Chat (choline O-acetyltransferase) - Rat Genome Database

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Gene: Chat (choline O-acetyltransferase) Rattus norvegicus
Analyze
Symbol: Chat
Name: choline O-acetyltransferase
RGD ID: 1304627
Description: Enables choline O-acetyltransferase activity and choline binding activity. Involved in several processes, including acetylcholine biosynthetic process; antral ovarian follicle growth; and response to ethanol. Predicted to be located in axon and neuronal cell body. Predicted to be active in cytoplasm and neuron projection. Used to study depressive disorder. Biomarker of Alzheimer's disease; asthma; and depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase); PARTICIPATES IN acetylcholine metabolic pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (R,R,R)-alpha-tocopherol.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: VALIDATED
Previously known as: CHOACTase; choline acetylase; choline acetyltransferase; LOC290567
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,663,665 - 7,723,416 (-)NCBIGRCr8
mRatBN7.2167,657,362 - 7,717,093 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,657,362 - 7,717,093 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,669,484 - 7,729,053 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,814,418 - 8,873,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,668,166 - 7,727,881 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,576,858 - 8,686,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,577,840 - 8,686,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,603,449 - 10,652,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0168,493,024 - 8,526,303 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,913,026 - 7,965,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,913,023 - 7,968,456 (-)NCBI
Celera167,483,676 - 7,543,221 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(20R)-protopanaxadiol  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bifenthrin  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
catalpol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cis-caffeic acid  (ISO)
clothianidin  (ISO)
cocaine  (ISO)
curcumin  (EXP)
cyanamide  (EXP)
cyfluthrin  (EXP)
cypermethrin  (EXP)
cytarabine  (EXP)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diazinon  (EXP)
dichlorvos  (EXP)
dimethylarsinic acid  (ISO)
dizocilpine maleate  (EXP)
doxorubicin  (EXP)
ethanol  (EXP,ISO)
fulvestrant  (ISO)
galactose  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
herbicide  (ISO)
hydrogen peroxide  (ISO)
Icaritin  (ISO)
inositol  (EXP)
isoflurane  (EXP)
L-ascorbic acid  (EXP)
lipoic acid  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
meloxicam  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methamphetamine  (ISO)
methimazole  (EXP)
methyllycaconitine  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleamide  (ISO)
paraquat  (EXP)
parathion  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
physostigmine  (EXP)
progesterone  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (EXP)
quinolinic acid  (EXP)
resveratrol  (EXP,ISO)
rivastigmine  (EXP)
rotenone  (ISO)
rutin  (EXP)
Salidroside  (EXP)
sarin  (EXP)
scopolamine  (ISO)
serotonin  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
tacrine  (ISO)
taurine  (EXP)
terbutaline  (EXP)
thioacetamide  (EXP)
trans-caffeic acid  (ISO)
tributylstannane  (ISO)
triclosan  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
cytoplasm  (IBA,ISO)
neuron projection  (IBA,ISO)
neuronal cell body  (ISO)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The effect of chronic ethanol intake on brain NGF level and on NGF-target tissues of adult mice. Aloe L, etal., Drug Alcohol Depend. 1993 Jan;31(2):159-67. doi: 10.1016/0376-8716(93)90068-2.
2. Multiple forms of choline-O-acetyltransferase in mouse and rat brain: solubilization and characterization. Benishin CG and Carroll PT, J Neurochem. 1983 Oct;41(4):1030-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Enzymes of the cholinergic system in islets of Langerhans. Godfrey DA and Matschinsky FM, J Histochem Cytochem. 1975 Sep;23(9):645-51.
5. Structural insights and functional implications of choline acetyltransferase. Govindasamy L, etal., J Struct Biol 2004 Nov;148(2):226-35.
6. Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior. Han S, etal., Sci Rep. 2017 Apr 18;7(1):900. doi: 10.1038/s41598-017-01088-6.
7. Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde. Jamal M, etal., Neuroscience. 2007 Jan 5;144(1):232-8. Epub 2006 Oct 11.
8. Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse. Lips KS, etal., Life Sci. 2007 May 30;80(24-25):2263-9. Epub 2007 Jan 23.
9. Docosahexaenoic acid supports cell growth and expression of choline acetyltransferase and muscarinic receptors in NG108-15 cell line. Machova E, etal., J Mol Neurosci. 2006;30(1-2):25-6.
10. FSH regulates acetycholine production by ovarian granulosa cells. Mayerhofer A, etal., Reprod Biol Endocrinol. 2006 Jul 17;4:37.
11. Temporal memory in mature and aged rats is sensitive to choline acetyltransferase inhibition. Meck WH Brain Res. 2006 Sep 7;1108(1):168-75. Epub 2006 Jul 18.
12. Expression of acetylcholine receptors by experimental rat renal allografts. Meixner M, etal., Biomed Res Int. 2014;2014:289656. doi: 10.1155/2014/289656. Epub 2014 Jul 9.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease. Mubumbila V, etal., Neurosci Lett 2002 Nov 15;333(1):9-12.
15. Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans. Ohno K, etal., Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2017-22.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Quantitative histochemical studies of the hypothalamus enzymes of acetylcholine metabolism. Packman PM, etal., J Histochem Cytochem. 1977 Nov;25(11):1237-46.
18. L-3-n-butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats. Peng Y, etal., J Pharmacol Exp Ther. 2007 Mar 20;.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Distributions of choline acetyltransferase and acetylcholinesterase activities in layers of rat superior colliculus. Ross CD and Godfrey DA, J Histochem Cytochem. 1985 Jul;33(7):631-41.
25. Regional distributions of choline acetyltransferase and acetylcholinesterase activities in layers of rat cerebellar vermis. Ross CD, etal., J Histochem Cytochem. 1983 Jul;31(7):927-37.
26. Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep. Row BW, etal., Behav Brain Res. 2007 Feb 27;177(2):308-14. Epub 2007 Jan 10.
27. Cholinergic neuronal defect without cell loss in Huntington's disease. Smith R, etal., Hum Mol Genet. 2006 Nov 1;15(21):3119-31. Epub 2006 Sep 20.
28. The mature/pro nerve growth factor ratio is decreased in the brain of diabetic rats: Analysis by ELISA methods. Soligo M, etal., Brain Res. 2015 Oct 22;1624:455-468. doi: 10.1016/j.brainres.2015.08.005. Epub 2015 Aug 15.
29. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Szutowicz A, etal., Neurochem Res. 2013 Aug;38(8):1523-42. doi: 10.1007/s11064-013-1060-x. Epub 2013 May 16.
30. [Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease] Tang Y, etal., Zhong Xi Yi Jie He Xue Bao. 2006 Jul;4(4):374-7.
31. Effects of aging and amyloid-beta peptides on choline acetyltransferase activity in rat brain. Zambrzycka A, etal., Neurochem Res 2002 Apr;27(4):277-81.
Additional References at PubMed
PMID:2160042   PMID:7493935   PMID:8381893   PMID:8479291   PMID:9853118   PMID:12115678   PMID:12441053   PMID:12533614   PMID:14747730   PMID:15048690   PMID:15131697   PMID:15278359  
PMID:15531135   PMID:15739235   PMID:15820692   PMID:16270756   PMID:16909201   PMID:17049807   PMID:17192612   PMID:17542812   PMID:17668622   PMID:18521856   PMID:18614015   PMID:19137611  
PMID:19524025   PMID:19906978   PMID:20176735   PMID:20510655   PMID:20632124   PMID:20965859   PMID:21798270   PMID:22607230   PMID:23250574   PMID:23643989   PMID:23681475   PMID:24010172  
PMID:24462097   PMID:24657285   PMID:24908085   PMID:25405505   PMID:25453770   PMID:30177425   PMID:34071104  


Genomics

Comparative Map Data
Chat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,663,665 - 7,723,416 (-)NCBIGRCr8
mRatBN7.2167,657,362 - 7,717,093 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,657,362 - 7,717,093 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,669,484 - 7,729,053 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,814,418 - 8,873,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,668,166 - 7,727,881 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,576,858 - 8,686,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,577,840 - 8,686,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,603,449 - 10,652,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0168,493,024 - 8,526,303 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,913,026 - 7,965,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,913,023 - 7,968,456 (-)NCBI
Celera167,483,676 - 7,543,221 (+)NCBICelera
Cytogenetic Map16p16NCBI
CHAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381049,609,095 - 49,667,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1049,609,095 - 49,667,942 (+)EnsemblGRCh38hg38GRCh38
GRCh371050,817,141 - 50,875,988 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361050,487,147 - 50,543,156 (+)NCBINCBI36Build 36hg18NCBI36
Celera1044,403,227 - 44,459,207 (+)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1045,081,909 - 45,138,016 (+)NCBIHuRef
CHM1_11051,099,225 - 51,155,226 (+)NCBICHM1_1
T2T-CHM13v2.01050,457,901 - 50,516,753 (+)NCBIT2T-CHM13v2.0
Chat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,130,160 - 32,187,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,130,160 - 32,187,946 (-)EnsemblGRCm39 Ensembl
GRCm381432,408,203 - 32,465,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,408,203 - 32,465,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371433,221,389 - 33,279,095 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,237,212 - 31,294,918 (-)NCBIMGSCv36mm8
Celera1428,665,793 - 28,723,609 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
Chat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556650,279 - 693,276 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955556650,290 - 695,135 (-)NCBIChiLan1.0ChiLan1.0
CHAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2861,882,509 - 61,936,005 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11061,887,829 - 61,941,325 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01044,574,925 - 44,629,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CHAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,480,364 - 1,528,858 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,482,202 - 1,528,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,713,916 - 1,766,663 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,656,110 - 1,708,901 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,657,532 - 1,708,818 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,453,354 - 1,506,122 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,490,456 - 1,543,271 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,622,347 - 1,675,117 (+)NCBIUU_Cfam_GSD_1.0
Chat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,450,747 - 79,499,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728654,638 - 700,213 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936728653,654 - 702,433 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,117,464 - 90,167,611 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,117,464 - 90,167,611 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,025,088 - 98,075,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q25-q27NCBI
CHAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1942,159,367 - 42,216,137 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl942,162,601 - 42,214,705 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660481,904,633 - 1,957,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624928360,704 - 399,714 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624928357,812 - 401,668 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chat
870 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:111
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000034283
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
RH138865  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,657,417 - 7,657,590 (+)MAPPERmRatBN7.2
Rnor_6.0168,576,914 - 8,577,086NCBIRnor6.0
Rnor_5.0168,493,080 - 8,493,252UniSTSRnor5.0
RGSC_v3.4167,911,749 - 7,911,921UniSTSRGSC3.4
Celera167,542,993 - 7,543,165UniSTS
RH 3.4 Map1670.3UniSTS
Cytogenetic Map16p16UniSTS
UniSTS:547010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,714,288 - 7,715,197 (+)MAPPERmRatBN7.2
Rnor_6.0168,683,327 - 8,684,235NCBIRnor6.0
Rnor_5.01610,649,509 - 10,650,417UniSTSRnor5.0
Celera167,485,572 - 7,486,480UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 9 15 44 2 13 9
Below cutoff 10 19 12 3 12 8 10 20 8 17 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034283   ⟹   ENSRNOP00000036251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl168,578,204 - 8,678,915 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080202   ⟹   ENSRNOP00000070752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,657,362 - 7,717,093 (-)Ensembl
Rnor_6.0 Ensembl168,577,840 - 8,686,131 (-)Ensembl
RefSeq Acc Id: NM_001170593   ⟹   NP_001164064
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,663,665 - 7,723,416 (-)NCBI
mRatBN7.2167,657,362 - 7,717,093 (-)NCBI
Rnor_6.0168,576,858 - 8,686,131 (-)NCBI
Rnor_5.0168,493,024 - 8,526,303 (-)NCBI
Rnor_5.01610,603,449 - 10,652,313 (-)NCBI
Celera167,483,676 - 7,543,221 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063275138   ⟹   XP_063131208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,663,665 - 7,699,175 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001164064 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131208 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88915 (Get FASTA)   NCBI Sequence Viewer  
  P32738 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001164064   ⟸   NM_001170593
- UniProtKB: Q64342 (UniProtKB/Swiss-Prot),   Q63849 (UniProtKB/Swiss-Prot),   P32738 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070752   ⟸   ENSRNOT00000080202
RefSeq Acc Id: ENSRNOP00000036251   ⟸   ENSRNOT00000034283
RefSeq Acc Id: XP_063131208   ⟸   XM_063275138
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32738-F1-model_v2 AlphaFold P32738 1-640 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304627 AgrOrtholog
BioCyc Gene G2FUF-12108 BioCyc
Ensembl Genes ENSRNOG00000025012 Ensembl
Gene3D-CATH 3.30.559.10 UniProtKB/Swiss-Prot
  3.30.559.70 UniProtKB/Swiss-Prot
InterPro Carn_acyl_trans UniProtKB/Swiss-Prot
  CAT-like_dom_sf UniProtKB/Swiss-Prot
  Cho/carn_acyl_trans UniProtKB/Swiss-Prot
  Cho/carn_acyl_trans_2 UniProtKB/Swiss-Prot
NCBI Gene 290567 ENTREZGENE
PANTHER CHOLINE O-ACETYLTRANSFERASE UniProtKB/Swiss-Prot
  PTHR22589 UniProtKB/Swiss-Prot
Pfam Carn_acyltransf UniProtKB/Swiss-Prot
PharmGKB CHAT RGD
PhenoGen Chat PhenoGen
PROSITE ACYLTRANSF_C_1 UniProtKB/Swiss-Prot
  ACYLTRANSF_C_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025012 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot
UniProt CLAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63849 ENTREZGENE
  Q64342 ENTREZGENE
UniProt Secondary Q63849 UniProtKB/Swiss-Prot
  Q64342 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Chat  choline O-acetyltransferase  Chat  choline acetyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Chat  choline acetyltransferase   Chat_predicted  choline acetyltransferase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Chat_predicted  choline acetyltransferase (predicted)      Symbol and Name status set to approved 70820 APPROVED