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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:732651 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GABRA6 mRNA | CTD | PMID:21296121 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62153 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GABRA6 protein | CTD | PMID:18227101 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:62153 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GABRA6 protein | CTD | PMID:18227101 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62153 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GABRA6 protein | CTD | PMID:18227101 | 3alpha-hydroxy-5beta-pregnan-20-one | increases response to substance | ISO | RGD:62153 | 6480464 | GABRA6 protein results in increased susceptibility to Pregnanolone | CTD | PMID:9281599 | acamprosate | affects response to substance | ISO | RGD:732651 | 6480464 | GABRA6 affects the susceptibility to acamprosate | CTD | PMID:19523047 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GABRA6 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:732651 | 6480464 | Benzo(a)pyrene results in increased expression of GABRA6 mRNA | CTD | PMID:22316170 | carbonyl sulfide | increases expression | EXP | | 6480464 | carbonyl sulfide results in increased expression of GABRA6 mRNA | CTD | PMID:19395590 | carmustine | decreases expression | ISO | RGD:732651 | 6480464 | Carmustine results in decreased expression of GABRA6 mRNA | CTD | PMID:15980968 | Delta(9)-tetrahydrocannabinol | decreases expression | EXP | | 6480464 | Tetrahydrocannabinol results in decreased expression of GABRA6 mRNA | CTD | PMID:16616335 | delta-hexachlorocyclohexane | multiple interactions | ISO | RGD:732651 | 6480464 | delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; more ... | CTD | PMID:9316872 | diazepam | decreases response to substance | ISO | RGD:62153 | 6480464 | GABRA6 protein results in decreased susceptibility to Diazepam | CTD | PMID:9281599 | diazepam | increases expression | EXP | | 6480464 | Diazepam results in increased expression of GABRA6 mRNA | CTD | PMID:15802192 | diazepam | decreases response to substance | ISO | RGD:62153 | 6480464 | GABRA6 gene results in decreased susceptibility to Diazepam | CTD | PMID:9987027 | ethanol | decreases expression | EXP | | 6480464 | Ethanol deficiency results in decreased expression of GABRA6 mRNA | CTD | PMID:17403139 | felbamate | multiple interactions | ISO | RGD:732651 | 6480464 | felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] | CTD | PMID:17056029 | flumazenil | multiple interactions | ISO | RGD:732651 | 6480464 | Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; more ... | CTD | PMID:8632757 | flumazenil | affects binding | ISO | RGD:732651 | 6480464 | Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein] | CTD | PMID:8632757 | gamma-aminobutyric acid | multiple interactions | EXP | | 6480464 | gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]; more ... | CTD | PMID:11123204 | gamma-aminobutyric acid | multiple interactions | ISO | RGD:732651 | 6480464 | gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; more ... | CTD | PMID:9316872 | gamma-aminobutyric acid | multiple interactions | ISO | RGD:732651 | 6480464 | Ro 15-4513 promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; more ... | CTD | PMID:8632757 | gamma-hexachlorocyclohexane | multiple interactions | ISO | RGD:732651 | 6480464 | Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]] | CTD | PMID:9316872 | maneb | multiple interactions | ISO | RGD:62153 | 6480464 | [Paraquat co-treated with Maneb] affects the expression of GABRA6 mRNA | CTD | PMID:22563483 | mercury atom | increases expression | ISO | RGD:732651 | 6480464 | Mercury results in increased expression of GABRA6 mRNA | CTD | PMID:16823088 | mercury(0) | increases expression | ISO | RGD:732651 | 6480464 | Mercury results in increased expression of GABRA6 mRNA | CTD | PMID:16823088 | naltrexone | affects response to substance | ISO | RGD:732651 | 6480464 | GABRA6 affects the susceptibility to Naltrexone | CTD | PMID:19523047 | paraquat | multiple interactions | ISO | RGD:62153 | 6480464 | [Paraquat co-treated with Maneb] affects the expression of GABRA6 mRNA | CTD | PMID:22563483 | pentobarbital | increases expression | EXP | | 6480464 | Pentobarbital results in increased expression of GABRA6 mRNA | CTD | PMID:8787126 | pirinixic acid | multiple interactions | ISO | RGD:62153 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GABRA6 mRNA | CTD | PMID:19710929 | topiramate | multiple interactions | EXP | | 6480464 | topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] | CTD | PMID:11123204 | valproic acid | affects expression | ISO | RGD:62153 | 6480464 | Valproic Acid affects the expression of GABRA6 mRNA | CTD | PMID:17292431 | zinc atom | increases response to substance | ISO | RGD:62153 | 6480464 | GABRA6 protein results in increased susceptibility to Zinc | CTD | PMID:9281599 | zinc(0) | increases response to substance | ISO | RGD:62153 | 6480464 | GABRA6 protein results in increased susceptibility to Zinc | CTD | PMID:9281599 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | GABAergic synapse |
| Morphine addiction | |
| Neuroactive ligand-receptor interaction | |
| Nicotine addiction | |
| Retrograde endocannabinoid signaling | |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | GABAergic synapse |
| Morphine addiction | |
| Neuroactive ligand-receptor interaction | |
| Nicotine addiction | |
| Retrograde endocannabinoid signaling | |
Phenotype Annotations
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References - curated| 1. |
Carr LG, etal., Alcohol. 2003 Aug-Oct;31(1-2):93-7. |
| 2. |
GOA data from the GO Consortium |
| 3. |
Hadley SH and Amin J, J Physiol. 2007 Jun 15;581(Pt 3):1001-18. Epub 2007 Mar 29. |
| 4. |
Luddens H, etal., Nature 1990 Aug 16;346(6285):648-51. |
| 5. |
MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Nusser Z, etal., J Neurosci. 1996 Jan;16(1):103-14. |
| 8. |
Poltl A, etal., J Neurochem. 2003 Dec;87(6):1444-55. |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
Rosmond R, etal., Int J Obes Relat Metab Disord. 2002 Jul;26(7):938-41. |
| 12. |
Santhakumar V, etal., J Neurosci. 2006 Mar 22;26(12):3357-64. |
| 13. |
Xiao C, etal., J Physiol. 2007 May 1;580(Pt.3):731-43. Epub 2007 Feb 15. |
References - uncuratedRGD Disease Portals| Gabra6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gabra6 (Rattus norvegicus) |
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| GABRA6 (Homo sapiens) |
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| Gabra6 (Mus musculus) |
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Position Markers| RH138854 |
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| X51986 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat StrainsNucleotide Sequences| Nucleotide RefSeqs | NM_021841 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06063436 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06063437 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01063406 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L08495 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X55742 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_021841 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_068613 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_068613 | (Get FASTA) |
| GenBank Protein | AAC42034 | (Get FASTA) |
| CAA39273 | (Get FASTA) | |
| EDM04122 | (Get FASTA) | |
| EDM04123 | (Get FASTA) | |
| P30191 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003569 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000004877 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000004877 | UniProtKB/TrEMBL |
| Entrez Gene | 29708 | ENTREZGENE |
| Gene3D-CATH | Neur_chan_lig_bd | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000003569 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20220 | ENTREZGENE |
| InterPro | GABAA_rcpt | UniProtKB/Swiss-Prot |
| GABAAa_rcpt | UniProtKB/Swiss-Prot | |
| GABBAa6_rcpt | UniProtKB/Swiss-Prot | |
| Neur_chan_lig_bd | UniProtKB/Swiss-Prot | |
| Neur_channel | UniProtKB/Swiss-Prot | |
| Neurotrans-gated_channel_TM | UniProtKB/Swiss-Prot | |
| Neurotransmitter_ion_chnl_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00206049 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:29708 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Neur_channel | UniProtKB/Swiss-Prot |
| Pfam | Neur_chan_LBD | UniProtKB/Swiss-Prot |
| Neur_chan_memb | UniProtKB/Swiss-Prot | |
| PRINTS | GABAARALPHA | UniProtKB/Swiss-Prot |
| GABAARALPHA6 | UniProtKB/Swiss-Prot | |
| GABAARECEPTR | UniProtKB/Swiss-Prot | |
| NRIONCHANNEL | UniProtKB/Swiss-Prot | |
| PROSITE | NEUROTR_ION_CHANNEL | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Neu_channel_TM | UniProtKB/Swiss-Prot |
| Neur_chan_LBD | UniProtKB/Swiss-Prot | |
| TIGRFAMs | LIC | UniProtKB/Swiss-Prot |
| UniGene | Rn.29890 | ENTREZGENE |
| UniProt | G3V6G3_RAT | UniProtKB/TrEMBL |
| GBRA6_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-11-04 | Gabra6 | gamma-aminobutyric acid (GABA) A receptor, alpha 6 | Gabra6 | gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Gabra6 | gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6 | gamma-aminobutyric acid A receptor, alpha 6 | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Gabra6 | gamma-aminobutyric acid A receptor, alpha 6 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | differentially expressed in the central nervous system | 61594 |
| More on Gabra6 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61861 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.