DUSP16 (dual specificity phosphatase 16) - Rat Genome Database

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Gene: DUSP16 (dual specificity phosphatase 16) Homo sapiens
Analyze
Symbol: DUSP16
Name: dual specificity phosphatase 16
RGD ID: 1321793
HGNC Page HGNC
Description: Enables JUN kinase binding activity; mitogen-activated protein kinase p38 binding activity; and phosphoprotein phosphatase activity. Involved in MAPK export from nucleus; negative regulation of JUN kinase activity; and protein dephosphorylation. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasm and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity protein phosphatase 16; FLJ36298; FLJ40991; KIAA1700; MAP kinase phosphatase 7; MAPK phosphatase-7; MGC129701; MGC129702; mitogen-activated protein kinase phosphatase 7; MKP-7; MKP7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1212,473,282 - 12,562,863 (-)EnsemblGRCh38hg38GRCh38
GRCh381212,473,282 - 12,562,863 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,626,216 - 12,715,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,520,098 - 12,606,584 (-)NCBINCBI36hg18NCBI36
Build 341212,520,097 - 12,606,584NCBI
Celera1217,770,364 - 17,859,590 (-)NCBI
Cytogenetic Map12p13.2NCBI
HuRef1212,391,458 - 12,480,660 (-)NCBIHuRef
CHM1_11212,591,206 - 12,680,469 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clothianidin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
entinostat  (EXP)
fipronil  (ISO)
fluoranthene  (ISO)
fumonisin B1  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
glyphosate  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
MeIQx  (EXP)
methylmercury chloride  (EXP)
N-nitrosodimethylamine  (ISO)
orphenadrine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
rotenone  (EXP)
sertraline  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
torcetrapib  (EXP)
trichloroethene  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11214970   PMID:11359773   PMID:11489891   PMID:12477932   PMID:12524447   PMID:12794087   PMID:14586399   PMID:14702039   PMID:15489334   PMID:15689616   PMID:15888437   PMID:16344560  
PMID:18854154   PMID:19228121   PMID:19307591   PMID:20122898   PMID:20379614   PMID:20551953   PMID:20936779   PMID:21873635   PMID:22182512   PMID:22245064   PMID:23077088   PMID:23128233  
PMID:23233447   PMID:23639976   PMID:23926106   PMID:24531476   PMID:26186194   PMID:26354767   PMID:26381291   PMID:26988444   PMID:27432908   PMID:27609421   PMID:27880917   PMID:28065597  
PMID:28330616   PMID:28514442   PMID:28675297   PMID:29507755   PMID:29676528   PMID:29880481   PMID:30021884   PMID:31391242   PMID:32296183   PMID:32814053   PMID:33077868   PMID:33326930  
PMID:33863904   PMID:33961781  


Genomics

Comparative Map Data
DUSP16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1212,473,282 - 12,562,863 (-)EnsemblGRCh38hg38GRCh38
GRCh381212,473,282 - 12,562,863 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,626,216 - 12,715,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,520,098 - 12,606,584 (-)NCBINCBI36hg18NCBI36
Build 341212,520,097 - 12,606,584NCBI
Celera1217,770,364 - 17,859,590 (-)NCBI
Cytogenetic Map12p13.2NCBI
HuRef1212,391,458 - 12,480,660 (-)NCBIHuRef
CHM1_11212,591,206 - 12,680,469 (-)NCBICHM1_1
Dusp16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396134,692,431 - 134,769,687 (-)NCBIGRCm39mm39
GRCm39 Ensembl6134,692,431 - 134,769,588 (-)Ensembl
GRCm386134,715,468 - 134,807,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,715,468 - 134,792,625 (-)EnsemblGRCm38mm10GRCm38
MGSCv376134,665,491 - 134,742,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv366134,681,161 - 134,758,168 (-)NCBImm8
Celera6137,667,708 - 137,745,584 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.77NCBI
Dusp16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24167,546,780 - 167,629,949 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4167,548,155 - 167,629,980 (-)Ensembl
Rnor_6.04168,470,141 - 168,551,346 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,472,412 - 168,517,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,751,520 - 232,802,419 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,620,395 - 171,667,593 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14171,868,691 - 171,912,166 (-)NCBI
Celera4156,146,862 - 156,191,111 (-)NCBICelera
Cytogenetic Map4q43NCBI
Dusp16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554139,385,100 - 9,474,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,404,259 - 9,481,061 (-)NCBIChiLan1.0ChiLan1.0
DUSP16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11212,865,400 - 12,963,732 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1212,865,400 - 12,912,502 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01212,497,185 - 12,585,591 (-)NCBIMhudiblu_PPA_v0panPan3
DUSP16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12733,728,209 - 33,831,258 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2733,789,557 - 33,832,075 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2712,612,785 - 12,734,244 (-)NCBI
ROS_Cfam_1.02734,055,803 - 34,140,045 (+)NCBI
ROS_Cfam_1.0 Ensembl2734,019,158 - 34,137,506 (+)Ensembl
UMICH_Zoey_3.12733,948,602 - 34,032,763 (+)NCBI
UNSW_CanFamBas_1.02733,898,280 - 33,982,495 (+)NCBI
UU_Cfam_GSD_1.02712,346,927 - 12,468,377 (-)NCBI
Dusp16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494594,983,450 - 95,075,107 (+)NCBI
SpeTri2.0NW_0049365874,711,085 - 4,801,030 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl559,753,048 - 59,961,844 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1559,869,902 - 59,961,839 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DUSP16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11112,369,713 - 12,462,134 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,372,449 - 12,419,136 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606922,857,949 - 22,950,225 (+)NCBIVero_WHO_p1.0
Dusp16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475225,340,997 - 25,413,561 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D12S358  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,639,357 - 12,639,497UniSTSGRCh37
GRCh371212,639,365 - 12,639,625UniSTSGRCh37
Build 361212,530,624 - 12,530,764RGDNCBI36
Celera1217,783,513 - 17,783,773UniSTS
Celera1217,783,505 - 17,783,645RGD
Cytogenetic Map12p13UniSTS
HuRef1212,404,601 - 12,404,855UniSTS
HuRef1212,404,593 - 12,404,727UniSTS
Marshfield Genetic Map1226.23UniSTS
Marshfield Genetic Map1226.23RGD
Genethon Genetic Map1227.2UniSTS
TNG Radiation Hybrid Map124814.0UniSTS
Stanford-G3 RH Map12713.0UniSTS
GeneMap99-GB4 RH Map1259.94UniSTS
Whitehead-RH Map12106.1UniSTS
Whitehead-YAC Contig Map12 UniSTS
GeneMap99-G3 RH Map12713.0UniSTS
RH76656  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,627,607 - 12,627,817UniSTSGRCh37
Build 361212,518,874 - 12,519,084RGDNCBI36
Celera1217,771,754 - 17,771,964RGD
Cytogenetic Map12p13UniSTS
HuRef1212,392,848 - 12,393,058UniSTS
RH99168  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,627,434 - 12,627,576UniSTSGRCh37
Build 361212,518,701 - 12,518,843RGDNCBI36
Celera1217,771,582 - 17,771,724RGD
Cytogenetic Map12p13UniSTS
HuRef1212,392,676 - 12,392,818UniSTS
GeneMap99-GB4 RH Map1262.06UniSTS
G62270  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,662,431 - 12,662,559UniSTSGRCh37
Build 361212,553,698 - 12,553,826RGDNCBI36
Celera1217,806,574 - 17,806,702RGD
Cytogenetic Map12p13UniSTS
HuRef1212,427,646 - 12,427,774UniSTS
G62398  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,654,013 - 12,654,192UniSTSGRCh37
Build 361212,545,280 - 12,545,459RGDNCBI36
Celera1217,798,159 - 17,798,338RGD
Cytogenetic Map12p13UniSTS
HuRef1212,419,246 - 12,419,425UniSTS
G41291  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,662,388 - 12,662,525UniSTSGRCh37
Build 361212,553,655 - 12,553,792RGDNCBI36
Celera1217,806,531 - 17,806,668RGD
Cytogenetic Map12p13UniSTS
HuRef1212,427,603 - 12,427,740UniSTS
SHGC-83859  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,686,840 - 12,687,177UniSTSGRCh37
Build 361212,578,107 - 12,578,444RGDNCBI36
Celera1217,830,985 - 17,831,322RGD
Cytogenetic Map12p13UniSTS
HuRef1212,452,058 - 12,452,395UniSTS
TNG Radiation Hybrid Map124871.0UniSTS
DUSP16_2046  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,629,603 - 12,630,488UniSTSGRCh37
Build 361212,520,870 - 12,521,755RGDNCBI36
Celera1217,773,750 - 17,774,635RGD
HuRef1212,394,844 - 12,395,729UniSTS
G41293  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,686,379 - 12,686,616UniSTSGRCh37
Build 361212,577,646 - 12,577,883RGDNCBI36
Celera1217,830,524 - 17,830,761RGD
Cytogenetic Map12p13UniSTS
HuRef1212,451,597 - 12,451,834UniSTS
WI-11609  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,628,865 - 12,628,968UniSTSGRCh37
Build 361212,520,132 - 12,520,235RGDNCBI36
Celera1217,773,012 - 17,773,115RGD
Cytogenetic Map12p13UniSTS
HuRef1212,394,106 - 12,394,209UniSTS
GeneMap99-GB4 RH Map1255.13UniSTS
Whitehead-RH Map12106.0UniSTS
NCBI RH Map12173.4UniSTS
A009A32  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,646,448 - 12,646,669UniSTSGRCh37
Build 361212,537,715 - 12,537,936RGDNCBI36
Celera1217,790,596 - 17,790,817RGD
Cytogenetic Map12p13UniSTS
HuRef1212,411,679 - 12,411,900UniSTS
GeneMap99-GB4 RH Map1255.13UniSTS
NCBI RH Map12173.4UniSTS
D12S1217E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,647,913 - 12,648,098UniSTSGRCh37
Build 361212,539,180 - 12,539,365RGDNCBI36
Celera1217,792,061 - 17,792,246RGD
Cytogenetic Map12p13UniSTS
HuRef1212,413,144 - 12,413,329UniSTS
GeneMap99-GB4 RH Map1255.13UniSTS
STS-F10818  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,627,256 - 12,627,433UniSTSGRCh37
Build 361212,518,523 - 12,518,700RGDNCBI36
Celera1217,771,404 - 17,771,581RGD
Cytogenetic Map12p13UniSTS
HuRef1212,392,498 - 12,392,675UniSTS
GeneMap99-GB4 RH Map1256.86UniSTS
NCBI RH Map12175.1UniSTS
G20275  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,647,873 - 12,648,165UniSTSGRCh37
Build 361212,539,140 - 12,539,432RGDNCBI36
Celera1217,792,021 - 17,792,313RGD
Cytogenetic Map12p13UniSTS
HuRef1212,413,104 - 12,413,396UniSTS
A005C29  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,647,873 - 12,648,165UniSTSGRCh37
Build 361212,539,140 - 12,539,432RGDNCBI36
Celera1217,792,021 - 17,792,313RGD
Cytogenetic Map12p13UniSTS
HuRef1212,413,104 - 12,413,396UniSTS
GeneMap99-GB4 RH Map1259.94UniSTS
NCBI RH Map12159.2UniSTS
RH65799  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371212,634,763 - 12,634,909UniSTSGRCh37
Build 361212,526,030 - 12,526,176RGDNCBI36
Celera1217,778,911 - 17,779,057RGD
Cytogenetic Map12p13UniSTS
HuRef1212,400,004 - 12,400,150UniSTS
GeneMap99-GB4 RH Map1257.74UniSTS
D12S358  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p13UniSTS
TNG Radiation Hybrid Map124814.0UniSTS
Stanford-G3 RH Map12713.0UniSTS
GeneMap99-G3 RH Map12713.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR24-2hsa-miR-24-3pOncomiRDBexternal_infoNANA19826043
MIR24-1hsa-miR-24-3pOncomiRDBexternal_infoNANA19826043

Predicted Target Of
Summary Value
Count of predictions:1612
Count of miRNA genes:879
Interacting mature miRNAs:1011
Transcripts:ENST00000228862, ENST00000298573, ENST00000536236, ENST00000539940, ENST00000541207, ENST00000545864
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1770 1374 1648 564 1060 408 3371 723 1909 268 1378 1570 169 880 2065 4
Low 662 1599 74 58 868 55 984 1469 1799 149 70 38 2 324 723 1
Below cutoff 2 12 1 1 17 1 1 2 2 5 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_021402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005253488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB051487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB052156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF506796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK022103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX260340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX278461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX405700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY038927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC109234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC109235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB094627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000228862   ⟹   ENSP00000228862
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1212,475,897 - 12,562,383 (-)Ensembl
RefSeq Acc Id: ENST00000298573   ⟹   ENSP00000298573
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1212,473,282 - 12,562,863 (-)Ensembl
RefSeq Acc Id: ENST00000536236
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1212,521,327 - 12,560,886 (-)Ensembl
RefSeq Acc Id: ENST00000539940   ⟹   ENSP00000443039
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1212,521,024 - 12,561,125 (-)Ensembl
RefSeq Acc Id: ENST00000541207   ⟹   ENSP00000441250
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1212,521,081 - 12,561,077 (-)Ensembl
RefSeq Acc Id: ENST00000545864
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1212,477,886 - 12,506,187 (-)Ensembl
RefSeq Acc Id: NM_030640   ⟹   NP_085143
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,473,282 - 12,562,863 (-)NCBI
GRCh371212,626,216 - 12,715,773 (-)NCBI
Build 361212,520,098 - 12,606,584 (-)NCBI Archive
HuRef1212,391,458 - 12,480,660 (-)ENTREZGENE
CHM1_11212,591,206 - 12,680,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005253488   ⟹   XP_005253545
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,474,220 - 12,562,514 (-)NCBI
GRCh371212,626,216 - 12,715,773 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006719155   ⟹   XP_006719218
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,474,220 - 12,561,125 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011520856   ⟹   XP_011519158
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,474,220 - 12,561,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019988   ⟹   XP_016875477
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,474,220 - 12,561,125 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_085143   ⟸   NM_030640
- UniProtKB: Q9BY84 (UniProtKB/Swiss-Prot),   A0A024RAR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005253545   ⟸   XM_005253488
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006719218   ⟸   XM_006719155
- Peptide Label: isoform X1
- UniProtKB: Q9BY84 (UniProtKB/Swiss-Prot),   A0A024RAR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011519158   ⟸   XM_011520856
- Peptide Label: isoform X1
- UniProtKB: Q9BY84 (UniProtKB/Swiss-Prot),   A0A024RAR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016875477   ⟸   XM_017019988
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000441250   ⟸   ENST00000541207
RefSeq Acc Id: ENSP00000228862   ⟸   ENST00000228862
RefSeq Acc Id: ENSP00000298573   ⟸   ENST00000298573
RefSeq Acc Id: ENSP00000443039   ⟸   ENST00000539940
Promoters
RGD ID:7223227
Promoter ID:EPDNEW_H17358
Type:initiation region
Name:DUSP16_2
Description:dual specificity phosphatase 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17359  EPDNEW_H17360  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,561,098 - 12,561,158EPDNEW
RGD ID:7223225
Promoter ID:EPDNEW_H17359
Type:initiation region
Name:DUSP16_1
Description:dual specificity phosphatase 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17358  EPDNEW_H17360  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,562,311 - 12,562,371EPDNEW
RGD ID:7223229
Promoter ID:EPDNEW_H17360
Type:initiation region
Name:DUSP16_3
Description:dual specificity phosphatase 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17359  EPDNEW_H17358  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381212,562,417 - 12,562,477EPDNEW
RGD ID:6810234
Promoter ID:HG_ACW:15891
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:BLONER.AAPR07-UNSPLICED,   DUSP16.BAPR07,   DUSP16.CAPR07,   DUSP16.HAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361212,605,381 - 12,606,042 (+)MPROMDB
RGD ID:6789919
Promoter ID:HG_KWN:15067
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000298573,   NM_030640
Position:
Human AssemblyChrPosition (strand)Source
Build 361212,606,286 - 12,607,112 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.2-13.1(chr12:11771233-13547775)x1 copy number loss See cases [RCV000050816] Chr12:11771233..13547775 [GRCh38]
Chr12:11924167..13700709 [GRCh37]
Chr12:11815434..13591976 [NCBI36]
Chr12:12p13.2-13.1
pathogenic
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22
pathogenic
GRCh38/hg38 12p13.2-12.3(chr12:12388842-15540422)x1 copy number loss See cases [RCV000052780] Chr12:12388842..15540422 [GRCh38]
Chr12:12541776..15693356 [GRCh37]
Chr12:12433043..15584623 [NCBI36]
Chr12:12p13.2-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.2-12.3(chr12:12363649-15280588)x1 copy number loss See cases [RCV000135331] Chr12:12363649..15280588 [GRCh38]
Chr12:12514722..15433522 [GRCh37]
Chr12:12405989..15324789 [NCBI36]
Chr12:12p13.2-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.2-12.3(chr12:11121039-15908154)x1 copy number loss See cases [RCV000142882] Chr12:11121039..15908154 [GRCh38]
Chr12:11273638..16061088 [GRCh37]
Chr12:11164905..15952355 [NCBI36]
Chr12:12p13.2-12.3
likely pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p13.2-13.1(chr12:12419642-13256423)x3 copy number gain Ductal breast carcinoma [RCV000207111] Chr12:12419642..13256423 [GRCh37]
Chr12:12p13.2-13.1
uncertain significance
chr12:10074776-18800953 complex variant complex Ductal breast carcinoma [RCV000207105] Chr12:10074776..18800953 [GRCh37]
Chr12:12p13.31-12.3
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1
likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.2(chr12:12546745-12773521)x3 copy number gain not provided [RCV000683407] Chr12:12546745..12773521 [GRCh37]
Chr12:12p13.2
uncertain significance
GRCh37/hg19 12p13.2-13.1(chr12:10717428-14032860)x1 copy number loss not provided [RCV000683470] Chr12:10717428..14032860 [GRCh37]
Chr12:12p13.2-13.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21
pathogenic
NM_030640.3(DUSP16):c.1080_1083del (p.Pro361fs) deletion not provided [RCV000950778] Chr12:12477748..12477751 [GRCh38]
Chr12:12630682..12630685 [GRCh37]
Chr12:12p13.2
benign
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.2-13.1(chr12:10336209-13535349) copy number loss Multiple endocrine neoplasia, type 4 [RCV000767604] Chr12:10336209..13535349 [GRCh37]
Chr12:12p13.2-13.1
pathogenic
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
NM_030640.3(DUSP16):c.229-7A>C single nucleotide variant not provided [RCV000888003] Chr12:12520007 [GRCh38]
Chr12:12672941 [GRCh37]
Chr12:12p13.2
benign
NM_030640.3(DUSP16):c.663G>T (p.Pro221=) single nucleotide variant not provided [RCV000897830] Chr12:12487056 [GRCh38]
Chr12:12639990 [GRCh37]
Chr12:12p13.2
likely benign
GRCh37/hg19 12p13.2-12.3(chr12:11737824-16780886)x1 copy number loss not provided [RCV001006482] Chr12:11737824..16780886 [GRCh37]
Chr12:12p13.2-12.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17909 AgrOrtholog
COSMIC DUSP16 COSMIC
Ensembl Genes ENSG00000111266 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000280962 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000228862 UniProtKB/Swiss-Prot
  ENSP00000298573 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000443039 UniProtKB/TrEMBL
  ENSP00000485919 UniProtKB/TrEMBL
  ENSP00000487034 UniProtKB/Swiss-Prot
  ENSP00000487512 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000228862 UniProtKB/Swiss-Prot
  ENST00000298573 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000539940 UniProtKB/TrEMBL
  ENST00000626413 UniProtKB/Swiss-Prot
  ENST00000626461 UniProtKB/TrEMBL
  ENST00000628303 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000111266 GTEx
  ENSG00000280962 GTEx
HGNC ID HGNC:17909 ENTREZGENE
Human Proteome Map DUSP16 Human Proteome Map
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:80824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 80824 ENTREZGENE
OMIM 607175 OMIM
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38475 PharmGKB
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RAR2 ENTREZGENE, UniProtKB/TrEMBL
  DUS16_HUMAN UniProtKB/Swiss-Prot
  F5H5X4_HUMAN UniProtKB/TrEMBL
  Q32MA0_HUMAN UniProtKB/TrEMBL
  Q8IVT8_HUMAN UniProtKB/TrEMBL
  Q9BY84 ENTREZGENE
UniProt Secondary Q547C7 UniProtKB/Swiss-Prot
  Q96QS2 UniProtKB/Swiss-Prot
  Q9C0G3 UniProtKB/Swiss-Prot