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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ticlopidine
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Accession:CHEBI:9588 term browser browse the term
Definition:A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
Synonyms:exact_synonym: 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
 related_synonym: Formula=C14H14ClNS;   InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2;   InChIKey=PHWBOXQYWZNQIN-UHFFFAOYSA-N;   SMILES=Clc1ccccc1CN1CCc2sccc2C1;   ticlopidina;   ticlopidinum
 xref: CAS:55142-85-3;   DrugBank:DB00208;   Drug_Central:2657;   KEGG:C07140;   KEGG:D08594;   LINCS:LSM-1986
 xref_mesh: MESH:D013988
 xref: PMID:19180126;   Patent:DE2404308;   Patent:US4051141;   Patent:US4127580;   Reaxys:1216802;   Wikipedia:Ticlopidine


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ticlopidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
decreases expression		 ISO
EXP		 Ticlopidine results in decreased activity of ABCB11 protein
Ticlopidine results in decreased expression of ABCB11 mRNA		 CTD PMID:22646477 PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression		 ISO
EXP		 Ticlopidine results in decreased activity of ABCC2 protein
Ticlopidine results in increased expression of ABCC2 mRNA		 CTD PMID:22646477 PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Ticlopidine results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP Ticlopidine results in increased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Ticlopidine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP3 protein]		 CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Ticlopidine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression EXP Ticlopidine results in increased expression of COL18A1 protein CTD PMID:11353854 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO CYP1A2 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP1A2 protein		 CTD PMID:10759690 PMID:19053182 PMID:19170597 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ticlopidine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity		 ISO Ticlopidine binds to and results in decreased activity of CYP2B6 protein; Ticlopidine inhibits the reaction [CYP2B6 protein affects the metabolism of Endosulfan]; Ticlopidine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Ticlopidine results in decreased activity of CYP2B6 protein		 CTD PMID:16855053 PMID:19328226 PMID:23850985 PMID:28887089 PMID:33253783 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity		 ISO CYP2C19 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with NADP] results in decreased activity of CYP2C19 protein]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP2C19 protein		 CTD PMID:10759690 PMID:15333513 PMID:15860655 PMID:16049126 PMID:19053182 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO CYP2C8 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity		 ISO CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite
Ticlopidine results in decreased activity of CYP2D6 protein		 CTD PMID:10759690 PMID:19170597 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases degradation
increases response to substance
multiple interactions		 ISO CYP3A4 protein results in increased degradation of Ticlopidine
CYP3A4 protein results in increased susceptibility to Ticlopidine
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ticlopidine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]		 CTD PMID:19170597 PMID:19299527 PMID:22651985 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO CYP3A5 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Ticlopidine results in increased expression of HMOX1 mRNA] CTD PMID:18227147 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Ticlopidine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects response to substance ISO HLA-A gene polymorphism affects the susceptibility to Ticlopidine CTD PMID:28043905 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Ticlopidine results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Ticlopidine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ticlopidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO Ticlopidine affects the expression of THBS1 mRNA CTD PMID:14687031 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Ticlopidine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases activity ISO Ticlopidine results in decreased activity of VEGFA protein CTD PMID:26327247 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
clopidogrel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases uptake
decreases expression
increases secretion
decreases activity
affects response to substance		 ISO
EXP		 ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]
[Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel
ABCB1 protein results in decreased uptake of clopidogrel
clopidogrel results in decreased expression of ABCB1 mRNA; clopidogrel results in decreased expression of ABCB1 protein
ABCB1 protein results in increased secretion of clopidogrel
clopidogrel results in decreased activity of ABCB1 protein
ABCB1 gene affects the susceptibility to clopidogrel; ABCB1 gene polymorphism affects the susceptibility to clopidogrel; ABCB1 gene SNP affects the susceptibility to clopidogrel		 CTD PMID:17112805 PMID:19106083 PMID:19934793 PMID:20180610 PMID:21900887 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA] CTD PMID:19172522 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Arhgap31 Rho GTPase activating protein 31 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ARHGAP31 mRNA] CTD PMID:19172522 NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases secretion ISO clopidogrel results in decreased secretion of BDNF protein CTD PMID:21803431 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G C4b complement C4B multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA] CTD PMID:19172522 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CABIN1 mRNA] CTD PMID:19172522 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CAMKK2 mRNA] CTD PMID:19172522 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO clopidogrel results in increased expression of CCL11 mRNA CTD PMID:19155974 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO clopidogrel results in increased expression of CCL4 mRNA CTD PMID:16856976 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO clopidogrel results in increased expression of CCL5 mRNA CTD PMID:16856976 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases expression		 ISO clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]
clopidogrel results in decreased expression of CD40LG protein
Clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD40LG protein]		 CTD PMID:11297035 PMID:17043144 PMID:19155974 PMID:30537341 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA] CTD PMID:19172522 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CLCN7 mRNA] CTD PMID:19172522 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2RB mRNA] CTD PMID:19172522 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Clopidogrel results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases oxidation		 ISO CYP1A2 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; furafylline inhibits the reaction [CYP1A2 protein results in increased oxidation of Clopidogrel]
CYP1A2 protein results in increased oxidation of clopidogrel		 CTD PMID:19170597 PMID:19812348 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Clopidogrel results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
increases expression
multiple interactions		 ISO CYP2B6 protein results in increased oxidation of clopidogrel
Clopidogrel results in increased expression of CYP2B6 mRNA
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA		 CTD PMID:19812348 PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
increases oxidation
increases metabolic processing
decreases response to substance
increases response to substance
decreases metabolic processing
affects abundance
affects response to substance		 ISO ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]; CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene polymorphism results in decreased metabolism of and results in decreased activity of clopidogrel; CYP2C19 gene SNP promotes the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]; CYP2C19 protein results in increased metabolism of and results in increased activity of clopidogrel; CYP2C19 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite; CYP2C9 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; N-3-benzylnirvanol inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
CYP2C19 protein results in increased metabolism of clopidogrel
CYP2C19 gene polymorphism results in decreased susceptibility to clopidogrel; CYP2C19 gene SNP results in decreased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in increased susceptibility to clopidogrel; CYP2C19 gene SNP results in increased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in decreased metabolism of clopidogrel; CYP2C19 gene SNP results in decreased metabolism of clopidogrel
CYP2C19 gene polymorphism affects the abundance of clopidogrel metabolite
CYP2C19 gene affects the susceptibility to clopidogrel; CYP2C19 gene polymorphism affects the susceptibility to clopidogrel; CYP2C19 gene SNP affects the susceptibility to clopidogrel		 CTD PMID:16772608 PMID:17697139 PMID:17900275 PMID:18532997 PMID:18577829 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO CYP2C8 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases response to substance
increases degradation
affects response to substance
multiple interactions		 ISO Clopidogrel results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to Clopidogrel
CYP3A4 protein results in increased degradation of Clopidogrel
CYP3A4 gene polymorphism affects the susceptibility to Clopidogrel
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]		 CTD PMID:16645157 PMID:19170597 PMID:22651985 PMID:31312845 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
multiple interactions		 ISO CYP3A5 gene polymorphism affects the susceptibility to clopidogrel
CYP3A5 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite		 CTD PMID:16754899 PMID:19170597 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of DUSP1 mRNA] CTD PMID:19172522 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Eif1a eukaryotic translation initiation factor 1A multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of EIF1A mRNA] CTD PMID:19172522 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:17043144 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor affects response to substance ISO F2R gene SNP affects the susceptibility to clopidogrel CTD PMID:16194864 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein] CTD PMID:30537341 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Clopidogrel results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO clopidogrel results in decreased expression of ICAM1 mRNA; clopidogrel results in decreased expression of ICAM1 protein CTD PMID:19155974 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA] CTD PMID:19172522 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA] CTD PMID:19172522 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30537341 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 increases expression ISO clopidogrel results in increased expression of IL4 mRNA CTD PMID:19155974 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases response to substance		 ISO clopidogrel promotes the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]
clopidogrel results in decreased expression of IL6 mRNA
IL6 protein results in increased susceptibility to clopidogrel
clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:17537833 PMID:19155974 PMID:24793913 PMID:24849676 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel] CTD PMID:15205592 PMID:16214444 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgb3 integrin subunit beta 3 decreases response to substance
affects response to substance		 ISO ITGB3 gene SNP results in decreased susceptibility to clopidogrel
ITGB3 gene SNP affects the susceptibility to clopidogrel		 CTD PMID:15166949 PMID:19530321 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of LTB4R1 mRNA] CTD PMID:19172522 NCBI chr15:29,263,199...29,265,716 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 mRNA] CTD PMID:19172522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MCCC2 mRNA] CTD PMID:19172522 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Mir155 microRNA 155 increases expression ISO Clopidogrel results in increased expression of MIR155 mRNA CTD PMID:33208005 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir17 microRNA 17 decreases expression ISO Clopidogrel results in decreased expression of MIR17 mRNA CTD PMID:33208005 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir363 microRNA 363 increases expression ISO Clopidogrel results in increased expression of MIR363 mRNA CTD PMID:33208005 NCBI chr  X:132,421,791...132,421,877
Ensembl chr  X:132,421,791...132,421,877 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity EXP clopidogrel results in decreased activity of MMP9 protein CTD PMID:20195827 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Clopidogrel inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:20133375 PMID:30537341 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions		 ISO Clopidogrel affects the localization of NR1I3 protein mutant form
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; Clopidogrel binds to and results in increased activity of NR1I3 protein alternative form; Clopidogrel inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]		 CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ocln occludin decreases expression
multiple interactions		 ISO clopidogrel results in decreased expression of OCLN protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of OCLN protein]		 CTD PMID:23220562 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions
increases response to substance
affects response to substance		 ISO clopidogrel binds to and results in decreased activity of P2RY12 protein; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
P2RY12 protein results in increased susceptibility to clopidogrel
P2RY12 gene affects the susceptibility to clopidogrel; P2RY12 gene SNP affects the susceptibility to clopidogrel; P2RY12 protein affects the susceptibility to clopidogrel		 CTD PMID:11413167 PMID:15933261 PMID:18404433 PMID:18485500 PMID:18577829 More... NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Clopidogrel results in increased expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO clopidogrel results in decreased expression of PDGFB mRNA; clopidogrel results in decreased expression of PDGFB protein CTD PMID:19155974 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pon1 paraoxonase 1 affects response to substance
multiple interactions		 ISO PON1 gene polymorphism affects the susceptibility to clopidogrel
PON1 protein results in increased metabolism of and results in increased activity of clopidogrel		 CTD PMID:21170047 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA] CTD PMID:19172522 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Ran RAN, member RAS oncogene family multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of RAN mRNA] CTD PMID:19172522 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of S100A11 mRNA] CTD PMID:19172522 NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Clopidogrel results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E decreases expression ISO clopidogrel results in decreased expression of SELE mRNA; clopidogrel results in decreased expression of SELE protein CTD PMID:19155974 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selp selectin P multiple interactions
decreases expression		 ISO Clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SELP protein]
clopidogrel results in decreased expression of SELP mRNA; clopidogrel results in decreased expression of SELP protein		 CTD PMID:17043144 PMID:19155974 PMID:30537341 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SLC3A1 mRNA] CTD PMID:19172522 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA] CTD PMID:19172522 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SUCLA2 mRNA] CTD PMID:19172522 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]
clopidogrel results in increased expression of TGFB1 mRNA		 CTD PMID:19155974 PMID:19172522 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO clopidogrel results in increased expression of THBS1; clopidogrel results in increased expression of THBS1 mRNA; clopidogrel results in increased expression of THBS1 protein CTD PMID:9447704 PMID:11875746 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thrsp thyroid hormone responsive increases expression ISO Clopidogrel results in increased expression of THRSP mRNA CTD PMID:31312845 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions		 ISO clopidogrel results in decreased expression of TJP1 protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]		 CTD PMID:23220562 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tmem69 transmembrane protein 69 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TMEM69 mRNA] CTD PMID:19172522 NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO clopidogrel results in increased expression of TNF mRNA
Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:19155974 PMID:30537341 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO clopidogrel results in increased expression of TP53 mRNA; clopidogrel results in increased expression of TP53 protein CTD PMID:9447704 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein] CTD PMID:16772608 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      application 19668
        pharmaceutical 19508
          drug 19508
            fibrin modulating drug 165
              ticlopidine 84
                7-hydroxyticlopidine 0
                clopidogrel + 69
                ticlopidine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                carbocyclic compound 18588
                                  benzenoid aromatic compound 17999
                                    benzenes 17862
                                      chlorobenzenes 14844
                                        monochlorobenzenes 11643
                                          ticlopidine 84
                                            7-hydroxyticlopidine 0
                                            clopidogrel + 69
                                            ticlopidine hydrochloride 0
paths to the root