KLF6 (KLF transcription factor 6) - Rat Genome Database

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Gene: KLF6 (KLF transcription factor 6) Chlorocebus sabaeus
Analyze
Symbol: KLF6
Name: KLF transcription factor 6
RGD ID: 18660786
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cellular response to cycloheximide (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to organic cyclic compound (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); fibrillar center (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Krueppel-like factor 6; Kruppel like factor 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.193,872,376 - 3,881,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl93,875,356 - 3,881,229 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660519,015,716 - 9,024,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
KLF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.193,872,376 - 3,881,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl93,875,356 - 3,881,229 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660519,015,716 - 9,024,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KLF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38103,775,996 - 3,785,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl103,775,996 - 3,785,281 (-)EnsemblGRCh38hg38GRCh38
GRCh37103,818,188 - 3,827,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36103,811,234 - 3,817,455 (-)NCBINCBI36Build 36hg18NCBI36
Build 34103,811,240 - 3,817,455NCBI
Celera103,763,066 - 3,772,350 (-)NCBICelera
Cytogenetic Map10p15.2NCBI
HuRef103,754,750 - 3,764,030 (-)NCBIHuRef
CHM1_1103,818,788 - 3,828,068 (-)NCBICHM1_1
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBIT2T-CHM13v2.0
Klf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39135,911,488 - 5,920,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl135,911,481 - 5,920,393 (+)EnsemblGRCm39 Ensembl
GRCm38135,861,489 - 5,870,393 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl135,861,482 - 5,870,394 (+)EnsemblGRCm38mm10GRCm38
MGSCv37135,860,735 - 5,869,639 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36135,860,735 - 5,869,639 (+)NCBIMGSCv36mm8
Celera135,806,926 - 5,815,830 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.94NCBI
Klf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81769,449,483 - 69,458,478 (-)NCBIGRCr8
mRatBN7.21764,539,456 - 64,548,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1764,531,463 - 64,588,570 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1768,038,144 - 68,047,153 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,866,987 - 71,875,996 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,913,871 - 65,922,847 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01767,887,939 - 67,945,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1767,887,939 - 67,945,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01769,616,967 - 69,674,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41775,578,498 - 75,585,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11775,589,332 - 75,595,905 (-)NCBI
Celera1764,125,707 - 64,134,702 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Klf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554291,838,537 - 1,846,915 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554291,838,537 - 1,846,915 (+)NCBIChiLan1.0ChiLan1.0
KLF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2816,278,053 - 16,286,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11016,283,374 - 16,292,148 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0103,781,797 - 3,790,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1103,789,893 - 3,798,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl103,789,893 - 3,796,379 (-)Ensemblpanpan1.1panPan2
KLF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,654,142 - 31,664,009 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,654,175 - 31,662,351 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha228,683,538 - 28,693,072 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,036,878 - 32,046,413 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,036,907 - 32,046,041 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1229,123,207 - 29,131,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0229,962,128 - 29,971,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0230,688,899 - 30,698,432 (+)NCBIUU_Cfam_GSD_1.0
Klf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934434,305,208 - 34,311,507 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648410,470,332 - 10,478,119 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648410,470,384 - 10,476,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1066,488,391 - 66,497,844 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11066,488,445 - 66,497,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21072,992,298 - 73,001,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Klf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247961,531,910 - 1,539,970 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247961,531,934 - 1,539,728 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 22 20 15
Low 14 45
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008002114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000012048   ⟹   ENSCSAP00000010097
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl93,875,356 - 3,881,229 (-)Ensembl
RefSeq Acc Id: XM_008002114   ⟹   XP_008000305
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.193,872,376 - 3,881,238 (-)NCBI
Vero_WHO_p1.0NW_0236660519,015,716 - 9,024,467 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008000305 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010097
  ENSCSAP00000010097.1
Reference Protein Sequences
RefSeq Acc Id: XP_008000305   ⟸   XM_008002114
- UniProtKB: A0A0D9RNA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010097   ⟸   ENSCSAT00000012048


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013954 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012048.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report csab:103237791 UniProtKB/TrEMBL
NCBI Gene KLF6 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 6 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0D9RNA8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-12 KLF6  KLF transcription factor 6  KLF6  Kruppel like factor 6  Symbol and/or name change 5135510 APPROVED