Gene: Furin (furin (paired basic amino acid cleaving enzyme)) Rattus norvegicus
Symbol: Furin
Name: furin (paired basic amino acid cleaving enzyme)
Description: ENCODES a protein that exhibits serine-type endopeptidase activity; endopeptidase activity (ortholog); nerve growth factor binding (ortholog); INVOLVED IN aging; positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental; Arteriosclerosis (ortholog); Carcinoma (ortholog); FOUND IN endoplasmic reticulum membrane; Golgi cisterna; plasma membrane; INTERACTS WITH 7,12-dimethyltetraphene; ammonium chloride; bisphenol A
Type: protein-coding
Also known as: dibasic-processing enzyme; LOC360309; Pace; Paired basic amino acid cleaving enzyme (furin); paired basic amino acid residue cleaving enzyme; paired basic amino acid residue-cleaving enzyme; Pcsk3; prohormone convertase 3; Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme furin membrane associated receptor protein); Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); proprotein convertase subtilisin/kexin type3
Homo sapiens (human) : FURIN (furin, paired basic amino acid cleaving enzyme)  HGNC
Mus musculus (house mouse) : Furin (furin (paired basic amino acid cleaving enzyme))  MGI
Pan paniscus (bonobo/pygmy chimpanzee) : FURIN (furin, paired basic amino acid cleaving enzyme)
Canis lupus familiaris (dog) : FURIN (furin, paired basic amino acid cleaving enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Furin (furin, paired basic amino acid cleaving enzyme)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBI
Cytogenetic Map1q31NCBImapview
RH 3.4 Map11074.0RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Furin
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 3274
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-03-14
Status: ACTIVE