Gene: RT1-Ba (RT1 class II, locus Ba)
Rattus norvegicus
Symbol:
RT1-Ba
Name:
RT1 class II, locus Ba
Description:
ENCODES a protein that exhibits protein heterodimerization activity; peptide antigen binding (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus; negative regulation of T cell proliferation; antigen processing and presentation (ortholog); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma disease pathway; ASSOCIATED WITH Encephalomyelitis, Autoimmune, Experimental; Hypersensitivity, Delayed; Uveitis; FOUND IN external side of plasma membrane (ortholog); lysosome (ortholog); MHC class II protein complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
activated B cell RT1Bl alpha chain; MGC105667; MHC class II antigen RT1.B alpha chain; rano class II histocompatibility antigen, B alpha chain; Rano class II histocompatibility antigen, B alpha chain; RT1 class II antigen, Ba chain; RT1 class II, locus Ba; RT1 class II, locus Ba (mapped); RT1-B alpha; RT1-Ba_mapped
Orthologs:
Homo sapiens : HLA-DQA1
(major histocompatibility complex, class II, DQ alpha 1)
HGNC
Mus musculus : H2-Aa
(histocompatibility 2, class II antigen A, alpha)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 20 p12 NCBI RGSC Genome Assembly v5.0 20 6,146,271 - 6,150,864 - NCBI RGSC Genome Assembly v3.4 20 4,697,971 - 4,702,564 + NCBI Rat Celera Assembly 20 6,176,966 - 6,181,559 + NCBI
Model
Disease Annotations
Amyopathic dermatomyositis ISS RGD:1351810 5147796 DNA:polymorphism (human) RGD Amyopathic dermatomyositis ISS RGD:1351810 5147790 RGD Antiphospholipid Syndrome ISS RGD:1351810 5147862 DNA:polymorphism (human) RGD Aortic Aneurysm, Abdominal ISS RGD:1351810 5147824 DNA:polymorphism (human) RGD Arthritis ISS RGD:1351810 5147787 DNA:polymorphism (human) RGD Arthritis, Juvenile Rheumatoid ISS RGD:1351810 5147815 RGD Arthritis, Juvenile Rheumatoid ISS RGD:1351810 5147863 DNA:polymorphism (human) RGD Arthritis, Rheumatoid ISS RGD:1351810 5147860 DNA:polymorphism (human) RGD Arthritis, Rheumatoid ISS rgd:1351810 5147859 DNA:polymorphisms (human) RGD Asthma ISS RGD:1351810 5147831 DNA:polymorphisms (human) RGD Asthma ISS RGD:1351810 1331670 DNA:polymorphism (human) RGD Asthma ISS RGD:1351810 5147617 DNA:polymorphisms (human) RGD Asthma ISS RGD:1351810 5147799 DNA:polymorphisms (human) RGD Autoimmune Diseases ISS RGD:1351810 5147554 associated with Diabetes Mellitus, Type 1;DNA:polymorphisms: :multiple (human) RGD Brain Infarction ISS RGD:1351810 5147807 DNA:polymorphisms (human) RGD Breast Neoplasms ISS RGD:1351810 5147786 DNA:polymorphism (human) RGD Celiac Disease ISS RGD:1351810 5147808 associated with Thyroiditis, Autoimmune;DNA:polymorphism (human) RGD Celiac Disease ISS RGD:1351810 7240710 OMIM Celiac Disease ISS RGD:1351810 5147854 associated with Down Syndrome;DNA:polymorphism (human) RGD Celiac Disease Susceptibility ISS RGD:1351810 5147625 DNA:polymorphism (human) RGD Celiac Disease Susceptibility ISS RGD:1351810 2301813 associated with Diabetes Mellitus, Insulin-Dependent RGD Celiac Disease ISS RGD:1351810 5147791 DNA:polymorphisms (human) RGD Celiac Disease ISS RGD:1351810 5147789 DNA:polymorphism (human) RGD Chorea ISS RGD:1351810 5147792 associated with Rheumatic Fever;DNA:polymorphisms (human) RGD Diabetes Mellitus, Type 1 ISS RGD:1351810 2301817 DNA:polymorphisms: :multiple RGD Diabetes Mellitus, Type 1 ISS RGD:1351810 5147626 DNA:polymorphism (human) RGD Diabetes Mellitus, Type 1 Susceptibility ISS RGD:1351810 2301811 RGD Diabetes Mellitus, Type 1 Onset ISS RGD:1351810 2301812 RGD Diabetes Mellitus, Type 2 Susceptibility ISS RGD:1351810 2301814 RGD Encephalomyelitis, Autoimmune, Experimental IPM 5147639 RGD Encephalomyelitis, Autoimmune, Experimental IPM 5147622 RGD Encephalomyelitis, Autoimmune, Experimental IED 5147666 RGD Esophageal Achalasia ISS RGD:1351810 5147806 DNA:polymorphism (human) RGD Fatigue Syndrome, Chronic ISS RGD:1351810 5147827 DNA:polymorphism (human) RGD Glomerulonephritis, Membranous ISS RGD:1351810 5147785 DNA:SNP: :rs2187668 (human) RGD Glucose Intolerance Susceptibility ISS RGD:1351810 2301815 associated with Diabetes Mellitus RGD Hashimoto Disease Susceptibility ISS RGD:1351810 5147613 DNA:polymorphism (human) RGD Helicobacter Infections Resistance ISS RGD:1351810 2301818 associated with Diabetes Mellitus, Insulin-Dependent RGD HIV Infections ISS RGD:1351810 5147817 DNA:polymorphisms (human) RGD Hypersensitivity ISS RGD:1351810 5147826 DNA:polymorphism (human) RGD Hypersensitivity ISS RGD:1351810 5147866 DNA:polymorphisms (human) RGD Hypersensitivity Susceptibility ISS RGD:1351810 5147651 DNA:polymorphism (human) RGD Hypersensitivity, Delayed IED 5147666 RGD Hypertension ISS RGD:1351810 5147807 DNA:polymorphisms (human) RGD Idiopathic dilation cardiomyopathy Susceptibility ISS RGD:1351810 5147795 DNA:polymorphisms (human) RGD Idiopathic dilation cardiomyopathy Susceptibility ISS RGD:1351810 5147858 DNA:polymorphisms (human) RGD Idiopathic dilation cardiomyopathy Susceptibility ISS RGD:1351810 5147650 DNA:polymorphism (human) RGD Lymphoma, B-Cell, Marginal Zone ISS RGD:1351810 5147794 associated with Helicobacter Infections;DNA:polymorphism (human) RGD Multiple Sclerosis Susceptibility ISS RGD:1351810 5147555 DNA:polymorphism (human) RGD Myasthenia Gravis Susceptibility ISS RGD:1351810 5147612 DNA:polymorphisms (human) RGD Myasthenia Gravis ISS RGD:1351810 5147855 DNA:polymorphisms (human) RGD Myositis ISS RGD:1351810 5147793 DNA:polymorphisms (human) RGD Myositis ISS RGD:1351810 5147869 RGD Myositis ISS RGD:1351810 5147629 DNA:polymorphism (human) RGD Narcolepsy Susceptibility ISS RGD:1351810 5147861 DNA:polymorphisms (human) RGD Nasal Polyps ISS RGD:1351810 5147813 associated with Asthma;DNA:polymorphism (human) RGD Pemphigus ISS RGD:1351810 5147619 DNA:polymorphisms (human) RGD Polyendocrinopathies, Autoimmune ISS RGD:1351810 5147646 DNA:polymorphisms: :multiple (human) RGD Polyendocrinopathies, Autoimmune ISS RGD:1351810 5147800 DNA:polymorphisms (human) RGD Polyendocrinopathies, Autoimmune Susceptibility ISS RGD:1351810 5147565 DNA:polymorphisms: :multiple (human) RGD Pseudomonas Infections ISS RGD:1351810 5147865 associated with Cystic Fibrosis:DNA:polymorphism (human) RGD Psoriasis ISS RGD:1351810 5147797 DNA:polymorphisms (human) RGD Purpura ISS RGD:1351810 5147830 DNA:polymorphisms (human) RGD Rheumatic Fever ISS RGD:1351810 5147792 DNA:polymorphisms (human) RGD Rheumatic Heart Disease ISS RGD:1351810 5147792 DNA:polymorphisms (human) RGD Rhinitis ISS RGD:1351810 5147798 DNA:polymorphisms (human) RGD Sjogren's Syndrome ISS RGD:1351810 5147809 DNA:polymorphism (human) RGD Spondylitis, Ankylosing Severity ISS RGD:1351810 5147611 DNA:polymorphism (human) RGD Stroke ISS RGD:1351810 5147807 DNA:polymorphisms (human) RGD Thyroiditis, Autoimmune Susceptibility ISS RGD:1351810 2301816 associated with Diabetes Mellitus, Insulin-Dependent RGD Tubulointerstitial nephritis and uveitis ISS RGD:1351810 5147802 DNA:polymorphism (human) RGD Uveitis IPM 5147639 associated with Encephalomyelitis, Autoimmune, Experimental RGD
Gene-Chemical Interaction Annotations
2,2',4,4',5,5'-hexachlorobiphenyl affects expression ISO RGD:1351810 6480464 2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of HLA-DQA1 mRNA CTD PMID:20638727 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of RT1-BA mRNA CTD PMID:22808131 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of RT1-BA mRNA CTD PMID:19162173 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of RT1-BA mRNA CTD PMID:16483693 arsenic atom affects expression ISO RGD:1351810 6480464 Arsenic affects the expression of HLA-DQA1 mRNA CTD PMID:18414638 auranofin increases response to substance ISO RGD:1351810 6480464 HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin CTD PMID:11436868 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of RT1-BA mRNA CTD PMID:21318169 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of RT1-BA promoter CTD PMID:22457795 copper atom decreases expression EXP 6480464 Copper results in decreased expression of RT1-BA mRNA CTD PMID:22465980 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of RT1-BA mRNA CTD PMID:22465980 coumarin increases expression EXP 6480464 coumarin results in increased expression of RT1-BA mRNA CTD PMID:18480146 dexamethasone increases expression ISO RGD:1351810 6480464 Dexamethasone results in increased expression of HLA-DQA1 mRNA; more ... CTD PMID:12732289 dichloromethane increases expression EXP 6480464 Methylene Chloride results in increased expression of RT1-BA mRNA CTD PMID:20955722 ethylbenzene increases expression EXP 6480464 ethylbenzene results in increased expression of RT1-BA mRNA CTD PMID:20955722 menadione affects expression ISO RGD:1619269 6480464 Vitamin K 3 affects the expression of HLA-DQA1 mRNA CTD PMID:20829426 mercury atom decreases expression ISO RGD:1351810 6480464 Mercury results in decreased expression of HLA-DQA1 mRNA CTD PMID:19937285 PMID:16823088 mercury atom decreases expression ISO RGD:1351810 6480464 Mercury results in decreased expression of HLA-DQA1 mRNA CTD PMID:16823088 PMID:19937285 mercury(0) decreases expression ISO RGD:1351810 6480464 Mercury results in decreased expression of HLA-DQA1 mRNA CTD PMID:19937285 PMID:16823088 mercury(0) decreases expression ISO RGD:1351810 6480464 Mercury results in decreased expression of HLA-DQA1 mRNA CTD PMID:16823088 PMID:19937285 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of RT1-BA mRNA CTD PMID:19638242 quercetin increases expression ISO RGD:1619269 6480464 Quercetin results in increased expression of HLA-DQA1 mRNA CTD PMID:16455785 tamoxifen multiple interactions EXP 6480464 [bexarotene co-treated with Tamoxifen] results in decreased expression of RT1-BA mRNA CTD PMID:17630414 testosterone enanthate affects expression ISO RGD:1351810 6480464 testosterone enanthate affects the expression of HLA-DQA1 mRNA CTD PMID:17440010 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of RT1-BA mRNA CTD PMID:20955722
1641893 Alcrsp7 Alcohol response QTL 7 Alcohol response loss of righting reflex 20 1 27477794 Rat 2317851 Alcrsp22 Alcohol response QTL 22 3.2 .05 Alcohol response 20 1 27477794 Rat 1641915 Colcr9 Colorectal carcinoma resistance QTL 9 2.97 .0024 Colorectal carcinoma resistance 20 1 32560683 Rat 6893685 Bw111 Body weight QTL 111 2.7 .004 Body weight salt-loaded 20 1 32910115 Rat 2305926 Iddm37 Insulin dependent diabetes mellitus QTL 37 6 Glucose level 20 1616332 46616332 Rat 2306850 Pia40 Pristane induced arthritis QTL 40 .0001 Joint/bone inflammation pristane induced 20 1616449 5447380 Rat 2317057 Aia27 Adjuvant induced arthritis QTL 27 2.83 Joint/bone inflammation adjuvant induced 20 3039759 37383914 Rat 1598816 Memor12 Memory QTL 12 2.4 Memory navigation-spatial 20 3055886 48055886 Rat 1300152 Bp195 Blood pressure QTL 195 3.46 Blood pressure salt-loaded systolic 20 3660638 9534510 Rat 1331772 Cdexp2 CD45RC expression in CD8 T cells QTL 2 5.7 CD8 T cell CD45RC expression level 20 3660638 10410227 Rat 737973 Pia21 Pristane induced arthritis QTL 21 3.3 Joint/bone inflammation arthritis severity 20 3660646 4740814 Rat 61432 Cia1 Collagen induced arthritis QTL 1 Joint/bone inflammation type II collagen induced 20 3660646 14605852 Rat 7175099 Tcs2 T cell selection QTL 2 T cell selection expression 20 4625383 4829535 Rat