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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fibrin modulating drug
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Accession:CHEBI:48676 term browser browse the term
Definition:A drug that affects the function of fibrin in blood coagulation.
Synonyms:related_synonym: fibrin modulating agent;   fibrin modulating agents;   fibrin modulating drugs



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6-aminohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Aminocaproic Acid results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Folh1 folate hydrolase 1 multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein] CTD PMID:24508213 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
JBrowse link
G Grpr gastrin releasing peptide receptor multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein] CTD PMID:24508213 NCBI chr  X:30,998,425...31,038,442
Ensembl chr  X:30,998,416...31,038,442
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17482686 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Plg plasminogen multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]; Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Aminocaproic Acid results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
anagrelide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fli1 Fli-1 proto-oncogene, ETS transcription factor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA] CTD PMID:20586925 NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433
JBrowse link
G Gata1 GATA binding protein 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein] CTD PMID:20586925 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA] CTD PMID:20586925 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA] CTD PMID:20586925 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797
JBrowse link
G Nfe2 nuclear factor, erythroid 2 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA] CTD PMID:20586925 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO anagrelide results in increased expression of PDGFB mRNA CTD PMID:15682418 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO anagrelide results in decreased expression of TGFB1 mRNA CTD PMID:15682418 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thpo thrombopoietin multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein]; anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Zfpm1 zinc finger protein, multitype 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 NCBI chr19:50,334,352...50,391,029
Ensembl chr19:50,334,682...50,390,591
JBrowse link
camostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cckar cholecystokinin A receptor increases expression EXP camostat results in increased expression of CCKAR mRNA CTD PMID:10458643 NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA] CTD PMID:27773435 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA] CTD PMID:25766432 PMID:27773435 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO mirdametinib inhibits the reaction [camostat results in increased expression of CCND1 protein] CTD PMID:25104499 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO mirdametinib inhibits the reaction [camostat results in increased expression of CCND3 protein] CTD PMID:25104499 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO camostat results in increased expression of CCNE1 protein
mirdametinib inhibits the reaction [camostat results in increased expression of CCNE1 protein]
CTD PMID:25104499 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL1A1 mRNA] CTD PMID:25766432 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL3A1 mRNA] CTD PMID:25766432 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of CYBB mRNA] CTD PMID:25766432 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO mirdametinib inhibits the reaction [camostat results in increased expression of EGR1 mRNA] CTD PMID:25104499 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO camostat results in increased expression of and results in increased secretion of FGF21 protein CTD PMID:30920846 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO mirdametinib inhibits the reaction [camostat results in increased expression of FOS mRNA] CTD PMID:25104499 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Ier3 immediate early response 3 increases expression ISO camostat results in increased expression of IER3 mRNA CTD PMID:25104499 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
ISO camostat results in increased expression of JUN mRNA
camostat results in increased phosphorylation of JUN protein
CTD PMID:25104499 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO camostat results in increased expression of JUNB mRNA CTD PMID:25104499 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO mirdametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein] CTD PMID:25104499 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO camostat results in increased phosphorylation of MAPK3 protein
mirdametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]
CTD PMID:25104499 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
multiple interactions
ISO camostat results in increased expression of MKI67 protein
mirdametinib inhibits the reaction [camostat results in increased expression of MKI67 protein]
CTD PMID:25104499 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP camostat results in increased expression of NOS3 mRNA CTD PMID:10458643 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of NOX1 mRNA] CTD PMID:25766432 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO mirdametinib inhibits the reaction [camostat results in increased expression of PCNA protein] CTD PMID:25104499 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Plg plasminogen decreases activity
multiple interactions
EXP camostat results in decreased activity of PLG protein modified form
camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA]
CTD PMID:27773435 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation ISO camostat results in increased phosphorylation of RPS6 protein CTD PMID:25104499 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of SERPINE1 mRNA] CTD PMID:25766432 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO camostat inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:26599507 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO camostat results in increased phosphorylation of STAT3 protein CTD PMID:25104499 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
camostat inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
camostat inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA]
CTD PMID:25766432 PMID:26599507 PMID:27773435 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
camostat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA]
CTD PMID:20023007 PMID:27773435 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO cilostazol increases expression of abca1 protein in liver
cilostazol reverses the reaction [palmitate decreases expression of abca1 protein in hepatoma cells]
RGD PMID:26362727 PMID:26362727 RGD:21408552, RGD:21408552 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization ISO cilostazol results in increased localization of AIFM1 protein CTD PMID:20131233 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]
cilostazol results in increased phosphorylation of AKT1 protein
CTD PMID:12807996 PMID:15978173 PMID:18556572 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions
affects expression
ISO (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]
cilostazol affects the expression of APP protein
CTD PMID:24254769 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression EXP cilostazol affects the expression of ATP2A2 mRNA; cilostazol affects the expression of ATP2A2 protein CTD PMID:18088389 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
affects expression
multiple interactions
ISO
EXP
cilostazol results in increased expression of BAX protein
cilostazol affects the expression of BAX protein
cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]
CTD PMID:15978173 PMID:16822680 PMID:20131233 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
ISO
EXP
cilostazol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]
cilostazol affects the expression of BCL2 protein
cilostazol results in decreased expression of BCL2 protein
CTD PMID:15978173 PMID:16822680 PMID:20131233 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in decreased expression of BID protein modified form]; cilostazol inhibits the reaction [Nitroprusside results in increased cleavage of and results in increased localization of BID protein] CTD PMID:18311796 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
KT 5720 inhibits the reaction [cilostazol results in increased activity of CASP3 protein]
cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP3 protein]
CTD PMID:18311796 PMID:20131233 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP7 protein] CTD PMID:18311796 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein] CTD PMID:18311796 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]] CTD PMID:19967051 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cilostazol results in decreased expression of CCNA2 protein CTD PMID:15723965 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cilostazol results in increased expression of CDKN1A protein CTD PMID:10642304 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO cilostazol promotes the reaction [CFTR protein affects the secretion of Chlorides]
cilostazol results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
ISO
EXP
Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]
cilostazol results in increased phosphorylation of CREB1 protein
CTD PMID:12807996 PMID:15978173 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases phosphorylation
multiple interactions
ISO cilostazol results in increased phosphorylation of CSNK2A1 protein
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein]; CSNK2A1 protein affects the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein]
CTD PMID:24254769 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO cilostazol results in decreased expression of E2F1 protein CTD PMID:15723965 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO cilostazol results in decreased expression of E2F2 protein CTD PMID:15723965 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Ep300 E1A binding protein p300 affects expression
multiple interactions
ISO cilostazol affects the expression of EP300 protein
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol affects the expression of EP300 protein]; KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein]; SIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein]; sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]
CTD PMID:24254769 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects phosphorylation
multiple interactions
ISO cilostazol affects the phosphorylation of GSK3B protein
SIRT1 protein affects the reaction [cilostazol affects the phosphorylation of GSK3B protein]
CTD PMID:24254769 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
increases expression
multiple interactions
ISO
EXP
HMOX1 results in increased susceptibility to cilostazol
cilostazol results in increased expression of HMOX1 mRNA; cilostazol results in increased expression of HMOX1 protein
copper protoporphyrin IX inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; HMOX1 protein promotes the reaction [cilostazol results in increased activity of PPARG protein]; NFE2L2 mutant form inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]
cilostazol inhibits the reaction [Nitroprusside results in decreased expression of HMOX1 protein]
CTD PMID:18311796 PMID:20131233 PMID:21256160 PMID:21660147 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
cilostazol results in decreased expression of IL1B protein
CTD PMID:20131233 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL5 protein] CTD PMID:15169552 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
cilostazol results in decreased expression of IL6 protein
CTD PMID:20131233 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein; SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein] CTD PMID:24254769 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
increases response to substance
multiple interactions
ISO cilostazol results in increased expression of NFE2L2 protein
NFE2L2 results in increased susceptibility to cilostazol
NFE2L2 mutant form inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]
CTD PMID:20131233 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO cilostazol results in increased expression of NFKBIA protein
zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of NFKBIA protein]
CTD PMID:20131233 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO cilostazol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:21256160 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
ISO cilostazol inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]
cilostazol results in increased phosphorylation of NOS3 protein
CTD PMID:18556572 PMID:19520256 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO cilostazol results in decreased expression of PCNA protein CTD PMID:15723965 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pln phospholamban affects expression EXP cilostazol affects the expression of PLN mRNA; cilostazol affects the expression of PLN protein CTD PMID:18088389 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
ISO cilostazol results in increased activity of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [cilostazol results in increased activity of PPARG protein]; HMOX1 protein promotes the reaction [cilostazol results in increased activity of PPARG protein]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased activity of PPARG protein]
CTD PMID:21660147 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
decreases phosphorylation
ISO
EXP
Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]
cilostazol results in decreased phosphorylation of PTEN protein
CTD PMID:12807996 PMID:15978173 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21256160 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]] CTD PMID:20131233 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases phosphorylation
affects expression
increases expression
ISO cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein]
cilostazol results in increased phosphorylation of SIRT1 protein
cilostazol affects the expression of SIRT1 mRNA
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; cilostazol affects the expression of and affects the activity of SIRT1 protein; cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]; CSNK2A1 protein affects the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein]; SIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein]; SIRT1 protein affects the reaction [cilostazol affects the phosphorylation of GSK3B protein]; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]
cilostazol results in increased expression of SIRT1 protein
CTD PMID:18556572 PMID:19520256 PMID:24254769 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cilostazol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO cilostazol inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]; cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine] CTD PMID:28041785 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
decreases expression
ISO [Cilostazol co-treated with Probucol] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]; Cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]; Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]; Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; HMOX1 mutant form inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]; zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Cilostazol results in decreased susceptibility to TNF protein]
cilostazol results in decreased susceptibility to TNF protein
cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of TNF protein]; cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
cilostazol results in decreased expression of TNF protein
CTD PMID:12807996 PMID:15169552 PMID:19967051 PMID:20131233 PMID:21256160 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO
EXP
cilostazol results in increased expression of TP53 protein
cilostazol inhibits the reaction [Nitroprusside results in increased phosphorylation of TP53 protein]
CTD PMID:10642304 PMID:18311796 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]] CTD PMID:19967051 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
clopidogrel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases uptake
decreases expression
increases secretion
decreases activity
affects response to substance
ISO
EXP
ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]
[Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel
ABCB1 protein results in decreased uptake of clopidogrel
clopidogrel results in decreased expression of ABCB1 mRNA; clopidogrel results in decreased expression of ABCB1 protein
ABCB1 protein results in increased secretion of clopidogrel
clopidogrel results in decreased activity of ABCB1 protein
ABCB1 gene affects the susceptibility to clopidogrel; ABCB1 gene polymorphism affects the susceptibility to clopidogrel; ABCB1 gene SNP affects the susceptibility to clopidogrel
CTD PMID:17112805 PMID:19106083 PMID:19934793 PMID:20180610 PMID:21900887 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA] CTD PMID:19172522 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ARHGAP31 mRNA] CTD PMID:19172522 NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases secretion ISO clopidogrel results in decreased secretion of BDNF protein CTD PMID:21803431 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G C4b complement C4B (Chido blood group) multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA] CTD PMID:19172522 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CABIN1 mRNA] CTD PMID:19172522 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CAMKK2 mRNA] CTD PMID:19172522 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO clopidogrel results in increased expression of CCL11 mRNA CTD PMID:19155974 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO clopidogrel results in increased expression of CCL4 mRNA CTD PMID:16856976 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO clopidogrel results in increased expression of CCL5 mRNA CTD PMID:16856976 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases expression
ISO clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]
clopidogrel results in decreased expression of CD40LG protein
Clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD40LG protein]
CTD PMID:11297035 PMID:17043144 PMID:19155974 PMID:30537341 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA] CTD PMID:19172522 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CLCN7 mRNA] CTD PMID:19172522 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2RB mRNA] CTD PMID:19172522 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Clopidogrel results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases oxidation
ISO CYP1A2 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; furafylline inhibits the reaction [CYP1A2 protein results in increased oxidation of Clopidogrel]
CYP1A2 protein results in increased oxidation of clopidogrel
CTD PMID:19170597 PMID:19812348 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Clopidogrel results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
increases expression
multiple interactions
ISO CYP2B6 protein results in increased oxidation of clopidogrel
Clopidogrel results in increased expression of CYP2B6 mRNA
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA
CTD PMID:19812348 PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases oxidation
increases metabolic processing
decreases response to substance
increases response to substance
decreases metabolic processing
affects abundance
affects response to substance
ISO ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]; CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene polymorphism results in decreased metabolism of and results in decreased activity of clopidogrel; CYP2C19 gene SNP promotes the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]; CYP2C19 protein results in increased metabolism of and results in increased activity of clopidogrel; CYP2C19 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite; CYP2C9 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; N-3-benzylnirvanol inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
CYP2C19 protein results in increased metabolism of clopidogrel
CYP2C19 gene polymorphism results in decreased susceptibility to clopidogrel; CYP2C19 gene SNP results in decreased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in increased susceptibility to clopidogrel; CYP2C19 gene SNP results in increased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in decreased metabolism of clopidogrel; CYP2C19 gene SNP results in decreased metabolism of clopidogrel
CYP2C19 gene polymorphism affects the abundance of clopidogrel metabolite
CYP2C19 gene affects the susceptibility to clopidogrel; CYP2C19 gene polymorphism affects the susceptibility to clopidogrel; CYP2C19 gene SNP affects the susceptibility to clopidogrel
CTD PMID:16772608 PMID:17697139 PMID:17900275 PMID:18532997 PMID:18577829 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO CYP2C8 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases response to substance
increases degradation
affects response to substance
multiple interactions
ISO Clopidogrel results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to Clopidogrel
CYP3A4 protein results in increased degradation of Clopidogrel
CYP3A4 gene polymorphism affects the susceptibility to Clopidogrel
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]
CTD PMID:16645157 PMID:19170597 PMID:22651985 PMID:31312845 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
multiple interactions
ISO CYP3A5 gene polymorphism affects the susceptibility to clopidogrel
CYP3A5 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite
CTD PMID:16754899 PMID:19170597 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of DUSP1 mRNA] CTD PMID:19172522 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Eif1a eukaryotic translation initiation factor 1A multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of EIF1A mRNA] CTD PMID:19172522 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
JBrowse link
G F2 coagulation factor II multiple interactions ISO clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:17043144 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor affects response to substance ISO F2R gene SNP affects the susceptibility to clopidogrel CTD PMID:16194864 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein] CTD PMID:30537341 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Clopidogrel results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO clopidogrel results in decreased expression of ICAM1 mRNA; clopidogrel results in decreased expression of ICAM1 protein CTD PMID:19155974 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA] CTD PMID:19172522 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il13 interleukin 13 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA] CTD PMID:19172522 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30537341 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 increases expression ISO clopidogrel results in increased expression of IL4 mRNA CTD PMID:19155974 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases response to substance
ISO clopidogrel promotes the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]
clopidogrel results in decreased expression of IL6 mRNA
IL6 protein results in increased susceptibility to clopidogrel
clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:17537833 PMID:19155974 PMID:24793913 PMID:24849676 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel] CTD PMID:15205592 PMID:16214444 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgb3 integrin subunit beta 3 decreases response to substance
affects response to substance
ISO ITGB3 gene SNP results in decreased susceptibility to clopidogrel
ITGB3 gene SNP affects the susceptibility to clopidogrel
CTD PMID:15166949 PMID:19530321 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of LTB4R1 mRNA] CTD PMID:19172522 NCBI chr15:29,263,126...29,265,716 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 mRNA] CTD PMID:19172522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MCCC2 mRNA] CTD PMID:19172522 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity EXP clopidogrel results in decreased activity of MMP9 protein CTD PMID:20195827 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Clopidogrel inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:20133375 PMID:30537341 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions
ISO Clopidogrel affects the localization of NR1I3 protein mutant form
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; Clopidogrel binds to and results in increased activity of NR1I3 protein alternative form; Clopidogrel inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ocln occludin decreases expression
multiple interactions
ISO clopidogrel results in decreased expression of OCLN protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of OCLN protein]
CTD PMID:23220562 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions
increases response to substance
affects response to substance
ISO clopidogrel binds to and results in decreased activity of P2RY12 protein; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
P2RY12 protein results in increased susceptibility to clopidogrel
P2RY12 gene affects the susceptibility to clopidogrel; P2RY12 gene SNP affects the susceptibility to clopidogrel; P2RY12 protein affects the susceptibility to clopidogrel
CTD PMID:11413167 PMID:15933261 PMID:18404433 PMID:18485500 PMID:18577829 More... NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Clopidogrel results in increased expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO clopidogrel results in decreased expression of PDGFB mRNA; clopidogrel results in decreased expression of PDGFB protein CTD PMID:19155974 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pon1 paraoxonase 1 affects response to substance
multiple interactions
ISO PON1 gene polymorphism affects the susceptibility to clopidogrel
PON1 protein results in increased metabolism of and results in increased activity of clopidogrel
CTD PMID:21170047 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA] CTD PMID:19172522 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Ran RAN, member RAS oncogene family multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of RAN mRNA] CTD PMID:19172522 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of S100A11 mRNA] CTD PMID:19172522 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Clopidogrel results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sele selectin E decreases expression ISO clopidogrel results in decreased expression of SELE mRNA; clopidogrel results in decreased expression of SELE protein CTD PMID:19155974 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Selp selectin P multiple interactions
decreases expression
ISO Clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SELP protein]
clopidogrel results in decreased expression of SELP mRNA; clopidogrel results in decreased expression of SELP protein
CTD PMID:17043144 PMID:19155974 PMID:30537341 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc3a1 solute carrier family 3 member 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SLC3A1 mRNA] CTD PMID:19172522 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA] CTD PMID:19172522 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SUCLA2 mRNA] CTD PMID:19172522 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]
clopidogrel results in increased expression of TGFB1 mRNA
CTD PMID:19155974 PMID:19172522 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO clopidogrel results in increased expression of THBS1; clopidogrel results in increased expression of THBS1 mRNA; clopidogrel results in increased expression of THBS1 protein CTD PMID:9447704 PMID:11875746 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thrsp thyroid hormone responsive increases expression ISO Clopidogrel results in increased expression of THRSP mRNA CTD PMID:31312845 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
ISO clopidogrel results in decreased expression of TJP1 protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]
CTD PMID:23220562 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tmem69 transmembrane protein 69 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TMEM69 mRNA] CTD PMID:19172522 NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO clopidogrel results in increased expression of TNF mRNA
Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:19155974 PMID:30537341 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO clopidogrel results in increased expression of TP53 mRNA; clopidogrel results in increased expression of TP53 protein CTD PMID:9447704 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein] CTD PMID:16772608 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
ticlopidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
decreases expression
ISO
EXP
Ticlopidine results in decreased activity of ABCB11 protein
Ticlopidine results in decreased expression of ABCB11 mRNA
CTD PMID:22646477 PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
ISO
EXP
Ticlopidine results in decreased activity of ABCC2 protein
Ticlopidine results in increased expression of ABCC2 mRNA
CTD PMID:22646477 PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Ticlopidine results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP Ticlopidine results in increased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Ticlopidine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP3 protein]
CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Ticlopidine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression EXP Ticlopidine results in increased expression of COL18A1 protein CTD PMID:11353854 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO CYP1A2 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP1A2 protein
CTD PMID:10759690 PMID:19053182 PMID:19170597 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ticlopidine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Ticlopidine binds to and results in decreased activity of CYP2B6 protein; Ticlopidine inhibits the reaction [CYP2B6 protein affects the metabolism of Endosulfan]; Ticlopidine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Ticlopidine results in decreased activity of CYP2B6 protein
CTD PMID:16855053 PMID:19328226 PMID:23850985 PMID:28887089 PMID:33253783 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO CYP2C19 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP2C19 protein
CTD PMID:10759690 PMID:15333513 PMID:15860655 PMID:16049126 PMID:19053182 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO CYP2C8 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite
Ticlopidine results in decreased activity of CYP2D6 protein
CTD PMID:10759690 PMID:19170597 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases degradation
increases response to substance
multiple interactions
ISO CYP3A4 protein results in increased degradation of Ticlopidine
CYP3A4 protein results in increased susceptibility to Ticlopidine
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ticlopidine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CTD PMID:19170597 PMID:19299527 PMID:22651985 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO CYP3A5 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Ticlopidine results in increased expression of HMOX1 mRNA] CTD PMID:18227147 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Ticlopidine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Ticlopidine results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Ticlopidine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ticlopidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO Ticlopidine affects the expression of THBS1 mRNA CTD PMID:14687031 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Ticlopidine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Vegfa vascular endothelial growth factor A decreases activity ISO Ticlopidine results in decreased activity of VEGFA protein CTD PMID:26327247 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
tranexamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased expression of BAX protein] CTD PMID:19539006 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:19539006 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:19539006 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] CTD PMID:19539006 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA] CTD PMID:24633426 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Krt19 keratin 19 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT19 protein] CTD PMID:24633426 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19539006 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA] CTD PMID:24633426 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA] CTD PMID:24633426 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20069
    role 20021
      application 19757
        pharmaceutical 19631
          drug 19631
            fibrin modulating drug 153
              antifibrinolytic drug + 48
              cilostazol 43
              ticlopidine + 80
              tirofiban + 0
paths to the root