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Gene: PRSS21 (serine protease 21) Homo sapiens
Symbol: PRSS21
Name: serine protease 21
Description: This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: eosinophil serine protease 1; ESP-1; ESP1; protease, serine 21; protease, serine, 21 (testisin); serine protease from eosinophils; TEST1; testisin
Mus musculus (house mouse) : Prss21 (protease, serine 21)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prss21 (serine protease 21)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : PRSS21 (serine protease 21)
Sus scrofa (pig) : LOC100737333 (testisin-like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38162,817,163 - 2,821,722 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37162,867,164 - 2,871,723 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,807,165 - 2,811,721 (+)NCBINCBI36hg18NCBI36
Build 34162,807,164 - 2,811,717NCBI
Celera163,067,095 - 3,071,651 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef162,833,834 - 2,838,393 (+)NCBIHuRef
CHM1_1162,867,197 - 2,871,755 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRSS21
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344108
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.