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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:busulfan
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Accession:CHEBI:28901 term browser browse the term
Definition:A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Synonyms:exact_synonym: butane-1,4-diyl dimethanesulfonate
 related_synonym: 1,4-Bis(methanesulfonoxy)butane;   1,4-Butanediol dimethanesulfonate;   1,4-Dimesyloxybutane;   1,4-Dimethanesulfonoxybutane;   Bisulfex;   Formula=C6H14O6S2;   InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3;   InChIKey=COVZYZSDYWQREU-UHFFFAOYSA-N;   Leucosulfan;   Mablin;   Mielucin;   Misulban;   Mitostan;   Myeloleukon;   Myleran;   SMILES=CS(=O)(=O)OCCCCOS(C)(=O)=O;   Tetramethylene bis(methanesulfonate);   busulfano;   busulfanum
 alt_id: CHEBI:18936;   CHEBI:3225
 xref: Beilstein:1791786;   CAS:55-98-1;   DrugBank:DB01008;   Drug_Central:438;   KEGG:C06862;   KEGG:D00248;   LINCS:LSM-5388
 xref_mesh: MESH:D002066
 xref: PMID:10523796;   PMID:19361744;   PMID:19611402;   Patent:US2917432;   Reaxys:1791786;   Wikipedia:Busulfan



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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 decreases response to substance ISO ADRB2 protein results in decreased susceptibility to Busulfan CTD PMID:7202579 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Busulfan results in increased expression of AHR mRNA CTD PMID:35641671 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of ANP32B protein CTD PMID:20933509 NCBI chr 5:60,743,077...60,765,726
Ensembl chr 5:60,743,443...60,765,717
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Busulfan CTD PMID:19470598 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Ar androgen receptor multiple interactions ISO Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions
affects response to substance
ISO ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein]
ARHGDIA mRNA affects the susceptibility to Busulfan
CTD PMID:17264767 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of ATF4 protein]
Busulfan results in increased expression of ATF4 mRNA
CTD PMID:35533795 PMID:35641671 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein CTD PMID:20933509 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Busulfan results in decreased expression of BMP4 mRNA CTD PMID:15786497 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP3 protein; [decitabine co-treated with Busulfan] results in increased activity of CASP3 protein; ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] CTD PMID:17264767 PMID:18339423 PMID:19732952 PMID:20933509 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO Busulfan results in increased activity of CASP8 protein
[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]
CTD PMID:18339423 PMID:19732952 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP9 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP9 protein] CTD PMID:19732952 PMID:20933509 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein CTD PMID:20933509 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Busulfan results in decreased expression of CDK2 mRNA CTD PMID:15388331 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Busulfan results in decreased expression of CDK4 mRNA CTD PMID:15388331 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Busulfan results in increased expression of CDKN1A protein
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of CDKN1A protein
CTD PMID:16882877 PMID:20933509 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Busulfan results in increased expression of CDKN2A mRNA CTD PMID:14500376 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein CTD PMID:20933509 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cldn11 claudin 11 decreases expression
multiple interactions
ISO Busulfan results in decreased expression of CLDN11 mRNA; Busulfan results in decreased expression of CLDN11 protein
4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of CLDN11 protein]
CTD PMID:35533795 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO Busulfan affects the expression of COL4A1 mRNA CTD PMID:15941629 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Busulfan results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide] CTD PMID:28744217 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of DDIT3 protein] CTD PMID:35533795 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein] CTD PMID:35533795 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO Busulfan results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2S1 protein]
CTD PMID:35533795 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Faslg Fas ligand decreases expression ISO Busulfan results in decreased expression of FASL mRNA CTD PMID:15388331 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression EXP Busulfan results in decreased expression of FGF8 mRNA CTD PMID:15786497 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Gdnf glial cell derived neurotrophic factor affects expression
increases expression
ISO Busulfan affects the expression of GDNF mRNA
Busulfan results in increased expression of GDNF mRNA
CTD PMID:20684317 PMID:22082982 PMID:26524245 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression
multiple interactions
ISO Busulfan results in decreased expression of GJA1 mRNA; Busulfan results in decreased expression of GJA1 protein
4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of GJA1 protein]
CTD PMID:35533795 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression
ISO Busulfan results in decreased expression of and results in decreased activity of GPX4 protein; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] CTD PMID:32416107 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
decreases response to substance
affects abundance
affects metabolic processing
affects response to substance
ISO GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]
GSTA1 protein results in decreased susceptibility to Busulfan
GSTA1 gene polymorphism affects the abundance of Busulfan
GSTA1 gene polymorphism affects the metabolism of Busulfan; GSTA1 protein affects the metabolism of Busulfan
GSTA1 polymorphism affects the susceptibility to Busulfan
CTD PMID:8886613 PMID:10437668 PMID:10570028 PMID:12429583 PMID:20672371 More... NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing
multiple interactions
affects response to substance
affects abundance
ISO GSTM1 protein affects the metabolism of Busulfan
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan; [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]
GSTM1 gene polymorphism affects the susceptibility to Busulfan
GSTM1 gene polymorphism affects the abundance of Busulfan
CTD PMID:8886613 PMID:15142875 PMID:19584821 PMID:20672371 PMID:21215809 More... NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
affects abundance
ISO GSTP1 protein affects the metabolism of Busulfan
GSTP1 gene polymorphism affects the abundance of Busulfan
CTD PMID:8886613 PMID:20672371 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan CTD PMID:21215809 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO Busulfan results in increased phosphorylation of H2AX protein
[Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein
CTD PMID:18339423 PMID:20933509 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Busulfan results in increased expression of HIF1A mRNA CTD PMID:35641671 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased expression of HSPA5 protein] CTD PMID:35533795 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Inhba inhibin subunit beta A multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA mRNA]; bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA protein]
Busulfan results in increased expression of INHBA mRNA; Busulfan results in increased expression of INHBA protein
CTD PMID:12966370 PMID:22286157 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Busulfan results in decreased expression of KIT mRNA CTD PMID:15388331 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO Busulfan affects the expression of LAMA1 mRNA CTD PMID:15941629 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO Busulfan affects the expression of LAMA4 mRNA CTD PMID:15941629 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Busulfan results in increased activity of MAPK1 protein CTD PMID:16882877 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Busulfan results in increased activity of MAPK3 protein CTD PMID:16882877 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases response to substance ISO MGST2 protein results in decreased susceptibility to Busulfan CTD PMID:15779864 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 decreases expression ISO Busulfan results in decreased expression of MTF1 mRNA CTD PMID:35641671 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of MYC protein CTD PMID:20933509 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nanos2 nanos C2HC-type zinc finger 2 decreases expression ISO Busulfan results in decreased expression of NANOS2 mRNA; Busulfan results in decreased expression of NANOS2 protein CTD PMID:26524245 NCBI chr 1:78,635,668...78,637,128
Ensembl chr 1:78,635,668...78,637,128
JBrowse link
G Nanos3 nanos C2HC-type zinc finger 3 decreases expression ISO Busulfan results in decreased expression of NANOS3 mRNA CTD PMID:26524245 NCBI chr19:23,978,465...23,988,933
Ensembl chr19:23,985,504...23,988,932
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions
increases expression
ISO Busulfan results in decreased expression of NFE2L2 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]
Busulfan results in increased expression of NFE2L2 mRNA
CTD PMID:32416107 PMID:35641671 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Busulfan results in increased expression of NFKB1 mRNA CTD PMID:35641671 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] CTD PMID:20172040 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Ocln occludin decreases expression
multiple interactions
ISO Busulfan results in decreased expression of OCLN mRNA; Busulfan results in decreased expression of OCLN protein
4-phenylbutyric acid inhibits the reaction [Busulfan results in decreased expression of OCLN protein]
CTD PMID:35533795 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; [decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]
Busulfan results in increased cleavage of PARP1 protein
CTD PMID:18339423 PMID:19732952 PMID:20933509 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Phb1 prohibitin 1 affects expression ISO Busulfan affects the expression of PHB1 mRNA CTD PMID:15388331 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Busulfan affects the expression of PPARG mRNA CTD PMID:35641671 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Busulfan results in increased expression of PTGS2 mRNA
ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA]
CTD PMID:12966370 PMID:32416107 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pus7 pseudouridine synthase 7 increases expression ISO Busulfan results in increased expression of PUS7 mRNA CTD PMID:34097952 NCBI chr 4:11,360,169...11,401,139
Ensembl chr 4:11,360,188...11,401,172
JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Busulfan results in decreased expression of RAD51 mRNA CTD PMID:15388331 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Busulfan results in decreased phosphorylation of RB1 protein CTD PMID:15388331 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 increases expression ISO Busulfan results in increased expression of SAT2 mRNA; Busulfan results in increased expression of SAT2 protein CTD PMID:28578006 NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224
JBrowse link
G Serpinc1 serpin family C member 1 affects expression ISO Busulfan affects the expression of SERPINC1 protein CTD PMID:15580502 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions
ISO Busulfan results in increased expression of SERPINE1 mRNA; Busulfan results in increased expression of SERPINE1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA]
CTD PMID:22286157 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions
ISO Busulfan results in decreased expression of SLC40A1 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; sulforaphane inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]
CTD PMID:32416107 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Smc1a structural maintenance of chromosomes 1A multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein CTD PMID:20933509 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC3 protein CTD PMID:20933509 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO Busulfan affects the expression of STAT1 mRNA CTD PMID:35641671 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat2 signal transducer and activator of transcription 2 decreases expression ISO Busulfan results in decreased expression of STAT2 mRNA CTD PMID:35641671 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression ISO Busulfan results in decreased expression of STRA8 mRNA CTD PMID:15388331 NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
JBrowse link
G Tf transferrin multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of TF mRNA]
Busulfan results in increased expression of TF mRNA; Busulfan results in increased expression of TF protein
CTD PMID:12966370 PMID:22286157 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Busulfan results in decreased expression of TFPI mRNA CTD PMID:22286157 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions
ISO Busulfan results in decreased expression of TFRC protein
Deferoxamine promotes the reaction [Busulfan results in decreased expression of TFRC protein]
CTD PMID:32416107 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Busulfan results in increased expression of TGFB1 mRNA CTD PMID:22286157 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Busulfan results in increased expression of THBS1 mRNA CTD PMID:22286157 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Busulfan results in increased expression of TNF mRNA CTD PMID:22286157 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Busulfan affects the phosphorylation of and affects the activity of TP53 protein
Busulfan results in increased expression of TP53 mRNA
CTD PMID:16882877 PMID:35641671 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP Busulfan results in decreased activity of TXNRD1 protein CTD PMID:16085187 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Xbp1 X-box binding protein 1 affects expression ISO Busulfan affects the expression of XBP1 mRNA CTD PMID:35641671 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein CTD PMID:20933509 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 increases expression ISO Busulfan results in increased expression of ZBTB16 mRNA CTD PMID:26524245 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        aetiopathogenetic role 19237
          carcinogenic agent 18547
            busulfan 80
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19612
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              oxoacid 18783
                                chalcogen oxoacid 13780
                                  sulfur oxoacid 13568
                                    sulfonic acid 11607
                                      sulfo group 9921
                                        organosulfonic acid 9921
                                          alkanesulfonic acid 4011
                                            methanesulfonic acid 4001
                                              methanesulfonates 3998
                                                methanesulfonate ester 3997
                                                  busulfan 80
paths to the root