480464CTDGSTM1 gene polymorphism affects the susceptibility to Mercury; GSTM1 polymorphism affects the susceptibility to MercuryPMID:17716707 PMID:20194072
Gstm1multiple interactionsISOGSTM1 (Homo sapiens)6480464CTD[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury; [GSTP1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of Mercury; [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GSTM1 proteinPMID:19515364 PMID:24319713 PMID:30359721
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