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Gene: GADD45A (growth arrest and DNA damage inducible alpha) Homo sapiens
Symbol: GADD45A
Name: growth arrest and DNA damage inducible alpha
Description: Exhibits kinase binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including cellular response to ionizing radiation; cellular response to mechanical stimulus; and positive regulation of MAPK cascade. Localizes to the cytoplasm and nuclear speck.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DDIT-1; DDIT1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; GADD45; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible, alpha
Mus musculus (house mouse) : Gadd45a (growth arrest and DNA-damage-inducible 45 alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gadd45a (growth arrest and DNA-damage-inducible, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gadd45a (growth arrest and DNA damage inducible alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : GADD45A (growth arrest and DNA damage inducible alpha)
Canis lupus familiaris (dog) : GADD45A (growth arrest and DNA damage inducible alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gadd45a (growth arrest and DNA damage inducible alpha)
Sus scrofa (pig) : GADD45A (growth arrest and DNA damage inducible alpha)
Chlorocebus sabaeus (African green monkey) : GADD45A (growth arrest and DNA damage inducible alpha)
Heterocephalus glaber (naked mole-rat) : Gadd45a (growth arrest and DNA damage inducible alpha)
more info ...
Related Pseudogenes: GADD45AP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl167,685,201 - 67,688,334 (+)EnsemblGRCh38hg38GRCh38
GRCh38167,685,201 - 67,688,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37168,150,860 - 68,154,021 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,923,471 - 67,926,607 (+)NCBINCBI36hg18NCBI36
Build 34167,862,903 - 67,866,040NCBI
Celera166,441,746 - 66,444,882 (+)NCBI
Cytogenetic Map1p31.3NCBI
HuRef166,261,120 - 66,264,281 (+)NCBIHuRef
CHM1_1168,265,339 - 68,268,500 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GADD45A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733803
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.