KLF6 (KLF transcription factor 6) - Rat Genome Database

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Gene: KLF6 (KLF transcription factor 6) Homo sapiens
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Symbol: KLF6
Name: KLF transcription factor 6
RGD ID: 1349381
HGNC Page HGNC:2235
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; fibrillar center; and nucleoplasm. Implicated in prostate cancer and stomach cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: B-cell-derived protein 1; BCD1; CBA1; COPEB; core promoter element binding protein; core promoter element-binding protein; CPBP; DKFZp686N0199; GBF; GC-rich binding factor; GC-rich sites-binding factor GBF; Krueppel-like factor 6; Kruppel like factor 6; Kruppel-like factor 6; Kruppel-like zinc finger protein Zf9; PAC1; proto-oncogene BCD1; protooncogene B-cell derived 1; ST12; suppression of tumorigenicity 12 (prostate); suppressor of tumorigenicity 12 protein; transcription factor Zf9; ZF9
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38103,775,996 - 3,785,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl103,775,996 - 3,785,281 (-)EnsemblGRCh38hg38GRCh38
GRCh37103,818,188 - 3,827,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36103,811,234 - 3,817,455 (-)NCBINCBI36Build 36hg18NCBI36
Build 34103,811,240 - 3,817,455NCBI
Celera103,763,066 - 3,772,350 (-)NCBICelera
Cytogenetic Map10p15.2NCBI
HuRef103,754,750 - 3,764,030 (-)NCBIHuRef
CHM1_1103,818,788 - 3,828,068 (-)NCBICHM1_1
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF6HumanCOVID-19  HEP 30296672mRNA:increased expression:bronchoalveolar lavage (human)RGD 
KLF6Humanprostate cancer  IAGP 734811DNA:loss of heterozygosity and missense mutations:multiple RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF6HumanHypotension  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: HypotensionClinVarPMID:25741868 and PMID:28492532
KLF6HumanProstate Cancer, Somatic  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Prostate cancer and somaticClinVarPMID:11752579
KLF6Humanschizophrenia  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
KLF6Humanstomach cancer  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Gastric cancerClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF6HumanExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
KLF6HumanProstatic Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
KLF6HumanStomach Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF6Humanprostate cancer  IAGP 7240710 OMIM 
KLF6Humanstomach cancer  IAGP 7240710 OMIM 

1 to 20 of 275 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF6Human(-)-demecolcine increases expressionEXP 6480464Demecolcine results in increased expression of KLF6 mRNACTDPMID:23649840
KLF6Human(1->4)-beta-D-glucan multiple interactionsISOKlf6 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of KLF6 mRNACTDPMID:36331819
KLF6Human(S)-colchicine increases expressionEXP 6480464Colchicine results in increased expression of KLF6 mRNACTDPMID:24211769
KLF6Human1,1-dichloroethene increases expressionISOKlf6 (Mus musculus)6480464vinylidene chloride results in increased expression of KLF6 mRNACTDPMID:26682919
KLF6Human1,2-dimethylhydrazine decreases expressionISOKlf6 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of KLF6 mRNACTDPMID:22206623
KLF6Human1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of KLF6 mRNACTDPMID:16314067 and PMID:17374397
KLF6Human1-methylphenanthrene multiple interactionsEXP 6480464[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of KLF6 mRNACTDPMID:17690111
KLF6Human1-naphthyl isothiocyanate increases expressionISOKlf6 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of KLF6 mRNACTDPMID:25380136 and PMID:30723492
KLF6Human1-naphthyl isothiocyanate multiple interactionsEXP 6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of KLF6 mRNACTDPMID:27344345
KLF6Human15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactionsISOKlf6 (Mus musculus)6480464[15-deoxy-delta(12 more ...CTDPMID:16611854
KLF6Human17alpha-ethynylestradiol multiple interactionsISOKlf6 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF6 mRNACTDPMID:17942748
KLF6Human17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of KLF6 mRNACTDPMID:20106945
KLF6Human17beta-estradiol decreases expressionISOKlf6 (Mus musculus)6480464Estradiol results in decreased expression of KLF6 mRNACTDPMID:39298647
KLF6Human17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of KLF6 mRNACTDPMID:19167446 and PMID:24758408
KLF6Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol binds to ESR2 protein] which results in decreased expression of KLF6 mRNA more ...CTDPMID:20404318 more ...
KLF6Human17beta-hydroxy-5alpha-androstan-3-one increases expressionEXP 6480464Dihydrotestosterone results in increased expression of KLF6 mRNACTDPMID:38122923
KLF6Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOKlf6 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of KLF6 mRNACTDPMID:24058054 and PMID:37172768
KLF6Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of KLF6 mRNACTDPMID:20106945 more ...
KLF6Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOKlf6 (Mus musculus)6480464[Tetrachlorodibenzodioxin affects the methylation of KLF6 intron] which results in increased expression of KLF6 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF6 mRNACTDPMID:17942748 and PMID:33017471
KLF6Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOKlf6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of KLF6 mRNACTDPMID:21570461

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Cellular Component
1 to 9 of 9 rows

  
Object Symbol
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Term
Qualifier
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Reference
Notes
Source
Original Reference(s)
KLF6Humanchromatin located_inISAtfclass:2.3.1150520179 NTNU_SBGO_REF:0000113
KLF6Humancytoplasm located_inISOKlf6 (Mus musculus)9068941 PMID:15557439MGIPMID:15557439
KLF6Humancytosol located_inIDA 150520179 HPAGO_REF:0000052
KLF6Humanfibrillar center located_inIDA 150520179 HPAGO_REF:0000052
KLF6Humannucleolus located_inIDA 150520179 HPAGO_REF:0000052
KLF6Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
KLF6Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
KLF6Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
KLF6Humannucleus located_inTAS 150520179 PMID:9689109UniProtPMID:9689109
1 to 9 of 9 rows

Molecular Function
1 to 14 of 14 rows

  
Object Symbol
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Reference
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Original Reference(s)
KLF6HumanDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
KLF6HumanDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 150520179 PMID:18755691NTNU_SBPMID:18755691
KLF6HumanDNA-binding transcription factor activity  ISOKlf6 (Rattus norvegicus)9068941 RGDPMID:9689109 and REF_RGD_ID:62381
KLF6HumanDNA-binding transcription factor activity, RNA polymerase II-specific enablesISAtfclass:2.3.1150520179 NTNU_SBGO_REF:0000113
KLF6HumanDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000233 more ...150520179 GO_CentralGO_REF:0000033
KLF6Humandouble-stranded DNA binding  ISOKlf6 (Rattus norvegicus)9068941 RGDPMID:9689109 and REF_RGD_ID:62381
KLF6Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
KLF6Humanprotein binding enablesIPIUniProtKB:Q04206150520179 PMID:24634218IntActPMID:24634218
KLF6Humanprotein binding enablesIPIUniProtKB:P02545 more ...150520179 PMID:32814053IntActPMID:32814053
KLF6Humanprotein binding enablesIPIUniProtKB:O43149150520179 PMID:33227311UniProtPMID:33227311
KLF6HumanRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIDA 150520179 PMID:18755691NTNU_SBPMID:18755691
KLF6HumanRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:1277166 more ...150520179 GO_CentralGO_REF:0000033
KLF6Humansequence-specific double-stranded DNA binding enablesIDA 150520179 PMID:28473536ARUK-UCLPMID:28473536
KLF6Humanzinc ion binding enablesIEAUniProtKB-KW:KW-0863150520179 UniProtGO_REF:0000043
1 to 14 of 14 rows

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF6HumanProstate cancer  IAGP 734811DNA:loss of heterozygosity and missense mutations:multipleRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF6HumanHypotension  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: HypotensionClinVarPMID:25741868 and PMID:28492532
KLF6HumanSchizophrenia  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
KLF6HumanStomach cancer  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Stomach cancerClinVar 

#
Reference Title
Reference Citation
1. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Narla G, etal., Science 2001 Dec 21;294(5551):2563-6.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
1 to 10 of 18 rows
PMID:8889548   PMID:9000136   PMID:9083102   PMID:9503030   PMID:9685731   PMID:9689109   PMID:10802067   PMID:12433697   PMID:12477932   PMID:12508640   PMID:12590140   PMID:12651597  
PMID:12651626   PMID:12740910   PMID:12794452   PMID:15057748   PMID:15064720   PMID:15067324   PMID:15131018   PMID:15164054   PMID:15172998   PMID:15247715   PMID:15342556   PMID:15378003  
PMID:15486921   PMID:15489334   PMID:15735005   PMID:15824733   PMID:15917248   PMID:15937668   PMID:16044160   PMID:16054710   PMID:16169070   PMID:16189514   PMID:16385451   PMID:16431954  
PMID:16500425   PMID:16598737   PMID:16702959   PMID:16778100   PMID:16856969   PMID:16872311   PMID:16972326   PMID:16988269   PMID:17071613   PMID:17113081   PMID:17125911   PMID:17143513  
PMID:17207965   PMID:17223258   PMID:17347589   PMID:17347668   PMID:17514651   PMID:17621627   PMID:17636026   PMID:17663506   PMID:17893646   PMID:18053161   PMID:18174288   PMID:18190240  
PMID:18250346   PMID:18471523   PMID:18515091   PMID:18521079   PMID:18596922   PMID:18691883   PMID:18719336   PMID:18753303   PMID:18755691   PMID:18822210   PMID:19020536   PMID:19097929  
PMID:19101139   PMID:19274049   PMID:19328586   PMID:19333010   PMID:19435908   PMID:19808645   PMID:19967571   PMID:20014424   PMID:20116377   PMID:20126619   PMID:20237496   PMID:20453000  
PMID:20545576   PMID:20660366   PMID:20714872   PMID:20801538   PMID:20844588   PMID:21056892   PMID:21109018   PMID:21154818   PMID:21282102   PMID:21309496   PMID:21443094   PMID:21470678  
PMID:21538018   PMID:21799854   PMID:21832049   PMID:21849067   PMID:21873635   PMID:21928351   PMID:21940380   PMID:22095588   PMID:22169644   PMID:22277651   PMID:22486562   PMID:22535637  
PMID:22581522   PMID:22653055   PMID:22711891   PMID:22782870   PMID:22855058   PMID:22859706   PMID:23048070   PMID:23085750   PMID:23219426   PMID:23322324   PMID:23345610   PMID:23353867  
1 to 10 of 18 rows



KLF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38103,775,996 - 3,785,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl103,775,996 - 3,785,281 (-)EnsemblGRCh38hg38GRCh38
GRCh37103,818,188 - 3,827,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36103,811,234 - 3,817,455 (-)NCBINCBI36Build 36hg18NCBI36
Build 34103,811,240 - 3,817,455NCBI
Celera103,763,066 - 3,772,350 (-)NCBICelera
Cytogenetic Map10p15.2NCBI
HuRef103,754,750 - 3,764,030 (-)NCBIHuRef
CHM1_1103,818,788 - 3,828,068 (-)NCBICHM1_1
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBIT2T-CHM13v2.0
Klf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39135,911,488 - 5,920,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl135,911,481 - 5,920,393 (+)EnsemblGRCm39 Ensembl
GRCm38135,861,489 - 5,870,393 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl135,861,482 - 5,870,394 (+)EnsemblGRCm38mm10GRCm38
MGSCv37135,860,735 - 5,869,639 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36135,860,735 - 5,869,639 (+)NCBIMGSCv36mm8
Celera135,806,926 - 5,815,830 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.94NCBI
Klf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81769,449,483 - 69,458,478 (-)NCBIGRCr8
mRatBN7.21764,539,456 - 64,548,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1764,531,463 - 64,588,570 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1768,038,144 - 68,047,153 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,866,987 - 71,875,996 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,913,871 - 65,922,847 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01767,887,939 - 67,945,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1767,887,939 - 67,945,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01769,616,967 - 69,674,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41775,578,498 - 75,585,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11775,589,332 - 75,595,905 (-)NCBI
Celera1764,125,707 - 64,134,702 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Klf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554291,838,537 - 1,846,915 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554291,838,537 - 1,846,915 (+)NCBIChiLan1.0ChiLan1.0
KLF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2816,278,053 - 16,286,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11016,283,374 - 16,292,148 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0103,781,797 - 3,790,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1103,789,893 - 3,798,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl103,789,893 - 3,796,379 (-)Ensemblpanpan1.1panPan2
KLF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,654,142 - 31,664,009 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,654,175 - 31,662,351 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha228,683,538 - 28,693,072 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,036,878 - 32,046,413 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,036,907 - 32,046,041 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1229,123,207 - 29,131,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0229,962,128 - 29,971,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0230,688,899 - 30,698,432 (+)NCBIUU_Cfam_GSD_1.0
Klf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934434,305,208 - 34,311,507 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648410,470,332 - 10,478,119 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648410,470,384 - 10,476,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1066,488,391 - 66,497,844 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11066,488,445 - 66,497,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21072,992,298 - 73,001,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.193,872,376 - 3,881,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl93,875,356 - 3,881,229 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660519,015,716 - 9,024,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247961,531,910 - 1,539,970 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247961,531,934 - 1,539,728 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in KLF6
31 total Variants

1 to 10 of 74 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_001300.6(KLF6):c.346T>C (p.Ser116Pro) single nucleotide variant Prostate cancer, somatic [RCV000008005] Chr10:3781971 [GRCh38]
Chr10:3824163 [GRCh37]
Chr10:10p15.2
pathogenic|other
NM_001300.6(KLF6):c.410C>A (p.Ser137Ter) single nucleotide variant Prostate cancer, somatic [RCV000008006] Chr10:3781907 [GRCh38]
Chr10:3824099 [GRCh37]
Chr10:10p15.2
pathogenic|other
NM_001300.6(KLF6):c.368C>A (p.Ala123Asp) single nucleotide variant Prostate cancer, somatic [RCV000008007] Chr10:3781949 [GRCh38]
Chr10:3824141 [GRCh37]
Chr10:10p15.2
pathogenic|other
NM_001300.6(KLF6):c.190T>C (p.Trp64Arg) single nucleotide variant Prostate cancer, somatic [RCV000008008] Chr10:3782127 [GRCh38]
Chr10:3824319 [GRCh37]
Chr10:10p15.2
pathogenic|other
NM_001300.6(KLF6):c.506T>C (p.Leu169Pro) single nucleotide variant Prostate cancer, somatic [RCV000008009] Chr10:3781811 [GRCh38]
Chr10:3824003 [GRCh37]
Chr10:10p15.2
pathogenic|other
NM_001300.6(KLF6):c.465C>A (p.Ser155Arg) single nucleotide variant Gastric cancer [RCV000008010] Chr10:3781852 [GRCh38]
Chr10:3824044 [GRCh37]
Chr10:10p15.2
pathogenic|other
GRCh38/hg38 10p15.3-14(chr10:90421-6769994)x3 copy number gain See cases [RCV000051132] Chr10:90421..6769994 [GRCh38]
Chr10:224406..6811956 [GRCh37]
Chr10:126361..6851962 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-8442783)x3 copy number gain See cases [RCV000051107] Chr10:90421..8442783 [GRCh38]
Chr10:224406..8484746 [GRCh37]
Chr10:126361..8524752 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-15.1(chr10:69260-6209368)x1 copy number loss See cases [RCV000052493] Chr10:69260..6209368 [GRCh38]
Chr10:224406..6251331 [GRCh37]
Chr10:105200..6291337 [NCBI36]
Chr10:10p15.3-15.1
pathogenic
GRCh38/hg38 10p15.3-13(chr10:90421-15569528)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|See cases [RCV000052496] Chr10:90421..15569528 [GRCh38]
Chr10:224406..15611527 [GRCh37]
Chr10:126361..15651533 [NCBI36]
Chr10:10p15.3-13
pathogenic
1 to 10 of 74 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR181A2hsa-miR-181a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22581522
MIR181A2hsa-miR-181a-5pOncomiRDBexternal_infoNANA22581522
MIR181A1hsa-miR-181a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22581522
MIR181A1hsa-miR-181a-5pOncomiRDBexternal_infoNANA22581522

Predicted Target Of
Summary Value
Count of predictions:4748
Count of miRNA genes:1231
Interacting mature miRNAs:1563
Transcripts:ENST00000173785, ENST00000380946, ENST00000461124, ENST00000469435, ENST00000492125, ENST00000497571, ENST00000542957
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597076292GWAS1172366_Hheel bone mineral density QTL GWAS1172366 (human)1e-09heel bone mineral densitybone mineral density (CMO:0001226)1037809503780951Human
597324110GWAS1420184_Hschizophrenia QTL GWAS1420184 (human)5e-14schizophrenia1037793693779370Human
597095299GWAS1191373_Hschizophrenia QTL GWAS1191373 (human)0.000002schizophrenia1037793693779370Human
597081790GWAS1177864_Hmonocyte count QTL GWAS1177864 (human)3e-12monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)1037793693779370Human
407059402GWAS708378_Hheel bone mineral density QTL GWAS708378 (human)4e-19heel bone mineral densitybone mineral density (CMO:0001226)1037785953778596Human
597032956GWAS1129030_Hbalding measurement QTL GWAS1129030 (human)1e-08hair amount (VT:0000416)coat/hair morphological measurement (CMO:0001807)1037839593783960Human
597043356GWAS1139430_Hschizophrenia QTL GWAS1139430 (human)2e-09schizophrenia1037775223777523Human
597085676GWAS1181750_Hmonocyte count QTL GWAS1181750 (human)1e-13monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)1037793693779370Human
597089768GWAS1185842_Hmonocyte count QTL GWAS1185842 (human)2e-14monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)1037793693779370Human
597077417GWAS1173491_Hheel bone mineral density QTL GWAS1173491 (human)2e-10heel bone mineral densitybone mineral density (CMO:0001226)1037809503780951Human

1 to 10 of 11 rows
RH48829  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37103,821,077 - 3,821,205UniSTSGRCh37
Build 36103,811,077 - 3,811,205RGDNCBI36
Celera103,765,955 - 3,766,083RGD
Cytogenetic Map10p15UniSTS
HuRef103,757,639 - 3,757,767UniSTS
GeneMap99-GB4 RH Map1039.82UniSTS
NCBI RH Map10103.9UniSTS
G62122  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37103,821,519 - 3,821,638UniSTSGRCh37
Build 36103,811,519 - 3,811,638RGDNCBI36
Celera103,766,397 - 3,766,516RGD
Cytogenetic Map10p15UniSTS
HuRef103,758,081 - 3,758,200UniSTS
WI-12084  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37103,821,275 - 3,821,415UniSTSGRCh37
Build 36103,811,275 - 3,811,415RGDNCBI36
Celera103,766,153 - 3,766,293RGD
Cytogenetic Map10p15UniSTS
HuRef103,757,837 - 3,757,977UniSTS
GeneMap99-GB4 RH Map1039.82UniSTS
Whitehead-RH Map1039.0UniSTS
NCBI RH Map10103.9UniSTS
D10S1368E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37103,819,344 - 3,819,445UniSTSGRCh37
Build 36103,809,344 - 3,809,445RGDNCBI36
Celera103,764,222 - 3,764,323RGD
Cytogenetic Map10p15UniSTS
HuRef103,755,906 - 3,756,007UniSTS
GeneMap99-GB4 RH Map1038.19UniSTS
NCBI RH Map10103.9UniSTS
D10S2364  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37103,819,191 - 3,819,288UniSTSGRCh37
Build 36103,809,191 - 3,809,288RGDNCBI36
Celera103,764,068 - 3,764,165RGD
Cytogenetic Map10p15UniSTS
HuRef103,755,752 - 3,755,849UniSTS
Stanford-G3 RH Map10117.0UniSTS
NCBI RH Map1081.8UniSTS
GeneMap99-G3 RH Map10117.0UniSTS
STS-AA018922  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37103,823,873 - 3,824,114UniSTSGRCh37
Build 36103,813,873 - 3,814,114RGDNCBI36
Celera103,768,751 - 3,768,992RGD
Cytogenetic Map10p15UniSTS
HuRef103,760,430 - 3,760,671UniSTS
GeneMap99-GB4 RH Map1039.82UniSTS
NCBI RH Map10103.9UniSTS
COPEB_2513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37103,821,100 - 3,821,710UniSTSGRCh37
Build 36103,811,100 - 3,811,710RGDNCBI36
Celera103,765,978 - 3,766,588RGD
HuRef103,757,662 - 3,758,272UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2435 2788 2247 4954 1724 2351 5 622 1950 465 2269 7297 6465 53 3716 852 1740 1617 175 1


1 to 30 of 32 rows
RefSeq Transcripts NG_012277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001160124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001160125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB017493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF001461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF284036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI355637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL450322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL513303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM544849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM695496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP357332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ017028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD742988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR975091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR994352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ619623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI573934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI573936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 32 rows

Ensembl Acc Id: ENST00000173785
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl103,779,047 - 3,782,051 (-)Ensembl
Ensembl Acc Id: ENST00000380946
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl103,781,808 - 3,785,183 (-)Ensembl
Ensembl Acc Id: ENST00000461124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl103,775,996 - 3,780,217 (-)Ensembl
Ensembl Acc Id: ENST00000469435   ⟹   ENSP00000419079
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl103,780,327 - 3,785,193 (-)Ensembl
Ensembl Acc Id: ENST00000492125
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl103,779,550 - 3,780,496 (-)Ensembl
Ensembl Acc Id: ENST00000497571   ⟹   ENSP00000419923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl103,775,996 - 3,785,209 (-)Ensembl
Ensembl Acc Id: ENST00000542957   ⟹   ENSP00000445301
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl103,775,997 - 3,785,281 (-)Ensembl
RefSeq Acc Id: NM_001160124   ⟹   NP_001153596
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38103,775,996 - 3,785,209 (-)NCBI
GRCh37103,818,188 - 3,827,473 (-)ENTREZGENE
HuRef103,754,750 - 3,764,030 (-)ENTREZGENE
CHM1_1103,818,788 - 3,828,068 (-)NCBI
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001160125   ⟹   NP_001153597
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38103,775,996 - 3,785,209 (-)NCBI
GRCh37103,818,188 - 3,827,473 (-)ENTREZGENE
HuRef103,754,750 - 3,764,030 (-)ENTREZGENE
CHM1_1103,818,788 - 3,828,068 (-)NCBI
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001300   ⟹   NP_001291
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38103,775,996 - 3,785,209 (-)NCBI
GRCh37103,818,188 - 3,827,473 (-)ENTREZGENE
Build 36103,811,234 - 3,817,455 (-)NCBI Archive
HuRef103,754,750 - 3,764,030 (-)ENTREZGENE
CHM1_1103,818,788 - 3,828,068 (-)NCBI
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBI
Sequence:
RefSeq Acc Id: NR_027653
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38103,775,996 - 3,785,209 (-)NCBI
GRCh37103,818,188 - 3,827,473 (-)ENTREZGENE
HuRef103,754,750 - 3,764,030 (-)ENTREZGENE
CHM1_1103,818,788 - 3,828,068 (-)NCBI
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001153596   ⟸   NM_001160124
- Peptide Label: isoform B
- UniProtKB: D3GC14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153597   ⟸   NM_001160125
- Peptide Label: isoform C
- UniProtKB: Q99612 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001291   ⟸   NM_001300
- Peptide Label: isoform A
- UniProtKB: Q5VUT8 (UniProtKB/Swiss-Prot),   Q5VUT7 (UniProtKB/Swiss-Prot),   F5H3M5 (UniProtKB/Swiss-Prot),   D3DRR1 (UniProtKB/Swiss-Prot),   B4DDN0 (UniProtKB/Swiss-Prot),   B2RE86 (UniProtKB/Swiss-Prot),   Q9BT79 (UniProtKB/Swiss-Prot),   Q99612 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000445301   ⟸   ENST00000542957
Ensembl Acc Id: ENSP00000419079   ⟸   ENST00000469435
C2H2-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q99612-F1-model_v2 AlphaFold Q99612 1-283 view protein structure

RGD ID:7216875
Promoter ID:EPDNEW_H14184
Type:initiation region
Name:KLF6_1
Description:Kruppel like factor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38103,785,209 - 3,785,269EPDNEW
RGD ID:6815824
Promoter ID:HG_SPT:6431
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:AI355637,   BE617725,   CD742988
Position:
Human AssemblyChrPosition (strand)Source
Build 36103,807,661 - 3,808,412 (+)MPROMDB
RGD ID:6787837
Promoter ID:HG_KWN:8388
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000046499,   OTTHUMT00000046500
Position:
Human AssemblyChrPosition (strand)Source
Build 36103,812,426 - 3,813,627 (-)MPROMDB
RGD ID:6787834
Promoter ID:HG_KWN:8389
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000046498
Position:
Human AssemblyChrPosition (strand)Source
Build 36103,813,786 - 3,815,217 (-)MPROMDB
RGD ID:6787833
Promoter ID:HG_KWN:8390
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000322510,   NM_001160124,   NM_001160125,   NR_027653,   OTTHUMT00000046495,   OTTHUMT00000046497,   UC001IHB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36103,817,061 - 3,818,277 (-)MPROMDB
RGD ID:6851684
Promoter ID:EP73644
Type:initiation region
Name:HS_COPEB
Description:Core promoter element binding protein.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36103,817,401 - 3,817,461EPD


1 to 40 of 41 rows
Database
Acc Id
Source(s)
COSMIC KLF6 COSMIC
Ensembl Genes ENSG00000067082 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000469435.1 UniProtKB/Swiss-Prot
  ENST00000497571 ENTREZGENE
  ENST00000497571.6 UniProtKB/Swiss-Prot
  ENST00000542957 ENTREZGENE
  ENST00000542957.1 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000067082 GTEx
HGNC ID HGNC:2235 ENTREZGENE
Human Proteome Map KLF6 Human Proteome Map
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report hsa:1316 UniProtKB/Swiss-Prot
NCBI Gene 1316 ENTREZGENE
OMIM 602053 OMIM
PANTHER KRUEPPEL-LIKE FACTOR 6 UniProtKB/Swiss-Prot
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PharmGKB PA26751 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt B2RE86 ENTREZGENE
  B4DDN0 ENTREZGENE
  D3DRR1 ENTREZGENE
  D3GC14 ENTREZGENE, UniProtKB/TrEMBL
  F5H3M5 ENTREZGENE
  KLF6_HUMAN UniProtKB/Swiss-Prot
  Q5VUT7 ENTREZGENE
  Q5VUT8 ENTREZGENE
  Q99612 ENTREZGENE
  Q9BT79 ENTREZGENE
UniProt Secondary B2RE86 UniProtKB/Swiss-Prot
  B4DDN0 UniProtKB/Swiss-Prot
  D3DRR1 UniProtKB/Swiss-Prot
  F5H3M5 UniProtKB/Swiss-Prot
  Q5VUT7 UniProtKB/Swiss-Prot
  Q5VUT8 UniProtKB/Swiss-Prot
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-11 KLF6  KLF transcription factor 6  KLF6  Kruppel like factor 6  Symbol and/or name change 19259463 PROVISIONAL
2016-06-07 KLF6  Kruppel like factor 6  KLF6  Kruppel-like factor 6  Symbol and/or name change 5135510 APPROVED