Gene: Furin (furin (paired basic amino acid cleaving enzyme)) Rattus norvegicus
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Symbol: Furin
Name: furin (paired basic amino acid cleaving enzyme)
Description: ENCODES a protein that exhibits serine-type endopeptidase activity; endopeptidase activity (ortholog); nerve growth factor binding (ortholog); INVOLVED IN aging; positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental; Arteriosclerosis (ortholog); arteriosclerosis (ortholog); FOUND IN endoplasmic reticulum membrane; Golgi cisterna; plasma membrane; INTERACTS WITH 7,12-dimethyltetraphene; ammonium chloride; bisphenol A
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dibasic-processing enzyme; LOC360309; Pace; Paired basic amino acid cleaving enzyme (furin); paired basic amino acid residue cleaving enzyme; paired basic amino acid residue-cleaving enzyme; Pcsk3; prohormone convertase 3; Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme furin membrane associated receptor protein); Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); proprotein convertase subtilisin/kexin type3
Orthologs:
Homo sapiens (human) : FURIN (furin, paired basic amino acid cleaving enzyme)  HGNC  AGR
Mus musculus (house mouse) : Furin (furin (paired basic amino acid cleaving enzyme))  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Furin (furin, paired basic amino acid cleaving enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : FURIN (furin, paired basic amino acid cleaving enzyme)
Canis lupus familiaris (dog) : FURIN (furin, paired basic amino acid cleaving enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Furin (furin, paired basic amino acid cleaving enzyme)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBI
Cytogenetic Map1q31NCBImapview
RH 3.4 Map11074.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Furin
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 3274
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE