Gene: Slc11a2 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2)  Rattus norvegicus

Symbol: Slc11a2
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Description: ENCODES a protein that exhibits cadmium ion binding; cadmium ion transmembrane transporter activity; cobalt ion binding; INVOLVED IN cadmium ion transmembrane transport; cellular response to hypoxia; cellular response to iron ion; PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH abnormal iron homeostasis; ASSOCIATED WITH Anemia, Hypochromic; Anemia, Iron-Deficiency; Brain Ischemia; FOUND IN apical part of cell; cytoplasm; integral to membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: divalent cation transporter 1; divalent metal transporter 1; DMT-1; DMT1; Dmt1; natural resistance-associated macrophage protein 2; NRAMP 2; Nramp2; solute carrier family 11 member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)
Orthologs: Homo sapiens : SLC11A2 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2)  HGNC
Mus musculus : Slc11a2 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2)  MGI
Latest Assembly: RGSC Genome Assembly v3.4
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
MapChrPositionStrandSource
Rat Cytogenetic Map7q36 NCBI
RGSC Genome Assembly v5.07139,837,654 - 139,870,637-NCBI
RGSC Genome Assembly v3.47139,094,505 - 139,127,427-NCBI
Rat Celera Assembly7127,985,198 - 128,017,825-NCBI
Genome Assembly 3.17139,170,941 - 139,203,864-NCBI
Model

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v3.4)

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc11a2
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RGD Object Information
RGD ID: 3684
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2013-05-28
Status: ACTIVE