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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imidazoquinoxaline
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Accession:CHEBI:76605 term browser browse the term
Definition:Any organic heterotricyclic compound with a skeleton consisting of an imidazole ring ortho-fused to a quinoxaline.
Synonyms:related_synonym: imidazoquinoxalines


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MeIQx term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects transport ISO ABCB1A protein affects the transport of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:18322075 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ABCC9 mRNA CTD PMID:20816883 NCBI chr12:21,797,389...21,941,426
Ensembl chr12:21,797,389...21,942,543 		JBrowse link
G ABCD3 ATP binding cassette subfamily D member 3 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ABCD3 mRNA CTD PMID:20816883 NCBI chr 1:94,385,131...94,518,663
Ensembl chr 1:94,418,389...94,518,666 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) affects transport ISO ABCG2 protein affects the transport of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:18322075 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ACSS1 acyl-CoA synthetase short chain family member 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ACSS1 mRNA CTD PMID:20816883 NCBI chr20:25,006,237...25,058,139
Ensembl chr20:25,006,230...25,058,980 		JBrowse link
G ADORA2B adenosine A2b receptor increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ADORA2B mRNA CTD PMID:20816883 NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746 		JBrowse link
G ADSS2 adenylosuccinate synthase 2 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ADSS2 mRNA CTD PMID:20816883 NCBI chr 1:244,408,494...244,452,060
Ensembl chr 1:244,408,494...244,451,909 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
increases expression		 EXP AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of AHR protein		 CTD PMID:20816883 PMID:27644595 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein CTD PMID:37005939 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 multiple interactions EXP [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein CTD PMID:37005939 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536 		JBrowse link
G AKT3 AKT serine/threonine kinase 3 multiple interactions EXP [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein CTD PMID:37005939 NCBI chr 1:243,488,233...243,851,079
Ensembl chr 1:243,488,233...243,851,079 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ALDH3A1 mRNA CTD PMID:20816883 NCBI chr17:19,737,984...19,748,298
Ensembl chr17:19,737,984...19,748,943 		JBrowse link
G ANLN anillin, actin binding protein increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ANLN mRNA CTD PMID:20816883 NCBI chr 7:36,389,862...36,453,791
Ensembl chr 7:36,389,821...36,453,791 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of APAF1 mRNA CTD PMID:20816883 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433 		JBrowse link
G ARG1 arginase 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ARG1 mRNA CTD PMID:20816883 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator affects response to substance EXP ARNT protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:23208499 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ASAP1 mRNA CTD PMID:20816883 NCBI chr 8:130,052,104...130,443,674
Ensembl chr 8:130,052,104...130,443,674 		JBrowse link
G ATP11B ATPase phospholipid transporting 11B (putative) increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ATP11B mRNA CTD PMID:20816883 NCBI chr 3:182,793,504...182,921,629
Ensembl chr 3:182,793,503...182,921,629 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of BAX mRNA CTD PMID:23810796 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 protein CTD PMID:23810796 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G C1QTNF7 C1q and TNF related 7 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of C1QTNF7 mRNA CTD PMID:20816883 NCBI chr 4:15,339,786...15,446,167
Ensembl chr 4:15,339,818...15,446,167 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CACNA1D mRNA CTD PMID:20816883 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased activity of CASP3 protein
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased activity of CASP3 protein		 CTD PMID:20307560 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CASP8 mRNA CTD PMID:20816883 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CCDC47 coiled-coil domain containing 47 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CCDC47 mRNA CTD PMID:20816883 NCBI chr17:63,745,255...63,773,597
Ensembl chr17:63,745,255...63,776,351 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL2 mRNA CTD PMID:23681119 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL3 mRNA CTD PMID:23681119 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL4 mRNA CTD PMID:23681119 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCL7 C-C motif chemokine ligand 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL7 mRNA CTD PMID:23681119 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242 		JBrowse link
G CCNA2 cyclin A2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNA2 mRNA CTD PMID:23681119 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB1 mRNA CTD PMID:23681119 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCNB2 cyclin B2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB2 mRNA CTD PMID:23681119 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045 		JBrowse link
G CCND1 cyclin D1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCND1 mRNA CTD PMID:23681119 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNE1 mRNA CTD PMID:23681119 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR2 mRNA CTD PMID:23681119 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR7 mRNA CTD PMID:23681119 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472 		JBrowse link
G CDC25C cell division cycle 25C increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDC25C mRNA CTD PMID:20816883 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355 		JBrowse link
G CDK1 cyclin dependent kinase 1 increases expression
multiple interactions		 EXP
ISO		 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDK1 mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CDK1 mRNA		 CTD PMID:20816883 PMID:23681119 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK13 cyclin dependent kinase 13 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDK13 mRNA CTD PMID:20816883 NCBI chr 7:39,950,256...40,099,580
Ensembl chr 7:39,950,121...40,099,580 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDKN1A mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDKN1A protein CTD PMID:23810796 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases phosphorylation
affects response to substance		 EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased phosphorylation of CEBPB protein
CEBPB protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline		 CTD PMID:23208499 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G CEP55 centrosomal protein 55 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CEP55 mRNA CTD PMID:20816883 NCBI chr10:93,496,612...93,529,092
Ensembl chr10:93,496,612...93,529,092 		JBrowse link
G CFAP45 cilia and flagella associated protein 45 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CFAP45 mRNA CTD PMID:20816883 NCBI chr 1:159,872,364...159,900,165
Ensembl chr 1:159,872,364...159,900,165 		JBrowse link
G CFHR4 complement factor H related 4 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CFHR4 mRNA CTD PMID:20816883 NCBI chr 1:196,888,052...196,918,633
Ensembl chr 1:196,888,014...196,918,795 		JBrowse link
G CHEK1 checkpoint kinase 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CHEK1 mRNA CTD PMID:23681119 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CLDN14 claudin 14 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CLDN14 mRNA CTD PMID:20816883 NCBI chr21:36,460,621...36,576,569
Ensembl chr21:36,460,621...36,576,569 		JBrowse link
G CLYBL citramalyl-CoA lyase decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CLYBL mRNA CTD PMID:20816883 NCBI chr13:99,606,690...99,909,444
Ensembl chr13:99,606,669...99,909,459 		JBrowse link
G COL9A2 collagen type IX alpha 2 chain increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of COL9A2 mRNA CTD PMID:20816883 NCBI chr 1:40,300,489...40,317,286
Ensembl chr 1:40,300,489...40,317,813 		JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CSGALNACT1 mRNA CTD PMID:20816883 NCBI chr 8:19,404,161...19,757,908
Ensembl chr 8:19,404,161...19,758,029 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
affects activity		 EXP
ISO		 [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A1 mRNA
CYP1A1 affects the activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline		 CTD PMID:2334931 PMID:20307560 PMID:20816883 PMID:22138251 PMID:23681119 More... NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases expression
affects oxidation
increases oxidation
increases activity
affects metabolic processing
decreases activity		 EXP
ISO		 [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; [CYP1A2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] which results in increased chemical synthesis of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline metabolite; [CYP1A2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] which results in increased chemical synthesis of 2-amino-4-hydroxymethyl-3,8-dimethylimidazo(4,5-f)quinoxaline; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA
CYP1A2 affects the oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline promotes the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 protein]; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with alpha-naphthoflavone] results in increased expression of CYP1A2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Carbon Tetrachloride] results in increased expression of CYP1A2 mRNA; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein]
CYP1A2 protein results in increased oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; CYP1A2 results in increased oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased activity of CYP1A2 protein; CYP1A2 results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CYP1A2 protein affects the metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CYP1A2 protein results in decreased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline		 CTD PMID:2334931 PMID:2655891 PMID:9202738 PMID:9581821 PMID:10503887 More... NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression
affects response to substance
multiple interactions		 EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1B1 mRNA
CYP1B1 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1B1 mRNA		 CTD PMID:19223546 PMID:20307560 PMID:20816883 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2A7 cytochrome P450 family 2 subfamily A member 7 multiple interactions ISO CYP2A3 protein results in increased metabolism of and results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:8403195 NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP2B10 mRNA CTD PMID:23681119 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP2C11 mRNA CTD PMID:14965361 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CYP2C8 mRNA CTD PMID:20816883 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 multiple interactions EXP [CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:7625840 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of CYP7B1 mRNA CTD PMID:23681119 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G DAPL1 death associated protein like 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DAPL1 mRNA CTD PMID:20816883 NCBI chr 2:158,795,317...158,815,990
Ensembl chr 2:158,795,317...158,862,781 		JBrowse link
G DDX42 DEAD-box helicase 42 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DDX42 mRNA CTD PMID:20816883 NCBI chr17:63,773,800...63,819,317
Ensembl chr17:63,773,603...63,819,317 		JBrowse link
G DHRS2 dehydrogenase/reductase 2 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of DHRS2 mRNA CTD PMID:20816883 NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639 		JBrowse link
G DIAPH3 diaphanous related formin 3 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DIAPH3 mRNA CTD PMID:20816883 NCBI chr13:59,665,583...60,163,928
Ensembl chr13:59,665,583...60,163,928 		JBrowse link
G DMXL2 Dmx like 2 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of DMXL2 mRNA CTD PMID:20816883 NCBI chr15:51,447,791...51,622,771
Ensembl chr15:51,447,711...51,622,833 		JBrowse link
G DUOX2 dual oxidase 2 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DUOX2 mRNA CTD PMID:20816883 NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172 		JBrowse link
G DUSP16 dual specificity phosphatase 16 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DUSP16 mRNA CTD PMID:20816883 NCBI chr12:12,473,282...12,562,863
Ensembl chr12:12,473,282...12,562,863 		JBrowse link
G E2F7 E2F transcription factor 7 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of E2F7 mRNA CTD PMID:20816883 NCBI chr12:77,021,251...77,065,569
Ensembl chr12:77,021,248...77,065,569 		JBrowse link
G EGR1 early growth response 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of EGR1 mRNA CTD PMID:20816883 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G EPS8L3 EPS8 signaling adaptor L3 affects response to substance EXP EPS8L3 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:19223546 NCBI chr 1:109,750,080...109,763,923
Ensembl chr 1:109,750,080...109,764,027 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ERCC1 mRNA CTD PMID:22100608 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828 		JBrowse link
G ERCC6L ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ERCC6L mRNA CTD PMID:20816883 NCBI chr  X:72,204,665...72,239,027
Ensembl chr  X:72,204,657...72,239,027 		JBrowse link
G ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ESCO2 mRNA CTD PMID:20816883 NCBI chr 8:27,771,974...27,819,660
Ensembl chr 8:27,771,949...27,812,640 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases activity		 EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of ESR1 protein		 CTD PMID:16533016 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G EXO1 exonuclease 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of EXO1 mRNA CTD PMID:23681119 NCBI chr 1:241,847,986...241,889,939
Ensembl chr 1:241,847,967...241,895,148 		JBrowse link
G FAM153A family with sequence similarity 153 member A decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FAM153A mRNA CTD PMID:20816883 NCBI chr 5:177,694,247...177,783,425
Ensembl chr 5:177,707,981...177,784,435 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FHIT mRNA CTD PMID:22100608 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 EXP
ISO		 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FOS mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of FOS mRNA		 CTD PMID:20816883 PMID:23681119 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOXO1 forkhead box O1 increases expression
decreases phosphorylation		 EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of FOXO1 mRNA
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased phosphorylation of FOXO1 protein		 CTD PMID:37005939 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G FSD1 fibronectin type III and SPRY domain containing 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FSD1 mRNA CTD PMID:20816883 NCBI chr19:4,304,598...4,323,836
Ensembl chr19:4,304,598...4,323,843 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of G6PC1 mRNA CTD PMID:37005939 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G GABPB1 GA binding protein transcription factor subunit beta 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GABPB1 mRNA CTD PMID:20816883 NCBI chr15:50,275,389...50,355,198
Ensembl chr15:50,275,389...50,355,408 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GADD45A mRNA CTD PMID:23810796 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GJC3 gap junction protein gamma 3 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GJC3 mRNA CTD PMID:20816883 NCBI chr 7:99,923,266...99,930,747
Ensembl chr 7:99,923,266...99,929,620 		JBrowse link
G GNAT1 G protein subunit alpha transducin 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GNAT1 mRNA CTD PMID:20816883 NCBI chr 3:50,191,610...50,197,696
Ensembl chr 3:50,191,610...50,197,696 		JBrowse link
G GNMT glycine N-methyltransferase decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GNMT mRNA CTD PMID:20816883 PMID:22100608 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880 		JBrowse link
G GPATCH1 G-patch domain containing 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GPATCH1 mRNA CTD PMID:20816883 NCBI chr19:33,081,181...33,130,542
Ensembl chr19:33,080,899...33,130,542 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GSTA1 mRNA CTD PMID:22138251 PMID:23810796 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 affects response to substance EXP GSTM1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:22564066 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 affects response to substance EXP GSTP1 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:19223546 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 affects response to substance EXP GSTT1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:22564066
G H2AX H2A.X variant histone increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of H6PD mRNA CTD PMID:20816883 NCBI chr 1:9,234,774...9,271,337
Ensembl chr 1:9,234,774...9,271,337 		JBrowse link
G HIPK3 homeodomain interacting protein kinase 3 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of HIPK3 mRNA CTD PMID:20816883 NCBI chr11:33,256,672...33,357,023
Ensembl chr11:33,256,672...33,357,023 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of HMOX1 mRNA
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of HMOX1 mRNA		 CTD PMID:20307560 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of HPRT1 gene CTD PMID:12467141 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513 		JBrowse link
G HRAS HRas proto-oncogene, GTPase increases mutagenesis ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of HRAS gene CTD PMID:2009133 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of IL1B mRNA CTD PMID:23681119 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL36B interleukin 36 beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of IL36B mRNA CTD PMID:23681119 NCBI chr 2:113,022,089...113,052,867
Ensembl chr 2:113,022,089...113,052,867 		JBrowse link
G IL3RA interleukin 3 receptor subunit alpha increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of IL3RA mRNA CTD PMID:20816883 NCBI chr  X:1,336,785...1,382,689
NCBI chr  Y:1,336,785...1,382,689
Ensembl chr  Y:1,336,616...1,382,689
Ensembl chr  X:1,336,616...1,382,689 		JBrowse link
G IMPG2 interphotoreceptor matrix proteoglycan 2 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of IMPG2 mRNA CTD PMID:20816883 NCBI chr 3:101,222,546...101,320,575
Ensembl chr 3:101,222,546...101,320,575 		JBrowse link
G INCENP inner centromere protein increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of INCENP mRNA CTD PMID:20816883 NCBI chr11:62,124,011...62,153,169
Ensembl chr11:62,123,998...62,153,169 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of INPP5D mRNA CTD PMID:20816883 NCBI chr 2:233,060,342...233,207,903
Ensembl chr 2:233,059,967...233,207,903 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of JUN mRNA CTD PMID:23681119 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KCNV1 potassium voltage-gated channel modifier subfamily V member 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KCNV1 mRNA CTD PMID:20816883 NCBI chr 8:109,963,636...109,975,771
Ensembl chr 8:109,963,636...109,975,771 		JBrowse link
G KCTD2 potassium channel tetramerization domain containing 2 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KCTD2 mRNA CTD PMID:20816883 NCBI chr17:75,032,571...75,065,886
Ensembl chr17:75,032,575...75,065,889 		JBrowse link
G KIF1B kinesin family member 1B increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KIF1B mRNA CTD PMID:20816883 NCBI chr 1:10,210,570...10,381,603
Ensembl chr 1:10,210,570...10,381,603 		JBrowse link
G KIFC1 kinesin family member C1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KIFC1 mRNA CTD PMID:20816883 NCBI chr 6:33,391,461...33,409,896
Ensembl chr 6:33,391,823...33,409,896 		JBrowse link
G KLF1 KLF transcription factor 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KLF1 mRNA CTD PMID:20816883 NCBI chr19:12,884,422...12,887,201
Ensembl chr19:12,884,422...12,887,201 		JBrowse link
G KLF6 KLF transcription factor 6 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KLF6 mRNA CTD PMID:20816883 NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281 		JBrowse link
G KNL1 kinetochore scaffold 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KNL1 mRNA CTD PMID:20816883 NCBI chr15:40,594,249...40,664,342
Ensembl chr15:40,594,020...40,664,342 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase increases mutagenesis ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of KRAS gene CTD PMID:18271921 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936 		JBrowse link
G LAMA1 laminin subunit alpha 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of LAMA1 mRNA CTD PMID:20816883 NCBI chr18:6,941,742...7,117,797
Ensembl chr18:6,941,742...7,117,797 		JBrowse link
G LIF LIF interleukin 6 family cytokine decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of LIF mRNA CTD PMID:20816883 NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759 		JBrowse link
G LRRC58 leucine rich repeat containing 58 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of LRRC58 mRNA CTD PMID:20816883 NCBI chr 3:120,324,509...120,349,354
Ensembl chr 3:120,324,509...120,349,354 		JBrowse link
G LTF lactotransferrin multiple interactions ISO LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein] CTD PMID:12079509 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234 		JBrowse link
G MAT2A methionine adenosyltransferase 2A increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of MAT2A mRNA CTD PMID:20816883 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281 		JBrowse link
G MKI67 marker of proliferation Ki-67 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of MKI67 mRNA CTD PMID:20816883 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MT-CYB mitochondrially encoded cytochrome b decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CYTB mRNA CTD PMID:20816883 NCBI chr MT:14,747...15,887
Ensembl chr MT:14,747...15,887 		JBrowse link
G NAT2 N-acetyltransferase 2 multiple interactions
affects activity
increases acetylation
increases response to substance		 EXP
ISO		 [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline affects the activity of NAT2 polymorphism] which affects the chemical synthesis of Glucose; [CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
NAT2 protein results in increased acetylation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
NAT2 protein results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
[Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of NAT2 mRNA		 CTD PMID:7625840 PMID:19666988 PMID:22138251 PMID:23681119 PMID:28160022 More... NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G NEK2 NIMA related kinase 2 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NEK2 mRNA CTD PMID:20816883 NCBI chr 1:211,658,256...211,675,621
Ensembl chr 1:211,658,657...211,675,630 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NFE2L2 mRNA
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of NFE2L2 mRNA		 CTD PMID:20307560 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NFKB2 mRNA CTD PMID:23681119 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524 		JBrowse link
G NMU neuromedin U increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NMU mRNA CTD PMID:20816883 NCBI chr 4:55,595,231...55,636,793
Ensembl chr 4:55,595,229...55,636,698 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of NR0B2 mRNA CTD PMID:20816883 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G OAT ornithine aminotransferase multiple interactions EXP [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:9581821 PMID:10503888 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976 		JBrowse link
G ORC1 origin recognition complex subunit 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ORC1 mRNA CTD PMID:20816883 NCBI chr 1:52,372,829...52,409,503
Ensembl chr 1:52,372,829...52,404,423 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of PCK1 mRNA CTD PMID:37005939 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PDZD7 PDZ domain containing 7 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PDZD7 mRNA CTD PMID:20816883 NCBI chr10:101,007,679...101,031,129
Ensembl chr10:101,007,679...101,032,295 		JBrowse link
G PGM5 phosphoglucomutase 5 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PGM5 mRNA CTD PMID:20816883 NCBI chr 9:68,356,611...68,531,061
Ensembl chr 9:68,328,308...68,531,061 		JBrowse link
G PIM2 Pim-2 proto-oncogene, serine/threonine kinase decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PIM2 mRNA CTD PMID:22100608 NCBI chr  X:48,913,182...48,919,024
Ensembl chr  X:48,913,182...48,919,024 		JBrowse link
G PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase like 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PIP5KL1 mRNA CTD PMID:20816883 NCBI chr 9:127,920,881...127,930,777
Ensembl chr 9:127,920,881...127,930,785 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions EXP [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:9581821 PMID:10503888 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G POTED POTE ankyrin domain family member D increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of POTED mRNA CTD PMID:20816883 NCBI chr21:13,609,777...13,645,823
Ensembl chr21:13,609,777...13,645,823 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of PPARA mRNA CTD PMID:37005939 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PPARGC1A mRNA CTD PMID:37005939 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRSS21 serine protease 21 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PRSS21 mRNA CTD PMID:20816883 NCBI chr16:2,817,237...2,821,719
Ensembl chr16:2,817,180...2,826,304 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases metabolic processing EXP PTGS1 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:11159734 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases metabolic processing EXP PTGS2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:11159734 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RAB7B RAB7B, member RAS oncogene family increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAB7B mRNA CTD PMID:20816883 NCBI chr 1:205,976,740...206,003,395
Ensembl chr 1:205,976,740...206,003,461 		JBrowse link
G RAD18 RAD18 E3 ubiquitin protein ligase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA CTD PMID:23681119 NCBI chr 3:8,877,075...8,963,472
Ensembl chr 3:8,775,402...8,963,773 		JBrowse link
G RAD23B RAD23 homolog B, nucleotide excision repair protein decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAD23B mRNA CTD PMID:20816883 NCBI chr 9:107,283,279...107,332,194
Ensembl chr 9:107,283,137...107,332,192 		JBrowse link
G RAD51 RAD51 recombinase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD51 mRNA CTD PMID:23681119 NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340 		JBrowse link
G RAD51AP1 RAD51 associated protein 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAD51AP1 mRNA CTD PMID:20816883 NCBI chr12:4,538,890...4,560,047
Ensembl chr12:4,538,798...4,560,047 		JBrowse link
G RAD54L RAD54 like increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAD54L mRNA CTD PMID:20816883 NCBI chr 1:46,247,688...46,278,473
Ensembl chr 1:46,246,461...46,278,480 		JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAPGEF1 mRNA CTD PMID:20816883 NCBI chr 9:131,576,775...131,740,076
Ensembl chr 9:131,576,770...131,740,076 		JBrowse link
G RBBP6 RB binding protein 6, ubiquitin ligase decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RBBP6 mRNA CTD PMID:20816883 NCBI chr16:24,539,566...24,572,863
Ensembl chr16:24,537,693...24,572,863 		JBrowse link
G RNF125 ring finger protein 125 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RNF125 mRNA CTD PMID:20816883 NCBI chr18:32,018,825...32,088,144
Ensembl chr18:32,018,825...32,073,219 		JBrowse link
G RNF186 ring finger protein 186 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RNF186 mRNA CTD PMID:20816883 NCBI chr 1:19,814,029...19,815,283
Ensembl chr 1:19,814,029...19,815,283 		JBrowse link
G RPS6KA5 ribosomal protein S6 kinase A5 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RPS6KA5 mRNA CTD PMID:20816883 NCBI chr14:90,847,861...91,060,641
Ensembl chr14:90,847,861...91,060,641 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RRM2 mRNA CTD PMID:20816883 NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725 		JBrowse link
G S100A2 S100 calcium binding protein A2 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of S100A2 mRNA CTD PMID:20816883 NCBI chr 1:153,561,108...153,565,844
Ensembl chr 1:153,561,108...153,567,890 		JBrowse link
G SERPINI2 serpin family I member 2 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SERPINI2 mRNA CTD PMID:20816883 NCBI chr 3:167,441,933...167,476,963
Ensembl chr 3:167,441,914...167,478,972 		JBrowse link
G SHCBP1 SHC binding and spindle associated 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SHCBP1 mRNA CTD PMID:20816883 NCBI chr16:46,578,591...46,621,379
Ensembl chr16:46,578,591...46,621,379 		JBrowse link
G SLC15A1 solute carrier family 15 member 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SLC15A1 mRNA CTD PMID:20816883 NCBI chr13:98,683,801...98,752,672
Ensembl chr13:98,683,801...98,752,672 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions
decreases activity		 EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A2 protein		 CTD PMID:30189235 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions
decreases activity		 EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A3 protein		 CTD PMID:30189235 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577 		JBrowse link
G SLC2A14 solute carrier family 2 member 14 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SLC2A14 mRNA CTD PMID:20816883 NCBI chr12:7,812,514...7,891,196
Ensembl chr12:7,812,512...7,891,148 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SLC7A11 mRNA CTD PMID:20816883 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SMYD3 SET and MYND domain containing 3 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SMYD3 mRNA CTD PMID:22100608 NCBI chr 1:245,749,347...246,507,279
Ensembl chr 1:245,749,342...246,507,312 		JBrowse link
G SPDYE1 speedy/RINGO cell cycle regulator family member E1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SPDYE1 mRNA CTD PMID:20816883 NCBI chr 7:43,997,897...44,010,124
Ensembl chr 7:43,997,897...44,010,124 		JBrowse link
G TAS2R20 taste 2 receptor member 20 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of TAS2R20 mRNA CTD PMID:20816883 NCBI chr12:10,995,961...10,998,304
Ensembl chr12:10,995,961...10,998,304 		JBrowse link
G TBC1D25 TBC1 domain family member 25 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TBC1D25 mRNA CTD PMID:20816883 NCBI chr  X:48,539,714...48,562,609
Ensembl chr  X:48,539,714...48,562,609 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of TNF mRNA CTD PMID:23681119 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFSF9 TNF superfamily member 9 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TNFSF9 mRNA CTD PMID:20816883 NCBI chr19:6,531,026...6,535,924
Ensembl chr19:6,531,026...6,535,924 		JBrowse link
G TOP2A DNA topoisomerase II alpha increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TOP2A mRNA CTD PMID:20816883 NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896 		JBrowse link
G TP53 tumor protein p53 increases mutagenesis
increases expression		 ISO
EXP		 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of TP53 gene
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TP53 protein		 CTD PMID:8844820 PMID:23810796 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRAPPC9 trafficking protein particle complex subunit 9 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of TRAPPC9 mRNA CTD PMID:22100608 NCBI chr 8:139,727,725...140,458,579
Ensembl chr 8:139,727,725...140,458,579 		JBrowse link
G TRIM63 tripartite motif containing 63 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TRIM63 mRNA CTD PMID:20816883 NCBI chr 1:26,051,301...26,067,630
Ensembl chr 1:26,051,301...26,068,436 		JBrowse link
G TRIM72 tripartite motif containing 72 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TRIM72 mRNA CTD PMID:20816883 NCBI chr16:31,214,119...31,231,537
Ensembl chr16:31,214,119...31,231,537 		JBrowse link
G UBE2J2 ubiquitin conjugating enzyme E2 J2 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UBE2J2 mRNA CTD PMID:20816883 NCBI chr 1:1,253,912...1,273,854
Ensembl chr 1:1,253,909...1,273,864 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UGT1A1 mRNA CTD PMID:22138251 PMID:23810796 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 multiple interactions EXP [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of UGT2B1 mRNA CTD PMID:23681119 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UHRF1 mRNA CTD PMID:20816883 NCBI chr19:4,903,080...4,962,154
Ensembl chr19:4,903,080...4,962,154 		JBrowse link
G VAMP1 vesicle associated membrane protein 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of VAMP1 mRNA CTD PMID:20816883 NCBI chr12:6,462,237...6,470,677
Ensembl chr12:6,462,237...6,470,677 		JBrowse link
G VIL1 villin 1 decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of VIL1 mRNA CTD PMID:20816883 NCBI chr 2:218,419,123...218,453,295
Ensembl chr 2:218,419,121...218,453,295 		JBrowse link
G WASL WASP like actin nucleation promoting factor increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of WASL mRNA CTD PMID:20816883 NCBI chr 7:123,681,943...123,749,003
Ensembl chr 7:123,681,943...123,749,003 		JBrowse link
G YAP1 Yes1 associated transcriptional regulator decreases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of YAP1 mRNA CTD PMID:20816883 NCBI chr11:102,110,447...102,233,424
Ensembl chr11:102,110,447...102,233,424 		JBrowse link
G ZNF343 zinc finger protein 343 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ZNF343 mRNA CTD PMID:20816883 NCBI chr20:2,481,817...2,524,999
Ensembl chr20:2,481,817...2,524,702 		JBrowse link
G ZNF799 zinc finger protein 799 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ZNF799 mRNA CTD PMID:20816883 NCBI chr19:12,390,016...12,415,084
Ensembl chr19:12,390,016...12,401,271 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    chemical entity 26019
      atom 26015
        nonmetal atom 25503
          nitrogen atom 22528
            nitrogen molecular entity 22528
              organonitrogen compound 21922
                organonitrogen heterocyclic compound 20332
                  imidazoquinoxaline 179
                    MeIQx + 179
                    N-hydroxy-MeIQx 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  organic heteropolycyclic compound 21317
                                    organic heterotricyclic compound 15971
                                      imidazoquinoxaline 179
                                        MeIQx + 179
                                        N-hydroxy-MeIQx 0
paths to the root