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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-anisomycin | increases phosphorylation | ISO | RGD:1321393 | 6480464 | Anisomycin results in increased phosphorylation of SRF protein | CTD | PMID:12660819 | (-)-anisomycin | multiple interactions | ISO | RGD:1321393 | 6480464 | SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein] | CTD | PMID:12660819 | (S)-amphetamine | multiple interactions | EXP | | 6480464 | [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; more ... | CTD | PMID:12510024 | 2,2',4,4',5,5'-hexachlorobiphenyl | increases expression | ISO | RGD:1321393 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SRF mRNA | CTD | PMID:23146750 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SRF mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1321394 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SRF mRNA | CTD | PMID:21570461 | 2-butoxyethanol | increases expression | ISO | RGD:1321394 | 6480464 | n-butoxyethanol results in increased expression of SRF mRNA | CTD | PMID:19812364 | 2-methylcholine | affects expression | ISO | RGD:1321393 | 6480464 | beta-methylcholine affects the expression of SRF mRNA | CTD | PMID:21179406 | benzo[a]pyrene | decreases expression | ISO | RGD:1321394 | 6480464 | Benzo(a)pyrene results in decreased expression of SRF mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SRF protein | CTD | PMID:21467743 | benzo[a]pyrene | increases expression | ISO | RGD:1321394 | 6480464 | Benzo(a)pyrene results in increased expression of SRF mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:1321394 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SRF mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:1321394 | 6480464 | Benzo(a)pyrene results in decreased expression of SRF mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:1321394 | 6480464 | Benzo(a)pyrene results in decreased expression of SRF mRNA | CTD | PMID:19770486 PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:1321394 | 6480464 | Benzo(a)pyrene results in decreased expression of SRF mRNA | CTD | PMID:21715664 PMID:19770486 | benzo[a]pyrene | affects activity | ISO | RGD:1321393 | 6480464 | Benzo(a)pyrene affects the activity of SRF protein | CTD | PMID:20624995 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of SRF mRNA | CTD | PMID:19167457 | cadmium sulfate | multiple interactions | ISO | RGD:1321393 | 6480464 | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA | CTD | PMID:18654764 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of SRF mRNA | CTD | PMID:20691718 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of SRF mRNA | CTD | PMID:18668222 | cobalt dichloride | multiple interactions | ISO | RGD:1321393 | 6480464 | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA | CTD | PMID:18654764 | diarsenic trioxide | decreases expression | ISO | RGD:1321393 | 6480464 | arsenic trioxide results in decreased expression of SRF mRNA | CTD | PMID:20458559 | dibutyl phthalate | increases expression | ISO | RGD:1321394 | 6480464 | Dibutyl Phthalate results in increased expression of SRF mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:1321394 | 6480464 | Dibutyl Phthalate results in increased expression of SRF mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of SRF mRNA | CTD | PMID:21266533 | hydrogen peroxide | decreases expression | ISO | RGD:1321393 | 6480464 | Hydrogen Peroxide results in decreased expression of SRF mRNA | CTD | PMID:12419474 | leflunomide | decreases expression | ISO | RGD:1321394 | 6480464 | leflunomide results in decreased expression of SRF mRNA | CTD | PMID:19751817 | mangiferin | decreases expression | ISO | RGD:1321394 | 6480464 | mangiferin results in decreased expression of SRF mRNA | CTD | PMID:15135318 | mercury atom | decreases expression | ISO | RGD:1321393 | 6480464 | Mercury results in decreased expression of SRF mRNA | CTD | PMID:16823088 | mercury(0) | decreases expression | ISO | RGD:1321393 | 6480464 | Mercury results in decreased expression of SRF mRNA | CTD | PMID:16823088 | paracetamol | affects expression | ISO | RGD:1321394 | 6480464 | Acetaminophen affects the expression of SRF mRNA | CTD | PMID:17562736 | phencyclidine | multiple interactions | EXP | | 6480464 | [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; more ... | CTD | PMID:12510024 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SRF mRNA | CTD | PMID:20797428 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1321393 | 6480464 | tert-Butylhydroperoxide results in decreased expression of SRF mRNA | CTD | PMID:12419474 | trans-resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SRF mRNA | CTD | PMID:20797428 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SRF mRNA | CTD | PMID:14565619 | trimethyltin | decreases expression | ISO | RGD:1321394 | 6480464 | trimethyltin results in decreased expression of SRF mRNA | CTD | PMID:21435392 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | HTLV-I infection |
| MAPK signaling pathway | |
| Viral carcinogenesis | |
| Pathway Interaction Database | Coregulation of Androgen receptor activity (PID:200049) |
| ErbB1 downstream signaling (PID:200133) | |
| p38 signaling mediated by MAPKAP kinases (PID:200157) | |
| PDGFR-alpha signaling pathway (PID:200162) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| RhoA signaling pathway (PID:200009) | |
| Signaling events mediated by HDAC Class II (PID:200023) | |
| Trk receptor signaling mediated by the MAPK pathway (PID:200213) | |
References - curated| 1. |
Chang J, etal., Circulation. 2003 Jul 29;108(4):407-13. Epub 2003 Jul 21. |
| 2. |
Dash PK, etal., J Neurochem. 2005 Apr;93(2):269-78. |
| 3. |
Davis FJ, etal., Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1521-33. |
| 4. |
Etkin A, etal., Neuron. 2006 Apr 6;50(1):127-43. |
| 5. |
Han YJ, etal., Mol Biol Cell. 2006 Jul 5;. |
| 6. |
Kaplan-Albuquerque N, etal., Circ Res. 2005 Sep 2;97(5):427-33. Epub 2005 Aug 4. |
| 7. |
Maeda Y, etal., Cancer Lett. 1997 Nov 11;119(2):137-41. |
| 8. |
Miano JM, etal., Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7. Epub 2004 Nov 29. |
| 9. |
Miralles F, etal., Lab Invest. 2006 Oct;86(10):1020-36. Epub 2006 Aug 7. |
| 10. |
Parlakian A, etal., Circulation. 2005 Nov 8;112(19):2930-9. Epub 2005 Oct 31. |
| 11. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
| 15. |
Shan ZX, etal., FEBS Lett. 2010 Aug 20;584(16):3592-600. Epub 2010 Jul 24. |
| 16. |
Zhang X, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R552-60. |
| 17. |
Zhe X, etal., Am J Respir Cell Mol Biol. 2003 Apr;28(4):504-11. |
References - uncurated| PubMed | 14999078 |
| 15180964 | |
| 15256479 | |
| 15550677 | |
| 15857835 | |
| 15950986 | |
| 16395403 | |
| 16824956 | |
| 16987998 | |
| 18035064 | |
| 18945672 | |
| 19778940 | |
| 21393865 | |
| 21525490 | |
| 21940949 | |
| 22049076 | |
| 22157009 | |
| 22454534 |
RGD Disease Portals| Srf has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Srf (Rattus norvegicus) |
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| SRF (Homo sapiens) |
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| Srf (Mus musculus) |
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Position Markers| RH127508 |
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| AW049942 |
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| SRF_3467 |
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| PMC305791P1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001109302 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06058796 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01058287 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473987 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001109302 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001102772 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001102772 | (Get FASTA) |
| GenBank Protein | EDM18828 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018232 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000058149 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000061430 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 501099 | ENTREZGENE |
| HomoloGene Group ID | 31135 | ENTREZGENE |
| InterPro | TF_MADSbox | UniProtKB/TrEMBL |
| IPI | IPI00565301 | UniProtKB/TrEMBL |
| KEGG Report | rno:501099 | ENTREZGENE |
| Pfam | SRF-TF | UniProtKB/TrEMBL |
| PRINTS | MADSDOMAIN | UniProtKB/TrEMBL |
| PROSITE | MADS_BOX_1 | UniProtKB/TrEMBL |
| MADS_BOX_2 | UniProtKB/TrEMBL | |
| SMART | MADS | UniProtKB/TrEMBL |
| Superfamily-SCOP | TF_MADSbox | UniProtKB/TrEMBL |
| UniGene | Rn.1501 | ENTREZGENE |
| UniProt | D3ZHH8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-18 | Srf | serum response factor (c-fos serum response element-binding transcription factor) | Srf | serum response factor | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Srf | serum response factor | Srf_predicted | serum response factor (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2006-08-22 | Srf_predicted | serum response factor (predicted) | RGD1559787_predicted | similar to serum response factor (predicted) | Symbol and Name updated to reflect Human and Mouse nomenclature | 10779 | APPROVED |
| 2006-03-07 | RGD1559787_predicted | similar to serum response factor (predicted) | LOC501099 | similar to serum response factor | Symbol and Name status set to approved | 10779 | APPROVED |
| 2006-02-09 | LOC501099 | similar to serum response factor | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Srf | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1559787 |
| Created: | 2006-02-09 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




